{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:12:29Z","timestamp":1773868349785,"version":"3.50.1"},"reference-count":116,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Science and Technology- FCT\/MCTES","award":["UIDB\/04423\/2020"],"award-info":[{"award-number":["UIDB\/04423\/2020"]}]},{"name":"Foundation for Science and Technology- FCT\/MCTES","award":["UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDP\/04423\/2020"]}]},{"name":"Foundation for Science and Technology- FCT\/MCTES","award":["UIDB\/50006\/2020 DOI 10.54499\/UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020 DOI 10.54499\/UIDB\/50006\/2020"]}]},{"name":"Foundation for Science and Technology- FCT\/MCTES","award":["LA\/P\/0008\/2020 DOI 10.54499\/LA\/P\/0008\/2020"],"award-info":[{"award-number":["LA\/P\/0008\/2020 DOI 10.54499\/LA\/P\/0008\/2020"]}]},{"name":"Foundation for Science and Technology- FCT\/MCTES","award":["UIDP\/50006\/2020 DOI 10.54499\/UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020 DOI 10.54499\/UIDP\/50006\/2020"]}]},{"name":"Foundation for Science and Technology- FCT\/MCTES","award":["C644915664-00000026"],"award-info":[{"award-number":["C644915664-00000026"]}]},{"name":"Foundation for Science and Technology- FCT\/MCTES","award":["C644915664-00000026"],"award-info":[{"award-number":["C644915664-00000026"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["UIDB\/04423\/2020"],"award-info":[{"award-number":["UIDB\/04423\/2020"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDP\/04423\/2020"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["UIDB\/50006\/2020 DOI 10.54499\/UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020 DOI 10.54499\/UIDB\/50006\/2020"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["LA\/P\/0008\/2020 DOI 10.54499\/LA\/P\/0008\/2020"],"award-info":[{"award-number":["LA\/P\/0008\/2020 DOI 10.54499\/LA\/P\/0008\/2020"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["UIDP\/50006\/2020 DOI 10.54499\/UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020 DOI 10.54499\/UIDP\/50006\/2020"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["C644915664-00000026"],"award-info":[{"award-number":["C644915664-00000026"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["C644915664-00000026"],"award-info":[{"award-number":["C644915664-00000026"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["UIDB\/04423\/2020"],"award-info":[{"award-number":["UIDB\/04423\/2020"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDP\/04423\/2020"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["UIDB\/50006\/2020 DOI 10.54499\/UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020 DOI 10.54499\/UIDB\/50006\/2020"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["LA\/P\/0008\/2020 DOI 10.54499\/LA\/P\/0008\/2020"],"award-info":[{"award-number":["LA\/P\/0008\/2020 DOI 10.54499\/LA\/P\/0008\/2020"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["UIDP\/50006\/2020 DOI 10.54499\/UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020 DOI 10.54499\/UIDP\/50006\/2020"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["C644915664-00000026"],"award-info":[{"award-number":["C644915664-00000026"]}]},{"name":"PRR, The Portuguese Republic, and the European Union","award":["C644915664-00000026"],"award-info":[{"award-number":["C644915664-00000026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Neurodegenerative diseases are linked to the process of neurodegeneration. This can be caused by several mechanisms, including inflammation and accumulation of reactive oxygen species. Despite their high incidence, there is still no effective treatment or cure for these diseases. Cyanobacteria have been seen as a possible source for new compounds with anti-inflammatory and antioxidant potential, such as polysaccharides (sacran), phycobiliproteins (phycocyanin) and lipopeptides (honaucins and malyngamides), which can be interesting to combat neurodegeneration. As a promising case of success, Arthrospira (formerly Spirulina) has revealed a high potential for preventing neurodegeneration. Additionally, advantageous culture conditions and sustainable production of cyanobacteria, which are allied to the development of genetic, metabolic, and biochemical engineering, are promising. The aim of this review is to compile and highlight research on the anti-inflammatory and antioxidant potential of cyanobacteria with focus on the application as neuroprotective agents. Also, a major goal is to address essential features that brand cyanobacteria as an ecoefficient and economically viable option, linking health to sustainability.<\/jats:p>","DOI":"10.3390\/molecules29204799","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T11:34:36Z","timestamp":1728560076000},"page":"4799","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Neuroprotective Role of Cyanobacteria with Focus on the Anti-Inflammatory and Antioxidant Potential: Current Status and Perspectives"],"prefix":"10.3390","volume":"29","author":[{"given":"Fl\u00e1via","family":"Rodrigues","sequence":"first","affiliation":[{"name":"School of Health, Polytechnic Institute of Porto (E2S\/P.PORTO), Rua Dr. Ant\u00f3nio Bernardino de Almeida, 400, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8737-2138","authenticated-orcid":false,"given":"Mariana","family":"Reis","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research, University of Porto (CIIMAR\/CIMAR), Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos s\/n, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2337-3152","authenticated-orcid":false,"given":"Leonor","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research, University of Porto (CIIMAR\/CIMAR), Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos s\/n, 4450-208 Matosinhos, Portugal"},{"name":"Department of Biology, Faculty of Sciences, University of Porto (FCUP), Rua do Campo Alegre, Edif\u00edcio FC4, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2457-8267","authenticated-orcid":false,"given":"Clara","family":"Grosso","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, School of Engineering, Polytechnic Institute of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1761-117X","authenticated-orcid":false,"given":"Ricardo","family":"Ferraz","sequence":"additional","affiliation":[{"name":"School of Health, Polytechnic Institute of Porto (E2S\/P.PORTO), Rua Dr. Ant\u00f3nio Bernardino de Almeida, 400, 4200-072 Porto, Portugal"},{"name":"Center for Translational Health and Medical Biotechnology Research (TBIO\/Health Research Network (RISE-Health), E2S\/P.PORTO), Rua Dr. Ant\u00f3nio Bernardino de Almeida, 400, 4200-072 Porto, Portugal"},{"name":"LAQV\/REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculty of Sciences, University of Porto (FCUP), 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8687-4811","authenticated-orcid":false,"given":"M\u00f3nica","family":"Vieira","sequence":"additional","affiliation":[{"name":"School of Health, Polytechnic Institute of Porto (E2S\/P.PORTO), Rua Dr. Ant\u00f3nio Bernardino de Almeida, 400, 4200-072 Porto, Portugal"},{"name":"Center for Translational Health and Medical Biotechnology Research (TBIO\/Health Research Network (RISE-Health), E2S\/P.PORTO), Rua Dr. Ant\u00f3nio Bernardino de Almeida, 400, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-2417","authenticated-orcid":false,"given":"Vitor","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre of Marine and Environmental Research, University of Porto (CIIMAR\/CIMAR), Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos s\/n, 4450-208 Matosinhos, Portugal"},{"name":"Department of Biology, Faculty of Sciences, University of Porto (FCUP), Rua do Campo Alegre, Edif\u00edcio FC4, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-4651","authenticated-orcid":false,"given":"Ros\u00e1rio","family":"Martins","sequence":"additional","affiliation":[{"name":"School of Health, Polytechnic Institute of Porto (E2S\/P.PORTO), Rua Dr. Ant\u00f3nio Bernardino de Almeida, 400, 4200-072 Porto, Portugal"},{"name":"Interdisciplinary Centre of Marine and Environmental Research, University of Porto (CIIMAR\/CIMAR), Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos s\/n, 4450-208 Matosinhos, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dugger, B.N., and Dickson, D.W. (2017). Pathology of Neurodegenerative Diseases. Cold Spring Harb. Perspect. 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