{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:25:35Z","timestamp":1767835535028,"version":"3.49.0"},"reference-count":51,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ag\u00eancia para o Investimento e Com\u00e9rcio Externo de Portugal, E.P.E. (AICEP)","award":["POCI\u201301\u20130247\u2013FEDER\u2013027578"],"award-info":[{"award-number":["POCI\u201301\u20130247\u2013FEDER\u2013027578"]}]},{"name":"Amyris Inc.","award":["POCI\u201301\u20130247\u2013FEDER\u2013027578"],"award-info":[{"award-number":["POCI\u201301\u20130247\u2013FEDER\u2013027578"]}]},{"name":"Ra\u00edzen","award":["POCI\u201301\u20130247\u2013FEDER\u2013027578"],"award-info":[{"award-number":["POCI\u201301\u20130247\u2013FEDER\u2013027578"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Sugarcane is a popular crop whose cultivation generates a wide range of by-products. The aim was to optimize the hydrothermal extraction of hemicellulose from sugarcane straw using response-surface methods with a two-factor composite design and to assess its functional qualities. Three process parameters were subject to optimization: solid\/liquid ratio (1:6\u20131:18), temperature (143\u2013186 \u00b0C), and extraction time (20\u201360 min). A xylooligosaccharide (XOS)-enriched extract was characterized regarding its chemical composition, molecular weight, and antioxidant and antimicrobial potential. The optimized extraction yield was 24.46 g\/100 g of straw with a polymerization degree of 17.40. Both hemicellulose and XOS demonstrated notable antioxidant properties, with antioxidant effects of 73% and 85%, respectively. Regarding skin enzyme activity, hemicellulose inhibited elastase by more than 50%, while XOS showed no significant effect. However, both extracts exhibited collagenase (MMP1) inhibition comparable to the positive control. In terms of production feasibility, the estimated costs were 130.5 EUR\/kg for hemicellulose and 272.5 EUR\/kg for XOS. Overall, the optimized XOS-enriched sugarcane straw extract demonstrated promising anti-aging, antioxidant, and preservative properties, highlighting its potential for cosmetic applications.<\/jats:p>","DOI":"10.3390\/molecules30061208","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:22:52Z","timestamp":1741350172000},"page":"1208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sugarcane Straw Hemicellulose Extraction by Autohydrolysis for Cosmetic Applications"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-2534","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Pereira","sequence":"first","affiliation":[{"name":"CBQF\u2013Centro de Biotecnologia e Qu\u00edmica Fina\u2013Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua de Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2055-8031","authenticated-orcid":false,"given":"S\u00edlvia S.","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"CBQF\u2013Centro de Biotecnologia e Qu\u00edmica Fina\u2013Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua de Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"given":"Joana R.","family":"Costa","sequence":"additional","affiliation":[{"name":"CBQF\u2013Centro de Biotecnologia e Qu\u00edmica Fina\u2013Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua de Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"given":"Maria Jo\u00e3o","family":"Carvalho","sequence":"additional","affiliation":[{"name":"CBQF\u2013Centro de Biotecnologia e Qu\u00edmica Fina\u2013Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua de Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"given":"T\u00e2nia","family":"Neto","sequence":"additional","affiliation":[{"name":"CBQF\u2013Centro de Biotecnologia e Qu\u00edmica Fina\u2013Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua de Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-1032","authenticated-orcid":false,"given":"Ana L.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"CBQF\u2013Centro de Biotecnologia e Qu\u00edmica Fina\u2013Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua de Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0760-3184","authenticated-orcid":false,"given":"Manuela","family":"Pintado","sequence":"additional","affiliation":[{"name":"CBQF\u2013Centro de Biotecnologia e Qu\u00edmica Fina\u2013Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua de Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"given":"Ana Raquel","family":"Madureira","sequence":"additional","affiliation":[{"name":"CBQF\u2013Centro de Biotecnologia e Qu\u00edmica Fina\u2013Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua de Diogo Botelho 1327, 4169-005 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113274","DOI":"10.1016\/j.indcrop.2021.113274","article-title":"Circular Bioeconomy and Integrated Biorefinery in the Production of Xylooligosaccharides from Lignocellulosic Biomass: A Review","volume":"162","author":"Nabarlatz","year":"2021","journal-title":"Ind. Crops Prod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.biortech.2017.07.080","article-title":"Sugars and Char Formation on Subcritical Water Hydrolysis of Sugarcane Straw","volume":"243","author":"Tompsett","year":"2017","journal-title":"Bioresour. Technol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.carbpol.2014.07.052","article-title":"Sugarcane Biomass for Biorefineries: Comparative Composition of Carbohydrate and Non-Carbohydrate Components of Bagasse and Straw","volume":"114","author":"Szczerbowski","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Brenelli, L.B., Bhatia, R., Djajadi, D.T., Thygesen, L.G., Rabelo, S.C., Leak, D.J., Franco, T.T., and Gallagher, J.A. (2022). Xylo-Oligosaccharides, Fermentable Sugars, and Bioenergy Production from Sugarcane Straw Using Steam Explosion Pretreatment at Pilot-Scale. Bioresour. Technol., 357.","DOI":"10.1016\/j.biortech.2022.127093"},{"key":"ref_5","unstructured":"(2023, December 07). Conab-P\u00e1gina Inicial, Available online: https:\/\/www.conab.gov.br\/."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Aguiar, A., Milessi, T.S., Mulinari, D.R., Lopes, M.S., da Costa, S.M., and Candido, R.G. (2021). Sugarcane Straw as a Potential Second Generation Feedstock for Biorefinery and White Biotechnology Applications. Biomass Bioenergy, 144.","DOI":"10.1016\/j.biombioe.2020.105896"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.biortech.2011.09.139","article-title":"Effect of Alkaline and Autohydrolysis Processes on the Purity of Obtained Hemicelluloses from Corn Stalks","volume":"103","author":"Sanchez","year":"2012","journal-title":"Bioresour. Technol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Scapini, T., dos Santos, M.S.N., Bonatto, C., Wancura, J.H.C., Mulinari, J., Camargo, A.F., Klanovicz, N., Zabot, G.L., Tres, M.V., and Fongaro, G. (2021). Hydrothermal Pretreatment of Lignocellulosic Biomass for Hemicellulose Recovery. Bioresour. Technol., 342.","DOI":"10.1016\/j.biortech.2021.126033"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"119050","DOI":"10.1016\/j.carbpol.2021.119050","article-title":"Effects of Hydrothermal Pretreatment on the Dissolution and Structural Evolution of Hemicelluloses and Lignin: A Review","volume":"281","author":"Sun","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"128332","DOI":"10.1016\/j.jclepro.2021.128332","article-title":"Developing a Sustainable Bioprocess for the Cleaner Production of Xylooligosaccharides: An Approach towards Lignocellulosic Waste Management","volume":"316","author":"Kumar","year":"2021","journal-title":"J. Clean. Prod."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Valladares-Diestra, K.K., Porto de Souza Vandenberghe, L., and Soccol, C.R. (2021). A Biorefinery Approach for Enzymatic Complex Production for the Synthesis of Xylooligosaccharides from Sugarcane Bagasse. Bioresour. Technol., 333.","DOI":"10.1016\/j.biortech.2021.125174"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.15673\/fst.v11i3.606","article-title":"Xylooligosaccharides from Agricultural By-Products: Characterization, Production and Physiological Effects","volume":"11","author":"Kaprelyants","year":"2017","journal-title":"Food Sci. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.carres.2012.07.017","article-title":"The Potential for Oligosaccharide Production from the Hemicellulose Fraction of Biomasses through Pretreatment Processes: Xylooligosaccharides (XOS), Arabinooligosaccharides (AOS), and Mannooligosaccharides (MOS)","volume":"360","author":"Otieno","year":"2012","journal-title":"Carbohydr. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.carbpol.2018.04.010","article-title":"Effect of Autohydrolysis on Pinus Radiata Wood for Hemicellulose Extraction","volume":"194","author":"Santos","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.biortech.2006.07.049","article-title":"Autohydrolysis of Agricultural Residues: Study of Reaction Byproducts","volume":"98","author":"Garrote","year":"2007","journal-title":"Bioresour. Technol."},{"key":"ref_16","unstructured":"Mochane, M.J. (2017). Sugarcane Bagasse and Cellulose Polymer Composites, IntechOpen. Chapter 12."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Costa, J.R., Pereira, M.J., Pedrosa, S.S., Gull\u00f3n, B., de Carvalho, N.M., Pintado, M.E., and Madureira, A.R. (2023). Sugarcane Straw as a Source of Arabinoxylans: Optimization and Economic Viability of a Two-Step Alkaline Extraction. Foods, 12.","DOI":"10.3390\/foods12122280"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12155-018-9941-0","article-title":"Key Factors Affecting the Recalcitrance and Conversion Process of Biomass","volume":"12","author":"Melati","year":"2019","journal-title":"BioEnergy Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/jctb.2518","article-title":"Evaluation of a Hydrothermal Process for Pretreatment of Wheat Straw-Effect of Particle Size and Process Conditions","volume":"86","author":"Ruiz","year":"2011","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0032-9592(00)00253-3","article-title":"Kinetic Modelling of Corncob Autohydrolysis","volume":"36","author":"Garrote","year":"2001","journal-title":"Process biochemistry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6676","DOI":"10.1016\/j.biortech.2010.03.080","article-title":"Production of Oligosaccharides and Sugars from Rye Straw: A Kinetic Approach","volume":"101","author":"Alonso","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1021\/jf040456q","article-title":"Extraction and Characterization of Original Lignin and Hemicelluloses from Wheat Straw","volume":"53","author":"Sun","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.carbpol.2012.11.054","article-title":"Biorefinery Valorization of Autohydrolysis Wheat Straw Hemicellulose to Be Applied in a Polymer-Blend Film","volume":"92","author":"Ruiz","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.1021\/jf900986b","article-title":"Comparative Study of Hemicelluloses Obtained by Graded Ethanol Precipitation from Sugarcane Bagasse","volume":"57","author":"Peng","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1021\/ie051051d","article-title":"Removal of Lignin and Associated Impurities from Xylo-Oligosaccharides by Activated Carbon Adsorption","volume":"45","author":"Nabarlatz","year":"2006","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_26","unstructured":"Riley, G.L. (2016). Sugarcane Bagasse Hemicellulose Properties, Extraction Technologies and Xylooligosaccharides Production. Food Waste, Nova Science Publishers, Inc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.ijbiomac.2020.12.175","article-title":"Cellulosic and Hemicellulosic Fractions of Sugarcane Bagasse: Potential, Challenges and Future Perspective","volume":"169","author":"Alokika","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.indcrop.2013.12.005","article-title":"Simultaneous Production of Xylooligosaccharides and Antioxidant Compounds from Sugarcane Bagasse via Enzymatic Hydrolysis","volume":"52","author":"Mandelli","year":"2014","journal-title":"Ind. Crops. Prod."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0144-8617(02)00045-0","article-title":"Hydrothermally Treated Xylan Rich By-Products Yield Different Classes of Xylo-Oligosaccharides","volume":"50","author":"Kabel","year":"2002","journal-title":"Carbohydr. Polym."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.indcrop.2015.04.021","article-title":"Assessment of Chemical Transformations in Eucalyptus, Sugarcane Bagasse and Straw during Hydrothermal, Dilute Acid, and Alkaline Pretreatments","volume":"73","author":"Sevastyanova","year":"2015","journal-title":"Ind. Crops. Prod."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kumar, N., and Goel, N. (2019). Phenolic Acids: Natural Versatile Molecules with Promising Therapeutic Applications. Biotechnol. Rep., 24.","DOI":"10.1016\/j.btre.2019.e00370"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Gomez-Molina, M., Albaladejo-Marico, L., Yepes-Molina, L., Nicolas-Espinosa, J., Navarro-Le\u00f3n, E., Garcia-Iba\u00f1ez, P., and Carvajal, M. (2024). Exploring Phenolic Compounds in Crop By-Products for Cosmetic Efficacy. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202404.1410.v1"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.foodchem.2014.03.109","article-title":"Phenolic Compounds, Organic Acids and Antioxidant Activity of Grape Juices Produced from New Brazilian Varieties Planted in the Northeast Region of Brazil","volume":"161","author":"Lima","year":"2014","journal-title":"Food Chem."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Panzella, L. (2020). Natural Phenolic Compounds for Health, Food and Cosmetic Applications. Antioxidants, 9.","DOI":"10.3390\/antiox9050427"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1007\/s12649-019-00690-1","article-title":"Spectrophotometric Estimation of Total Phenolic Content and Antioxidant Capacity of Molasses and Vinasses Generated from the Sugarcane Industry","volume":"11","author":"Quimbaya","year":"2020","journal-title":"Waste Biomass Valorization"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Oliveira, A.L.S., Carvalho, M.J., Oliveira, D.L., Costa, E., Pintado, M., and Madureira, A.R. (2022). Sugarcane Straw Polyphenols as Potential Food and Nutraceutical Ingredient. Foods, 11.","DOI":"10.3390\/foods11244025"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s12010-014-1308-1","article-title":"Biological Activities of Xylooligosaccharides Generated from Garlic Straw Xylan by Purified Xylanase from Bacillus Mojavensis UEB-FK","volume":"175","author":"Kallel","year":"2015","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.foodchem.2015.03.120","article-title":"The Antibiotic Activity and Mechanisms of Sugarcane (Saccharum officinarum L.) Bagasse Extract against Food-Borne Pathogens","volume":"185","author":"Zhao","year":"2015","journal-title":"Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Bratcher, D.F. (2008). Other Corynebacteria. Principles and Practice of Pediatric Infectious Disease, Elsevier. [3rd ed.].","DOI":"10.1016\/B978-0-7020-3468-8.50137-1"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Yang, X. (2014). Moraxellaceae. Encyclopedia of Food Microbiology, Elsevier. [2nd ed.].","DOI":"10.1016\/B978-0-12-384730-0.00441-9"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Prieto-Granada, C.N., Lobo, A.Z.C., and Mihm, M.C. (2010). Skin Infections. Diagnostic Pathology of Infectious Disease, Elsevier.","DOI":"10.1016\/B978-1-4160-3429-2.00019-5"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Fourni\u00e8re, M., Latire, T., Souak, D., Feuilloley, M.G.J., and Bedoux, G. (2020). Staphylococcus Epidermidis and Cutibacterium Acnes: Two Major Sentinels of Skin Microbiota and the Influence of Cosmetics. Microorganisms, 8.","DOI":"10.3390\/microorganisms8111752"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"113625","DOI":"10.1016\/j.indcrop.2021.113625","article-title":"Potential of Sugarcane Extracts as Cosmetic and Skincare Ingredients","volume":"169","author":"Carvalho","year":"2021","journal-title":"Ind. Crops. Prod."},{"key":"ref_44","first-page":"1","article-title":"Determination of Structural Carbohydrates and Lignin in Biomass","volume":"1617","author":"Sluiter","year":"2008","journal-title":"Lab. Anal. Proced. LAP"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.biortech.2016.03.153","article-title":"Assessment of Suitability of Vine Shoots for Hemicellulosic Oligosaccharides Production through Aqueous Processing","volume":"211","author":"Gordobil","year":"2016","journal-title":"Bioresour. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Pablo, G., Gull\u00f3n, B., P\u00e9rez-P\u00e9rez, A., Roman\u00ed, A., and Garrote, G. (2021). Microwave Hydrothermal Processing of the Invasive Macroalgae Sargassum Muticum within a Green Biorefinery Scheme. Bioresour. Technol., 340.","DOI":"10.1016\/j.biortech.2021.125733"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1021\/jf8020199","article-title":"Effects of Elevated CO2 on Grapevine (Vitis vinifera L.): Volatile Composition, Phenolic Content, and in Vitro Antioxidant Activity of Red Wine","volume":"57","author":"Falco","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_48","first-page":"M7-A7","article-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically: Approved Standard","volume":"26","author":"Wikler","year":"2006","journal-title":"Clsi Nccls"},{"key":"ref_49","unstructured":"Hecht, D.W., Citron, D.M., Dzink-Fox, J., Gregory, W.W., Jacobus, N.V., Jenkins, S.G., Rosenblatt, J.E., Schuetz, A.N., and Wexler, H. (2012). M11-A8 Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria; Approved Standard-Eighth Edition, Clinical and Laboratory Standards Institute. Number 5."},{"key":"ref_50","unstructured":"Pfaller, M.A., and National Committee for Clinical Laboratory Standards (2002). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts: Approved Standard, National Committee for Clinical Laboratory Standards."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"106175","DOI":"10.1016\/j.jece.2021.106175","article-title":"Olive Leaf Phenolic Extract from Two Portuguese Cultivars \u2013Bioactivities for Potential Food and Cosmetic Application","volume":"9","author":"Oliveira","year":"2021","journal-title":"J. Environ. Chem. Eng."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/6\/1208\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:49:15Z","timestamp":1760028555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/6\/1208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":51,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["molecules30061208"],"URL":"https:\/\/doi.org\/10.3390\/molecules30061208","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]}}}