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The study analyzed 1299 cosmetic products from 2021 to 2024 to understand the market impact of phenolic compounds and their mechanism of action against photo-induced skin damage. A total of 28 active phenolic compounds were identified and the prevalence of phenolics was 13.2% in anti-aging products, 5.2% in sunscreens and 4.8% in aftersun products. Bakuchiol and polyphenols, such as resveratrol, chrysin, and hesperidin methyl chalcone, were found in anti-aging products. Sunscreens and aftersun products were counted with ferulic and caffeic acids, and salicylic acid, respectively. Antioxidant activity was found to be the primary mechanism of action of phenolic compounds by scavenging reactive species, thus mitigating oxidative stress. Ferulic and caffeic acids, chrysin, and glucosylrutin can also absorb UV radiation, acting preventively against solar-induced skin damage. This study provides insights into the limited use of phenolic compounds in commercial cosmetics, despite their diverse biological activities, and suggests potential barriers to wider use in skin and sun care products.<\/jats:p>","DOI":"10.3390\/molecules30071423","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T04:48:18Z","timestamp":1742791698000},"page":"1423","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Phenolics as Active Ingredients in Skincare Products: A Myth or Reality?"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7425-9750","authenticated-orcid":false,"given":"Ana","family":"Jesus","sequence":"first","affiliation":[{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0128-6532","authenticated-orcid":false,"given":"Smeera","family":"Ratanji","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-1779","authenticated-orcid":false,"given":"Honorina","family":"Cidade","sequence":"additional","affiliation":[{"name":"Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"CIIMAR\u2014Interdisciplinary Centre of Marine and Environmental Research, 4450-208 Matosinhos, Portugal"},{"name":"UNIPRO\u2014Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (CESPU), 4585-116 Gandra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5397-4672","authenticated-orcid":false,"given":"Em\u00edlia","family":"Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"CIIMAR\u2014Interdisciplinary Centre of Marine and Environmental Research, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9846-6754","authenticated-orcid":false,"given":"Maria T.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra, 3004-531 Coimbra, Portugal"},{"name":"CNC\u2014Center for Neuroscience and Cell Biology, 3004-504 Coimbra, Portugal"}]},{"given":"Rita","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"FP-BHS\u2014Biomedical and Health Sciences Research Unit, FFP-I3ID Faculty of Health Sciences, University of Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"RISE\u2014Health, Faculty of Health Sciences, Fernando Pessoa University, Fernando Pessoa Teaching and Culture Foundation, Rua Carlos da Maia 296, 4200-150 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-048X","authenticated-orcid":false,"given":"Isabel F.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,23]]},"reference":[{"key":"ref_1","first-page":"1934578X211069721","article-title":"A Brief Review of Phenolic Compounds Identified from Plants: Their Extraction, Analysis, and Biological Activity","volume":"17","author":"Zhang","year":"2022","journal-title":"Nat. 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