{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:03:29Z","timestamp":1770141809838,"version":"3.49.0"},"reference-count":59,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT\u2014Foundation for Science and Technology and Portuguese National Budget","doi-asserted-by":"publisher","award":["UIDB\/05183 MED"],"award-info":[{"award-number":["UIDB\/05183 MED"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by impaired glucose regulation. This study evaluated the antioxidant and antidiabetic potential of aqueous extracts from four plant species from the southern Algarve: Aristolochia baetica, Chelidonium majus, Dittrichia viscosa, and Lavandula viridis, using non-cellular in vitro assays. HPLC\/PDA was used to identify active compounds. Antioxidant activity was assessed by using TAA, FRAP, RP, and DPPH assays; antidiabetic potential through \u03b1-glucosidase and \u03b1-amylase inhibition; and wound healing relevance through elastase, collagenase, and lipoxygenase inhibition. D. viscosa showed the highest antioxidant activity (FRAP: 1132.99 \u00b1 19.54 mg TE\/g dw; DPPH IC50 = 25.85 \u00b1 0.75 \u03bcg\/mL) and total phenolic\/flavonoid content, with a diverse profile including caffeic and chlorogenic acids, isoquercetin, and quercetin. It also exhibited potent \u03b1-glucosidase inhibition (IC50 = 0.61 \u00b1 0.06 mg\/mL), outperforming acarbose. L. viridis had the highest total phenolic content (39.04 mg\/g), while A. baetica demonstrated the strongest anti-elastase, anti-collagenase, and lipoxygenase activity, suggesting wound-healing potential. C. majus showed the weakest effects. A strong correlation was observed between phenolic content and antioxidant\/antidiabetic activity. These findings support further in vivo studies on D. viscosa and A. baetica for potential use in T2DM management and diabetic wound healing.<\/jats:p>","DOI":"10.3390\/molecules30112432","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T08:34:13Z","timestamp":1748853253000},"page":"2432","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plant-Based Potential in Diabetes Management: In Vitro Antioxidant, Wound-Healing, and Enzyme Inhibitory Activities of Southern Algarve Species"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8057-3404","authenticated-orcid":false,"given":"Isabel S.","family":"Carvalho","sequence":"first","affiliation":[{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development, CHANGE\u2014Global Change and Sustainability Institute, Food Science Laboratory, Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Campus de Gambelas, Ed. 8, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6668-2778","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Viegas","sequence":"additional","affiliation":[{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development, CHANGE\u2014Global Change and Sustainability Institute, Food Science Laboratory, Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Campus de Gambelas, Ed. 8, 8005-139 Faro, Portugal"},{"name":"Center for Marine Sciences (CCMar), Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9338-3677","authenticated-orcid":false,"given":"Marta","family":"Markiewicz","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland"},{"name":"Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, 16 \u0141azarza Str., 31-530 Cracow, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5636-8646","authenticated-orcid":false,"given":"Agnieszka","family":"Galanty","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4821-4492","authenticated-orcid":false,"given":"Pawe\u0142","family":"Pa\u015bko","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1714-6706","authenticated-orcid":false,"given":"Lejsa","family":"Jakupovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy University of Zagreb Faculty of Pharmacy and Biochemistry, Ante Kova\u010di\u0107a 1, 10000 Zagreb, Croatia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8787-6667","authenticated-orcid":false,"given":"Marijana Zovko","family":"Kon\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy University of Zagreb Faculty of Pharmacy and Biochemistry, Ante Kova\u010di\u0107a 1, 10000 Zagreb, Croatia"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.47672\/ejb.409","article-title":"A modern overview on diabetes mellitus: A chronic endocrine disorder","volume":"5","author":"Mukhtar","year":"2020","journal-title":"Eur. 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