{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:56:11Z","timestamp":1767902171786,"version":"3.49.0"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT\/MCTES (Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia and Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior)","award":["UID\/50006\u2014Laborat\u00f3rio Associado para a Qu\u00edmica Verde\u2014Tecnologias e Processos Limpos"],"award-info":[{"award-number":["UID\/50006\u2014Laborat\u00f3rio Associado para a Qu\u00edmica Verde\u2014Tecnologias e Processos Limpos"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>An efficient protocol was developed for the microwave-mediated metallation of 5-(4-methoxycarbonylphenyl)-10,15,20-tris(pentafluorophenyl)porphyrin (P1) with bis(benzonitrile)platinum dichloride salt and subsequent 1,3-dipolar cycloaddition of the resulting PtP1 with an azomethine ylide to give two isomeric metallochlorins: PtC1 (main isomer) and PtC3. The methyl ester group of metalloporphyrin PtP1 and metallochlorin PtC1 was successfully hydrolysed in an alkaline medium to yield the corresponding derivatives PtP2 and PtC2 in moderate-to-good yields. As a proof of concept of the reactivity of the carboxy group in PtP2 and PtC2, these compounds were conjugated with a hydroxylated derivative of indomethacin, a known potent non-steroidal anti-inflammatory, obtaining the conjugates PtP2-Ind and PtC2-Ind. The obtained platinum(II) porphyrins and chlorins were characterized by UV-Vis, NMR spectroscopy and mass spectrometry. The structure of PtP1 was also confirmed by X-ray crystallography. Singlet oxygen generation studies were carried out, as well as theoretical calculations, which demonstrated that the prepared Pt(II) complexes can be considered potential photosensitizers for PDT.<\/jats:p>","DOI":"10.3390\/molecules30122496","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T11:08:31Z","timestamp":1749208111000},"page":"2496","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New Conjugatable Platinum(II) Chlorins: Synthesis, Reactivity and Singlet Oxygen Generation"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2656-6443","authenticated-orcid":false,"given":"Jos\u00e9","family":"Almeida","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade do Porto, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8773-2359","authenticated-orcid":false,"given":"Giampaolo","family":"Barone","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche, Universit\u00e0 di Palermo, Viale delle Scienze, Edificio 17, 90128 Palermo, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9229-1412","authenticated-orcid":false,"given":"Lu\u00eds","family":"Cunha-Silva","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade do Porto, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2306-638X","authenticated-orcid":false,"given":"Ana F. R.","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4331-714X","authenticated-orcid":false,"given":"Augusto C.","family":"Tom\u00e9","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0998-1437","authenticated-orcid":false,"given":"Maria","family":"Rangel","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-1655","authenticated-orcid":false,"given":"Ana M. G.","family":"Silva","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Almeida, J., Silva, A.M.G., and Rangel, M. (2024). Application of Photosensitizers in Photodynamic Diagnosis and Therapy of Cancer. Interdisciplinary Cancer Research, Springer.","DOI":"10.1007\/16833_2024_365"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/phpp.12489","article-title":"Photodynamic Therapy for Solid Tumors: A Review of the Literature","volume":"35","author":"Yanovsky","year":"2019","journal-title":"Photodermatol. Photoimmunol. 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