{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:04:21Z","timestamp":1777518261953,"version":"3.51.4"},"reference-count":267,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UID\/00616\/2025"],"award-info":[{"award-number":["UID\/00616\/2025"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Dietary bioactive compounds derived from plant-based and fermented foods act as plei-otropic modulators of human health, exerting antioxidant, anti-inflammatory, cardiopro-tective, neuroprotective, and metabolic effects beyond basic nutrition. Whole foods (fruits, vegetables, grains, nuts) provide synergistic mixtures of bioactives, whereas fermented foods generate a wide range of microbial-derived metabolites (peptides, organic acids) as well as probiotics that enhance nutrient bioavailability and support gut health. The gut microbiota plays a central mediating role in the biological effects of dietary bioactives through a dynamic, bidirectional interaction: dietary compounds shape microbial composition by promoting beneficial taxa and suppressing pathogens, while microbial metabolism converts these compounds into bioactive metabolites, including short-chain fatty acids, that profoundly influence host health. Despite their demonstrated health potential, the clinical translation of many dietary bioactives is limited by low bioavailability, which is influenced by digestion processes, food matrix and processing conditions, host genetics, and individual microbiota profile. Overcoming these limitations requires a deeper understanding of the synergistic interactions among dietary bioactives, probiotics, microbial metabolites, and host signaling pathways. This review provides an integrated perspective of the sources, mechanisms of action, and health effects of food-derived bioactive compounds and probiotic mediated effects, while highlighting current translational challenges and future directions for the development of effective functional foods and personalized nutrition strategies.<\/jats:p>","DOI":"10.3390\/molecules31020345","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:58:54Z","timestamp":1768834734000},"page":"345","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Probiotic and Bioactive Compounds in Foods: From Antioxidant Properties to Gut Microbiota Modulation"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5764-024X","authenticated-orcid":false,"given":"Berta","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Tr\u00e1s-of-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1615-2418","authenticated-orcid":false,"given":"Alice","family":"Vilela","sequence":"additional","affiliation":[{"name":"Chemistry Research Centre-Vila Real (CQ-VR), University of Tr\u00e1s-of-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6291-8413","authenticated-orcid":false,"given":"Alfredo","family":"Aires","sequence":"additional","affiliation":[{"name":"Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Tr\u00e1s-of-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"}]},{"given":"Ivo","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Tr\u00e1s-of-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-1456","authenticated-orcid":false,"given":"Carla","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Tr\u00e1s-of-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-6741","authenticated-orcid":false,"given":"Teresa","family":"Pinto","sequence":"additional","affiliation":[{"name":"Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Tr\u00e1s-of-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5924-1050","authenticated-orcid":false,"given":"Fernanda","family":"Cosme","sequence":"additional","affiliation":[{"name":"Chemistry Research Centre-Vila Real (CQ-VR), University of Tr\u00e1s-of-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1515\/jcim-2013-0021","article-title":"Phytonutrients as therapeutic agents","volume":"11","author":"Gupta","year":"2014","journal-title":"J. Complement. Integr. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"21138","DOI":"10.3390\/molecules201219753","article-title":"Antioxidant phytochemicals for the prevention and treatment of chronic diseases","volume":"20","author":"Zhang","year":"2015","journal-title":"Molecules"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Nahar, L., Xiao, J., and Sarker, S.D. (2020). Introduction of phytonutrients. Handbook of Dietary Phytochemicals, Springer.","DOI":"10.1007\/978-981-13-1745-3_2-1"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sorrenti, V., Bur\u00f2, I., Consoli, V., and Vanella, L. (2023). Recent advances in health benefits of bioactive compounds from food wastes and by-products: Biochemical aspects. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032019"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100354","DOI":"10.1016\/j.foohum.2024.100354","article-title":"Bioactive compounds of foods: Phytochemicals and peptides","volume":"3","author":"Xavier","year":"2024","journal-title":"Food Humanit."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/gidisord4010005","article-title":"Probiotics and phytochemicals: Role on gut microbiota and efficacy on irritable bowel syndrome, functional dyspepsia, and functional constipation","volume":"4","author":"Bousdouni","year":"2022","journal-title":"Gastrointest. Disord."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Santacroce, L., Bottalico, L., Charitos, I.A., Castellaneta, F., Gaxhja, E., Topi, S., Palmirotta, R., and Jirillo, E. (2024). Exploitation of Natural By-Products for the Promotion of Healthy Outcomes in Humans: Special Focus on Antioxidant and Anti-Inflammatory Mechanisms and Modulation of the Gut Microbiota. Antioxidants, 13.","DOI":"10.3390\/antiox13070796"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Munteanu, C., and Schwartz, B. (2024). Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25158250"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Hsu, C.-N., Lin, Y.-J., Hou, C.-Y., Chen, Y.-W., Chang-Chien, G.-P., Lin, S.-F., and Tain, Y.-L. (2025). Antioxidants, Gut Microbiota, and Cardiovascular Programming: Unraveling a Triad of Early-Life Interactions. Antioxidants, 14.","DOI":"10.3390\/antiox14091049"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev-food-032519-051708","article-title":"Functional foods: Product development, technological trends, efficacy testing, and safety","volume":"11","author":"Granato","year":"2020","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Temple, N.J. (2022). A rational definition for functional foods: A perspective. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.957516"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1007\/s13197-021-05193-3","article-title":"Functional foods and their impact on health","volume":"60","author":"Essa","year":"2023","journal-title":"J. Food Sci. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cofs.2021.06.003","article-title":"Berry polyphenols and human health: Evidence of antioxidant, anti-inflammatory, microbiota modulation, and cell-protecting effects","volume":"42","author":"Pap","year":"2021","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"P., N.P.V., and Joye, I.J. (2020). Dietary Fibre from Whole Grains and Their Benefits on Metabolic Health. Nutrients, 12.","DOI":"10.3390\/nu12103045"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.nutres.2022.02.006","article-title":"Probiotic kefir consumption improves serum apolipoprotein A1 levels in metabolic syndrome patients: A randomized controlled clinical trial","volume":"102","author":"Karagozlu","year":"2022","journal-title":"Nutr. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Bellikci-Koyu, E., Sarer-Yurekli, B.P., Akyon, Y., Aydin-Kose, F., Karagozlu, C., Ozgen, A.G., Brinkmann, A., Nitsche, A., Ergunay, K., and Yilmaz, E. (2019). Effects of regular kefir consumption on gut microbiota in patients with metabolic syndrome: A parallel-group, randomized, controlled study. Nutrients, 11.","DOI":"10.3390\/nu11092089"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Anumudu, C.K., Miri, T., and Onyeaka, H. (2024). Multifunctional applications of lactic acid bacteria: Enhancing safety, quality, and nutritional value in foods and fermented beverages. Foods, 13.","DOI":"10.3390\/foods13233714"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1039\/D3FB00015J","article-title":"Current Status and Future Prospects of Bioactive Molecules Delivered through Sustainable Encapsulation Techniques for Food Fortification","volume":"1","author":"Dahiya","year":"2023","journal-title":"Sustain. Food Technol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mekini\u0107, I.G., and \u0160imat, V. (2025). Bioactive Compounds in Foods: New and Novel Sources, Characterization, Strategies, and Applications. Foods, 14.","DOI":"10.3390\/foods14091617"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"101407","DOI":"10.1016\/j.fbio.2021.101407","article-title":"A review of the bioactive ingredients of berries and their applications in curing diseases","volume":"44","author":"Bilawal","year":"2021","journal-title":"Food Biosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3390\/nu5041169","article-title":"Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health","volume":"5","author":"Akhtar","year":"2013","journal-title":"Nutrients"},{"key":"ref_22","first-page":"8248","article-title":"Determination of glucosinolates and isothiocyanates in glucosinolate-rich vegetables and oilseeds using infrared spectroscopy: A systematic review","volume":"64","author":"Torquati","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/j.jfca.2005.12.009","article-title":"Flavanones in grapefruit, lemons, and limes: A compilation and review of the data from the analytical literature","volume":"19","author":"Peterson","year":"2006","journal-title":"J. Food Compos. Anal."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1365-2125.2012.04425.x","article-title":"Bioavailability of bioactive food compounds: A challenging journey to bioefficacy","volume":"75","author":"Rein","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"103095","DOI":"10.1016\/j.redox.2024.103095","article-title":"Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies","volume":"71","author":"Favari","year":"2024","journal-title":"Redox Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.1080\/10408398.2021.1901650","article-title":"Influence of food matrix and food processing on the chemical interaction and bioaccessibility of dietary phytochemicals: A review","volume":"62","author":"Shahidi","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"C\u0103linoiu, L.F., and Vodnar, D.C. (2018). Whole Grains and Phenolic Acids: A Review on Bioactivity, Functionality, Health Benefits and Bioavailability. Nutrients, 10.","DOI":"10.3390\/nu10111615"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Khan, J., Khan, M.Z., Ma, Y., Meng, Y., Mushtaq, A., Shen, Q., and Xue, Y. (2022). Overview of the Composition of Whole Grains\u2019 Phenolic Acids and Dietary Fibre and Their Effect on Chronic Non-Communicable Diseases. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19053042"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Guo, F., Danielski, R., Santhiravel, S., and Shahidi, F. (2024). Unlocking the Nutraceutical Potential of Legumes and Their By-Products: Paving the Way for the Circular Economy in the Agri-Food Industry. Antioxidants, 13.","DOI":"10.3390\/antiox13060636"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Gervasi, T., Barreca, D., Lagan\u00e0, G., and Mandalari, G. (2021). Health Benefits Related to Tree Nut Consumption and Their Bioactive Compounds. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115960"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Khan, J., Gul, P., Rashid, M.T., Li, Q., and Liu, K. (2024). Composition of Whole Grain Dietary Fiber and Phenolics and Their Impact on Markers of Inflammation. Nutrients, 16.","DOI":"10.3390\/nu16071047"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Shahidi, F., and De Camargo, A.C. (2016). Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17101745"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"116171","DOI":"10.1016\/j.lwt.2024.116171","article-title":"Effects of Dietary Lipids on Bioaccessibility and Bioavailability of Natural Carotenoids","volume":"200","author":"Yan","year":"2024","journal-title":"LWT"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"i2716","DOI":"10.1136\/bmj.i2716","article-title":"Whole Grain Consumption and Risk of Cardiovascular Disease, Cancer, and All-Cause and Cause-Specific Mortality: Systematic Review and Dose\u2013Response Meta-Analysis of Prospective Studies","volume":"353","author":"Aune","year":"2016","journal-title":"BMJ"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8961","DOI":"10.29219\/fnr.v67.8961","article-title":"Nuts and Seeds Consumption and Risk of Cardiovascular Disease, Type 2 Diabetes and Their Risk Factors: A Systematic Review and Meta-Analysis","volume":"67","author":"Arnesen","year":"2023","journal-title":"Food Nutr. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G.A.D., Gasbarrini, A., and Mele, M.C. (2019). What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms, 7.","DOI":"10.3390\/microorganisms7010014"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Wang, Q., Huang, H., Yang, Y., Yang, X., Li, X., Zhong, W., Wen, B., He, F., and Li, J. (2024). Reinventing gut health: Leveraging dietary bioactive compounds for the prevention and treatment of diseases. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1491821"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tifs.2019.09.004","article-title":"Prebiotics: Trends in food, health and technological applications","volume":"93","author":"Farias","year":"2019","journal-title":"Trends Food. Sci. Technol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrmicro3344","article-title":"The gut microbiota, bacterial metabolites and colorectal cancer","volume":"12","author":"Louis","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Dimidi, E., Belogianni, K., Whelan, K., and Lomer, M.C.E. (2023). Gut Symptoms during FODMAP Restriction and Symptom Response to Food Challenges during FODMAP Reintroduction: A Real-World Evaluation in 21,462 Participants Using a Mobile Application. Nutrients, 15.","DOI":"10.3390\/nu15122683"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e14241","DOI":"10.1111\/nmo.14241","article-title":"Long-term personalized low FODMAP diet improves symptoms and maintains luminal Bifidobacteria abundance in irritable bowel syndrome","volume":"34","author":"Staudacher","year":"2022","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: An overview","volume":"5","author":"Panche","year":"2016","journal-title":"J. Nutr. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/oxim.2.5.9498","article-title":"Plant Polyphenols as Dietary Antioxidants in Human Health and Disease","volume":"2","author":"Pandey","year":"2009","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.foodchem.2010.02.034","article-title":"Screening of vegetables and fruits from Panama for rich sources of lutein and zeaxanthin","volume":"122","author":"Murillo","year":"2010","journal-title":"Food Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1105\/tpc.111.087916","article-title":"Plant science and human nutrition: Challenges in assessing health-promoting properties of phytochemicals","volume":"23","author":"Traka","year":"2011","journal-title":"Plant Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1039\/b802662a","article-title":"Dietary phenolics: Chemistry, bioavailability and effects on health","volume":"26","author":"Crozier","year":"2009","journal-title":"Nat. Prod. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"108689","DOI":"10.1016\/j.pharmthera.2024.108689","article-title":"Vitamins and fatty acids against chemotherapy-induced intestinal mucositis","volume":"261","author":"Alcorta","year":"2024","journal-title":"Pharmacol. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11103-007-9149-8","article-title":"Tomato linalool synthase is induced in trichomes by jasmonic acid","volume":"64","author":"Haring","year":"2007","journal-title":"Plant Mol. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Saini, R.K., Ranjit, A., Sharma, K., Prasad, P., Shang, X., Gowda, K.G.M., and Keum, Y.-S. (2022). Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes. Antioxidants, 11.","DOI":"10.3390\/antiox11020239"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.copbio.2016.11.010","article-title":"Health benefits of fermented foods: Microbiota and beyond","volume":"44","author":"Marco","year":"2017","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Jia, Y.P., Sun, L., Yu, H.S., Liang, L.P., Li, W., Ding, H., Song, X.B., and Zhang, L.J. (2017). The Pharmacological Effects of Lutein and Zeaxanthin on Visual Disorders and Cognition Diseases. Molecules, 22.","DOI":"10.3390\/molecules22040610"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Connolly, E.L., Sim, M., Travica, N., Marx, W., Beasy, G., Lynch, G.S., Bondonno, C.P., Lewis, J.R., Hodgson, J.M., and Blekkenhorst, L.C. (2021). Glucosinolates from Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.767975"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"9966750","DOI":"10.1155\/2022\/9966750","article-title":"Flavonols and Flavones as Potential anti-Inflammatory, Antioxidant, and Antibacterial Compounds","volume":"2022","author":"Chagas","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"131843","DOI":"10.1016\/j.jhazmat.2023.131843","article-title":"Cardioprotective properties of quercetin in fescue toxicosis-induced cardiotoxicity via heart-gut axis in lambs (Ovis aries)","volume":"458","author":"Ge","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13020-024-00936-8","article-title":"Therapeutic potentials of allicin in cardiovascular disease: Advances and future directions","volume":"19","author":"Gao","year":"2024","journal-title":"Chin. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.21873\/invivo.12133","article-title":"Tomato Juice Consumption Could Improve Breast Skin Adverse Effects of Radiotherapy in Breast Cancer Patients","volume":"34","author":"Fukushi","year":"2020","journal-title":"In Vivo"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"8715","DOI":"10.1002\/fsn3.4502","article-title":"Nutritional Benefits of Lycopene and Beta-Carotene: A Comprehensive Overview","volume":"12","author":"Tufail","year":"2024","journal-title":"Food Sci. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"P375","DOI":"10.1016\/j.phytochem.2013.07.011","article-title":"Polyacetylenes from the leaves of Vernonia scorpioides (Asteraceae) and their antiproliferative and antiherpetic activities","volume":"95","author":"Pollo","year":"2013","journal-title":"Phytochemistry"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Vlaicu, P.A., Untea, A.E., Varzaru, I., Saracila, M., and Oancea, A.G. (2023). Designing Nutrition for Health\u2014Incorporating Dietary By-Products into Poultry Feeds to Create Functional Foods with Insights into Health Benefits, Risks, Bioactive Compounds, Food Component Functionality and Safety Regulations. Foods, 12.","DOI":"10.3390\/foods12214001"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/1541-4337.12049","article-title":"Analytical Methods for Determining Bioavailability and Bioaccessibility of Bioactive Compounds from Fruits and Vegetables: A Review","volume":"13","author":"Buniowska","year":"2014","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Dhalaria, R., Verma, R., Kumar, D., Puri, S., Tapwal, A., Kumar, V., Nepovimova, E., and Kuca, K. (2020). Bioactive Compounds of Edible Fruits with Their Anti-Aging Properties: A Comprehensive Review to Prolong Human Life. Antioxidants, 9.","DOI":"10.3390\/antiox9111123"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Dabeek, W.M., and Marra, M.V. (2019). Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans. Nutrients, 11.","DOI":"10.3390\/nu11102288"},{"key":"ref_63","first-page":"8","article-title":"Bioactive compounds in fruits: Health benefits and effect of storage conditions","volume":"4","author":"Olivas","year":"2008","journal-title":"Stewart Postharvest Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.profoo.2013.04.008","article-title":"Sources of Variability in the Flavonoid Content of Foods","volume":"2","author":"Haytowitz","year":"2013","journal-title":"Procedia Food Sci."},{"key":"ref_65","unstructured":"(2025, October 03). USDA National Nutrient Database for Standard Reference, Release 28 (Slightly Revised). Version: May 2016. US Department of Agriculture (USDA), Agricultural Research Service (ARS), Nutrient Data Laboratory, Beltsville (MD), Available online: http:\/\/www.ars.usda.gov\/ba\/bhnrc\/ndl."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1021\/jf071736j","article-title":"Evolution of Antioxidant Capacity during Storage of Selected Fruits and Vegetables","volume":"55","author":"Kevers","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Mieszczakowska-Fr\u0105c, M., Dickinson, N.J., and Konopacka, D. (2025). Effect of Postharvest Ripening on the Phytochemical Composition and Antioxidant Properties of Fruits from Ten Plum (Prunus domestica L.) Cultivars. Agronomy, 15.","DOI":"10.3390\/agronomy15061351"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"128334","DOI":"10.1016\/j.foodchem.2020.128334","article-title":"Curing and Low-Temperature Combined Post-Harvest Storage Enhances Anthocyanin Biosynthesis in Blood Oranges","volume":"342","author":"Carmona","year":"2021","journal-title":"Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e29125","DOI":"10.1016\/j.heliyon.2024.e29125","article-title":"Vitamin C variation in citrus in response to genotypes, storage temperatures, and storage times: A systematic review and meta-analysis","volume":"10","author":"Budiarto","year":"2024","journal-title":"Heliyon"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Deledda, A., Annunziata, G., Tenore, G.C., Palmas, V., Manzin, A., and Velluzzi, F. (2021). Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation. Antioxidants, 10.","DOI":"10.3390\/antiox10050708"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e2100976","DOI":"10.1002\/mnfr.202100976","article-title":"Dietary Flavonoids and Human Cognition: A Meta-Analysis","volume":"66","author":"Cheng","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Adriouch, S., Lampur\u00e9, A., Nechba, A., Baudry, J., Assmann, K., Kesse-Guyot, E., Hercberg, S., Scalbert, A., Touvier, M., and Fezeu, L.K. (2018). Prospective Association between Total and Specific Dietary Polyphenol Intakes and Cardiovascular Disease Risk in the Nutrinet-Sant\u00e9 French Cohort. Nutrients, 10.","DOI":"10.3390\/nu10111587"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41430-022-01213-3","article-title":"The influence of dietary vegetables and fruits on endometrial cancer risk: A meta-analysis of observational studies","volume":"77","author":"Lu","year":"2023","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Lai, B., Li, Z., and Li, J. (2025). Cruciferous vegetables intake and risk of colon cancer: A dose\u2013response meta-analysis. BMC Gastroenterol., 25.","DOI":"10.1186\/s12876-025-04163-9"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jand.2018.11.007","article-title":"The Associations of Fruit and Vegetable Intakes with Burden of Diseases: A Systematic Review of Meta-Analyses","volume":"119","author":"Yip","year":"2019","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/10408390802248734","article-title":"Health Benefits of Whole Grain Phytochemicals","volume":"50","author":"Okarter","year":"2010","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"S\u0142awi\u0144ska, N., and Olas, B. (2022). Selected Seeds as Sources of Bioactive Compounds with Diverse Biological Activities. Nutrients, 15.","DOI":"10.3390\/nu15010187"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.foodres.2008.04.001","article-title":"Barley \u03b2-Glucans and Arabinoxylans: Molecular Structure, Physicochemical Properties, and Uses in Food Products\u2014A Review","volume":"41","author":"Izydorczyk","year":"2008","journal-title":"Food Res. Int."},{"key":"ref_79","first-page":"100619","article-title":"A Comprehensive Review on Nutraceutical Potential of Underutilized Cereals and Cereal-Based Products","volume":"12","author":"Rawat","year":"2023","journal-title":"J. Agric. Food Res."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Ariyarathna, P., Mizera, P., Walkowiak, J., and Dziedzic, K. (2025). Physicochemical and Functional Properties of Soluble and Insoluble Dietary Fibers in Whole Grains and Their Health Benefits. Foods, 14.","DOI":"10.20944\/preprints202506.0349.v1"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1649S","DOI":"10.3945\/ajcn.2009.26736R","article-title":"Nuts and Novel Biomarkers of Cardiovascular Disease","volume":"89","author":"Ros","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Olas, B. (2024). The Cardioprotective Properties of Selected Nuts: Their Functional Ingredients and Molecular Mechanisms. Foods, 13.","DOI":"10.3390\/foods13020242"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/09637486.2025.2499045","article-title":"The Impact of Nut Consumption on Vascular Endothelial Function: A GRADE-Assessed Systematic Review and Meta-Analysis of Data from Randomised Controlled Trials","volume":"76","author":"Arabi","year":"2025","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s40001-023-01203-6","article-title":"A Comprehensive Review of the Health Benefits of Flaxseed Oil in Relation to Its Chemical Composition and Comparison with Other Omega-3-Rich Oils","volume":"28","author":"Ashmawy","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"97","DOI":"10.22271\/phyto.2025.v14.i1b.15225","article-title":"Health Benefits of Nutritional Seeds\u2014A Review","volume":"14","author":"Panthagada","year":"2025","journal-title":"J. Pharmacogn. Phytochem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"101093","DOI":"10.1016\/j.afres.2025.101093","article-title":"Nutritional and Therapeutic Interest of Most Widely Produced and Consumed Plant Oils by Humans: A Review","volume":"5","author":"Zio","year":"2025","journal-title":"Appl. Food Res."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Timm, M., Offringa, L.C., Van Klinken, B.J.-W., and Slavin, J. (2023). Beyond Insoluble Dietary Fiber: Bioactive Compounds in Plant Foods. Nutrients, 15.","DOI":"10.3390\/nu15194138"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e70101","DOI":"10.1002\/fsn3.70101","article-title":"Dietary Phytochemicals in Health and Disease: Mechanisms, Clinical Evidence, and Applications\u2014A Comprehensive Review","volume":"13","author":"Hossain","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.3945\/jn.108.103622","article-title":"Regular Consumption of Nuts Is Associated with a Lower Risk of Cardiovascular Disease in Women with Type 2 Diabetes","volume":"139","author":"Li","year":"2009","journal-title":"J. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Gaesser, G.A. (2020). Whole Grains, Refined Grains, and Cancer Risk: A Systematic Review of Meta-Analyses of Observational Studies. Nutrients, 12.","DOI":"10.3390\/nu12123756"},{"key":"ref_91","first-page":"1045","article-title":"Chemical Composition and Health Benefits of Flaxseed","volume":"2","author":"Bernacchia","year":"2014","journal-title":"Austin J. Nutr. Food Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"70067","DOI":"10.1002\/efd2.70067","article-title":"Bioavailability and Bioaccessibility of Grain Polyphenols: A Comprehensive Review","volume":"6","author":"Tariq","year":"2025","journal-title":"eFood"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1021\/jf0603937","article-title":"Determination of Flavonoids and Phenolics and Their Distribution in Almonds","volume":"54","author":"Milbury","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Garc\u00eda, C., S\u00e1nchez-Quesada, C., Toledo, E., Delgado-Rodr\u00edguez, M., and Gaforio, J.J. (2019). Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?. Molecules, 24.","DOI":"10.3390\/molecules24050917"},{"key":"ref_95","first-page":"263","article-title":"Phytosterol Content and Fatty Acid Pattern of Ten Different Nut Types","volume":"83","author":"Wagner","year":"2014","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/ffj.3585","article-title":"Vitamin E (\u03b1-, \u03b2+\u03b3- and \u03b4-Tocopherol) levels in Plant Oils","volume":"35","author":"Korkut","year":"2020","journal-title":"Flavour Fragr. J."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Szewczyk, K., and G\u00f3rnicka, M. (2023). Dietary Vitamin E Isoforms Intake: Development of a New Tool to Assess Tocopherols and Tocotrienols Intake in Adults. Nutrients, 15.","DOI":"10.3390\/nu15173759"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"443S","DOI":"10.3945\/ajcn.113.071514","article-title":"Health Benefits of Plant-Derived \u03b1-Linolenic Acid","volume":"100","author":"Rajaram","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1093\/advances\/nmac016","article-title":"Impact of \u03b1-Linolenic Acid, the Vegetable \u03c9-3 Fatty Acid, on Cardiovascular Disease and Cognition","volume":"13","author":"Fleming","year":"2022","journal-title":"Adv. Nutr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e12653","DOI":"10.1111\/jfbc.12653","article-title":"Comparison of Total Carotenoids, Lutein, Zeaxanthin, and \u03b2-Carotene Content in Maize Employing Solvent Extraction and In Vitro Physiological Methods","volume":"42","author":"Hossain","year":"2018","journal-title":"J. Food Biochem."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Nin\u010devi\u0107 Grassino, A., Rimac Brn\u010di\u0107, S., Badanjak Sabolovi\u0107, M., \u0160ic \u017dlabur, J., Marovi\u0107, R., and Brn\u010di\u0107, M. (2023). Carotenoid Content and Profiles of Pumpkin Products and By-Products. Molecules, 28.","DOI":"10.3390\/molecules28020858"},{"key":"ref_102","first-page":"101343","article-title":"Arabinoxylan as Well as \u03b2-Glucan in Barley Promotes GLP-1 Secretion by Increasing Short-Chain Fatty Acids Production","volume":"32","author":"Mio","year":"2022","journal-title":"Biochem. Biophys. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1600715","DOI":"10.1002\/mnfr.201600715","article-title":"Whole Grain Oats, more than Just a Fiber: Role of Unique Phytochemicals","volume":"61","author":"Sang","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Bljahhina, A., Kuhtinskaja, M., and Kri\u0161\u010diunaite, T. (2023). Development of Extraction Method for Determination of Saponins in Soybean-Based Yoghurt Alternatives: Effect of Sample pH. Foods, 12.","DOI":"10.3390\/foods12112164"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Terpou, A., Dahiya, D., and Nigam, P. (2025). Evolving Dynamics of Fermented Food Microbiota and the Gut Microenvironment: Strategic Pathways to Enhance Human Health. Foods, 14.","DOI":"10.3390\/foods14132361"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Park, I., and Mannaa, M. (2025). Fermented Foods as Functional Systems: Microbial Communities and Metabolites Influencing Gut Health and Systemic Outcomes. Foods, 14.","DOI":"10.3390\/foods14132292"},{"key":"ref_107","first-page":"422","article-title":"Bioactive Peptides Derived from Fermented Foods: Preparation and Biological Activities","volume":"105","author":"Guo","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"111133","DOI":"10.1016\/j.foodres.2022.111133","article-title":"Fermented Foods: An Update on Evidence-Based Health Benefits and Future Perspectives","volume":"156","author":"Astiazaran","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Peres Fabbri, L., Cavallero, A., Vidotto, F., and Gabriele, M. (2024). Bioactive Peptides from Fermented Foods: Production Approaches, Sources, and Potential Health Benefits. Foods, 13.","DOI":"10.3390\/foods13213369"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.foodres.2017.09.031","article-title":"Fruits and vegetables, as a source of nutritional compounds and phytochemicals: Changes in bioactive compounds during lactic fermentation","volume":"104","author":"Remize","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1111\/1541-4337.12651","article-title":"Bioactive peptides from food fermentation: A comprehensive review of their sources, bioactivities, applications, and future development","volume":"19","author":"Chai","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Mathur, H., Beresford, T., and Cotter, P. (2020). Health Benefits of Lactic Acid Bacteria (LAB) Fermentates. Nutrients, 12.","DOI":"10.3390\/nu12061679"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s43393-022-00125-4","article-title":"Bioactive peptides in fermented foods and their application: A critical review","volume":"3","author":"Chourasia","year":"2022","journal-title":"Syst. Microbiol. Biomanufacturing"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Deveci, G., \u00c7elik, E., A\u011fag\u00fcnd\u00fcz, D., Bartkien\u0117, E., Rocha, J., and \u00d6zo\u011ful, F. (2023). Certain Fermented Foods and Their Possible Health Effects with a Focus on Bioactive Compounds and Microorganisms. Fermentation, 9.","DOI":"10.3390\/fermentation9110923"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Melini, F., Melini, V., Luziatelli, F., Ficca, A., and Ruzzi, M. (2019). Health-Promoting Components in Fermented Foods: An Up-to-Date Systematic Review. Nutrients, 11.","DOI":"10.3390\/nu11051189"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.cmet.2024.03.007","article-title":"Our Extended Microbiome: The Human-Relevant Metabolites and Biology of Fermented Foods","volume":"36","author":"Caffrey","year":"2024","journal-title":"Cell Metab."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e70074","DOI":"10.1111\/1750-3841.70074","article-title":"Evaluation of Antiobesogenic Properties of Fermented Foods: In Silico Insights","volume":"90","author":"Jimoh","year":"2025","journal-title":"J. Food Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1007\/s13197-022-05528-8","article-title":"Bioactive metabolites in functional and fermented foods and their role as immunity boosters and anti-viral innate mechanisms","volume":"60","author":"Varsha","year":"2022","journal-title":"J. Food Sci. Technol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s40168-023-01536-8","article-title":"Metagenomics reveals the habitat specificity of biosynthetic potential of secondary metabolites in global food fermentations","volume":"11","author":"Du","year":"2023","journal-title":"Microbiome"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Owusu-Kwarteng, J., Agyei, D., Akabanda, F., Atuna, R., and Amagloh, F. (2022). Plant-Based Alkaline Fermented Foods as Sustainable Sources of Nutrients and Health-Promoting Bioactive Compounds. Front. Sustain. Food Syst., 6.","DOI":"10.3389\/fsufs.2022.885328"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1080\/10408398.2023.2172546","article-title":"Yeasts originating from fermented foods, their potential as probiotics and therapeutic implication for human health and disease","volume":"64","author":"Kunyeit","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"102016","DOI":"10.1016\/j.fochx.2024.102016","article-title":"Integrated Microbiomic and Metabolomic Dynamics of Yi Traditional Fermented Liquor","volume":"24","author":"Liang","year":"2024","journal-title":"Food Chem. X"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Iarusso, I., Mahony, J., Pannella, G., Lombardi, S.J., Gagliardi, R., Coppola, F., Pellegrini, M., Succi, M., and Tremonte, P. (2025). Diversity of Lactiplantibacillus plantarum in Wild Fermented Food Niches. Foods, 14.","DOI":"10.3390\/foods14101765"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"8925","DOI":"10.1021\/acs.jafc.0c03254","article-title":"Variation of Microbiological and Biochemical Profiles of Laowo Dry-cured Ham, an Indigenous Fermented Food, During Ripening by GC-TOF-MS and UPLC-QTOF-MS","volume":"68","author":"Lin","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Raghuvanshi, R., Grayson, A., Schena, I., Amanze, O., Suwintono, K., and Quinn, R. (2019). Microbial Transformations of Organically Fermented Foods. Metabolites, 9.","DOI":"10.3390\/metabo9080165"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Dania, M., Faraji, B., and Wachira, J. (2022). Micronutrient Biosynthesis Potential of Spontaneous Grain Fermentation Microbiomes. Int. J. Environ. Res. Public Health, 19.","DOI":"10.20944\/preprints202211.0548.v1"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Sharma, R., Garg, P., Kumar, P., Bhatia, S., and Kulshrestha, S. (2020). Microbial Fermentation and Its Role in Quality Improvement of Fermented Foods. Fermentation, 6.","DOI":"10.3390\/fermentation6040106"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"12938","DOI":"10.1039\/D2FO02501A","article-title":"Deep Shotgun metagenomic and 16S rRNA analysis revealed the microbial diversity of lactic acid bacteria in traditional fermented foods of eastern Hainan, China","volume":"13","author":"Wu","year":"2022","journal-title":"Food Funct."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Gautam, A., Poopalarajah, R., Ahmed, A., Rana, B., Denekew, T., Ahn, N., Utenova, L., Kunwar, Y., Bhandari, N., and Jha, A. (2024). Ecological factors that drive microbial communities in culturally diverse fermented foods. bioRxiv.","DOI":"10.1101\/2024.08.20.608727"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Xu, M., Su, S., Zhang, Z., Jiang, S., Zhang, J., Xu, Y., and Hu, X. (2022). Two sides of the same coin: Meta-analysis uncovered the potential benefits and risks of traditional fermented foods at a large geographical scale. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1045096"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e00522-20","DOI":"10.1128\/mSystems.00522-20","article-title":"Fermented-Food Metagenomics Reveals Substrate-Associated Differences in Taxonomy and Health-Associated and Antibiotic Resistance Determinants","volume":"5","author":"Leech","year":"2020","journal-title":"mSystems"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Yao, Z., Xie, T., Deng, H., Xiao, S., and Yang, T. (2025). Directed Evolution of Microbial Communities in Fermented Foods: Strategies, Mechanisms, and Challenges. Foods, 14.","DOI":"10.3390\/foods14020216"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"100871","DOI":"10.1016\/j.fochx.2023.100871","article-title":"The regulation of key flavor of traditional fermented food by microbial metabolism: A review","volume":"19","author":"Zhang","year":"2023","journal-title":"Food Chem. X"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Sarkar, S., Sha, S., and Ghatani, K. (2023). Metabolomics of ethnic fermented foods and beverages: Understanding new aspects through Omic techniques. Front. Sustain. Food Syst., 7.","DOI":"10.3389\/fsufs.2023.1040567"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Mota, J., and Vilela, A. (2024). Exploring Microbial Dynamics: The Interaction between Yeasts and Acetic Acid Bacteria in Port Wine Vinegar and Its Implications on Chemical Composition and Sensory Acceptance. Fermentation, 10.","DOI":"10.3390\/fermentation10080421"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Mota, J., and Vilela, A. (2024). Aged to Perfection: The Scientific Symphony behind Port Wine, Vinegar, and Acetic Acid Bacteria. Fermentation, 10.","DOI":"10.3390\/fermentation10040200"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Gustaw, K., Nied\u017awied\u017a, I., Rachwa\u0142, K., and Polak-Berecka, M. (2021). New Insight into Bacterial Interaction with the Matrix of Plant-Based Fermented Foods. Foods, 10.","DOI":"10.3390\/foods10071603"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Cheng, W., Chen, X., Lan, W., Liu, G., Xue, X., Li, R., Pan, T., Li, N., Zhou, D., and Chen, X. (2023). Insights into the influence of physicochemical parameters on the microbial community and volatile compounds during the ultra-long fermentation of compound-flavor Baijiu. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1272559"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Arrieta-Echeverri, M., Fernandez, G., Duarte-Riveros, A., Correa-\u00c1lvarez, J., Bardales, J., Villanueva-Mej\u00eda, D., and Sierra-Zapata, L. (2023). Multi-omics characterization of the microbial populations and chemical space composition of a water kefir fermentation. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1223863"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Palmn\u00e4s-B\u00e9dard, M., De Santa Izabel, A., Dicksved, J., and Landberg, R. (2023). Characterization of the Bacterial Composition of 47 Fermented Foods in Sweden. Foods, 12.","DOI":"10.3390\/foods12203827"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Yasir, M., Alkhaldy, A., Soliman, S., Turkistani, S., and Azhar, E. (2023). Metagenomic Insights into the Microbiome and Resistance Genes of Traditional Fermented Foods in Arabia. Foods, 12.","DOI":"10.3390\/foods12183342"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41538-022-00130-w","article-title":"African fermented foods: Overview, emerging benefits, and novel approaches to microbiome profiling","volume":"6","author":"Obafemi","year":"2022","journal-title":"npj Sci. Food"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Adesemoye, E., Sanni, A., Spano, G., Capozzi, V., and Fragasso, M. (2025). Lactic Acid Bacteria Diversity in Fermented Foods as Potential Bio-Resources Contributing to Alleviate Malnutrition in Developing Countries: Nigeria as a Case Study. Fermentation, 11.","DOI":"10.3390\/fermentation11020103"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"13863","DOI":"10.1038\/s41598-019-50190-4","article-title":"Comparison of the microbial composition of African fermented foods using amplicon sequencing","volume":"9","author":"Diaz","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Tamang, J., Watanabe, K., and Holzapfel, W. (2016). Review: Diversity of Microorganisms in Global Fermented Foods and Beverages. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00377"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Deka, P., Mehetre, G., Lalnunmawii, E., Upadhyaya, K., Singh, G., Hashem, A., Al-Arjani, A., Abd_Allah, E., and Singh, B. (2021). Metagenomic Analysis of Bacterial Diversity in Traditional Fermented Foods Reveals Food-Specific Dominance of Specific Bacterial Taxa. Fermentation, 7.","DOI":"10.3390\/fermentation7030167"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"110842","DOI":"10.1016\/j.foodres.2021.110842","article-title":"Consumers\u2019 acceptability and health consciousness of probiotic and prebiotic of non-dairy products","volume":"151","author":"Cosme","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"108270","DOI":"10.1016\/j.ijfoodmicro.2019.108270","article-title":"Comparative study on metabolic changes of Aspergillus oryzae isolated from fermented foods according to culture conditions","volume":"307","author":"Park","year":"2019","journal-title":"Int. J. Food Microbiol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s00217-020-03549-1","article-title":"Vinegar production from Citrus bergamia by-products and preservation of bioactive compounds","volume":"246","author":"Bartella","year":"2020","journal-title":"Eur. Food Res. Technol."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Hosseini, E., Tsegay, Z., Smaoui, S., and Varzakas, T. (2025). Lactic Acid Bacteria in Vinegar Fermentation: Diversity, Functionality and Health Benefits. Foods, 14.","DOI":"10.20944\/preprints202502.0201.v1"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"104565","DOI":"10.1016\/j.fm.2024.104565","article-title":"Changes of microbial communities and metabolites in the fermentation of persimmon vinegar by bioaugmentation fermentation","volume":"122","author":"Zhang","year":"2024","journal-title":"Food Microbiol."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Vilela, A. (2023). Microbial Dynamics in Sour\u2013Sweet Wine Vinegar: Impacts on Chemical and Sensory Composition. Appl. Sci., 13.","DOI":"10.3390\/app13137366"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Dom\u017ca\u0142-K\u0119dzia, M., Ostrowska, M., Lewi\u0144ska, A., and \u0141ukaszewicz, M. (2023). Recent Developments and Applications of Microbial Levan, A Versatile Polysaccharide-Based Biopolymer. Molecules, 28.","DOI":"10.3390\/molecules28145407"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Yermagambetova, A., Tazhibayeva, S., Takhistov, P., Tyussyupova, B., Tapia-Hern\u00e1ndez, J., and Musabekov, K. (2024). Microbial Polysaccharides as Functional Components of Packaging and Drug Delivery Applications. Polymers, 16.","DOI":"10.3390\/polym16202854"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e70217","DOI":"10.1111\/1541-4337.70217","article-title":"Innovations in Edible Packaging Films, Coatings, and Antimicrobial Agents for Applications in Food Industry","volume":"24","author":"Kumar","year":"2025","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Ne\u0161i\u0107, A., Cabrera-Barjas, G., Dimitrijevi\u0107-Brankovi\u0107, S., Davidovi\u0107, S., Radovanovi\u0107, N., and Delattre, C. (2020). Prospect of Polysaccharide-Based Materials as Advanced Food Packaging. Molecules, 25.","DOI":"10.3390\/molecules25010135"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.copbio.2007.01.010","article-title":"Yeasts in foods and beverages: Impact on product quality and safety","volume":"18","author":"Fleet","year":"2007","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s13197-024-06089-8","article-title":"Probiotic lychee wine fermented by Saccharomyces boulardii: Addition influence of yerba mate on physicochemical and sensory characteristics","volume":"62","author":"Terhaag","year":"2025","journal-title":"J. Food Sci. Technol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1039\/D5FO01577D","article-title":"Effects of lyophilized Korean rice wine (Makgeolli) on intestinal function and bowel activity in loperamide-induced constipation in rats","volume":"16","author":"Jung","year":"2025","journal-title":"Food Funct."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s12602-023-10177-0","article-title":"Antimicrobial Compounds in Wine","volume":"16","author":"Todorov","year":"2024","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Vilela, A. (2019). The Importance of Yeasts on Fermentation Quality and Human Health-Promoting Compounds. Fermentation, 5.","DOI":"10.3390\/fermentation5020046"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Vilela, A., Cosme, F., and In\u00eas, A. (2020). Wine and Non-Dairy Fermented Beverages: A Novel Source of Pro- and Prebiotics. Fermentation, 6.","DOI":"10.3390\/fermentation6040113"},{"key":"ref_163","first-page":"110681","article-title":"A consortium of different Saccharomyces species enhances the content of bioactive tryptophan-derived compounds in wine fermentations","volume":"2","author":"Kazakova","year":"2024","journal-title":"Int. J. Food Microbiol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/fft2.70018","article-title":"Exploring Proteomic and Metabolomic Interactions in a Yeast Consortium Designed to Enhance Bioactive Compounds in Wine Fermentations","volume":"6","author":"Quintas","year":"2025","journal-title":"Food Front."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"9692","DOI":"10.1021\/jf802050h","article-title":"Akt\/FOXO3a\/SIRT1-Mediated Cardioprotection by n-Tyrosolagainst Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival and Longevity","volume":"56","author":"Samuel","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"127576","DOI":"10.1016\/j.foodchem.2020.127576","article-title":"Antioxidant and Antimicrobial Properties of Tyrosol and Derivative Compounds in the Presence of Vitamin B2: Assays of Synergistic Antioxidant Effect with Commercial Food Additives","volume":"335","author":"Casadey","year":"2021","journal-title":"Food Chem."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Agarbati, A., Canonico, L., Marini, E., Zannini, E., Ciani, M., and Comitini, F. (2020). Potential Probiotic Yeasts Sourced from Natural Environmental and Spontaneous Processed Foods. Foods, 9.","DOI":"10.3390\/foods9030287"},{"key":"ref_168","first-page":"e9169","article-title":"Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 21: Suitability of taxonomic units notified to EFSA until September 2024","volume":"23","author":"Allende","year":"2025","journal-title":"EFSA J."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"e70155","DOI":"10.1002\/fsn3.70155","article-title":"Diversity and Functional Roles of Microorganisms in Anatolian Black Pine Cone Vinegar Fermentation","volume":"13","author":"Bulantekin","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Marques, C., Correia, E., Aires, A., Dinis, L.-T., and Vilela, A. (2024). A Comprehensive Study on the Amino Acids and Tryptophan-Derived Molecules in Iberian Wine Vinegar. Foods, 13.","DOI":"10.3390\/foods13213384"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/jib.432","article-title":"Screening of bioactive components in grape and apple vinegars: Antioxidant and antimicrobial potential","volume":"123","author":"Kelebek","year":"2017","journal-title":"J. Inst. Brew."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"9009","DOI":"10.1111\/ijfs.17415","article-title":"Study on changes of bioactive substances and flavour characteristics during fermentation of jujube vinegar","volume":"59","author":"Zhao","year":"2024","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"126309","DOI":"10.1016\/j.foodchem.2020.126309","article-title":"Bioactivity of food melanoidins is mediated by gut microbiota","volume":"316","author":"Rajakaruna","year":"2020","journal-title":"Food Chem."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"8275","DOI":"10.1002\/jsfa.13663","article-title":"Orange passion fruit (Passiflora caerulea L.) as a new raw material for acetic fermentation: Evaluation of organic acids and phenolic profile, in vitro digestion, and biological activities","volume":"104","author":"Deolindo","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in Health and Diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1627s","DOI":"10.3945\/ajcn.2009.26736N","article-title":"Health effects of vegan diets","volume":"89","author":"Craig","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"Ley","year":"2005","journal-title":"Science"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1158\/2159-8290.CD-21-0999","article-title":"Cancer Induces a Stress Ileopathy Depending on \u03b2-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis","volume":"12","author":"Yonekura","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1126\/science.aan4834","article-title":"Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania","volume":"357","author":"Smits","year":"2017","journal-title":"Science"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1007\/s00018-017-2509-x","article-title":"Mechanisms and consequences of intestinal dysbiosis","volume":"74","author":"Weiss","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.chom.2019.07.004","article-title":"Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition","volume":"26","author":"Thingholm","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"112875","DOI":"10.1016\/j.nut.2025.112875","article-title":"Association between gut microbiota and pediatric obesity: A systematic review","volume":"140","author":"Costa","year":"2025","journal-title":"Nutrition"},{"key":"ref_184","first-page":"e22156","article-title":"The Association of Microbiome Dysbiosis with Colorectal Cancer","volume":"14","author":"Artemev","year":"2022","journal-title":"Cureus"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1007\/s12035-020-02073-3","article-title":"Gut Microbiota and Dysbiosis in Alzheimer\u2019s Disease: Implications for Pathogenesis and Treatment","volume":"57","author":"Liu","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Shabbir, U., Arshad, M.S., Sameen, A., and Oh, D.H. (2021). Crosstalk between Gut and Brain in Alzheimer\u2019s Disease: The Role of Gut Microbiota Modulation Strategies. Nutrients, 13.","DOI":"10.3390\/nu13020690"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"102659","DOI":"10.1016\/j.arr.2025.102659","article-title":"Gut microbiota in Alzheimer\u2019s disease: Understanding molecular pathways and potential therapeutic perspectives","volume":"104","author":"Lista","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Herselman, M.F., Bailey, S., and Bobrovskaya, L. (2022). The Effects of Stress and Diet on the \u201cBrain\u2013Gut\u201d and \u201cGut\u2013Brain\u201d Pathways in Animal Models of Stress and Depression. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042013"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"104527","DOI":"10.1016\/j.ebiom.2023.104527","article-title":"Gut microbiota and its metabolites in depression: From pathogenesis to treatment","volume":"90","author":"Liu","year":"2023","journal-title":"EBioMedicine"},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Kawabata, K., Yoshioka, Y., and Terao, J. (2019). Role of intestinal microbiota in the bioavailability and physiological functions of dietary polyphenols. Molecules, 24.","DOI":"10.3390\/molecules24020370"},{"key":"ref_191","first-page":"9051542","article-title":"ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals","volume":"14","author":"NavaneethaKrishnan","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"113976","DOI":"10.1016\/j.jep.2021.113976","article-title":"Phytochemical Profiling of Bioactive Compounds, Anti-Inflammatory and Analgesic Potentials of Habenaria Digitata Lindl.: Molecular Docking Based Synergistic Effect of the Identified Compounds","volume":"273","author":"Mahnashi","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Kang, H., and Kim, B. (2023). Bioactive Compounds as Inhibitors of Inflammation, Oxidative Stress and Metabolic Dysfunctions via Regulation of Cellular Redox Balance and Histone Acetylation State. Foods, 12.","DOI":"10.3390\/foods12050925"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/nu7010017","article-title":"The impact of diet and lifestyle on gut microbiota and human health","volume":"7","author":"Conlon","year":"2014","journal-title":"Nutrients"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Pinto, T., Aires, A., Cosme, F., Bacelar, E., Morais, M.C., Oliveira, I., Anjos, R., Vilela, A., and Gon\u00e7alves, B. (2021). Bioactive (Poly)phenols, Volatile Compounds from Vegetables, Medicinal and Aromatic Plants. Foods, 10.","DOI":"10.3390\/foods10010106"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1016\/j.lfs.2005.09.041","article-title":"Inhibitory Effects of Irigenin from the Rhizomes of Belamcanda Chinensis on Nitric Oxide and Prostaglandin E(2) Production in Murine Macrophage RAW 264.7 Cells","volume":"78","author":"Ahn","year":"2006","journal-title":"Life Sci."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jnutbio.2012.12.013","article-title":"Modulation of Adipose Tissue Inflammation by Bioactive Food Compounds","volume":"24","author":"Siriwardhana","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_198","unstructured":"Barba, F.J., Saraiva, J.M.A., Cravotto, G., and Lorenzo, J.M. (2019). Methods for Determining Bioavailability and Bioaccessibility of Bioactive Compounds and Nutrients. Innovative Thermal and Non-Thermal Processing, Bioaccessibility and Bioavailability of Nutrients and Bioactive Compounds, Elsevier."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Daza, M.C., Pulido-Mateos, E.C., Lupien-Meilleur, J., Guyonnet, D., Desjardins, Y., and Roy, D. (2021). Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.689456"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Wang, X., Qi, Y., and Zheng, H. (2022). Dietary Polyphenol, Gut Microbiota, and Health Benefits. Antioxidants, 11.","DOI":"10.3390\/antiox11061212"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Corr\u00eaa, T.A.F., Rogero, M.M., Hassimotto, N.M.A., and Lajolo, F.M. (2019). The Two-Way Polyphenols-Microbiota Interactions and Their Effects on Obesity and Related Metabolic Diseases. Front. Nutr., 6.","DOI":"10.3389\/fnut.2019.00188"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anaerobe.2013.11.007","article-title":"Prebiotic effects of almonds and almond skins on intestinal microbiota in healthy adult humans","volume":"26","author":"Liu","year":"2014","journal-title":"Anaerobe"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s13679-015-0172-9","article-title":"Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts","volume":"4","author":"Varin","year":"2015","journal-title":"Curr. Obes. Rep."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Xiong, H.-H., Lin, S.-Y., Chen, L.-L., Ouyang, K.-H., and Wang, W.-J. (2023). The Interaction between Flavonoids and Intestinal Microbes: A Review. Foods, 12.","DOI":"10.3390\/foods12020320"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1039\/c3fo60630a","article-title":"Effects of Resveratrol on Gut Microbiota and Fat Storage in a Mouse Model with High-Fat- Induced Obesity","volume":"5","author":"Qiao","year":"2014","journal-title":"Food Funct."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/mnfr.200800446","article-title":"Polyphenol metabolites from colonic microbiota exert anti-inflammatory activity on different inflammation models","volume":"53","author":"Larrosa","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/biof.1081","article-title":"Flavonols Enhanced Production of Anti-Inflammatory Substance(s) by Bifidobacterium Adolescentis: Prebiotic Actions of Galangin, Quercetin, and Fisetin: Prebiotic Actions of Flavonols to B. adolescentis","volume":"39","author":"Kawabata","year":"2013","journal-title":"Biofactors"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2337\/db16-0680","article-title":"Improved Glucose Homeostasis in Obese Mice Treated with Resveratrol Is Associated with Alterations in the Gut Microbiome","volume":"66","author":"Sung","year":"2017","journal-title":"Diabetes"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"e1800066","DOI":"10.1002\/mnfr.201800066","article-title":"Resveratrol prevents the development of hypertension programmed by maternal plus post-weaning high-fructose consumption through modulation of oxidative stress, nutrient-sensing signals, and gut microbiota","volume":"62","author":"Tain","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Wang, L., Gao, M., Kang, G., and Huang, H. (2021). The Potential Role of Phytonutrients Flavonoids Influencing Gut Microbiota in the Prophylaxis and Treatment of Inflammatory Bowel Disease. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.798038"},{"key":"ref_211","first-page":"100217","article-title":"Terpenes and Terpenoids as Main Bioactive Compounds of Essential Oils, Their Roles in Human Health and Potential Application as Natural Food Preservatives","volume":"13","author":"Masyita","year":"2022","journal-title":"Food Chem."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.chom.2018.05.012","article-title":"The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease","volume":"23","author":"Makki","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Bamberger, C., Rossmeier, A., Lechner, K., Wu, L., Waldmann, E., Fischer, S., Stark, R.G., Altenhofer, J., Henze, K., and Parhofer, K.G. (2018). A Walnut-Enriched Diet Affects Gut Microbiome in Healthy Caucasian Subjects: A Randomized, Controlled Trial. Nutrients, 10.","DOI":"10.3390\/nu10020244"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/JLB.3A1218-476RR","article-title":"Resveratrol Modulates the Gut Microbiota to Prevent Murine Colitis Development through Induction of Tregs and Suppression of Th17 Cells","volume":"106","author":"Alrafas","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Maioli, T.U., Borras-Nogues, E., Torres, L., Barbosa, S.C., Martins, V.D., Langella, P., Azevedo, V.A., and Chatel, J.-M. (2021). Possible Benefits of Faecalibacterium Prausnitzii for Obesity-Associated Gut Disorders. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.740636"},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Gloria, J.L., Rada, K.M., Ju\u00e1rez-Rojas, J.G., S\u00e1nchez-Lozada, L.G., Rubio-Gayosso, I., S\u00e1nchez-Mu\u00f1oz, F., and Osorio-Alonso, H. (2022). Role of Sulfur Compounds in Garlic as Potential Therapeutic Option for Inflammation and Oxidative Stress in Asthma. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415599"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbi.2016.12.022","article-title":"Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome","volume":"64","author":"Fourrier","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Parada Venegas, D., De la Fuente, M.K., Landskron, G., Gonz\u00e1lez, M.J., Quera, R., Dijkstra, G., Harmsen, H.J.M., Faber, K.N., and Hermoso, M.A. (2019). Corrigendum: Short Chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01486"},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Salehi, B., Mishra, A.P., Nigam, M., Sener, B., Kilic, M., Sharifi-Rad, M., Fokou, P.V.T., Martins, N., and Sharifi-Rad, J. (2018). Resveratrol: A double-edged sword in health benefits. Biomedicines, 6.","DOI":"10.3390\/biomedicines6030091"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3945\/ajcn.112.049379","article-title":"In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota","volume":"97","author":"Bode","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/10408360701612942","article-title":"Lignans and human health","volume":"44","author":"Adlercreutz","year":"2007","journal-title":"Crit. Ver. Clin. Lab. Sci."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12934-020-01341-0","article-title":"Impact of lignans in oilseed mix on gut microbiome composition and enterolignan production in younger healthy and premenopausal women: An in vitro pilot study","volume":"19","author":"Corona","year":"2020","journal-title":"Microb. Cell Factories"},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Wan, F., Zhong, R., Wang, M., Zhou, Y., Chen, Y., Yi, B., Hou, F., Liu, L., Zhao, Y., and Chen, L. (2021). Caffeic acid supplement alleviates colonic inflammation and oxidative stress potentially through improved gut microbiota community in mice. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.784211"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.aninu.2021.06.009","article-title":"Dietary ferulic acid and vanillic acid on inflammation, gut barrier function and growth performance in lipopolysaccharide-challenged piglets","volume":"8","author":"Hu","year":"2022","journal-title":"Anim. Nutr."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Alasalvar, C., Chang, S.K., Kris-Etherton, P.M., Sullivan, V.K., Petersen, K.S., Guasch-Ferr\u00e9, M., and Jenkins, D.J. (2023). Dried Fruits: Bioactives, Effects on Gut Microbiota, and Possible Health Benefits\u2014An Update. Nutrients, 15.","DOI":"10.3390\/nu15071611"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"111809","DOI":"10.1016\/j.foodres.2022.111809","article-title":"Fruit bioactive compounds: Effect on lactic acid bacteria and on intestinal microbiota","volume":"161","author":"Borgonovi","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"603","DOI":"10.17576\/jsm-2020-4903-15","article-title":"Effects of Plant Oligosaccharides Derived from Dragon Fruit on Gut Microbiota in Proximal and Distal Colon of Mice","volume":"49","author":"Peerakietkhajorn","year":"2020","journal-title":"Sains Malays."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3920\/BM2020.0057","article-title":"Short chain fatty acids in human gut and metabolic health","volume":"11","author":"Blaak","year":"2020","journal-title":"Benef. Microbes"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chom.2014.12.004","article-title":"Murine gut microbiota-diet trumps genes","volume":"1","author":"Walter","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40168-016-0178-x","article-title":"Variable responses of human microbiomes to dietary supplementation with resistant starch","volume":"4","author":"Venkataraman","year":"2016","journal-title":"Microbiome"},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Zheng, Y., Qin, C., Wen, M., Zhang, L., and Wang, W. (2024). The Effects of Food Nutrients and Bioactive Compounds on the Gut Microbiota: A Comprehensive Review. Foods, 13.","DOI":"10.3390\/foods13091345"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/apt.15818","article-title":"Review article: FODMAPS, prebiotics and gut health\u2014The FODMAP hypothesis revisited","volume":"52","author":"Gibson","year":"2020","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_234","first-page":"38","article-title":"The FODMAP diet for Gut Microbiome Restoration in Patients with Irritable Bowel Syndrome: A Narrative Review","volume":"13","author":"Valk","year":"2025","journal-title":"Iran. J. Color. Res."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Nordin, E., Hellstr\u00f6m, P.M., Dicksved, J., Pelve, E., Landberg, R., and Brunius, C. (2023). Effects of FODMAPs and Gluten on Gut Microbiota and Their Association with the Metabolome in Irritable Bowel Syndrome: A Double-Blind, Randomized, Cross-Over Intervention Study. Nutrients, 15.","DOI":"10.3390\/nu15133045"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.1039\/D3FO03717G","article-title":"Effects of a low FODMAP diet on the symptom management of patients with irritable bowel syndrome: A systematic umbrella review with the meta-analysis of clinical trials","volume":"15","author":"Sikaroudi","year":"2024","journal-title":"Food Funct."},{"key":"ref_237","first-page":"3505","article-title":"Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: A systematic review and meta-analysis","volume":"60","author":"Greyling","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Hahn, J., Choi, J., and Chang, M.J. (2021). Effect of Low FODMAPs Diet on Irritable Bowel Syndromes: A Systematic Review and Meta-Analysis of Clinical Trials. Nutrients, 13.","DOI":"10.3390\/nu13072460"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1053\/j.gastro.2017.06.010","article-title":"A Diet Low in FODMAPs Reduces Symptoms in Patients with Irritable Bowel Syndrome and a Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial","volume":"153","author":"Staudacher","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/jhn.12530","article-title":"The low FODMAP diet in the management of irritable bowel syndrome: An evidence-based review of FODMAP restriction, reintroduction and personalisation in clinical practice","volume":"31","author":"Whelan","year":"2018","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1177\/15598276211012968","article-title":"Dietary Modification for the Restoration of Gut Microbiome and Management of Symptoms in Irritable Bowel Syndrome","volume":"16","author":"Thomas","year":"2021","journal-title":"Am. J. Lifestyle Med."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1080\/10408398.2024.2448768","article-title":"Exploring the health benefits of food bioactive compounds from a perspective of NLRP3 inflammasome activation: An insight review","volume":"65","author":"Li","year":"2025","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1111\/1750-3841.16970","article-title":"Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications","volume":"89","author":"Rababah","year":"2024","journal-title":"J. Food Sci."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"102267","DOI":"10.1016\/j.fbio.2022.102267","article-title":"The recent progress on the bioactive compounds from algal biomass for human health applications","volume":"51","author":"Yang","year":"2023","journal-title":"Food Biosci."},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Garza, M.C., P\u00e9rez-Calahorra, S., Rodrigo-Carb\u00f3, C., S\u00e1nchez-Calavera, M.A., Jarauta, E., Mateo-Gallego, R., Gracia-Rubio, I., and Lamiquiz-Moneo, I. (2024). Effect of aromatic herbs and spices present in the Mediterranean diet on the glycemic profile in type 2 diabetes subjects: A systematic review and meta-analysis. Nutrients, 16.","DOI":"10.3390\/nu16060756"},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Maina, S., Misinzo, G., Bakari, G., and Kim, H.Y. (2020). Human, Animal and Plant Health Benefits of Glucosinolates and Strategies for Enhanced Bioactivity: A Systematic Review. Molecules, 25.","DOI":"10.3390\/molecules25163682"},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Ali, M.Y., Sina, A.A., Khandker, S.S., Neesa, L., Tanvir, E.M., Kabir, A., Khalil, M.I., and Gan, S.H. (2020). Nutritional Composition and Bioactive Compounds in Tomatoes and Their Impact on Human Health and Disease: A Review. Foods, 10.","DOI":"10.3390\/foods10010045"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1080\/10408398.2021.1948817","article-title":"Green coffee: Economic relevance and a systematic review of the effects on human health","volume":"63","author":"Bosso","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"e2000473","DOI":"10.1002\/mnfr.202000473","article-title":"The Effect of Plant Derived Bioactive Compounds on Inflammation: A Systematic Review and Meta-Analysis","volume":"64","author":"Poulsen","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"115829","DOI":"10.1016\/j.jep.2022.115829","article-title":"Molecular mechanism of the anti-inflammatory effects of plant essential oils: A systematic review","volume":"301","author":"Zhao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Pezantes-Orellana, C., German Berm\u00fadez, F., Mat\u00edas De la Cruz, C., Montalvo, J.L., and Orellana-Manzano, A. (2024). Essential oils: A systematic review on revolutionizing health, nutrition, and omics for optimal well-being. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1337785"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1080\/10408398.2018.1425978","article-title":"How does high DHA fish oil affect health? A systematic review of evidence","volume":"59","author":"Wang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"8728","DOI":"10.1080\/10408398.2023.2203229","article-title":"In vivo evidences of the health-promoting properties of bioactive compounds obtained from olive by-products and their use as food ingredient","volume":"64","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"11640","DOI":"10.1039\/D4FO04161E","article-title":"Association between olive oil consumption and all-cause, cardiovascular and cancer mortality in adult subjects: A systematic review and meta-analysis","volume":"15","author":"Visioli","year":"2024","journal-title":"Food Funct."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"109154","DOI":"10.1016\/j.jnutbio.2022.109154","article-title":"Blueberries and their bioactives in the modulation of oxidative stress, inflammation and cardio\/vascular function markers: A systematic review of human intervention studies","volume":"111","author":"Martini","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10654-022-00858-5","article-title":"Relationship between chocolate consumption and overall and cause-specific mortality, systematic review and updated meta-analysis","volume":"37","author":"Zhao","year":"2022","journal-title":"Eur. J. Epidemiol."},{"key":"ref_257","doi-asserted-by":"crossref","unstructured":"Gouveia, H., Urquiza-Mart\u00ednez, M.V., Manh\u00e3es-de-Castro, R., Costa-de-Santana, B.J.R., Villarreal, J.P., Mercado-Camargo, R., Torner, L., de Souza Aquino, J., Toscano, A.E., and Guzm\u00e1n-Quevedo, O. (2022). Effects of the Treatment with Flavonoids on Metabolic Syndrome Components in Humans: A Systematic Review Focusing on Mechanisms of Action. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158344"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"6797","DOI":"10.1080\/10408398.2022.2043821","article-title":"Garlic: A systematic review of the effects on cardiovascular diseases","volume":"63","author":"Imaizumi","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"113145","DOI":"10.1016\/j.biopha.2022.113145","article-title":"Preventive effects of Brassicaceae family for colon cancer prevention: A focus on in vitro studies","volume":"151","author":"Pena","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Costa-Perez, A., Nunez-Gomez, V., Baenas, N., Di Pede, G., Achour, M., Manach, C., Mena, P., Del Rio, D., Garcia-Viguera, C., and Moreno, D.A. (2023). Systematic review on the metabolic interest of glucosinolates and their bioactive derivatives for human health. Nutrients, 15.","DOI":"10.3390\/nu15061424"},{"key":"ref_261","doi-asserted-by":"crossref","unstructured":"Fabiani, R., Vella, N., and Rosignoli, P. (2021). Epigenetic modifications induced by olive oil and its phenolic compounds: A systematic review. Molecules, 26.","DOI":"10.3390\/molecules26020273"},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Mitra, S., Paul, S., Roy, S., Sutradhar, H., Bin Emran, T., Nainu, F., Khandaker, M.U., Almalki, M., Wilairatana, P., and Mubarak, M.S. (2022). Exploring the immune-boosting functions of vitamins and minerals as nutritional food bioactive compounds: A comprehensive review. Molecules, 27.","DOI":"10.3390\/molecules27020555"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"9081738","DOI":"10.1155\/2021\/9081738","article-title":"Bioactive compounds from kefir and their potential benefits on health: A systematic review and meta-analysis","volume":"2021","author":"Vieira","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.2174\/1871527321666220608085852","article-title":"The potential effect of blueberry on cognitive health and mood state based on human intervention studies: Systematic review and mini meta-analysis","volume":"22","author":"Soveid","year":"2023","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s11064-021-03376-0","article-title":"A pharmacological perspective on plant-derived bioactive molecules for epilepsy","volume":"46","author":"Quispe","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s44187-025-00412-8","article-title":"Enhancing Bioactive Stability and Applications: Microencapsulation in Fruit and Vegetable Waste Valorization","volume":"5","author":"Ingale","year":"2025","journal-title":"Discov. Food"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"101322","DOI":"10.1016\/j.afres.2025.101322","article-title":"Advancements in Extraction and Encapsulation of Immunomodulatory Mushroom Biomolecules for Enhanced Food Applications","volume":"5","author":"Agnihotri","year":"2025","journal-title":"Appl. Food Res."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/2\/345\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:27:27Z","timestamp":1768973247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/2\/345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":267,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["molecules31020345"],"URL":"https:\/\/doi.org\/10.3390\/molecules31020345","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]}}}