{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:06:19Z","timestamp":1760148379200,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Science and Technology (Portugal)","award":["UIDB\/04539\/2020","UIDP\/04539\/2020","VANGUARD 874700"],"award-info":[{"award-number":["UIDB\/04539\/2020","UIDP\/04539\/2020","VANGUARD 874700"]}]},{"name":"University of Geneva","award":["UIDB\/04539\/2020","UIDP\/04539\/2020","VANGUARD 874700"],"award-info":[{"award-number":["UIDB\/04539\/2020","UIDP\/04539\/2020","VANGUARD 874700"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MPs"],"abstract":"<jats:p>The last 18 years have brought an increasing interest in the therapeutic use of perinatal derivatives (PnD). Preclinical studies used to assess the potential of PnD therapy include a broad range of study designs. The COST SPRINT Action (CA17116) aims to provide systematic and comprehensive reviews of preclinical studies for the understanding of the therapeutic potential and mechanisms of PnD in diseases and injuries that benefit from PnD therapy. Here we describe the publication search and data mining, extraction, and synthesis strategies employed to collect and prepare the published data selected for meta-analyses and reviews of the efficacy of PnD therapies for different diseases and injuries. A coordinated effort was made to prepare the data suitable to make statements for the treatment efficacy of the different types of PnD, routes, time points, and frequencies of administration, and the dosage based on clinically relevant effects resulting in clear increase, recovery or amelioration of the specific tissue or organ function. According to recently proposed guidelines, the harmonization of the nomenclature of PnD types will allow for the assessment of the most efficient treatments in various disease models. Experts within the COST SPRINT Action (CA17116), together with external collaborators, are doing the meta-analyses and reviews using the data prepared with the strategies presented here in the relevant disease or research fields. Our final aim is to provide standards to assess the safety and clinical benefit of PnD and to minimize redundancy in the use of animal models following the 3R principles for animal experimentation.<\/jats:p>","DOI":"10.3390\/mps6030045","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T01:44:42Z","timestamp":1682473482000},"page":"45","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Guidelines to Analyze Preclinical Studies Using Perinatal Derivatives"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-4650","authenticated-orcid":false,"given":"Ana Salom\u00e9","family":"Pires","sequence":"first","affiliation":[{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-354 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1076-0823","authenticated-orcid":false,"given":"Sveva","family":"Bollini","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine (DIMES), University of Genova, 16132 Genova, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-1650","authenticated-orcid":false,"given":"Maria Filomena","family":"Botelho","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-354 Coimbra, Portugal"}]},{"given":"Ingrid","family":"Lang-Olip","sequence":"additional","affiliation":[{"name":"Division of Cell Biology, Histology, Embryology, Gottfried Schatz Research Center, Medical University of Graz, 8010 Graz, Austria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1892-6499","authenticated-orcid":false,"given":"Peter","family":"Ponsaerts","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-1173","authenticated-orcid":false,"given":"Carolina","family":"Balbi","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Cardiology, Istituto Cardiocentro Ticino, CH-6900 Lugano, Switzerland"},{"name":"Center for Molecular Cardiology, University of Zurich, CH-8057 Zurich, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7748-3413","authenticated-orcid":false,"given":"Anna","family":"Lange-Consiglio","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Science (DIVAS), Universit\u00e0 degli Studi di Milano, Via Celoria, 10, 20133 Milano, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-8983","authenticated-orcid":false,"given":"Mathilde","family":"F\u00e9nelon","sequence":"additional","affiliation":[{"name":"INSERM U1026, University of Bordeaux, Tissue Bioengineering (BioTis), F-33076 Bordeaux, France"},{"name":"CHU Bordeaux, Service de Chirurgie Orale, F-33076 Bordeaux, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-6720","authenticated-orcid":false,"given":"Slavko","family":"Mojsilovi\u0107","sequence":"additional","affiliation":[{"name":"Group for Hematology and Stem Cells, Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-1937","authenticated-orcid":false,"given":"Ekaterine","family":"Berishvili","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Engineering and Organ Regeneration, University of Geneva, CH-1211 Geneva, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-4626","authenticated-orcid":false,"given":"Fausto","family":"Cremonesi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Science (DIVAS), Universit\u00e0 degli Studi di Milano, Via Celoria, 10, 20133 Milano, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-6811","authenticated-orcid":false,"given":"Maria","family":"Gazouli","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Laboratory of Biology, Faculty of Medicine, School of Health Science, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}]},{"given":"Diana","family":"Bugarski","sequence":"additional","affiliation":[{"name":"Group for Hematology and Stem Cells, Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-4581","authenticated-orcid":false,"given":"Alexandra","family":"Gellhaus","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital Essen, University of Duisburg-Essen, D-45147 Essen, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-9728","authenticated-orcid":false,"given":"Halima","family":"Kerdjoudj","sequence":"additional","affiliation":[{"name":"Biomat\u00e9riaux et Inflammation en Site Osseux (BIOS), Universit\u00e9 de Reims Champagne Ardenne, F-51097 Reims, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6716-9551","authenticated-orcid":false,"given":"Andreina","family":"Schoeberlein","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Feto-maternal Medicine, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland"},{"name":"Department for BioMedical Research (DBMR), University of Bern, CH-3008 Bern, Switzerland"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3389\/fbioe.2020.610544","article-title":"Perinatal Derivatives: Where Do We Stand? 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