{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:04:32Z","timestamp":1773666272794,"version":"3.50.1"},"reference-count":65,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["19-01-00519-a"],"award-info":[{"award-number":["19-01-00519-a"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>The structures and properties of the diphenylalanine (FF) peptide nanotubes (PNTs), both L-chiral and D-chiral (L-FF and D-FF) and empty and filled with water\/ice clusters, are presented and analyzed. DFT (VASP) and semi-empirical calculations (HyperChem) to study these structural and physical properties of PNTs (including ferroelectric) were used. The results obtained show that after optimization the dipole moment and polarization of both chiral type L-FF and D-FF PNT and embedded water\/ice cluster are enhanced; the water\/ice cluster acquire the helix-like structure similar as L-FF and D-FF PNT. Ferroelectric properties of tubular water\/ice helix-like cluster, obtained after optimization inside L-FF and D-FF PNT, as well of the total L-FF and D-FF PNT with embedded water\/ice cluster, are discussed.<\/jats:p>","DOI":"10.3390\/nano10101999","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T10:18:00Z","timestamp":1602497880000},"page":"1999","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Structures and Properties of the Self-Assembling Diphenylalanine Peptide Nanotubes Containing Water Molecules: Modeling and Data Analysis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-9469","authenticated-orcid":false,"given":"Vladimir","family":"Bystrov","sequence":"first","affiliation":[{"name":"Institute of Mathematical Problems of Biology, Keldysh Institute of Applied Mathematics, RAS, Pushchino, Moscow 142290, Russia"}]},{"given":"Jose","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Department of Physics &amp; I3N, University of Aveiro, Campus Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-4785","authenticated-orcid":false,"given":"Pavel","family":"Zelenovskiy","sequence":"additional","affiliation":[{"name":"School of Natural Sciences and Mathematics, Ural Federal University, Ekaterinburg 620000, Russia"},{"name":"Department of Chemistry &amp; CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-2474","authenticated-orcid":false,"given":"Alla","family":"Nuraeva","sequence":"additional","affiliation":[{"name":"School of Natural Sciences and Mathematics, Ural Federal University, Ekaterinburg 620000, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3347-8628","authenticated-orcid":false,"given":"Svitlana","family":"Kopyl","sequence":"additional","affiliation":[{"name":"Department of Physics &amp; CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Olga","family":"Zhulyabina","sequence":"additional","affiliation":[{"name":"Faculty of Physics, Lomonosov Moscow State University, Moscow 119991, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7818-4944","authenticated-orcid":false,"given":"Vsevolod","family":"Tverdislov","sequence":"additional","affiliation":[{"name":"Faculty of Physics, Lomonosov Moscow State University, Moscow 119991, Russia"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,10]]},"reference":[{"key":"ref_1","unstructured":"Calvin, M. (1969). Chemical Evolution. Molecular Evolution, towards the Origin of Living System on the Earth and Elsewhere, Claredon."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1389203717666160724210122","article-title":"Formation of nanostructures by peptides","volume":"18","author":"Pachahara","year":"2017","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1016\/j.bios.2009.02.008","article-title":"Recent advances in self-assembled monolayers based biomolecular electronic devices","volume":"24","author":"Aryaa","year":"2009","journal-title":"J. Biosens. Bioelectron."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/wnan.1238","article-title":"Self-assembly in nature: Using the principles of nature to create complex nanobiomaterials","volume":"5","author":"Mendes","year":"2013","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"13752","DOI":"10.1021\/acs.chemrev.6b00354","article-title":"Supramolecular helical systems: Helical assemblies of small molecules, foldamers, and polymers with chiral amplification and their functions","volume":"116","author":"Yashima","year":"2016","journal-title":"Chem. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1134\/S0006350913010156","article-title":"Chirality as a primary switch of hierarchical levels in molecular biological systems","volume":"58","author":"Tverdislov","year":"2013","journal-title":"Biophysics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1134\/S0006350917030228","article-title":"A periodic system of chiral structures in molecular biology","volume":"62","author":"Tverdislov","year":"2017","journal-title":"Biophysics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-physchem-040214-121554","article-title":"Spintronics and chirality: Spin selectivity in electron transport through chiral molecules","volume":"66","author":"Naaman","year":"2015","journal-title":"Annu. Rev. Phys. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"10554","DOI":"10.1021\/jacs.5b03973","article-title":"Modular Design of Self-Assembling Peptide-Based Nanotubes","volume":"137","author":"Burgess","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8150","DOI":"10.1039\/C4CS00247D","article-title":"Design of nanostructures based on aromatic peptide amphiphiles","volume":"43","author":"Fleming","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1039\/c1cs15064b","article-title":"Integrating top-down and self-assembly in the fabrication of peptide and protein-based biomedical materials","volume":"40","author":"Smith","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"10205","DOI":"10.1021\/la4019162","article-title":"L-diphenylalanine microtubes as apotential drug-delivery system: Characterization, release kinetics, and cytotoxicity","volume":"29","author":"Silva","year":"2013","journal-title":"Langmuir"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jddst.2017.06.005","article-title":"Covalent diphenylalanine peptide nanotube conjugated to folic acid\/magnetic nanoparticles for anti-cancer drug delivery","volume":"41","author":"Emtiazi","year":"2017","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Azevedo, H.S., and da Silva, R.M.P. (2018). Molecular simulation of self-assembly. Self-Assembling Biomaterials. Molecular Design, Characterization and Application in Biology and Medicine, Elsevier Ltd.. [1st ed.].","DOI":"10.1016\/j.focat.2018.08.055"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1021\/ja110966y","article-title":"Atomistic molecular dynamics simulations of peptide amphiphile self-assembly into cylindrical nanofibers","volume":"133","author":"Lee","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00894-014-2520-1","article-title":"An approach to creating a more realistic working model from a protein data bank entry","volume":"21","author":"Brandon","year":"2015","journal-title":"J. Mol. Model."},{"key":"ref_17","unstructured":"Lehninger, A.L. (1972). Biochemistry. The Molecular Basis of Cell Structure and Function, Worth."},{"key":"ref_18","first-page":"11","article-title":"Piezoelectric and ferroelectric properties of various amino acids and tubular dipeptide nanostructures: Molecular modeling","volume":"2","author":"Bystrov","year":"2020","journal-title":"Nanomater. Sci. Eng."},{"key":"ref_19","unstructured":"Lines, M.E., and Glass, A.M. (1977). Principles and Applications of Ferroelectrics and Related Materials, Clarendon Press."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ciofani, G., and Menciassi, A. (2012). Piezoelectricity and Ferroelectricity in biomaterials: From proteins to self-assembled peptide nanotubes. Piezoelectric Nanomaterials for Biomedical Applications, Springer.","DOI":"10.1007\/978-3-642-28044-3"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"066803","DOI":"10.1063\/1.4891443","article-title":"Piezoelectricity and ferroelectricity in biomaterials: Molecular modeling and piezoresponse force microscopy measurements","volume":"116","author":"Bystrov","year":"2014","journal-title":"J. Appl. Phys."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1021\/nn901327v","article-title":"Strong piezoelectricity in bioinspired peptide nanotubes","volume":"4","author":"Kholkin","year":"2010","journal-title":"ACS Nano."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"13566","DOI":"10.1038\/ncomms13566","article-title":"Self-assembly of diphenylalanine peptide with controlled polarization for power generation","volume":"7","author":"Nguyen","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/00150193.2012.741923","article-title":"Bioferroelectricity: Diphenylalanine peptide nanotubes computational modeling and ferroelectric properties at the nanoscale","volume":"440","author":"Bystrov","year":"2012","journal-title":"Ferroelectrics"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00894-019-4080-x","article-title":"Molecular modeling and computational study of the chiral-dependent structures and properties of the self-assembling diphenylalanine peptide nanotubes","volume":"25","author":"Bystrov","year":"2019","journal-title":"J. Mol. Model."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/00150193.2018.1432832","article-title":"Investigation of physical properties of diphenylalanine peptide nanotubes having different chiralities and embedded water molecules","volume":"525","author":"Bystrov","year":"2018","journal-title":"Ferroelectrics"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"074104","DOI":"10.1063\/1.3699202","article-title":"Polarization switching and patterning in self-assembled peptide tubular structures","volume":"111","author":"Bdikin","year":"2012","journal-title":"J. Appl. Phys."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"94","DOI":"10.17537\/2019.14.94","article-title":"Chiral peculiar properties of self-organization of diphenylalanine peptide nanotubes: Modeling of structure and properties","volume":"14","author":"Bystrov","year":"2019","journal-title":"Math. Biol. Bioinform."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1021\/acs.cgd.9b00884","article-title":"Chirality-dependent growth of self-assembled diphenylalanine microtubes","volume":"19","author":"Zelenovskiy","year":"2019","journal-title":"Cryst. Growth Des."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1134\/S0006350920030057","article-title":"Visual-differential analysis of structural features of internal cavities of two chiral forms of diphenylalanine nanotubes","volume":"65","author":"Filippov","year":"2020","journal-title":"Biophysics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/00150193.2015.995577","article-title":"Morphology and piezoelectric properties of diphenylalanine microcrystals grown from methanol-water solution","volume":"475","author":"Zelenovskiy","year":"2015","journal-title":"Ferroelectrics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"29681","DOI":"10.1039\/C6CP04337B","article-title":"On the origin of the great rigidity of self-assembled diphenylalanine nanotubes","volume":"18","author":"Zelenovskiy","year":"2016","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1002\/1521-3765(20011203)7:23<5153::AID-CHEM5153>3.0.CO;2-N","article-title":"Nanotube formation by hydrophobic dipeptides","volume":"7","author":"Gorbitz","year":"2001","journal-title":"Chem. Eur. J."},{"key":"ref_34","first-page":"311","article-title":"Hydrophobic dipeptides: The final piece in the puzzle","volume":"B74","author":"Gorbitz","year":"2018","journal-title":"Acta. Cryst."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/adma.200901973","article-title":"Role of water in directing diphenylalanine assembly into nanotubes and nanowires","volume":"22","author":"Kim","year":"2010","journal-title":"Adv. Mater."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00214-016-1936-3","article-title":"Water-driven stabilization of diphenylalanine nanotube structures","volume":"135","author":"Martins","year":"2016","journal-title":"Theor. Chem. Acc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00894-016-3025-x","article-title":"A comparison of X-ray and calculated structures of the enzyme MTH1","volume":"22","author":"Ryan","year":"2016","journal-title":"J. Mol. Model."},{"key":"ref_38","unstructured":"Hypercube Inc (2002). HyperChem, Hypercube Inc.. Available online: http:\/\/www.hyper.com\/?tabid=360."},{"key":"ref_39","unstructured":"(2020, July 27). Available online: https:\/\/www.ccdc.cam.ac.uk\/."},{"key":"ref_40","unstructured":"(2020, July 27). VASP (Vienna Ab initio Simulation Package). Available online: https:\/\/www.vasp.at\/."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"11169","DOI":"10.1103\/PhysRevB.54.11169","article-title":"Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set","volume":"54","author":"Kresse","year":"1996","journal-title":"Phys. Rev. B Condens. Matter Mater. Phys."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1103\/PhysRevB.59.1758","article-title":"From ultrasoft pseudopotentials to the projector augmented-wave method","volume":"59","author":"Kresse","year":"1999","journal-title":"Phys. Rev. B Condens. Matter Mater. Phys."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1103\/PhysRevLett.77.3865","article-title":"Generalized Gradient Approximation Made Simple","volume":"77","author":"Perdew","year":"1996","journal-title":"Phys. Rev. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"234102","DOI":"10.1063\/1.1926272","article-title":"The Perdew-Burke-Ernzerhof exchange-correlation functional applied to the G2-1 test set using a plane-wave basis set","volume":"122","author":"Paier","year":"2005","journal-title":"J. Chem. Phys."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17953","DOI":"10.1103\/PhysRevB.50.17953","article-title":"Projector augmented-wave method","volume":"50","author":"Blochl","year":"1994","journal-title":"Phys. Rev. B Condens. Matter Mater. Phys."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"154104","DOI":"10.1063\/1.3382344","article-title":"A consistent and accurate ab initio parametrization of density functional dispersion correction (dft-d) for the 94 elements H-Pu","volume":"132","author":"Grimme","year":"2010","journal-title":"J. Chem. Phys."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1103\/PhysRevB.13.5188","article-title":"Special points for Brillouin-zone integrations","volume":"13","author":"Monkhorst","year":"1976","journal-title":"Phys. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"6146","DOI":"10.1021\/jp963277n","article-title":"Ab-initio total energy studies of the static and dynamical properties of ice Ih","volume":"101","author":"Morrison","year":"1997","journal-title":"J. Phys. Chem. B"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1021\/jp808873r","article-title":"First-principles study of water chains encapsulated in single-walled carbon nanotube","volume":"113","author":"Wang","year":"2009","journal-title":"J. Phys. Chem. C"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1021\/jp201882d","article-title":"First-principles study of water confined in single-walled silicon carbide nanotubes","volume":"115","author":"Yang","year":"2011","journal-title":"J. Phys. Chem. C"},{"key":"ref_51","unstructured":"Bystrov, V.S., Zhulyabina, O.A., Kopy, S.A., Zelenovskiy, P.S., Nuraeva, A.S., Tverdislov, V.A., Filippov, S.V., Salehli, F., Kholkin, A.L., and Shur, V.Y. (2020). Modeling and computer study of diphenylalanine peptide nanotubes, containing the water molecules. Abstract Book of the International Online Conference \u201cResearch Ferroelectric Materials by Russian Scientists. Centenary of Discovery Ferroelectricity \u201c(SE-100) (Yekaterinburg, 17\u201319 August 2020), Ural Federal University."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1021\/ja00299a024","article-title":"Development and use of quantum-mechanical molecular models. 76. AM1: A new general purpose quantum mechanical molecular model","volume":"107","author":"Dewar","year":"1985","journal-title":"J. Am. Chem. Soc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1021\/ja00285a033","article-title":"Evaluation of AM1 calculated proton affinities and deprotonation enthalpies","volume":"108","author":"Dewar","year":"1986","journal-title":"J. Am. Chem. Soc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00128336","article-title":"MOPAC: A semiempirical molecular orbital program","volume":"4","author":"Stewart","year":"1990","journal-title":"J. Comp. Aided Mol. Des."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/jcc.540100208","article-title":"Optimization of Parameters for Semiempirical Methods. I. Method","volume":"10","author":"Stewart","year":"1989","journal-title":"J. Comput. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jcc.540100209","article-title":"Optimization of parameters for semiempirical methods","volume":"10","author":"Stewart","year":"1989","journal-title":"II. Applications. J. Comput. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s00894-007-0233-4","article-title":"Optimization of parameters for semiempirical methods V: Modification of NDDO approximations and application to 70 elements","volume":"13","author":"Stewart","year":"2007","journal-title":"J. Mol. Mod."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/jcc.20425","article-title":"RM1: A Reparameterization of AM1 for Y, C, N, O, P, S, F, Cl, Br, and I","volume":"27","author":"Rocha","year":"2006","journal-title":"J. Comput. Chem."},{"key":"ref_59","first-page":"683","article-title":"RM1 Semiempirical Model: Chemistry, Pharmaceutical Research, Molecular Biology and Materials Science","volume":"30","author":"Lima","year":"2019","journal-title":"J. Braz. Chem. Soc."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"19664","DOI":"10.1073\/pnas.0608401104","article-title":"Multiwalled ice helixes and ice nanotubes","volume":"103","author":"Bai","year":"2006","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"11176","DOI":"10.1021\/acs.langmuir.8b00856","article-title":"First-Principles Study of Water Nanotubes Captured Inside Carbon\/Boron Nitride Nanotubes","volume":"34","author":"Shayeganfar","year":"2018","journal-title":"Langmuir"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1134\/S106378341408006X","article-title":"The study of ferroelectric phase transitions of water in nanoporous silicates with joint electrical noise and calorimetric measurements","volume":"56","author":"Bordonskiy","year":"2014","journal-title":"Phys. Solid State"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"043702","DOI":"10.1063\/1.3676417","article-title":"Evidence of ferroelectricity and phase transition in pressed diphenylalanine","volume":"100","author":"Bdikin","year":"2012","journal-title":"Appl. Phys. Lett."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Winarto, W., Yamamoto, E., and Yasuoka, K. (2017). Water Molecules in a Carbon Nanotube under an Applied Electric Field at Various Temperatures and Pressures. Water, 9.","DOI":"10.3390\/w9070473"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1021\/nn900221t","article-title":"Dielectric Properties of Water inside Single-Walled Carbon Nanotubes","volume":"3","author":"Mikami","year":"2009","journal-title":"ACS Nano"}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/10\/10\/1999\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:19:00Z","timestamp":1760177940000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/10\/10\/1999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,10]]},"references-count":65,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["nano10101999"],"URL":"https:\/\/doi.org\/10.3390\/nano10101999","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,10]]}}}