{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:18:09Z","timestamp":1769008689362,"version":"3.49.0"},"reference-count":56,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PROTEOMASS Scientific Society","award":["2019-2020 General Funding"],"award-info":[{"award-number":["2019-2020 General Funding"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SiSi4Bacter (PTDC\/QUI-COL\/1517\/2020"],"award-info":[{"award-number":["SiSi4Bacter (PTDC\/QUI-COL\/1517\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/QEQ-MED\/2118\/2014"],"award-info":[{"award-number":["PTDC\/QEQ-MED\/2118\/2014"]}]},{"name":"LAQV-REQUIMTE","award":["UIDB\/04077\/2020"],"award-info":[{"award-number":["UIDB\/04077\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>In this work, the successful preparation and characterization of gold nanorods (AuNRs) coated with a mesoporous silica shell (AuNRs@Simes) was achieved. Conjugation with methylene blue (MB) as a model drug using ultrasound-stimulated loading has been explored for further application in light-mediated antibacterial studies. Lyophilization of this conjugated nanosystem was analyzed using trehalose (TRH) as a cryogenic protector. The obtained stable dry formulation shows potent antimicrobial activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria after a simple post-treatment irradiation method with a red laser during a short time period.<\/jats:p>","DOI":"10.3390\/nano11051338","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T21:49:21Z","timestamp":1621460961000},"page":"1338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Synthesis of Mesoporous Silica Coated Gold Nanorods Loaded with Methylene Blue and Its Potentials in Antibacterial Applications"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3742-1186","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Fern\u00e1ndez-Lodeiro","sequence":"first","affiliation":[{"name":"BIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, FCT NOVA, NOVA University Lisbon, 2829-516 Lisbon, Portugal"},{"name":"PROTEOMASS Scientific Society, Rua dos Inventores, Madam Parque, Caparica Campus, 2829-516 Almada, Portugal"}]},{"given":"Jamila","family":"Djafari","sequence":"additional","affiliation":[{"name":"BIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, FCT NOVA, NOVA University Lisbon, 2829-516 Lisbon, Portugal"},{"name":"PROTEOMASS Scientific Society, Rua dos Inventores, Madam Parque, Caparica Campus, 2829-516 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8853-2631","authenticated-orcid":false,"given":"Javier","family":"Fern\u00e1ndez-Lodeiro","sequence":"additional","affiliation":[{"name":"BIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, FCT NOVA, NOVA University Lisbon, 2829-516 Lisbon, Portugal"},{"name":"PROTEOMASS Scientific Society, Rua dos Inventores, Madam Parque, Caparica Campus, 2829-516 Almada, Portugal"}]},{"given":"Maria Paula","family":"Duarte","sequence":"additional","affiliation":[{"name":"MEtRICs\/DCTB\/NOVA, School of Science and Technology, NOVA University Lisbon, Caparica Campus, 2829-516 Almada, Portugal"}]},{"given":"Elisabete","family":"Muchagato Mauricio","sequence":"additional","affiliation":[{"name":"CBIOS\/DREAMS, Universidade Lus\u00f3fona de Humanidades e Tecnologia, Campo Grande, 376, 1749-024 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6276-8507","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Capelo-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"BIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, FCT NOVA, NOVA University Lisbon, 2829-516 Lisbon, Portugal"},{"name":"PROTEOMASS Scientific Society, Rua dos Inventores, Madam Parque, Caparica Campus, 2829-516 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5582-5446","authenticated-orcid":false,"given":"Carlos","family":"Lodeiro","sequence":"additional","affiliation":[{"name":"BIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, FCT NOVA, NOVA University Lisbon, 2829-516 Lisbon, Portugal"},{"name":"PROTEOMASS Scientific Society, Rua dos Inventores, Madam Parque, Caparica Campus, 2829-516 Almada, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1021\/jp0107964","article-title":"Wet Chemical Synthesis of High Aspect Ratio Cylindrical Gold Nanorods","volume":"105","author":"Jana","year":"2001","journal-title":"J. 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