{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:43:57Z","timestamp":1775789037378,"version":"3.50.1"},"reference-count":104,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)\/Portugal through Research Unit grants   and  Projects \u201cMultifuctional Nanoseeds for Chemoradiotherapy of Glioblastoma.","award":["C2TN (UID\/Multi\/04349\/2019), IBB (UIDB\/04565\/2020), PTDC\/MEDQUI\/29649\/2017AP"],"award-info":[{"award-number":["C2TN (UID\/Multi\/04349\/2019), IBB (UIDB\/04565\/2020), PTDC\/MEDQUI\/29649\/2017AP"]}]},{"name":"FCT and Ag\u00eancia Nacional de Inova\u00e7\u00e3o (ANI) through the project \u201cIn-beam Time-of-Flight (TOF) Positron Emission Tomography (PET) for proton radiation therapy","award":["LISBOA-01-0247-FEDER-045904"],"award-info":[{"award-number":["LISBOA-01-0247-FEDER-045904"]}]},{"name":"Romanian National Authority for Scientific Research and Innovation, CNCS\/CCCDI \u2013 UEFISCDI, project GreenCatOx,","award":["PN-III-P2-2.1-PED-2019-3166, contract 299\/2020"],"award-info":[{"award-number":["PN-III-P2-2.1-PED-2019-3166, contract 299\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Root extracts from Danube Delta Nymphaea alba were used to prepare gold nanoparticles (AuNPRn) by reducing HAuCl4 at different pHs (6.4\u20138.4) using ultrasonic irradiation: an easy, cheap, eco-friendly and green approach. Their antibacterial and anticancer activities were evaluated against Staphylococcus aureus and Escherichia coli, and A2780 ovarian cancer cells, respectively. The AuNPRn were characterized concerning their phytoconstituents (polyphenols, flavonoids and condensed tannins) and gold content. All of the nanoparticles were negatively charged. AuNPRn exhibited a hydrodynamic size distribution ranging from 32 nm to 280 nm, with the larger nanoparticles being obtained with an Au\/root extract ratio of 0.56, pH 7 and 10 min of sonication (AuNPR1), whereas the smallest were obtained with an Au\/root extract ratio of 0.24, pH 7.8 and 40 min of sonication (AuNPR4). The TEM\/SEM images showed that the AuNPRn had different shapes. The ATR-FTIR indicated that AuNPRn interact mainly with hydroxyl groups present in the polyphenol compounds, which also confirm their high antioxidant capacity, except for AuNPR2 obtained at pH 6.4. Among the AuNPRn, the smallest ones exhibited enhanced antimicrobial and anticancer activities.<\/jats:p>","DOI":"10.3390\/nano11061562","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T22:25:46Z","timestamp":1623709546000},"page":"1562","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sono-Biosynthesis and Characterization of AuNPs from Danube Delta Nymphaea alba Root Extracts and Their Biological Properties"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2158-3877","authenticated-orcid":false,"given":"Mihaela","family":"Cudalbeanu","sequence":"first","affiliation":[{"name":"Faculty of Sciences and Environment, Department of Chemistry Physical and Environment, \u201cDun\u0103rea de Jos\u201d University of Galati, 111 Domneasc\u0103 Street, 800201 Galati, Romania"},{"name":"Research Center for Environmental Protection and Waste Management, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania"}]},{"given":"David","family":"Peitinho","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Campus Tecnol\u00f3gico e Nuclear, Estrada Nacional 10, Km 139.7, 2695-066 Bobadela, Portugal"}]},{"given":"Francisco","family":"Silva","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Campus Tecnol\u00f3gico e Nuclear, Estrada Nacional 10, Km 139.7, 2695-066 Bobadela, Portugal"}]},{"given":"Rosa","family":"Marques","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Campus Tecnol\u00f3gico e Nuclear, Estrada Nacional 10, Km 139.7, 2695-066 Bobadela, Portugal"},{"name":"Departamento de Engenharia e 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Nucleares (DECN), Instituto Superior T\u00e9cnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8297-8982","authenticated-orcid":false,"given":"Catarina F.","family":"Soeiro","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, iBB-Institute of Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, University of Lisbon, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9291-9169","authenticated-orcid":false,"given":"S\u00edlvia Andreia","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, iBB-Institute of Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, University of Lisbon, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-274X","authenticated-orcid":false,"given":"Jorge Humberto","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Department of 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Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1039\/C9TB00557A","article-title":"Recent advances in gold nanoparticles for biomedical applications: From hybrid structures to multi-functionality","volume":"7","author":"Jeong","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Silva, F., Cabral Campello, M.P., and Paulo, A. (2021). Radiolabeled Gold Nanoparticles for Imaging and Therapy of Cancer. Materials, 14.","DOI":"10.3390\/ma14010004"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kohout, C., Santi, C., and Polito, L. (2018). Anisotropic gold nanoparticles in biomedical applications. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113385"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8774","DOI":"10.1039\/D0CS01121E","article-title":"Active targeting of gold nanoparticles as cancer therapeutics","volume":"49","author":"Goddard","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.2217\/nnm-2016-0279","article-title":"Green synthesis of silver nanoparticles via plant extracts: Beginning a new era in cancer theranostics","volume":"11","author":"Ovais","year":"2016","journal-title":"Nanomedicine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jare.2010.02.002","article-title":"Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy","volume":"1","author":"Huang","year":"2010","journal-title":"J. Adv. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2147\/IJN.S233789","article-title":"Recent developments in the facile bio-synthesis of gold nanoparticles (AuNPs) and their biomedical applications","volume":"15","author":"Lee","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1039\/df9511100055","article-title":"A study of the nucleation and growth processes in the synthesis of colloidal gold. discuss","volume":"11","author":"Turkavich","year":"1951","journal-title":"Faraday Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.14356\/kona.2020011","article-title":"Synthesis of precision gold nanoparticles using turkevich method","volume":"37","author":"Dong","year":"2020","journal-title":"Kona"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.2741\/4284","article-title":"Gold nanoparticles: Various methods of synthesis and antibacterial applications","volume":"19","author":"Shah","year":"2014","journal-title":"Front. Biosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s13205-019-1577-z","article-title":"Gold nanoparticle surface engineering strategies and their applications in biomedicine and diagnostics","volume":"9","author":"Mahato","year":"2019","journal-title":"3 Biotech"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1021\/acs.bioconjchem.6b00102","article-title":"Interrogating the role of receptor-mediated mechanisms: Biological fate of peptide-functionalized radiolabeled gold nanoparticles in tumor mice","volume":"27","author":"Silva","year":"2016","journal-title":"Bioconjug. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1186\/1556-276X-9-627","article-title":"Yucca-derived synthesis of gold nanomaterial and their catalytic potential","volume":"9","author":"Krishnamurthy","year":"2014","journal-title":"Nanoscale Res. Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"10928","DOI":"10.1021\/acs.langmuir.6b02662","article-title":"Ostwald ripening growth mechanism of gold nanotriangles in vesicular template phases","volume":"32","author":"Liebig","year":"2016","journal-title":"Langmuir"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3109\/21691401.2014.971807","article-title":"Current methods for synthesis of gold nanoparticles","volume":"44","author":"Herizchi","year":"2016","journal-title":"Artificial Cells, Nanomed. Biotechnol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/17518253.2017.1349192","article-title":"A review of the green syntheses and anti-microbial applications of gold nanoparticles","volume":"10","author":"Nadeem","year":"2017","journal-title":"Green Chem. Lett. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.onano.2017.07.001","article-title":"Recent trends and methodologies in gold nanoparticle synthesis\u2013A prospective review on drug delivery aspect","volume":"2","author":"Sengani","year":"2017","journal-title":"OpenNano"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Yaseen, M., Humayun, M., Khan, A., Usman, M., Ullah, H., Tahir, A.A., and Ullah, H. (2021). Preparation, functionalization, modification, and applications of nanostructured gold: A critical review. Energies, 14.","DOI":"10.3390\/en14051278"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Freitas de Freitas, L., Costa Varca, G.H., Dos Santos Batista, J.G., and Ben\u00e9volo Lug\u00e3o, A. (2018). An overview of the synthesis of gold nanoparticles using radiation technologies. Nanomaterials, 8.","DOI":"10.3390\/nano8110939"},{"key":"ref_21","first-page":"113","article-title":"Synthesis of biogenic gold nanoparticles and its applications as theranostic agent: A review","volume":"1","author":"Sharon","year":"2017","journal-title":"Nanomed. Nanotechnol. J."},{"key":"ref_22","first-page":"22","article-title":"Microorganism assisted synthesis of gold nanoparticles: A review","volume":"8","author":"Sehgal","year":"2018","journal-title":"Asian J. Biomed. Pharm. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1039\/c1gc15386b","article-title":"Green synthesis of metal nanoparticles using plants","volume":"13","author":"Iravani","year":"2011","journal-title":"Green Chem."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Castillo-Henr\u00edquez, L., Alfaro-Aguilar, K., Ugalde-\u00c1lvarez, J., Vega-Fern\u00e1ndez, L., Montes de Oca-V\u00e1squez, G., and Vega-Baudrit, J.R. (2020). Green synthesis of gold and silver nanoparticles from plant extracts and their possible applications as antimicrobial agents in the agricultural area. Nanomaterials, 10.","DOI":"10.20944\/preprints202007.0318.v1"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1515\/revce-2018-0051","article-title":"Green gold nanoparticles from plant-derived materials: An overview of the reaction synthesis types, conditions, and applications","volume":"36","author":"Can","year":"2019","journal-title":"Rev. Chem. Eng."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"025005","DOI":"10.1088\/2043-6262\/7\/2\/025005","article-title":"Green synthesis of gold nanoparticles using aqueous extract of Dillenia indica","volume":"7","author":"Sett","year":"2016","journal-title":"Adv. Nat. Sci. Nanosci. Nanotechnol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.matpr.2020.04.589","article-title":"Biosynthesis of gold nanoparticles for detection of dichlorvos residue from different samples","volume":"29","author":"Bhagat","year":"2020","journal-title":"Mater. Today Proc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"102956","DOI":"10.1016\/j.arabjc.2020.102956","article-title":"Facile one-step green synthesis of gold nanoparticles (AuNp) using licorice root extract: Antimicrobial and anticancer study against HepG2 cell line","volume":"14","year":"2021","journal-title":"Arab. J. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/21691401.2017.1307213","article-title":"Biological synthesis of gold and silver chloride nanoparticles by Glycyrrhiza uralensis and in vitro applications","volume":"46","author":"Huo","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Majoumouo, M.S., Sharma, J.R., Sibuyi, N.R.S., Tincho, M.B., Boyom, F.F., and Meyer, M. (2020). Synthesis of biogenic gold nanoparticles from terminalia mantaly extracts and the evaluation of their in vitro cytotoxic effects in cancer cells. Molecules, 25.","DOI":"10.3390\/molecules25194469"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1080\/21691401.2016.1276923","article-title":"Lantana camara Linn root extract-mediated gold nanoparticles and their in vitro antioxidant and cytotoxic potentials","volume":"45","author":"Ramkumar","year":"2017","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.2147\/IJN.S113692","article-title":"Coalescence of functional gold and monodisperse silver nanoparticles mediated by black Panax ginseng Meyer root extract","volume":"11","author":"Wang","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s12088-018-0710-8","article-title":"Extracellular synthesis and characterization of gold nanoparticles using Mycobacterium sp. BRS2A-AR2 isolated from the aerial roots of the ghanaian mangrove plant, Rhizophora racemosa","volume":"58","author":"Camas","year":"2018","journal-title":"Indian J. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Shaikh, S., Nazam, N., Rizvi, S.M.D., Ahmad, K., Baig, M.H., Lee, E.J., and Choi, I. (2019). Mechanistic insights into the antimicrobial actions of metallic nanoparticles and their implications for multidrug resistance. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20102468"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"FSO239","DOI":"10.4155\/fsoa-2017-0062","article-title":"Green synthesis of capped gold nanoparticles and their effect on Gram-positive and Gram-negative bacteria","volume":"3","author":"Rao","year":"2017","journal-title":"Future Sci. OA"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Shamaila, S., Zafar, N., Riaz, S., Sharif, R., Nazir, J., and Naseem, S. (2016). Gold nanoparticles: An efficient antimicrobial agent against enteric bacterial human pathogen. Nanomaterials, 6.","DOI":"10.3390\/nano6040071"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1039\/c9mt00084d","article-title":"Antibacterial mechanism of gold nanoparticles on Streptococcus pneumoniae","volume":"11","author":"Quezada","year":"2019","journal-title":"Metallomics"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Nayem, S.M.A., Sultana, N., Haque, M.A., Miah, B., Hasan, M.M., Islam, T., Hasan, M.M., Awal, A., Uddin, J., and Aziz, M.A. (2020). Green synthesis of gold and silver nanoparticles by using amorphophallus paeoniifolius tuber extract and evaluation of their antibacterial activity. Molecules, 25.","DOI":"10.3390\/molecules25204773"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/lam.13082","article-title":"Antimicrobial activity and toxicity of gold nanoparticles: Research progress, challenges and prospects","volume":"67","author":"Tao","year":"2018","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_40","first-page":"1","article-title":"Antibacterial properties of functionalized gold nanoparticles and their application in oral biology","volume":"2020","author":"Su","year":"2020","journal-title":"J. Nanomater."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2005679","DOI":"10.1002\/adma.202005679","article-title":"Antibacterial action of nanoparticles by lethal stretching of bacterial cell membranes","volume":"32","author":"Linklater","year":"2020","journal-title":"Adv. Mater."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.molstruc.2018.11.055","article-title":"Spectroscopic study on interaction of Nymphaea nouchali leaf extract mediated bactericidal gold nanoparticles with human serum albumin","volume":"1179","author":"Maji","year":"2019","journal-title":"J. Mol. Struct."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6789","DOI":"10.1039\/c0jm00817f","article-title":"Antibiotic mediated synthesis of gold nanoparticles with potent antimicrobial activity and their application in antimicrobial coatings","volume":"20","author":"Rai","year":"2010","journal-title":"J. Mater. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Panzarini, E., Mariano, S., Carata, E., Mura, F., Rossi, M., and Dini, L. (2018). Intracellular transport of silver and gold nanoparticles and biological responses: An update. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051305"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jgeb.2016.05.007","article-title":"Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells","volume":"14","author":"Rajeshkumar","year":"2016","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"16631","DOI":"10.1039\/C5NR02970H","article-title":"Shape effect in cellular uptake of PEGylated nanoparticles: Comparison between sphere, rod, cube and disk","volume":"7","author":"Li","year":"2015","journal-title":"Nanoscale"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"111300","DOI":"10.1016\/j.jinorgbio.2020.111300","article-title":"Towards plant-mediated chemistry\u2013Au nanoparticles obtained using aqueous extract of Rosa damascena and their biological activity in vitro","volume":"214","author":"Sebastian","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jddst.2017.12.008","article-title":"Anticancer effects of one-pot synthesized biogenic gold nanoparticles (Mc-AuNps) against laryngeal carcinoma","volume":"44","author":"Kumar","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11051-015-2957-x","article-title":"Green synthesis of silver and gold nanoparticles from Gymnema sylvestre leaf extract: Study of antioxidant and anticancer activities","volume":"17","author":"Nakkala","year":"2015","journal-title":"J. Nanopart. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.colsurfb.2016.03.069","article-title":"Polyphenol stabilized colloidal gold nanoparticles from Abutilon indicum leaf extract induce apoptosis in HT-29 colon cancer cells","volume":"143","author":"Mata","year":"2016","journal-title":"Coll. Surf. B Biointerfaces"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1080\/21691401.2019.1575844","article-title":"Anticancer activity of green synthesised gold nanoparticles from Marsdenia tenacissima inhibits A549 cell proliferation through the apoptotic pathway","volume":"47","author":"Sun","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.procbio.2020.06.016","article-title":"Unveiling the anticancer and antimycobacterial potentials of bioengineered gold nanoparticles","volume":"96","author":"Govindaraju","year":"2020","journal-title":"Process Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Cudalbeanu, M., Ghinea, I.O., Furdui, B., Dah-Nouvlessounon, D., Raclea, R., Costache, T., Cucolea, I.E., Urlan, F., and Dinica, R.M. (2018). Exploring new antioxidant and mineral compounds from Nymphaea alba wild-grown in danube delta biosphere. Molecules, 23.","DOI":"10.3390\/molecules23061247"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Cudalbeanu, M., Furdui, B., C\u00e2r\u00e2c, G., Barbu, V., Iancu, A.V., Marques, F., Leit\u00e3o, J.H., Sousa, S.A., and Dinica, R.M. (2020). Antifungal, antitumoral and antioxidant potential of the danube delta nymphaea alba extracts. Antibiotics, 9.","DOI":"10.3390\/antibiotics9010007"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.colsurfb.2010.09.020","article-title":"In situ green synthesis of biocompatible ginseng capped gold nanoparticles with remarkable stability","volume":"82","author":"Leonard","year":"2011","journal-title":"Coll. Surf B Biointerfaces"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jare.2014.03.006","article-title":"An eco-friendly method of synthesizing gold nanoparticles using an otherwise worthless weed pistia (Pistia stratiotes L.)","volume":"6","author":"Anuradha","year":"2015","journal-title":"J. Adv. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jphotobiol.2016.04.034","article-title":"Biosynthesis of gold nanoparticles: A green approach","volume":"161","author":"Ahmed","year":"2016","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/BF01975154","article-title":"A colloidal gold prepared with ultrasonics","volume":"36","author":"Baigent","year":"1980","journal-title":"Experientia"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1021\/jp984796o","article-title":"Size and temperature dependence of the plasmon absorption of colloidal gold nanoparticles","volume":"103","author":"Link","year":"1999","journal-title":"J. Phys. Chem. B"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.arabjc.2017.04.003","article-title":"A helpful method for controlled synthesis of monodisperse gold nanoparticles through response surface modeling","volume":"13","author":"Oliveira","year":"2020","journal-title":"Arab. J. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s11671-019-3158-9","article-title":"Synthesis of gold nanoparticles using mimosa tenuiflora extract. Assessments of cytotoxicity, cellular uptake, and catalysis","volume":"14","author":"Navarro","year":"2019","journal-title":"Nanoscale Res. Lett."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11051-008-9446-4","article-title":"Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies","volume":"11","author":"Jiang","year":"2009","journal-title":"J. Nanopart. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11051-015-3302-0","article-title":"Behavior of colloidal gold nanoparticles in different ionic strength media","volume":"17","author":"Barreto","year":"2015","journal-title":"J. Nanopart. Res."},{"key":"ref_64","first-page":"147","article-title":"Measurement and application of zeta-potential","volume":"4","author":"Salopek","year":"1992","journal-title":"Rud. Geol. Naft. Zb."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s40089-020-00317-7","article-title":"A review on synthesis, optimization, characterization and antibacterial application of gold nanoparticles synthesized from plants","volume":"10","author":"Akintelu","year":"2020","journal-title":"Int. Nano Lett."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF03214921","article-title":"Growing and stability of gold nanoparticles and their functionalization by cysteine","volume":"42","author":"Majzik","year":"2009","journal-title":"Gold Bull."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s13204-015-0414-x","article-title":"Toxicity evaluation of pH dependent stable Achyranthes aspera herbal gold nanoparticles","volume":"6","author":"Tripathi","year":"2016","journal-title":"Appl. Nanosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1021\/la011278n","article-title":"Analysis of the nature of oxyanion adsorption on gold nanomaterial surfaces","volume":"18","author":"Cumberland","year":"2002","journal-title":"Langmuir"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.saa.2012.11.020","article-title":"Synthesis of monodispersed palladium nanoparticles using tannic acid and its optical non-linearity","volume":"103","author":"Kumari","year":"2013","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.saa.2011.02.051","article-title":"Phytosynthesis of Au, Ag and Au-Ag bimetallic nanoparticles using aqueous extract and dried leaf of Anacardium occidentale","volume":"79","author":"Sheny","year":"2011","journal-title":"Spectrochim. Acta A Part A"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.physe.2012.04.022","article-title":"facile one-pot synthesis of gold nanoparticles using tannic acid and its application in catalysis","volume":"44","author":"Aromal","year":"2012","journal-title":"Phys. E"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jphotobiol.2015.03.025","article-title":"Green synthesis of gold nanoparticles using Stevia rebaudiana leaf extracts: Characterization and their stability","volume":"148","author":"Sadeghi","year":"2015","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_73","first-page":"1","article-title":"Green synthesis of gold nanoparticles using aqueous extract of garcinia mangostana fruit peels","volume":"2016","author":"Lee","year":"2016","journal-title":"J. Nanomater."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Biao, L., Tan, S., Meng, Q., Gao, J., Zhang, X., Liu, Z., and Fu, Y. (2018). Green synthesis, characterization and application of proanthocyanidins-functionalized gold nanoparticles. Nanomaterials, 8.","DOI":"10.3390\/nano8010053"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1049\/iet-nbt.2016.0183","article-title":"Green synthesis of gold nanoparticles using Citrus maxima peel extract and their catalytic\/antibacterial activities","volume":"11","author":"Yuan","year":"2017","journal-title":"IET Nanobiotechnol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"9777","DOI":"10.1002\/slct.201701681","article-title":"Gold nanoparticles from vegetable extracts using different plants from the market: A study on stability, shape and toxicity","volume":"2","author":"Clemente","year":"2017","journal-title":"ChemistrySelect"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.saa.2013.08.066","article-title":"The Green synthesis of gold nanoparticles using an aqueous root extract of Morinda citrifolia L.","volume":"118","author":"Suman","year":"2014","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.saa.2012.05.083","article-title":"Green synthesis of gold nanoparticles using Trigonella foenum-graecum and its size-dependent catalytic activity","volume":"97","author":"Aromal","year":"2012","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1109\/TNANO.2017.2728600","article-title":"Gold nanoparticles biosynthesis: A simple route for control size using waste peel extract","volume":"16","author":"Lee","year":"2017","journal-title":"IEEE Trans. Nanotechnol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00449-014-1251-0","article-title":"Biosynthesis of gold nanoparticles using plant extracts","volume":"38","author":"Noruzi","year":"2015","journal-title":"Bioprocess Biosyst. Eng."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Stozhko, N.Y., Bukharinova, M.A., Khamzina, E.I., Tarasov, A.V., Vidrevich, M.B., and Brainina, K.Z. (2019). The effect of the antioxidant activity of plant extracts on the properties of gold nanoparticles. Nanomaterials, 9.","DOI":"10.3390\/nano9121655"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.saa.2013.10.092","article-title":"Phoenix dactylifera L. leaf extract phytosynthesized gold nanoparticles; controlled synthesis and catalytic activity","volume":"121","author":"Zayed","year":"2014","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/ejic.201501342","article-title":"What can electron microscopy tell us beyond crystal structures?","volume":"2016","author":"Zhou","year":"2016","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.matchar.2013.09.002","article-title":"Metrological characterization of X-ray diffraction methods at different acquisition geometries for determination of crystallite size in nano-scale materials","volume":"85","author":"Uvarov","year":"2013","journal-title":"Mater. Charact."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Osonga, F.J., Akgul, A., Yazgan, I., Akgul, A., Eshun, G.B., Sakhaee, L., and Sadik, O.A. (2020). Size and shape-dependent antimicrobial activities of silver and gold nanoparticles: A model study as potential fungicides. Molecules, 25.","DOI":"10.3390\/molecules25112682"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Rabiei, M., Palevicius, A., Monshi, A., Nasiri, S., Vilkauskas, A., and Janusas, G. (2020). Comparing methods for calculating nano crystal size of natural hydroxyapatite using X-ray diffraction. Nanomaterials, 10.","DOI":"10.3390\/nano10091627"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.colsurfb.2010.08.036","article-title":"Biomimetic synthesis of silver nanoparticles by Citrus limon (lemon) aqueous extract and theoretical prediction of particle size","volume":"82","author":"Prathna","year":"2011","journal-title":"Coll. Surf. B Biointerfaces"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.saa.2012.09.042","article-title":"Green synthesis of gold nanoparticles using Citrus fruits (Citrus limon, Citrus reticulata and Citrus sinensis) aqueous extract and its characterization","volume":"102","author":"Sujitha","year":"2013","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"112429","DOI":"10.1016\/j.jphotochem.2020.112429","article-title":"Controllable phytosynthesis of gold nanoparticles and investigation of their size and morphology-dependent photocatalytic activity under visible light","volume":"392","author":"Ahmad","year":"2020","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"8492016","DOI":"10.1155\/2020\/8492016","article-title":"Biosynthesis of silver and gold nanoparticles using aqueous extract of codonopsis pilosula roots for antibacterial and catalytic applications","volume":"2020","author":"Doan","year":"2020","journal-title":"J. Nanomater."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1007\/s11051-010-9911-8","article-title":"Toxicity and cellular uptake of gold nanoparticles: What we have learned so far?","volume":"12","author":"Alkilany","year":"2010","journal-title":"J. Nanopart. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-8916-4_1","article-title":"In vitro methods for assessing nanoparticle toxicity","volume":"1894","author":"Savage","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.jddst.2018.02.007","article-title":"Gold nanoparticle mediated delivery of fungal asparaginase against cancer cells","volume":"44","author":"Baskar","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1073\/pnas.1214547110","article-title":"Inhibition of tumor growth and metastasis by a self-therapeutic nanoparticle","volume":"110","author":"Arvizo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.2147\/IJN.S214008","article-title":"Size-and cell type-dependent cellular uptake, cytotoxicity and in vivo distribution of gold nanoparticles","volume":"14","author":"Xia","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_96","unstructured":"D\u00f6ssel, O., and Schlegel, W.C. (2009). Cellular uptake of gold nanoparticles into normal and cancer cells. Proceedings of the World Congress on Medical Physics and Biomedical Engineering, Munich, Germany, 7\u201312 September 2009, Springer."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Balanescu, F., Mihaila, M.D.I., C\u00e2r\u00e2c, G., Furdui, B., V\u00een\u0103toru, C., Avramescu, S.M., Lisa, E.L., Cudalbeanu, M., and Dinica, R.M. (2020). Flavonoid profiles of two new approved romanian ocimum hybrids. Molecules, 25.","DOI":"10.3390\/molecules25194573"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Chokki, M., Cud\u0103lbeanu, M., Zongo, C., Dah-Nouvlessounon, D., Ghinea, I.O., Furdui, B., Raclea, R., Savadogo, A., Baba-Moussa, L., and Avamescu, S.M. (2020). Exploring antioxidant and enzymes (A-Amylase and B-Glucosidase) inhibitory activity of morinda lucida and momordica Charantia leaves from benin. Foods, 9.","DOI":"10.3390\/foods9040434"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Ghinea, I.O., Ionica Mihaila, M.D., Blaga, G.-V., Avramescu, S.M., Cudalbeanu, M., Isticioaia, S.-F., Dinica, R.M., and Furdui, B. (2021). HPLC-DAD polyphenolic profiling and antioxidant activities of sorghum bicolor during germination. Agronomy, 11.","DOI":"10.3390\/agronomy11030417"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0584-8547(01)00285-3","article-title":"Quality assurance of X-ray spectrometry for chemical analysis","volume":"56","author":"Barreiros","year":"2001","journal-title":"Spectrochim. Acta Part B Atomic Spectrosc."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1039\/d0mt00064g","article-title":"Gold(III) bis(dithiolene) complexes: From molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents","volume":"12","author":"Fontinha","year":"2020","journal-title":"Metallomics"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1099\/00221287-6-1-2-95","article-title":"Staphylococcal coagulase: Mode of action and antigenicity","volume":"6","author":"Duthie","year":"1952","journal-title":"Microbiology"},{"key":"ref_103","first-page":"00969-14","article-title":"Complete genome assembly of Escherichia coli ATCC 25922, a serotype O6 reference strain","volume":"2","author":"Minogue","year":"2014","journal-title":"Genome Announc."},{"key":"ref_104","unstructured":"Wayne, P.A. (2018). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, Clinical and Laboratory Standards Institute. [11th ed.]."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/11\/6\/1562\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:14:01Z","timestamp":1760163241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/11\/6\/1562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,14]]},"references-count":104,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["nano11061562"],"URL":"https:\/\/doi.org\/10.3390\/nano11061562","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,14]]}}}