{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:21:05Z","timestamp":1772187665908,"version":"3.50.1"},"reference-count":25,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["MAT2016-76824-C3-2-R, \u201cDise\u00f1o de Nanohilos Magneticos para su uso en Tecnologias Limpias\u201d"],"award-info":[{"award-number":["MAT2016-76824-C3-2-R, \u201cDise\u00f1o de Nanohilos Magneticos para su uso en Tecnologias Limpias\u201d"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["Base Funding\u2014UIDB\/00511\/2020"],"award-info":[{"award-number":["Base Funding\u2014UIDB\/00511\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/QUIQFI\/ 28020\/2017"],"award-info":[{"award-number":["PTDC\/QUIQFI\/ 28020\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Cubic nanoparticles are referred to as the best shaped particles for magnetic hyperthermia applications. In this work, the best set of values for obtaining optimized shape and size of magnetic particles (namely: reagents quantities and proportions, type of solvents, temperature, etc.) is determined. A full industrial implementation study is also performed, including production system design and technical and economic viability.<\/jats:p>","DOI":"10.3390\/nano11071652","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T11:28:41Z","timestamp":1624447721000},"page":"1652","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cubic Nanoparticles for Magnetic Hyperthermia: Process Optimization and Potential Industrial Implementation"],"prefix":"10.3390","volume":"11","author":[{"given":"Omar S\u00e1nchez","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica y Textil, Facultad de Ciencias Qu\u00edmicas, Universidad de Salamanca, Plaza de los Ca\u00eddos, 1-5, 37008 Salamanca, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4359-0082","authenticated-orcid":false,"given":"Teresa","family":"Castelo-Grande","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-4226","authenticated-orcid":false,"given":"Paulo A.","family":"Augusto","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica y Textil, Facultad de Ciencias Qu\u00edmicas, Universidad de Salamanca, Plaza de los Ca\u00eddos, 1-5, 37008 Salamanca, Spain"},{"name":"Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, Campus Miguel de Unamuno, CSIC\/Universidad de Salamanca (GIR Cit\u00f3mica), 37007 Salamanca, Spain"}]},{"given":"Jos\u00e9 M.","family":"Compa\u00f1a","sequence":"additional","affiliation":[{"name":"Servicio de Difracci\u00f3n de Rayos-X, Universidad de Salamanca, Pza. de Los Ca\u00eddos s\/n, 37008 Salamanca, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-9775","authenticated-orcid":false,"given":"Domingos","family":"Barbosa","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,23]]},"reference":[{"key":"ref_1","unstructured":"Wild, C., Weiderpass, E., and Steward, B. (2020). World Cancer Report: Cancer Research for Cancer Prevention, International Agency for Research on Cancer, World Health Organization."},{"key":"ref_2","unstructured":"Bruvera, J.I. (2015). Disipaci\u00f3n de Potencia Por Nanopart\u00edculas Magn\u00e9ticas Expuestas a Campos de Radiofrecuencia Para Terapia Oncol\u00f3gica Por Hipertermia, Universidad Nacional de La Plata."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Horny, M.-C., Gamby, J., Dupuis, V., and Siaugue, J.-M. (2021). Magnetic Hyperthermia on \u03b3-Fe2O3@SiO2 Core-Shell Nanoparticles for mi-RNA 122 Detection. Nanomaterials, 11.","DOI":"10.3390\/nano11010149"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Caizer, C. (2021). Optimization Study on Specific Loss Power in Superparamagnetic Hyperthermia with Magnetite Nanoparticles for High Efficiency in Alternative Cancer Therapy. Nanomaterials, 11.","DOI":"10.3390\/nano11010040"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Veloso, S.R.S., Silva, J.F.G., Hilliou, L., Moura, C., Coutinho, P.J.G., Martins, J.A., Testa-Anta, M., Salgueiri\u00f1o, V., Correa-Duarte, M.A., and Ferreira, P.M.T. (2021). Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release. Nanomaterials, 11.","DOI":"10.3390\/nano11010016"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Strbak, O., Antal, I., Khmara, I., Koneracka, M., Kubovcikova, M., Zavisova, V., Molcan, M., Jurikova, A., Hnilicova, P., and Gombos, J. (2020). Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications. Nanomaterials, 10.","DOI":"10.3390\/nano10122468"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"056327","DOI":"10.1063\/1.4978458","article-title":"Magnetic hyperthermia performance of magnetite nanoparticle assemblies under different driving fields","volume":"7","author":"Wu","year":"2017","journal-title":"AIP Adv."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Augusto, P.A., Castelo-Grande, T., Vargas, D., Pascual, A., Hern\u00e1ndez, L., Estevez, A.M., and Barbosa, D. (2020). Upscale Design, Process Development, and Economic Analysis of Industrial Plants for Nanomagnetic Particle Production for Environmental and Biomedical Use. Materials, 13.","DOI":"10.3390\/ma13112477"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Augusto, P.A., Castelo-Grande, T., Vargas, D., Hern\u00e1ndez, L., Merch\u00e1n, L., Estevez, A.M., G\u00f3mez, J., Compa\u00f1a, J.M., and Barbosa, D. (2020). Water Decontamination with Magnetic Particles by Adsorption and Chemical Degradation. Influence of the Manufacturing Parameters. Materials, 13.","DOI":"10.3390\/ma13102219"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9894","DOI":"10.1038\/s41598-017-09897-5","article-title":"Correlation between particle size\/domain structure and magnetic properties of highly crystalline Fe3O4 nanoparticles","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1029\/JB080i029p04049","article-title":"Theoretical single-domain grain size range in magnetite and titanomagnetite","volume":"80","author":"Butler","year":"1975","journal-title":"J. Geophys. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1098\/rsif.2008.0462","article-title":"Critical superparamagnetic\/single-domain grain sizes in interacting magnetite particles: Implications for magnetosome crystals","volume":"6","author":"Muxworthy","year":"2009","journal-title":"J. R. Soc. Interface"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jmmm.2015.03.085","article-title":"Impact of magnetic field parameters and iron oxide nanoparticle properties on heat generation for use in magnetic hyperthermia","volume":"387","author":"Shah","year":"2015","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"17A337","DOI":"10.1063\/1.4919250","article-title":"Anisotropy effects in magnetic hyperthermia: A comparison between spherical and cubic exchange-coupled FeO\/Fe3O4 nanoparticles","volume":"117","author":"Khurshid","year":"2015","journal-title":"J. Appl. Phys."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Avugadda, S.K., Wickramasinghe, S., Niculaes, D., Ju, M., Lak, A., Silvestri, N., Nitti, S., Roy, I., Samia, A.C.S., and Pellegrino, T. (2021). Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters. Nanomaterials, 11.","DOI":"10.3390\/nano11010062"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.pnsc.2016.09.004","article-title":"Structural effects on the magnetic hyperthermia properties of iron oxide nanoparticles","volume":"26","author":"Abenojar","year":"2016","journal-title":"Prog. Nat. Sci. Mater. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/srep01652","article-title":"Learning from Nature to Improve the Heat Generation of Iron-Oxide Nanoparticles for Magnetic Hyperthermia Applications","volume":"3","author":"Simeonidis","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Reyes-Ortega, F., Delgado, \u00c1.V., and Iglesias, G.R. (2021). Modulation of theMagnetic Hyperthermia ResponseUsing Different Superparamagnetic Iron Oxide Nanoparticle Morphologies. Nanomaterials, 11.","DOI":"10.3390\/nano11030627"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.scitotenv.2018.08.056","article-title":"Landfill leachate treatment by sorption in magnetic particles: Preliminary study","volume":"648","author":"Augusto","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"111872","DOI":"10.1016\/j.jenvman.2020.111872","article-title":"Magnetic water treatment in a wastewater treatment plant: Part I\u2014Sorption and magnetic particles","volume":"281","author":"Augusto","year":"2021","journal-title":"J. Environ. Manag."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Castelo-Grande, T., Augusto, P.A., Rico, J., Marcos, J., Iglesias, R., Hern\u00e1ndez, L., and Barbosa, D. (2021). Magnetic water treatment in a wastewater treatment plant: Part II\u2014Processing Waters and Kinetic Study. J. Environ. Manag., acepted.","DOI":"10.1016\/j.jenvman.2021.112177"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez, L., Augusto, P.A., Castelo-Grande, T., and Barbosa, D. (2021). Regeneration and Reuse of Magnetic Particles for Contaminant Degradation in Water. J. Environ. Manag., acepted.","DOI":"10.1016\/j.jenvman.2021.112155"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1109\/TMAG.2008.2001998","article-title":"Preparation, Characterization, and Testing of Magnetic Carriers for Arsenic Removal From Water","volume":"44","author":"Estevez","year":"2008","journal-title":"IEEE Trans. Magn."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1021\/ja8086906","article-title":"Synthesis of Uniform Ferrimagnetic Magnetite Nanocubes","volume":"131","author":"Kim","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_25","unstructured":"G\u00f3mez Roca, A. (2009). Preparaci\u00f3n de Nanopart\u00edculas Magn\u00e9ticas Uniformes y de Alta Cristalinidad para Biomedicina, Instituto de Ciencia de Materiales de Madrid, Departamento de Qu\u00edmica F\u00edsica I, Universidad Complutense de Madrid."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/11\/7\/1652\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:22:08Z","timestamp":1760163728000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/11\/7\/1652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,23]]},"references-count":25,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["nano11071652"],"URL":"https:\/\/doi.org\/10.3390\/nano11071652","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,23]]}}}