{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T17:34:27Z","timestamp":1772559267409,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Tecnopolo per la medicina di precisione (TecnoMed Puglia)\u2014Regione Puglia","award":["2117 del 21\/11\/2018"],"award-info":[{"award-number":["2117 del 21\/11\/2018"]}]},{"name":"the Tecnopolo per la medicina di precisione (TecnoMed Puglia)\u2014Regione Puglia","award":["3449 del 7-08-2017"],"award-info":[{"award-number":["3449 del 7-08-2017"]}]},{"name":"Tecnopolo di Nanotecnologia e Fotonica per la medicina di precisione (TECNOMED)\u2014FISR\/MIUR-CNR","award":["2117 del 21\/11\/2018"],"award-info":[{"award-number":["2117 del 21\/11\/2018"]}]},{"name":"Tecnopolo di Nanotecnologia e Fotonica per la medicina di precisione (TECNOMED)\u2014FISR\/MIUR-CNR","award":["3449 del 7-08-2017"],"award-info":[{"award-number":["3449 del 7-08-2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Calcium carbonate (CaCO3) particles represent an appealing choice as a drug delivery system due to their biocompatibility, biodegradability, simplicity and cost-effectiveness of manufacturing, and stimulus-responsiveness. Despite this, the synthesis of CaCO3 particles with controlled size in the nanometer range via a scalable manufacturing method remains a major challenge. Here, by using a co-precipitation technique, we investigated the impact on the particle size of different synthesis parameters, such as the salt concentration, reaction time, stirring speed, and temperature. Among them, the salt concentration and temperature resulted in having a remarkable effect on the particle size, enabling the preparation of well-dispersed spherical nanoparticles with a size below 200 nm. Upon identification of optimized synthesis conditions, the encapsulation of the antitumoral agent resveratrol into CaCO3 nanoparticles, without significantly impacting the overall size and morphology, has been successfully achieved.<\/jats:p>","DOI":"10.3390\/nano12091494","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T22:20:06Z","timestamp":1651184406000},"page":"1494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Monodisperse and Nanometric-Sized Calcium Carbonate Particles Synthesis Optimization"],"prefix":"10.3390","volume":"12","author":[{"given":"Francesca","family":"Persano","sequence":"first","affiliation":[{"name":"Department of Mathematics and Physics, University of Salento, 73100 Lecce, Italy"},{"name":"CNR Nanotec\u2014Institute of Nanotechnology, 73100 Lecce, Italy"}]},{"given":"Concetta","family":"Nobile","sequence":"additional","affiliation":[{"name":"CNR Nanotec\u2014Institute of Nanotechnology, 73100 Lecce, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6339-716X","authenticated-orcid":false,"given":"Clara","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"CNR Nanotec\u2014Institute of Nanotechnology, 73100 Lecce, Italy"}]},{"given":"Giuseppe","family":"Gigli","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Physics, University of Salento, 73100 Lecce, Italy"},{"name":"CNR Nanotec\u2014Institute of Nanotechnology, 73100 Lecce, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5912-7565","authenticated-orcid":false,"given":"Stefano","family":"Leporatti","sequence":"additional","affiliation":[{"name":"CNR Nanotec\u2014Institute of Nanotechnology, 73100 Lecce, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.apsb.2019.08.003","article-title":"Recent progress in drug delivery","volume":"9","author":"Li","year":"2019","journal-title":"Acta Pharm. 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