{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T11:00:03Z","timestamp":1769943603548,"version":"3.49.0"},"reference-count":44,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministerio de Ciencia e Innovaci\u00f3n","award":["RTI2018-097805-B-I0"],"award-info":[{"award-number":["RTI2018-097805-B-I0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Aiming at the development of a greener ethylene removal alternative, the goal of this study was to scale up and ensure the safety of \u03b1-cyclodextrin nanosponges (\u03b1-CD-NS) for further use as ethylene scavengers. The solvent-free synthesis of \u03b1-CD-NS was successfully scaled up using \u03b1-cyclodextrin and N,N\u2032-carbonyldiimidazole as cross-linkers (1:4 molar ratio) by means of mechanical alloying using a PM 100 ball mill by focusing on varying the rotation frequency, as determined by FTIR-ATR, X-ray diffraction, and TGA. \u03b1-CD-NS washing optimization was performed in water by monitoring the imidazole concentration in the washing solution through the validation of a fast and sensitive HPLC-DAD method. After 6 h at 40 \u00b0C, all imidazole was extracted, allowing a faster and less energy-dependent extraction. \u03b1-CD-NS absorbent capacity and porosity were also evaluated through BET isotherms and ethylene absorption experiments using \u03b1-CD-NS and commercially available absorbents (zeolite and bentonite) were performed by means of gas chromatography (GC) coupled to a flame ionization detector (FID). With a 93 \u00b5L h\u22121 kgadsorbent\u22121 ethylene removal capacity, \u03b1-CD-NS revealed the best ethylene scavenging activity when compared to the other absorbents, opening the doors for a safer, innovative, and eco-friendlier ethylene removal active packaging.<\/jats:p>","DOI":"10.3390\/nano12172900","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:22:48Z","timestamp":1661300568000},"page":"2900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mechanochemically Scaled-Up Alpha Cyclodextrin Nanosponges: Their Safety and Effectiveness as Ethylene Scavenger"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7528-3864","authenticated-orcid":false,"given":"David","family":"Rup\u00e9rez","sequence":"first","affiliation":[{"name":"I3A\u2014Aragon Institute of Engineering Research, University of Zaragoza, 50018 Zaragoza, Spain"}]},{"given":"Nicol\u00e1s","family":"Gracia-Vall\u00e9s","sequence":"additional","affiliation":[{"name":"I3A\u2014Aragon Institute of Engineering Research, University of Zaragoza, 50018 Zaragoza, Spain"}]},{"given":"Eva","family":"Clavero","sequence":"additional","affiliation":[{"name":"I3A\u2014Aragon Institute of Engineering Research, University of Zaragoza, 50018 Zaragoza, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2931-4583","authenticated-orcid":false,"given":"Filomena","family":"Silva","sequence":"additional","affiliation":[{"name":"I3A\u2014Aragon Institute of Engineering Research, University of Zaragoza, 50018 Zaragoza, Spain"},{"name":"ARAID\u2014Agencia Aragonesa para la Investigaci\u00f3n y el Desarrollo, 50018 Zaragoza, Spain"},{"name":"Faculty of Veterinary Medicine, University of Zaragoza, 50013 Zaragoza, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2685-5739","authenticated-orcid":false,"given":"Cristina","family":"Ner\u00edn","sequence":"additional","affiliation":[{"name":"I3A\u2014Aragon Institute of Engineering Research, University of Zaragoza, 50018 Zaragoza, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"ref_1","unstructured":"FAO (2021). United Nations Environment Programme, Food Waste Index Report."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.3389\/fnut.2021.661693","article-title":"Utilization of Vegetable and Fruit By-Products as Functional Ingredient and Food","volume":"8","author":"Lau","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3389\/fpls.2019.00223","article-title":"Infection Strategies Deployed by Botrytis Cinerea, Fusarium Acuminatum, and Rhizopus Stolonifer as a Function of Tomato Fruit Ripening Stage","volume":"10","author":"Petrasch","year":"2019","journal-title":"Front. Plant Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.21273\/HORTSCI.38.5.1004","article-title":"A Perspective on Postharvest Horticulture (1978\u20132003)","volume":"38","author":"Kader","year":"2003","journal-title":"HortScience"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0925-5214(98)00091-X","article-title":"Effect of Ethylene on Quality of Fresh Fruits and Vegetables","volume":"15","author":"Saltveit","year":"1999","journal-title":"Postharvest Biol. Technol."},{"key":"ref_6","first-page":"1","article-title":"Postharvest Technology of Horticultural Crops\u2014An Overview from Farm to Fork","volume":"1","author":"Kader","year":"2013","journal-title":"J. Appl. Sci. Technol."},{"key":"ref_7","unstructured":"Abeles, F.B., Morgan, P.W., Saltveit, M.E., and Mikal, E. (1992). Ethylene in Plant Biology, Academic Press. [2nd ed.]."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"106934","DOI":"10.1016\/j.polymertesting.2020.106934","article-title":"Preparation of Novel Nano\u2013Based Films Impregnated by Potassium Permanganate as Ethylene Scavengers: An Optimization Study","volume":"93","author":"Ebrahimi","year":"2021","journal-title":"Polym. Test."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.18559\/SOEP.2017.7.1","article-title":"Preparation of Ethylene Scavenger Based on KMNO4 to the Extension of the Storage Time of Tomatoes","volume":"5","author":"Dobrucka","year":"2017","journal-title":"Stud. Oeconomica Posnaniensia"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s10311-018-0718-7","article-title":"High Adsorption of Ethylene by Alkali-Treated Halloysite Nanotubes for Food-Packaging Applications","volume":"16","author":"Gaikwad","year":"2018","journal-title":"Environ. Chem. Lett."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.foodchem.2016.09.138","article-title":"Selenium Delays Tomato Fruit Ripening by Inhibiting Ethylene Biosynthesis and Enhancing the Antioxidant Defense System","volume":"219","author":"Zhu","year":"2017","journal-title":"Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Alonso-Salinas, R., Acosta-Motos, J.R., N\u00fa\u00f1ez-Delicado, E., Gabald\u00f3n, J.A., and L\u00f3pez-Miranda, S. (2022). Combined Effect of Potassium Permanganate and Ultraviolet Light as Ethylene Scavengers on Post-Harvest Quality of Peach at Optimal and Stressful Temperatures. Agronomy, 12.","DOI":"10.3390\/agronomy12030616"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"374","DOI":"10.4028\/www.scientific.net\/AMM.731.374","article-title":"Analysis of the Application of Fungicide and Ethylene Absorbent for Extended Storage Life of Kyoho Grapes at Room Temperature","volume":"731","author":"Zhang","year":"2015","journal-title":"Appl. Mech. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"111061","DOI":"10.1016\/j.postharvbio.2019.111061","article-title":"Postharvest Quality Retention of Apricots by Using a Novel Sepiolite\u2013Loaded Potassium Permanganate Ethylene Scavenger","volume":"160","year":"2020","journal-title":"Postharvest Biol. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0032-9592(03)00258-9","article-title":"Cyclodextrins and Their Uses: A Review","volume":"39","year":"2004","journal-title":"Process Biochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"102177","DOI":"10.1016\/j.ifset.2019.102177","article-title":"Encapsulation of Coriander Essential Oil in Cyclodextrin Nanosponges: A New Strategy to Promote Its Use in Controlled-Release Active Packaging","volume":"56","author":"Silva","year":"2019","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Mashile, G.P., Mpupa, A., and Nomngongo, P.N. (2021). Magnetic Mesoporous Carbon\/\u03b2-Cyclodextrin\u2013Chitosan Nanocomposite for Extraction and Preconcentration of Multi-Class Emerging Contaminant Residues in Environmental Samples. Nanomaterials, 11.","DOI":"10.3390\/nano11020540"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Elgamouz, A., Nassab, C., Bihi, A., Mohamad, S.A.I., Almusafri, A.H.S.A., Alharthi, S.S., Abdulla, S.A.E., and Patole, S.P. (2021). Encapsulation Capacity of \u03b2-Cyclodextrin Stabilized Silver Nanoparticles towards Creatinine Enhances the Colorimetric Sensing of Hydrogen Peroxide in Urine. Nanomaterials, 11.","DOI":"10.3390\/nano11081897"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Iravani, S., and Varma, R.S. (2022). Nanosponges for Drug Delivery and Cancer Therapy: Recent Advances. Nanomaterials, 12.","DOI":"10.3390\/nano12142440"},{"key":"ref_20","unstructured":"Trotta, F., Shende, P., and Biasizzo, M. (2012). Method for Preparing Dextrin Nanosponges. (WO2012\/147069A1), PCT Patent Application."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3762\/bjoc.16.127","article-title":"Mechanochemical Green Synthesis of Hyper-Crosslinked Cyclodextrin Polymers","volume":"16","author":"Pedrazzo","year":"2020","journal-title":"Beilstein J. Org. Chem."},{"key":"ref_22","unstructured":"Anastas, P.T., and Warner, J.C. (1998). Green Chemistry: Theory and Practice, Oxford University Press."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.trechm.2021.02.008","article-title":"Upscaling Mechanochemistry: Challenges and Opportunities for Sustainable Industry","volume":"3","author":"Colacino","year":"2021","journal-title":"Trends Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1080\/00032719.2015.1045593","article-title":"Determination of Imidazole, 4-Methylimidazole, and 2-Methylimidazole in Cigarette Additives by Ultra-High Performance Liquid Chromatography","volume":"48","author":"Zhu","year":"2015","journal-title":"Anal. Lett."},{"key":"ref_25","unstructured":"U.S. Department of Health and Human Services\u2014Food and Drug Administration (2001). Guidance for Industry: Bioanalytical Method Validation."},{"key":"ref_26","unstructured":"International Conference on Harmonisation (2005). Validation of Analytical Procedures: Methodology ICH Q2B, International Conference on Harmonisation."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.lwt.2016.08.052","article-title":"The Effect of Edible Coatings on the Nutritional Quality of \u2018Bravo de Esmolfe\u2019 Fresh-Cut Apple through Shelf-Life","volume":"75","author":"Guerreiro","year":"2017","journal-title":"LWT\u2014Food Sci. Technol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1039\/c0cs00195c","article-title":"Ball Milling in Organic Synthesis: Solutions and Challenges","volume":"40","author":"Stolle","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1039\/D1CS01093J","article-title":"The Mechanochemical Synthesis of Polymers","volume":"51","author":"Krusenbaum","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1039\/D0MH00081G","article-title":"Mechanochemical Synthesis of Highly Porous Materials","volume":"7","author":"Szczesniak","year":"2020","journal-title":"Mater. Horizons"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1007\/s10967-019-06901-2","article-title":"Green Synthesis of Citric Acid-Crosslinked \u03b2-Cyclodextrin for Highly Efficient Removal of Uranium(VI) from Aqueous Solution","volume":"322","author":"Li","year":"2019","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s10544-011-9571-1","article-title":"Cyclodextrin\/Poly(Anhydride) Nanoparticles as Drug Carriers for the Oral Delivery of Atovaquone","volume":"13","author":"Calvo","year":"2011","journal-title":"Biomed. Microdevices"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1208\/s12249-011-9584-3","article-title":"Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterisation, Stability, Cytotoxicity and Permeation Study","volume":"12","author":"Ansari","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"ref_34","unstructured":"European Chemicals Agency (2012). Harmonised Classification and Labelling Report for Imidazole."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1021\/ja01059a019","article-title":"Nonlinear Structure-Reactivity Correlations. The Imidazole-Catalyzed Hydrolysis of Esters","volume":"86","author":"Kirsch","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8664","DOI":"10.1039\/c2ce26362a","article-title":"A Novel Hydrate of \u03b1-Cyclodextrin Crystallised under High-Pressure Conditions","volume":"14","author":"Lahoz","year":"2012","journal-title":"CrystEngComm"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cplett.2005.07.036","article-title":"A Look inside the Cavity of Hydrated \u03b1-Cyclodextrin: A Computer Simulation Study","volume":"413","author":"Georg","year":"2005","journal-title":"Chem. Phys. Lett."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1007\/s10924-018-1219-2","article-title":"Kinetic, Isotherm and Thermodynamic Studies for Removal of Methylene Blue Using \u03b2-Cyclodextrin\/Activated Carbon Aerogels","volume":"26","author":"Zhou","year":"2018","journal-title":"J. Polym. Environ."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.egypro.2017.03.1394","article-title":"Equilibrium and Kinetic Behaviour of CO2 Adsorption onto Zeolites, Carbon Molecular Sieve and Activated Carbons","volume":"114","author":"Sarker","year":"2017","journal-title":"Energy Procedia"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10847-011-9926-5","article-title":"Cyclodextrin Nanosponges as Effective Gas Carriers","volume":"71","author":"Trotta","year":"2011","journal-title":"J. Incl. Phenom. Macrocycl. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.addr.2007.05.012","article-title":"Cyclodextrins as Pharmaceutical Solubilizers","volume":"59","author":"Brewster","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.foodchem.2011.01.043","article-title":"Encapsulation of Ethylene Gas into \u03b1-Cyclodextrin and Characterisation of the Inclusion Complexes","volume":"127","author":"Ho","year":"2011","journal-title":"Food Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ijpharm.2010.09.025","article-title":"Nanosponge Formulations as Oxygen Delivery Systems","volume":"402","author":"Cavalli","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1021\/cr900398v","article-title":"Ethylene Removal and Fresh Product Storage: A Challenge at the Frontiers of Chemistry. Toward an Approach by Photocatalytic Oxidation","volume":"113","author":"Keller","year":"2013","journal-title":"Chem. Rev."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/12\/17\/2900\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:14:11Z","timestamp":1760141651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/12\/17\/2900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,23]]},"references-count":44,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["nano12172900"],"URL":"https:\/\/doi.org\/10.3390\/nano12172900","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,23]]}}}