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diagnosis and systemic toxicity associated with conventional treatments make oncological therapy significantly difficult. In this context, nanomedicine emerges as a new approach in the prevention, diagnosis and treatment of cancer. In this work, pH-sensitive solid magnetoliposomes (SMLs) were developed for controlled release of the chemotherapeutic drug doxorubicin (DOX). Shape anisotropic magnetic nanoparticles of magnesium ferrite with partial substitution by calcium (Mg0.75Ca0.25Fe2O4) were synthesized, with and without calcination, and their structural, morphological and magnetic properties were investigated. Their superparamagnetic properties were evaluated and heating capabilities proven, either by exposure to an alternating magnetic field (AMF) (magnetic hyperthermia) or by irradiation with near-infrared (NIR) light (photothermia). The Mg0.75Ca0.25Fe2O4 calcined nanoparticles were selected to integrate the SMLs, surrounded by a lipid bilayer of DOPE:Ch:CHEMS (45:45:10). DOX was encapsulated in the nanosystems with an efficiency above 98%. DOX release assays showed a much more efficient release of the drug at pH = 5 compared to the release kinetics at physiological pH. By subjecting tumor cells to DOX-loaded SMLs, cell viability was significantly reduced, confirming that they can release the encapsulated drug. These results point to the development of efficient pH-sensitive nanocarriers, suitable for a synergistic action in cancer therapy with magnetic targeting, stimulus-controlled drug delivery and dual hyperthermia (magnetic and plasmonic) therapy.<\/jats:p>","DOI":"10.3390\/nano13061051","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T04:39:45Z","timestamp":1678855185000},"page":"1051","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Development of pH-Sensitive Magnetoliposomes Containing Shape Anisotropic Nanoparticles for Potential Application in Combined Cancer Therapy"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8132-9363","authenticated-orcid":false,"given":"Ana Rita F.","family":"Pacheco","sequence":"first","affiliation":[{"name":"Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"Associate Laboratory LaPMET, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9804-2553","authenticated-orcid":false,"given":"Beatriz D.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"Associate Laboratory LaPMET, 4710-057 Braga, Portugal"}]},{"given":"Ana","family":"Pires","sequence":"additional","affiliation":[{"name":"Associate Laboratory LaPMET, 4169-007 Porto, Portugal"},{"name":"IFIMUP\u2014Instituto de F\u00edsica dos Materiais, University of Porto, R. Campo Alegre, 4169-007 Porto, Portugal"}]},{"given":"Andr\u00e9 M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Associate Laboratory LaPMET, 4169-007 Porto, Portugal"},{"name":"IFIMUP\u2014Instituto de F\u00edsica dos Materiais, University of Porto, R. Campo Alegre, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-7727","authenticated-orcid":false,"given":"Jo\u00e3o P.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Associate Laboratory LaPMET, 4169-007 Porto, Portugal"},{"name":"IFIMUP\u2014Instituto de F\u00edsica dos Materiais, University of Porto, R. Campo Alegre, 4169-007 Porto, Portugal"}]},{"given":"Violeta M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"MEtRICs, Mechanical Engineering Department, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"},{"name":"ALGORITMI Center, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"},{"name":"Center for MicroElectromechanical Systems (CMEMS-UMinho), University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"}]},{"given":"Raquel O.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Center for MicroElectromechanical Systems (CMEMS-UMinho), University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-9207","authenticated-orcid":false,"given":"Paulo J. G.","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"Associate Laboratory LaPMET, 4710-057 Braga, Portugal"}]},{"given":"Teresa","family":"Castelo-Grande","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"given":"Paulo A.","family":"Augusto","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-9775","authenticated-orcid":false,"given":"Domingos","family":"Barbosa","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3428-637X","authenticated-orcid":false,"given":"Rui A.","family":"Lima","sequence":"additional","affiliation":[{"name":"MEtRICs, Mechanical Engineering Department, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"},{"name":"CEFT\u2014Transport Phenomena Research Center, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7464-3944","authenticated-orcid":false,"given":"Senhorinha F. 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