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process. Thus, the use of bioactive materials such as bioactive glass has been studied to support the repair and restoration of hard and soft tissue. Thus, in this work Bioglass 45S5 was developed, adding 1 and 2%mol of SrO or MgO and the physical and biological properties were evaluated. The addition of MgO and SrO at the studied concentrations promoted the slight increase in non-bridging oxygens number, observed through the temperature shift in phase transitions to lower values compared to Bioglass 45S5. The insertion of the ions also showed a positive effect on Saos-2 cell viability, decreasing the cytotoxic of Bioglass 45S5. Besides the Ca\/P ratio on the pellets surface demonstrating no evidence of higher reactivity between Bioglass 45S5 and Bioglass with Sr and Mg, micrographs show that at 24 h the Ca\/P rich layer is denser than in Bioglass 45S5 after the contact with simulated body fluid. The samples with Sr and Mg show a higher antibacterial effect compared to Bioglass 45S5. The addition of the studied ions may benefit the biological response of Bioglass 45S5 in dental applications as scaffolds or coatings.<\/jats:p>","DOI":"10.3390\/nano13192717","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:17:26Z","timestamp":1696688246000},"page":"2717","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone Regeneration"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6216-3735","authenticated-orcid":false,"given":"S\u00edlvia Rodrigues","family":"Gavinho","sequence":"first","affiliation":[{"name":"I3N and Physics Department, Aveiro University, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5707-9157","authenticated-orcid":false,"given":"Ana Sofia","family":"P\u00e1dua","sequence":"additional","affiliation":[{"name":"I3N-CENIMAT and Physics Department, NOVA School of Science and Technology, Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"given":"Laura Isabel Vilas","family":"Holz","sequence":"additional","affiliation":[{"name":"TEMA and Mechanical Engineering Department, Aveiro University, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6665-7994","authenticated-orcid":false,"given":"Isabel","family":"S\u00e1-Nogueira","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-4272","authenticated-orcid":false,"given":"Jorge Carvalho","family":"Silva","sequence":"additional","affiliation":[{"name":"I3N-CENIMAT and Physics Department, NOVA School of Science and Technology, Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-6545","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"Borges","sequence":"additional","affiliation":[{"name":"I3N-CENIMAT and Materials Science Department, NOVA School of Science and Technology, Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-2199","authenticated-orcid":false,"given":"Manuel Almeida","family":"Valente","sequence":"additional","affiliation":[{"name":"I3N and Physics Department, Aveiro University, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-9507","authenticated-orcid":false,"given":"Manuel Pedro Fernandes","family":"Gra\u00e7a","sequence":"additional","affiliation":[{"name":"I3N and Physics Department, Aveiro University, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/1735-3327.338781","article-title":"Use of Bioactive Glass Doped with Magnesium or Strontium for Bone Regeneration: A Rabbit Critical-Size Calvarial Defects Study","volume":"19","author":"Esfahanizadeh","year":"2022","journal-title":"Dent. 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