{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:34:36Z","timestamp":1766136876367,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:00:00Z","timestamp":1499299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>The influence of copolymer composition on Poly(Lactide-co-Glycolide)\/nanohydroxyapatite (PLGA\/nHA) composite scaffolds is studied in the context of bone tissue engineering and regenerative medicine. The composite scaffolds are fabricated by thermally-induced phase separation and the effect of bioactive nanoparticles on their in vitro degradation in phosphate-buffered solution at 37 \u00b0C is analyzed over eight weeks. The indirect cytotoxicity evaluation of the samples followed an adaptation of the ISO 10993-5 standard test method. Based on the measurement of their molecular weight, molar mass, pH, water absorption and dimensions, the porous scaffolds of PLGA with a lower lactide\/glycolide (LA\/GA) molar ratio degraded faster due to their higher hydrophilicity. All of the samples without and with HA are not cytotoxic, demonstrating their potential for tissue engineering applications.<\/jats:p>","DOI":"10.3390\/nano7070173","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T10:55:45Z","timestamp":1499338545000},"page":"173","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Influence of Copolymer Composition on PLGA\/nHA Scaffolds\u2019 Cytotoxicity and In Vitro Degradation"],"prefix":"10.3390","volume":"7","author":[{"given":"Esperanza","family":"D\u00edaz","sequence":"first","affiliation":[{"name":"Departamento de Ingenier\u00eda Minera, Metal\u00fargica y Ciencia de Materiales, Universidad del Pa\u00eds Vasco (UPV\/EHU), 48920 Portugalete, Spain"},{"name":"BCMaterials, Parque Cient\u00edfico y Tecnol\u00f3gico de Bizkaia, 48160 Derio, Spain"}]},{"given":"Igor","family":"Puerto","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Minera, Metal\u00fargica y Ciencia de Materiales, Universidad del Pa\u00eds Vasco (UPV\/EHU), 48920 Portugalete, Spain"}]},{"given":"Silvie","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centro\/Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6791-7620","authenticated-orcid":false,"given":"Senentxu","family":"Lanceros-Mendez","sequence":"additional","affiliation":[{"name":"BCMaterials, Parque Cient\u00edfico y Tecnol\u00f3gico de Bizkaia, 48160 Derio, Spain"},{"name":"Centro\/Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal"},{"name":"IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain"}]},{"given":"Jos\u00e9 Manuel","family":"Barandiar\u00e1n","sequence":"additional","affiliation":[{"name":"BCMaterials, Parque Cient\u00edfico y Tecnol\u00f3gico de Bizkaia, 48160 Derio, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10047-005-0292-1","article-title":"Bone tissue engineering with porous hydroxyapatite ceramics","volume":"8","author":"Yoshikawa","year":"2005","journal-title":"J. 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