{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:42:42Z","timestamp":1771569762169,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>This work reports on the synthesis, with the thermally induced phase separation (TIPS) technique, of poly (l-lactide) (PLLA) scaffolds containing Fe-doped hydroxyapatite (FeHA) particles for bone regeneration. Magnetization curves and X-ray diffraction indicate two magnetic particle phases: FeHA and magnetite Fe3O4. Magnetic nanoparticles (MNPs) are approximately 30 \u00b1 5 nm in width and 125 \u00b1 25 nm in length, and show typical ferromagnetic properties, including coercivity and rapid saturation magnetization. Scanning electron microscopy (SEM) images of the magnetic scaffolds reveal their complex morphology changes with MNP concentration. Similarly, at compositions of approximately 20% MNPs, the phase separation changes, passing from solid\u2013liquid to liquid\u2013liquid as revealed by the hill-like structures, with low peaks that give the walls in the SEM images a surface pattern of micro-ruggedness typical of nucleation mechanisms and growth. In vitro degradation experiments, carried out for more than 28 weeks, demonstrated that the MNPs delay the scaffold degradation process. Cytotoxicity is appreciated for FeHA content above 20%.<\/jats:p>","DOI":"10.3390\/nano8090678","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T10:30:06Z","timestamp":1535625006000},"page":"678","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Development of Magnetically Active Scaffolds for Bone Regeneration"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6483-6593","authenticated-orcid":false,"given":"Esperanza","family":"D\u00edaz","sequence":"first","affiliation":[{"name":"Escuela de Ingenier\u00eda de Bilbao, Departamento de Ingenier\u00eda Minera, Metal\u00fargica y Ciencia de Materiales, Universidad del Pa\u00eds Vasco (UPV\/EHU), 48920 Portugalete, Spain"},{"name":"BCMaterials, Basque Centre for Materials, Applications and Nanostructures, UPV\/EHU Science Park, 48940 Leioa, Spain"}]},{"given":"M\u1d43","family":"Valle","sequence":"additional","affiliation":[{"name":"Facultad de Ciencia y Tecnolog\u00eda, Departamento de Electricidad y Electr\u00f3nica, University of the Basque Country (UPV\/EHU), Sarriena s\/n, 48940 Leioa, Spain"}]},{"given":"Sylvie","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centro\/Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal"},{"name":"Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Senentxu","family":"Lanceros-Mendez","sequence":"additional","affiliation":[{"name":"BCMaterials, Basque Centre for Materials, Applications and Nanostructures, UPV\/EHU Science Park, 48940 Leioa, Spain"},{"name":"IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain"}]},{"given":"Jos\u00e9","family":"Barandiar\u00e1n","sequence":"additional","affiliation":[{"name":"BCMaterials, Basque Centre for Materials, Applications and Nanostructures, UPV\/EHU Science Park, 48940 Leioa, Spain"},{"name":"Facultad de Ciencia y Tecnolog\u00eda, Departamento de Electricidad y Electr\u00f3nica, University of the Basque Country (UPV\/EHU), Sarriena s\/n, 48940 Leioa, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,30]]},"reference":[{"key":"ref_1","unstructured":"Shalak, R., and Fox, C.F. 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