{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:29:53Z","timestamp":1772252993172,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["(POCI-01-0145-FEDER-007569), POCI-01-0145-FEDER-028237 UID\/BIO\/04469, POCI-01-0145-FEDER-006684, NORTE-01-0145-FEDER-000004,  SFRH\/BD\/111478\/2015 (S.R.), SFRH\/BPD\/96707\/2013 (T.R.), SFRH\/BPD\/90870\/2012 (C.R.) and SFRH\/BPD\/121526\/2016 (D.C)."],"award-info":[{"award-number":["(POCI-01-0145-FEDER-007569), POCI-01-0145-FEDER-028237 UID\/BIO\/04469, POCI-01-0145-FEDER-006684, NORTE-01-0145-FEDER-000004,  SFRH\/BD\/111478\/2015 (S.R.), SFRH\/BPD\/96707\/2013 (T.R.), SFRH\/BPD\/90870\/2012 (C.R.) and SFRH\/BPD\/121526\/2016 (D.C)."]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["MAT2016-76039-C4-3-R (AEI\/FEDER, UE)"],"award-info":[{"award-number":["MAT2016-76039-C4-3-R (AEI\/FEDER, UE)"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005004","name":"Ekonomiaren Garapen eta Lehiakortasun Saila, Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["ELKARTEK and HAZITEK"],"award-info":[{"award-number":["ELKARTEK and HAZITEK"]}],"id":[{"id":"10.13039\/501100005004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Poly(vinylidene fluoride) nanocomposites processed with different morphologies, such as porous and non-porous films and fibres, have been prepared with silica nanoparticles (SiNPs) of varying diameter (17, 100, 160 and 300 nm), which in turn have encapsulated perylenediimide (PDI), a fluorescent molecule. The structural, morphological, optical, thermal, and mechanical properties of the nanocomposites, with SiNP filler concentration up to 16 wt %, were evaluated. Furthermore, cytotoxicity and cell proliferation studies were performed. All SiNPs are negatively charged independently of the pH and more stable from pH 5 upwards. The introduction of SiNPs within the polymer matrix increases the contact angle independently of the nanoparticle diameter. Moreover, the smallest ones (17 nm) also improve the PVDF Young\u2019s modulus. The filler diameter, physico-chemical, thermal and mechanical properties of the polymer matrix were not significantly affected. Finally, the SiNPs\u2019 inclusion does not induce cytotoxicity in murine myoblasts (C2C12) after 72 h of contact and proliferation studies reveal that the prepared composites represent a suitable platform for tissue engineering applications, as they allow us to combine the biocompatibility and piezoelectricity of the polymer with the possible functionalization and drug encapsulation and release of the SiNP.<\/jats:p>","DOI":"10.3390\/nano8110933","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T03:27:31Z","timestamp":1542079651000},"page":"933","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications"],"prefix":"10.3390","volume":"8","author":[{"given":"Sylvie","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Centro\/Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal"},{"name":"Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-5287","authenticated-orcid":false,"given":"T\u00e2nia","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica-F\u00edsica Molecular and Institute of Nanosciences and Nanotechnology, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"},{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9120-4847","authenticated-orcid":false,"given":"Clarisse","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centro\/Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal"},{"name":"CEB\u2014Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3118-4717","authenticated-orcid":false,"given":"Daniela M.","family":"Correia","sequence":"additional","affiliation":[{"name":"Chemical Department and CQ-VR, Universidade de Tr\u00e1s-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal"},{"name":"BCMaterials, Basque Centre for Materials, Applications and Nanostructures, UPV\/EHU Science Park, 48940 Leioa, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-5031","authenticated-orcid":false,"given":"Jos\u00e9 P. Sequeira","family":"Farinha","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica-F\u00edsica Molecular and Institute of Nanosciences and Nanotechnology, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"},{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]},{"given":"Andreia Castro","family":"Gomes","sequence":"additional","affiliation":[{"name":"Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7810-1747","authenticated-orcid":false,"given":"Carlos","family":"Baleiz\u00e3o","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica-F\u00edsica Molecular and Institute of Nanosciences and Nanotechnology, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"},{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6791-7620","authenticated-orcid":false,"given":"Senentxu","family":"Lanceros-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"BCMaterials, Basque Centre for Materials, Applications and Nanostructures, UPV\/EHU Science Park, 48940 Leioa, Spain"},{"name":"IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,9]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Nanocomposites: Synthesis, structure, properties and new application opportunities","volume":"12","author":"Camargo","year":"2009","journal-title":"Mater. 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