{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T19:06:34Z","timestamp":1762196794076,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ncRNA"],"abstract":"<jats:p>The field of non-coding RNA research is advancing at a breathtaking pace, continually uncovering new layers of regulatory complexity and functional diversity [...]<\/jats:p>","DOI":"10.3390\/ncrna11060075","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:21:46Z","timestamp":1762194106000},"page":"75","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Non-Coding RNA Journal Club: Highlights on Recent Papers\u201414"],"prefix":"10.3390","volume":"11","author":[{"given":"El Cheima","family":"Mhamedi","sequence":"first","affiliation":[{"name":"D\u00e9veloppement Adaptation et Vieillissement (Dev2a), CNRS UMR8263, INSERM U1345, IBPS, Sorbonne Universit\u00e9, 75005 Paris, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7560-2530","authenticated-orcid":false,"given":"Florent","family":"Hub\u00e9","sequence":"additional","affiliation":[{"name":"D\u00e9veloppement Adaptation et Vieillissement (Dev2a), CNRS UMR8263, INSERM U1345, IBPS, Sorbonne Universit\u00e9, 75005 Paris, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9651-6727","authenticated-orcid":false,"given":"Suresh K.","family":"Alahari","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, LSU School of Medicine, New Orleans, LA 70112, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-8557","authenticated-orcid":false,"given":"Francisco J.","family":"Enguita","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9571-4257","authenticated-orcid":false,"given":"Barbara","family":"Pardini","sequence":"additional","affiliation":[{"name":"Italian Institute for Genomic Medicine (IIGM), c\/o IRCCS Candiolo, 10060 Turin, Italy"},{"name":"Candiolo Cancer Institute, FPO IRCCS, Candiolo, 10060 Turin, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-3859","authenticated-orcid":false,"given":"Mark W.","family":"Feinberg","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Division of Cardiovascular Medicine, Harvard Medical School, Boston, MA 02115, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6557-955X","authenticated-orcid":false,"given":"Laura","family":"Poliseno","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, CNR, 56124 Pisa, Italy"},{"name":"Oncogenomics Unit, Core Research Laboratory, ISPRO, 56124 Pisa, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6062-7546","authenticated-orcid":false,"given":"Beshoy","family":"Armanios","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, School of Pharmacy, The University of Connecticut, 69 N Eagliville Road, Storrs, CT 06269, USA"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, School of Pharmacy, The University of Connecticut, 69 N Eagliville Road, Storrs, CT 06269, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6537-5415","authenticated-orcid":false,"given":"Xiao-Bo","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, School of Pharmacy, The University of Connecticut, 69 N Eagliville Road, Storrs, CT 06269, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2851-0291","authenticated-orcid":false,"given":"Nikolaos","family":"Sideris","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK"}]},{"given":"Salih","family":"Bayraktar","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3059-4829","authenticated-orcid":false,"given":"Leandro","family":"Castellano","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7231-375X","authenticated-orcid":false,"given":"Gaetano","family":"Santulli","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, New York, NY 10461, USA"}]},{"given":"Stanislovas S.","family":"Jankauskas","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, New York, NY 10461, USA"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8249-5743","authenticated-orcid":false,"given":"Will S.","family":"Plewa","sequence":"additional","affiliation":[{"name":"Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1376-4515","authenticated-orcid":false,"given":"Simon J.","family":"Conn","sequence":"additional","affiliation":[{"name":"Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7586-3922","authenticated-orcid":false,"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}]},{"given":"Patrick K. T.","family":"Shiu","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0637-7776","authenticated-orcid":false,"given":"Abhishek","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8328-9310","authenticated-orcid":false,"given":"Alexander","family":"Serganov","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA"}]},{"given":"Massimo","family":"Gentile","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2327-7515","authenticated-orcid":false,"given":"Giuseppe","family":"Viglietto","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Viale Europa, Campus Germaneto, 88100 Catanzaro, Italy"}]},{"given":"Nicola","family":"Amodio","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Viale Europa, Campus Germaneto, 88100 Catanzaro, Italy"}]},{"given":"Tijana","family":"Miti\u0107","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh EH16 4TJ, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2905-3096","authenticated-orcid":false,"given":"Andrea","family":"Caporali","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science, Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh EH16 4TJ, UK"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Shiu, P.K.T., DiStefano, J.K., Alahari, S.K., Enguita, F.J., Feinberg, M.W., Sideris, N., Bayraktar, S., Castellano, L., Buitrago, D.L., and Caporali, A. (2023). The Non-Coding RNA Journal Club: Highlights on Recent Papers\u201413. Non-Coding RNA, 9.","DOI":"10.3390\/ncrna9060076"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41580-025-00852-1","article-title":"Functions and therapeutic applications of pseudouridylation","volume":"26","author":"Luo","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1038\/s41467-025-60374-4","article-title":"Translation suppresses exogenous target RNA-mediated microRNA decay","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7637","DOI":"10.1016\/j.cell.2024.10.021","article-title":"Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells","volume":"187","author":"Liang","year":"2024","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/s41416-024-02831-3","article-title":"Circulating miRNA panels as a novel non-invasive diagnostic, prognostic, and potential predictive biomarkers in non-small cell lung cancer (NSCLC)","volume":"131","author":"Abdipourbozorgbaghi","year":"2024","journal-title":"Pap. Br. J. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1161\/CIRCRESAHA.120.318124","article-title":"MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease","volume":"128","author":"Monteiro","year":"2021","journal-title":"Circ. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1161\/CIRCRESAHA.120.318688","article-title":"CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice","volume":"128","author":"Vacante","year":"2021","journal-title":"Circ. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1161\/CIRCRESAHA.124.325196","article-title":"LncRNA MIR181A1HG Deficiency Attenuates Vascular Inflammation and Atherosclerosis","volume":"136","author":"Ni","year":"2025","journal-title":"Circ. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1161\/ATVBAHA.120.315911","article-title":"A Smooth Muscle Cell-Enriched Long Noncoding RNA Regulates Cell Plasticity and Atherosclerosis by Interacting with Serum Response Factor","volume":"41","author":"Ni","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1093\/cvr\/cvaf043","article-title":"Loss of conserved long non-coding RNA MIR503HG leads to altered NOTCH pathway signalling and left ventricular non-compaction cardiomyopathy","volume":"121","author":"Monteiro","year":"2025","journal-title":"Cardiovasc. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.18632\/aging.204147","article-title":"MIR503HG impeded ovarian cancer progression by interacting with SPI1 and preventing TMEFF1 transcription","volume":"14","author":"Tian","year":"2022","journal-title":"Aging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nm.3040","article-title":"An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension","volume":"19","author":"Kim","year":"2013","journal-title":"Nat. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"107521","DOI":"10.1016\/j.vph.2025.107521","article-title":"Targeting Cis-regulatory elements for CRISPR-mediated transcriptional activation of the human MIR503HG locus","volume":"160","author":"Monteiro","year":"2025","journal-title":"Vascul. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.atherosclerosis.2022.04.010","article-title":"Endothelial cell-specific deletion of a microRNA accelerates atherosclerosis","volume":"350","author":"Yang","year":"2022","journal-title":"Atherosclerosis"},{"key":"ref_15","first-page":"1973","article-title":"MicroRNA-181b regulates NF-kappaB-mediated vascular inflammation","volume":"122","author":"Sun","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/CIRCRESAHA.113.302089","article-title":"Systemic delivery of microRNA-181b inhibits nuclear factor-kappaB activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice","volume":"114","author":"Sun","year":"2014","journal-title":"Circ. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1161\/CIRCRESAHA.115.308166","article-title":"MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue","volume":"118","author":"Sun","year":"2016","journal-title":"Circ. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1096\/fj.201500163R","article-title":"MicroRNA-181b inhibits thrombin-mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10","volume":"30","author":"Lin","year":"2016","journal-title":"FASEB J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41392-024-01973-3","article-title":"Aptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy","volume":"9","author":"Xiao","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zhao, X., Xie, N., Zhang, H., Zhou, W., and Ding, J. (2023). Bacterial Drug Delivery Systems for Cancer Therapy: \u2018Why\u2019 and \u2018How\u2019. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15092214"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1053\/j.gastro.2025.03.015","article-title":"Systemic Identification of Functionally Conserved LncRNA Metabolic Regulators in Human and Mouse Livers","volume":"169","author":"Jiang","year":"2025","journal-title":"Gastroenterology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"10711","DOI":"10.1038\/s41467-024-54740-x","article-title":"Nuclear microRNA 9 mediates G-quadruplex formation and 3D genome organization during TGF-\u03b2-induced transcription","volume":"15","author":"Cordero","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s12933-025-02825-2","article-title":"Muscle-specific miR-499-5p delivered by small extracellular vesicles impairs endothelial function and ischemic hindlimb recovery in diabetic mice","volume":"24","author":"Cheng","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41568-024-00721-7","article-title":"Circular RNA in cancer","volume":"24","author":"Conn","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1016\/j.molcel.2024.11.022","article-title":"Circular RNAs trigger nonsense-mediated mRNA decay","volume":"84","author":"Boo","year":"2024","journal-title":"Mol. Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.adp9388","article-title":"Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing","volume":"386","author":"Lee","year":"2024","journal-title":"Science"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature08586","article-title":"Exceptional structured noncoding RNAs revealed by bacterial metagenome analysis","volume":"462","author":"Weinberg","year":"2009","journal-title":"Nature"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"10811","DOI":"10.1093\/nar\/gkx699","article-title":"Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions","volume":"45","author":"Weinberg","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"19490","DOI":"10.1073\/pnas.0607493103","article-title":"Identification of a large noncoding RNA in extremophilic eubacteria","volume":"103","author":"Barrick","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1126\/science.adv3451","article-title":"Cryo-EM reveals mechanisms of natural RNA multivalency","volume":"388","author":"Wang","year":"2025","journal-title":"Science"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41586-025-09073-0","article-title":"Naturally ornate RNA-only complexes revealed by cryo-EM","volume":"643","author":"Kretsch","year":"2025","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/s41586-025-09262-x","article-title":"Cryo-EM structure of a natural RNA nanocage","volume":"644","author":"Ling","year":"2025","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1182\/blood.2025028746","article-title":"CRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs","volume":"146","author":"Morelli","year":"2025","journal-title":"Blood"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1161\/CIRCRESAHA.124.325443","article-title":"Enhancer-Associated LncRNA-ITGA2 Promotes Vascular Remodeling Through ITGA2","volume":"136","author":"Guo","year":"2025","journal-title":"Circ. Res."}],"container-title":["Non-Coding RNA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2311-553X\/11\/6\/75\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:43:30Z","timestamp":1762195410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2311-553X\/11\/6\/75"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["ncrna11060075"],"URL":"https:\/\/doi.org\/10.3390\/ncrna11060075","relation":{},"ISSN":["2311-553X"],"issn-type":[{"value":"2311-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]}}}