{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:24:59Z","timestamp":1770881099642,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FEDER-Interreg Espa\u00f1a-Portugal","award":["0377_Iberphenol_6_E"],"award-info":[{"award-number":["0377_Iberphenol_6_E"]}]},{"name":"Fundation for Science and Technology","award":["UID\/AGR\/00690\/2013"],"award-info":[{"award-number":["UID\/AGR\/00690\/2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Tagetes erecta L. has long been consumed for culinary and medicinal purposes in different countries. The aim of this study was to explore the potential benefits from two cultivars of T. erecta related to its polyphenolic profile as well as antioxidant and anti-aging properties. The phenolic composition was analyzed by LC-DAD-ESI\/MSn. Folin-Ciocalteu, DPPH\u00b7, and FRAP assays were performed in order to evaluate reducing antiradical properties. The neuroprotective potential was evaluated using the enzymes acetylcholinesterase and monoamine oxidase. Caenorhabditis elegans was used as an in vivo model to assess extract toxicity, antioxidant activity, delayed aging, and reduced \u03b2-amyloid toxicity. Both extracts showed similar phenolic profiles and bioactivities. The main polyphenols found were laricitin and its glycosides. No acute toxicity was detected for extracts in the C. elegans model. T. erecta flower extracts showed promising antioxidant and neuroprotective properties in the different tested models. Hence, these results may add some information supporting the possibilities of using these plants as functional foods and\/or as nutraceutical ingredients.<\/jats:p>","DOI":"10.3390\/nu10122002","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T03:12:30Z","timestamp":1545102750000},"page":"2002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Edible Flowers of Tagetes erecta L. as Functional Ingredients: Phenolic Composition, Antioxidant and Protective Effects on Caenorhabditis elegans"],"prefix":"10.3390","volume":"10","author":[{"given":"Cristina","family":"Moliner","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50830 Villanueva de G\u00e1llego (Zaragoza), Spain"}]},{"given":"Lillian","family":"Barros","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"given":"Maria In\u00eas","family":"Dias","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6969-1055","authenticated-orcid":false,"given":"V\u00edctor","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50830 Villanueva de G\u00e1llego (Zaragoza), Spain"},{"name":"Instituto Agroalimentario de Arag\u00f3n-IA2 (CITA-Universidad de Zaragoza), 50013 Zaragoza, Spain"}]},{"given":"Elisa","family":"Langa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50830 Villanueva de G\u00e1llego (Zaragoza), Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-4882","authenticated-orcid":false,"given":"Isabel C.F.R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3982-2282","authenticated-orcid":false,"given":"Carlota","family":"G\u00f3mez-Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50830 Villanueva de G\u00e1llego (Zaragoza), Spain"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tifs.2011.04.006","article-title":"Fresh edible flowers of ornamental plants\u2014A new source of nutraceutical foods","volume":"22","author":"Mlcek","year":"2011","journal-title":"Trends Food Sci. 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