{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:15:52Z","timestamp":1769202952055,"version":"3.49.0"},"reference-count":43,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n (COLCIENCIAS)","doi-asserted-by":"publisher","award":["Contract N\u00ba 671-2014 Code 122265743978"],"award-info":[{"award-number":["Contract N\u00ba 671-2014 Code 122265743978"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"name":"undefined  &lt;span style=&quot;color:gray;font-size:10px;&quot;&gt;undefined&lt;\/span&gt;","award":["UID\/DTP\/00617\/2013"],"award-info":[{"award-number":["UID\/DTP\/00617\/2013"]}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DE150101921"],"award-info":[{"award-number":["DE150101921"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Results from several studies show that only obese, unfit subjects, but not obese, fit subjects, are at higher mortality risk than are normal-weight fit subjects. The aim of the study was two-fold: (1) to examine the differences in C-reactive protein levels across different metabolic phenotypes (healthy and unhealthy) of weight status and (2) ascertain whether high levels of cardiorespiratory fitness (CRF) attenuate the association of C-reactive protein and metabolic phenotypes of weight status. This was a pooled study, which included data from three cross-sectional projects (1706 youth (921 girls) aged 12\u201318 years). We used a Shuttle run test to assess CRF. Adolescents were classified into six metabolic phenotypes (healthy and unhealthy) of weight status (non-overweight, overweight and obese), based on age- and sex-specific cutoff points for triglycerides, systolic blood pressure, HDL-cholesterol, glucose and body mass index. High-sensitivity assays were used to obtain the C-reactive protein as inflammatory biomarker. After adjustment for potential confounders (age, sex, pubertal stage and country), the analysis of covariance (ANCOVA) shows that C-reactive protein is directly associated with metabolic phenotypes of weight status. Subjects with obesity, regardless of their metabolic profile, had higher levels of C-reactive protein Z-score. In addition, (after adjustments for potential confounders) a two-way ANCOVA showed that high levels of CRF attenuated the associations of C-reactive protein levels in metabolic healthy non-overweight and in adolescents with obesity. In conclusion, higher CRF levels may attenuate the detrimental association between obesity and C-reactive protein independently of metabolic phenotype. Findings from this study are important for prevention, clinical practice on issues associated with adiposity and metabolic disorders.<\/jats:p>","DOI":"10.3390\/nu12051461","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T11:34:14Z","timestamp":1589801654000},"page":"1461","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Higher Cardiorespiratory Fitness Levels May Attenuate the Detrimental Association between Weight Status, Metabolic Phenotype and C-Reactive Protein in Adolescents\u2014A Multi-Cohort Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9104-9042","authenticated-orcid":false,"given":"Cesar","family":"Agostinis-Sobrinho","sequence":"first","affiliation":[{"name":"Faculty of Health and Sciences, Klaipeda University, 92294 Klaipeda, Lithuania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-0007","authenticated-orcid":false,"given":"Rafaela","family":"Ros\u00e1rio","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Minho, 4710 Braga, Portugal"},{"name":"Health Sciences Research Unit: Nursing (UICISA: E), Nursing School of Coimbra (ESEnfC), 3000-232 Coimbra, Portugal"}]},{"given":"Rute","family":"Santos","sequence":"additional","affiliation":[{"name":"Research Centre in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto, 4200-450 Porto, Portugal"}]},{"given":"Sigute","family":"Norkiene","sequence":"additional","affiliation":[{"name":"Faculty of Health and Sciences, Klaipeda University, 92294 Klaipeda, Lithuania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7571-9181","authenticated-orcid":false,"given":"Jorge","family":"Mota","sequence":"additional","affiliation":[{"name":"Research Centre in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto, 4200-450 Porto, Portugal"}]},{"given":"Alona","family":"Rauckien\u0117-Michaelsson","sequence":"additional","affiliation":[{"name":"Faculty of Health and Sciences, Klaipeda University, 92294 Klaipeda, Lithuania"}]},{"given":"Katherine","family":"Gonz\u00e1lez-Ru\u00edz","sequence":"additional","affiliation":[{"name":"Grupo de Ejercicio F\u00edsico y Deportes, Vicerrector\u00eda de Investigaciones, Universidad Manuela Beltr\u00e1n, Bogot\u00e1 110231, Colombia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-4272","authenticated-orcid":false,"given":"Mikel","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Public University of Navarra, Navarrabiomed-IdiSNA, Complejo Hospitalario de Navarra (CHN), 31008 Pamplona, Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1397-7182","authenticated-orcid":false,"given":"Antonio","family":"Garcia-Hermoso","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Public University of Navarra, Navarrabiomed-IdiSNA, Complejo Hospitalario de Navarra (CHN), 31008 Pamplona, Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Laboratorio de Ciencias de la Actividad F\u00edsica, el Deporte y la Salud, Facultad de Ciencias M\u00e9dicas, Universidad de Santiago de Chile, USACH, Santiago 7500618, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3075-6960","authenticated-orcid":false,"given":"Robinson","family":"Ram\u00edrez-V\u00e9lez","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Public University of Navarra, Navarrabiomed-IdiSNA, Complejo Hospitalario de Navarra (CHN), 31008 Pamplona, Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S2213-8587(13)70062-7","article-title":"Metabolically healthy obesity: Epidemiology, mechanisms, and clinical implications","volume":"1","author":"Stefan","year":"2013","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"E1610","DOI":"10.1210\/jc.2013-2038","article-title":"Does inflammation determine metabolic health status in obese and nonobese adults?","volume":"98","author":"Phillips","year":"2013","journal-title":"J. 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