{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:42:22Z","timestamp":1767922942489,"version":"3.49.0"},"reference-count":44,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Hazelnuts (Corylus avellana L.) have an important role in human nutrition and health. However, they are a common cause of food allergy. Due to hazelnut varietal diversity, variety-dependent differences in the IgE-binding properties may be suspected, which could allow therapeutic strategies based on the use of hypoallergenic varieties to induce desensitization. In a proteogenomic approach, we aimed to evaluate the allergenic potential of a genetically diverse set of hazelnuts (n = 13 varieties). Minor differences were found at the level of genes encoding important allergens, namely Cor a 8, Cor a 9, and Cor a 14. Nevertheless, IgE-reactivity was similar for all varieties using sera from seven allergic individuals. The predominant IgE-reactive proteins were Cor a 9 (100%) and Cor a 1.04 (60%), with the former being the most frequently identified by a two-dimensional gel electrophoresis (2-DE)-based proteomic approach. Therefore, it seems that the conventional exclusion diet will hold its ground for the time being.<\/jats:p>","DOI":"10.3390\/nu12072100","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T10:54:46Z","timestamp":1594896886000},"page":"2100","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Natural Variation of Hazelnut Allergenicity: Is There Any Potential for Selecting Hypoallergenic Varieties?"],"prefix":"10.3390","volume":"12","author":[{"given":"Miguel","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Department of Genetics and Biotechnology, University of Tr\u00e1s-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal"},{"name":"Functional Genomics and Proteomics Unity, University of Tr\u00e1s-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal"},{"name":"LAQV-REQUIMTE, Faculty of Science and Technology, University Nova of Lisbon, 1000-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8229-2902","authenticated-orcid":false,"given":"Joana","family":"Costa","sequence":"additional","affiliation":[{"name":"REQUIMTE-LAQV, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-8895","authenticated-orcid":false,"given":"Isabel","family":"Mafra","sequence":"additional","affiliation":[{"name":"REQUIMTE-LAQV, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"given":"Sandra","family":"Cabo","sequence":"additional","affiliation":[{"name":"Department of Biology and Environment, Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Tr\u00e1s-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal"}]},{"given":"Ana Paula","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Agronomy, Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Tr\u00e1s-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5764-024X","authenticated-orcid":false,"given":"Berta","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Biology and Environment, Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Tr\u00e1s-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal"}]},{"given":"M\u00e9lanie","family":"Hillion","sequence":"additional","affiliation":[{"name":"INRAE, Plateforme d\u2019Exploration du M\u00e9tabolisme, Composante Prot\u00e9omique (PFEMcp), 63122 Saint-Gen\u00e8s Champanelle, France"},{"name":"Universit\u00e9 Clermont Auvergne, INRAE, UMR0454 Microbiologie Environnement Digestif Sant\u00e9 (MEDiS), 63122 Saint-Gen\u00e8s Champanelle, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0478-2575","authenticated-orcid":false,"given":"Michel","family":"H\u00e9braud","sequence":"additional","affiliation":[{"name":"INRAE, Plateforme d\u2019Exploration du M\u00e9tabolisme, Composante Prot\u00e9omique (PFEMcp), 63122 Saint-Gen\u00e8s Champanelle, France"},{"name":"Universit\u00e9 Clermont Auvergne, INRAE, UMR0454 Microbiologie Environnement Digestif Sant\u00e9 (MEDiS), 63122 Saint-Gen\u00e8s Champanelle, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6365-0735","authenticated-orcid":false,"given":"Gilberto","family":"Igrejas","sequence":"additional","affiliation":[{"name":"Department of Genetics and Biotechnology, University of Tr\u00e1s-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal"},{"name":"Functional Genomics and Proteomics Unity, University of Tr\u00e1s-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal"},{"name":"LAQV-REQUIMTE, Faculty of Science and Technology, University Nova of Lisbon, 1000-001 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nri.2016.111","article-title":"Food allergy: Immune mechanisms, diagnosis and immunotherapy","volume":"16","author":"Yu","year":"2016","journal-title":"Nat. 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