{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:12:32Z","timestamp":1767996752960,"version":"3.49.0"},"reference-count":43,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T00:00:00Z","timestamp":1614470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We aimed to report the implementation of a phenylketonuria (PKU) transition program and study the effects of follow-up with an adult team on metabolic control, adherence, and loss of follow-up. Fifty-five PKU patients were analysed in the study periods (SP): 2 years before (SP1) and after the beginning of adult care (SP2). Retrospective data on metabolic control and number of clinic appointments were collected for each SP, and protein intakes were analysed. In SP2, three patients (6%) were lost to follow-up. There was a small but statistically significant increase in median number of annual blood spots from SP1 to SP2: 11 (7\u201315) vs. 14 (7\u201320); p = 0.002. Mean \u00b1 SD of median blood Phe remained stable (525 \u00b1 248 \u00b5mol\/L vs. 552 \u00b1 225 \u00b5mol\/L; p = 0.100); median % of blood Phe &lt; 480 \u00b5mol\/L decreased (51 (4\u201396)% vs. 37 (5\u201385)%; p = 0.041) and median number of clinic appointments increased from SP1 to SP2: (5 (4\u20136) vs. 11 (8\u201313); p &lt; 0.001). No significant differences were found regarding any parameter of protein intake. Our results suggest that the implementation of an adult service was successful as impact on metabolic control was limited and attendance remained high. Continuous dietetic care likely contributed to these results by keeping patients in follow-up and committed to treatment.<\/jats:p>","DOI":"10.3390\/nu13030799","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T20:43:32Z","timestamp":1614545012000},"page":"799","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Implementing a Transition Program from Paediatric to Adult Services in Phenylketonuria: Results after Two Years of Follow-Up with an Adult Team"],"prefix":"10.3390","volume":"13","author":[{"given":"Maria","family":"Peres","sequence":"first","affiliation":[{"name":"Centro de Gen\u00e9tica M\u00e9dica, Centro Hospitalar Universit\u00e1rio do Porto (CHUP), 4099-028 Porto, Portugal"},{"name":"Faculdade de Ci\u00eancias da Nutri\u00e7\u00e3o e Alimenta\u00e7\u00e3o, UP, 4150-177 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-1314","authenticated-orcid":false,"given":"Manuela F.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Centro de Gen\u00e9tica M\u00e9dica, Centro Hospitalar Universit\u00e1rio do Porto (CHUP), 4099-028 Porto, Portugal"},{"name":"Centro de Refer\u00eancia na \u00e1rea de Doen\u00e7as Heredit\u00e1rias do Metabolismo, Centro Hospitalar Universit\u00e1rio do Porto-CHUP, 4099-001 Porto, Portugal"},{"name":"Unit for Multidisciplinary Research in Biomedicine, Abel Salazar Institute of Biomedical Sciences, University of Porto-UMIB\/ICBAS\/UP, 4050-313 Porto, Portugal"}]},{"given":"\u00c9lia J.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Centro de Gen\u00e9tica M\u00e9dica, Centro Hospitalar Universit\u00e1rio do Porto (CHUP), 4099-028 Porto, Portugal"},{"name":"Faculdade de Ci\u00eancias da Nutri\u00e7\u00e3o e Alimenta\u00e7\u00e3o, UP, 4150-177 Porto, Portugal"}]},{"given":"Carla","family":"Carmona","sequence":"additional","affiliation":[{"name":"Centro de Gen\u00e9tica M\u00e9dica, Centro Hospitalar Universit\u00e1rio do Porto (CHUP), 4099-028 Porto, Portugal"},{"name":"Centro de Refer\u00eancia na \u00e1rea de Doen\u00e7as Heredit\u00e1rias do Metabolismo, Centro Hospitalar Universit\u00e1rio do Porto-CHUP, 4099-001 Porto, Portugal"},{"name":"Unit for Multidisciplinary Research in Biomedicine, Abel Salazar Institute of Biomedical Sciences, University of Porto-UMIB\/ICBAS\/UP, 4050-313 Porto, Portugal"}]},{"given":"Sara","family":"Rocha","sequence":"additional","affiliation":[{"name":"Centro de Refer\u00eancia na \u00e1rea de Doen\u00e7as Heredit\u00e1rias do Metabolismo, Centro Hospitalar Universit\u00e1rio do Porto-CHUP, 4099-001 Porto, Portugal"}]},{"given":"Arlindo","family":"Guimas","sequence":"additional","affiliation":[{"name":"Centro de Refer\u00eancia na \u00e1rea de Doen\u00e7as Heredit\u00e1rias do Metabolismo, Centro Hospitalar Universit\u00e1rio do Porto-CHUP, 4099-001 Porto, Portugal"}]},{"given":"Rosa","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centro de Refer\u00eancia na \u00e1rea de Doen\u00e7as Heredit\u00e1rias do Metabolismo, Centro Hospitalar Universit\u00e1rio do Porto-CHUP, 4099-001 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9247-9391","authenticated-orcid":false,"given":"Esmeralda","family":"Martins","sequence":"additional","affiliation":[{"name":"Centro de Refer\u00eancia na \u00e1rea de Doen\u00e7as Heredit\u00e1rias do Metabolismo, Centro Hospitalar Universit\u00e1rio do Porto-CHUP, 4099-001 Porto, Portugal"},{"name":"Unit for Multidisciplinary Research in Biomedicine, Abel Salazar Institute of Biomedical Sciences, University of Porto-UMIB\/ICBAS\/UP, 4050-313 Porto, Portugal"}]},{"given":"Anabela","family":"Bandeira","sequence":"additional","affiliation":[{"name":"Centro de Refer\u00eancia na \u00e1rea de Doen\u00e7as Heredit\u00e1rias do Metabolismo, Centro Hospitalar Universit\u00e1rio do Porto-CHUP, 4099-001 Porto, Portugal"}]},{"given":"Anita","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Birmingham Women\u2019s and Children\u2019s Hospital, Birmingham B4 6NH, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4977-8345","authenticated-orcid":false,"given":"J\u00falio C.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Centro de Gen\u00e9tica M\u00e9dica, Centro Hospitalar Universit\u00e1rio do Porto (CHUP), 4099-028 Porto, Portugal"},{"name":"Centro de Refer\u00eancia na \u00e1rea de Doen\u00e7as Heredit\u00e1rias do Metabolismo, Centro Hospitalar Universit\u00e1rio do Porto-CHUP, 4099-001 Porto, Portugal"},{"name":"Centre for Health Technology and Services Research (CINTESIS), 4200-450 Porto, Portugal"},{"name":"Nutrition &amp; Metabolism, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, 1169-056 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(10)60961-0","article-title":"Phenylketonuria","volume":"376","author":"Blau","year":"2010","journal-title":"Lancet"},{"key":"ref_2","first-page":"1","article-title":"The complete European guidelines on phenylketonuria: Diagnosis and treatment","volume":"12","author":"MacDonald","year":"2017","journal-title":"Orphanet J. 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