{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T21:24:19Z","timestamp":1771536259201,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The research was funded by Laboratorios Th\u00e9a (Barcelona, Spain) and by research grants from the \u201cInstituto de Salud Carlos III\/European Regional Development Fund (ERDF)\u201d and RD16\/0008\/0011, OFTARED: Enfermedades oculares: \u201cPrevenci\u00f3n, detecci\u00f3n precoz, tr","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The purpose of this study is evaluate the efficacy and safety of medicinal products containing the original Age-Related Eye Disease group (AREDS) formulation at doses approved in Europe (EU, control group; n = 59) with a product that adds DHA, lutein, zeaxanthin, resveratrol and hydroxytyrosol to the formula (intervention group; n = 50). This was a multicenter, randomized, observer-blinded trial conducted in patients aged 50 years or older diagnosed with unilateral exudative Age related Macular Degeneration AMD. At month 12, the intervention did not have a significant differential effect on visual acuity compared with the control group, with an estimated treatment difference in Early Treatment Diabetic Retinopathy Study (ETDRS) of \u22121.63 (95% CI \u22120.83 to 4.09; p = 0.192). The intervention exhibited a significant and, in most cases, relevant effect in terms of a reduction in some inflammatory cytokines and a greater improvement in the fatty acid profile and serum lutein and zeaxantin concentration. In patients with unilateral wet AMD, the addition of lutein, zeaxanthin, resveratrol, hydroxytyrosol and DHA to the AREDS EU recommended doses in the short-term did not have a differential effect on visual acuity compared to a standard AREDS EU formula but, in addition to improving the fatty acid profile and increasing carotenoid serum levels, may provide a beneficial effect in improving the proinflammatory and proangiogenic profile of patients with AMD.<\/jats:p>","DOI":"10.3390\/nu13041253","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T05:52:00Z","timestamp":1618206720000},"page":"1253","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration"],"prefix":"10.3390","volume":"13","author":[{"given":"Alfredo","family":"Garc\u00eda-Layana","sequence":"first","affiliation":[{"name":"Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Cl\u00ednica Universidad de Navarra, Av. de P\u00edo XII, 36, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research, IdiSNA, C\/Irunlarrea, 3, 31008 Pamplona, Spain"},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa Sanitaria en Enfer-Medades Oculares (Oftared), Instituto de Salud Carlos III, Av. de Monforte de Lemos 5, 28029 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9328-9725","authenticated-orcid":false,"given":"Sergio","family":"Recalde","sequence":"additional","affiliation":[{"name":"Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Cl\u00ednica Universidad de Navarra, Av. de P\u00edo XII, 36, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research, IdiSNA, C\/Irunlarrea, 3, 31008 Pamplona, Spain"},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa Sanitaria en Enfer-Medades Oculares (Oftared), Instituto de Salud Carlos III, Av. de Monforte de Lemos 5, 28029 Madrid, Spain"}]},{"given":"Maria","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Cl\u00ednica Universidad de Navarra, Av. de P\u00edo XII, 36, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research, IdiSNA, C\/Irunlarrea, 3, 31008 Pamplona, Spain"},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa Sanitaria en Enfer-Medades Oculares (Oftared), Instituto de Salud Carlos III, Av. de Monforte de Lemos 5, 28029 Madrid, Spain"}]},{"given":"Maximino J.","family":"Abraldes","sequence":"additional","affiliation":[{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa Sanitaria en Enfer-Medades Oculares (Oftared), Instituto de Salud Carlos III, Av. de Monforte de Lemos 5, 28029 Madrid, Spain"},{"name":"Department of Ophthalmology, Complexo Hospitalario Universitario de Santiago de Compostela, Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain"}]},{"given":"Jo\u00e3o","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Retinal Department, Ophthalmology, Retina Lisbon Institut, Av. Duque de Loul\u00e9 N\u00ba5, 1050-085 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5927-0836","authenticated-orcid":false,"given":"Emiliano","family":"Hern\u00e1ndez-Galilea","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Salamanca, University Hospital of Salamanca, Paseo de San Vicente 182, 37007 Salamanca, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-5171","authenticated-orcid":false,"given":"Bego\u00f1a","family":"Olmedilla-Alonso","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Jos\u00e9 Antonio Novais 10, 28040 Madrid, Spain"}]},{"given":"Jose Juan","family":"Escobar-Barranco","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Dos de Maig, Carrer del Dos de Maig 301, 08025 Barcelona, Spain"}]},{"given":"Miguel Angel","family":"Zapata","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Vall Hebron, Passeig de la Vall d\u2019Hebron 119, 08035 Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8676-0833","authenticated-orcid":false,"given":"Rufino","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Pa\u00e7o das Escolas, 3004-531 Coimbra, Portugal"},{"name":"Ophthalmology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal"},{"name":"Association for Innovation and Biomedical Research on Light and Image (AIBILI), Azinhaga Sta. Comba, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1873-3977","authenticated-orcid":false,"given":"Mariana","family":"Caballero Arredondo","sequence":"additional","affiliation":[{"name":"Nutrition, Food Science and Gastronomy, University of Barcelona, Joan XXIII, 27-31, 08028 Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-7044","authenticated-orcid":false,"given":"Mar\u00eda Carmen","family":"Lopez-Sabater","sequence":"additional","affiliation":[{"name":"Nutrition, Food Science and Gastronomy, University of Barcelona, Joan XXIII, 27-31, 08028 Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6072-1545","authenticated-orcid":false,"given":"Silvia","family":"Mendez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Miguel Servet University Hospital, Paseo Isabel la Cat\u00f3lica 1-3, 50009 Zaragoza, Spain"},{"name":"Miguel Servet Ophthalmology Research Group (GIMSO), Aragon Health Research Institute (IIS Aragon), University of Zaragoza, Avda. De Juan Bosco 13, 50009 Zaragoza, Spain"}]},{"given":"Nieves","family":"Pardi\u00f1as-Bar\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Miguel Servet University Hospital, Paseo Isabel la Cat\u00f3lica 1-3, 50009 Zaragoza, Spain"},{"name":"Miguel Servet Ophthalmology Research Group (GIMSO), Aragon Health Research Institute (IIS Aragon), University of Zaragoza, Avda. De Juan Bosco 13, 50009 Zaragoza, Spain"}]},{"given":"Pilar","family":"Calvo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Miguel Servet University Hospital, Paseo Isabel la Cat\u00f3lica 1-3, 50009 Zaragoza, Spain"},{"name":"Miguel Servet Ophthalmology Research Group (GIMSO), Aragon Health Research Institute (IIS Aragon), University of Zaragoza, Avda. De Juan Bosco 13, 50009 Zaragoza, Spain"}]},{"given":"Patricia","family":"Fern\u00e1ndez-Robredo","sequence":"additional","affiliation":[{"name":"Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Cl\u00ednica Universidad de Navarra, Av. de P\u00edo XII, 36, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research, IdiSNA, C\/Irunlarrea, 3, 31008 Pamplona, Spain"},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa Sanitaria en Enfer-Medades Oculares (Oftared), Instituto de Salud Carlos III, Av. de Monforte de Lemos 5, 28029 Madrid, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,10]]},"reference":[{"key":"ref_1","first-page":"493","article-title":"Updates on the epidemiology of age-related macular degeneration","volume":"6","author":"Jonas","year":"2017","journal-title":"Asia Pac. J. 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