{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:01:16Z","timestamp":1776276076582,"version":"3.50.1"},"reference-count":181,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["804229"],"award-info":[{"award-number":["804229"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The rise of neurodegenerative diseases in an aging population is an increasing problem of health, social and economic consequences. Epidemiological and intervention studies have demonstrated that diets rich in (poly)phenols can have potent health benefits on cognitive decline and neurodegenerative diseases. Meanwhile, the role of gut microbiota is ever more evident in modulating the catabolism of (poly)phenols to dozens of low molecular weight (poly)phenol metabolites that have been identified in plasma and urine. These metabolites can reach circulation in higher concentrations than parent (poly)phenols and persist for longer periods of time. However, studies addressing their potential brain effects are still lacking. In this review, we will discuss different model organisms that have been used to study how low molecular weight (poly)phenol metabolites affect neuronal related mechanisms gathering critical insight on their potential to tackle the major hallmarks of neurodegeneration.<\/jats:p>","DOI":"10.3390\/nu13092940","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T23:25:50Z","timestamp":1629933950000},"page":"2940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1396-3039","authenticated-orcid":false,"given":"Diogo","family":"Carregosa","sequence":"first","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 1169-056 Lisboa, Portugal"}]},{"given":"Sara","family":"Mota","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 1169-056 Lisboa, Portugal"},{"name":"iBET, Institute of Experimental and Technological Biology, Apartado 12, 2781-901 Oeiras, Portugal"}]},{"given":"Sofia","family":"Ferreira","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 1169-056 Lisboa, Portugal"},{"name":"CBIOS, University Lus\u00f3fona\u2019s Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6289-2935","authenticated-orcid":false,"given":"Beatriz","family":"Alves-Dias","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 1169-056 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8350-1390","authenticated-orcid":false,"given":"Natasa","family":"Loncarevic-Vasiljkovic","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 1169-056 Lisboa, Portugal"},{"name":"Department of Neurobiology, Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d\u2014National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia"}]},{"given":"Carolina Lage","family":"Crespo","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 1169-056 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0552-8480","authenticated-orcid":false,"given":"Regina","family":"Menezes","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 1169-056 Lisboa, Portugal"},{"name":"iBET, Institute of Experimental and Technological Biology, Apartado 12, 2781-901 Oeiras, Portugal"},{"name":"CBIOS, University Lus\u00f3fona\u2019s Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0600-8842","authenticated-orcid":false,"given":"Rita","family":"Teodoro","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 1169-056 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5809-1924","authenticated-orcid":false,"given":"Cl\u00e1udia Nunes dos","family":"Santos","sequence":"additional","affiliation":[{"name":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 1169-056 Lisboa, Portugal"},{"name":"iBET, Institute of Experimental and Technological Biology, Apartado 12, 2781-901 Oeiras, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"bat070","DOI":"10.1093\/database\/bat070","article-title":"Phenol-Explorer 3.0: A major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content","volume":"2013","author":"Rothwell","year":"2013","journal-title":"Database"},{"key":"ref_2","unstructured":"da Silva, A., Giacomoni, F., Pavot, B., Fill\u00e2tre, Y., Rothwell, J.A., Sualdea, B.B., Veyrat, C., Garcia-Villalba, R., Gladine, C., and Kopec, R. 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