{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:14:20Z","timestamp":1768821260369,"version":"3.49.0"},"reference-count":122,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00681\/2020"],"award-info":[{"award-number":["UIDB\/00681\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019370","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["UIDB\/00681\/2020"],"award-info":[{"award-number":["UIDB\/00681\/2020"]}],"id":[{"id":"10.13039\/501100019370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Bovine colostrum (BC) is the initial mammary secretion after parturition, which is nature\u2019s bountiful source consisting of nutritional and bioactive components present in a highly concentrated low-volume format. All mammalian newborns require colostrum to enhance physiological processes such as lifelong immunity, gastrointestinal development, and resistance to microbial infections. The genetic, environmental, and processing methods can all have an impact on the biochemical contents of BC and its supplements. BC and its derivatives have been intensively researched for their potential use in functional foods, medicines, and animal feed. Evidence from clinical studies suggests that BC products are well-tolerated, nontoxic, and safe for human ingestion. Functional foods, feed, and pharmaceutical formulations based on bovine colostrum are playing noteworthy roles in the development of innovative products for promoting health and the prevention of chronic illnesses. This systematic review sheds light on recent research on (a) the effects of processing techniques on BC components, (b) emerging techniques used in the isolation and identification of novel components, (c) BC-based functional foods for human consumption and animal feed supplements, and (d) the role of BC in current drug delivery, as well as future recommendations.<\/jats:p>","DOI":"10.3390\/nu14030659","type":"journal-article","created":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T20:38:40Z","timestamp":1644179920000},"page":"659","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0299-4443","authenticated-orcid":false,"given":"Rahul","family":"Mehra","sequence":"first","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India"}]},{"given":"Renu","family":"Garhwal","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India"}]},{"given":"Karnam","family":"Sangwan","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0595-6805","authenticated-orcid":false,"given":"Raquel P. F.","family":"Guin\u00e9","sequence":"additional","affiliation":[{"name":"CERNAS Research Centre, Polytechnic Institute of Viseu, 3504-510 Viseu, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6346-8319","authenticated-orcid":false,"given":"Edite Teixeira","family":"Lemos","sequence":"additional","affiliation":[{"name":"CERNAS Research Centre, Polytechnic Institute of Viseu, 3504-510 Viseu, Portugal"}]},{"given":"Harpal Singh","family":"Buttar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"}]},{"given":"Pradeep Kumar Singh","family":"Visen","sequence":"additional","affiliation":[{"name":"Nutra-V Inc., Toronto, ON M1K 3B8, Canada"}]},{"given":"Naveen","family":"Kumar","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India"}]},{"given":"Anuradha","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"ICAR-National Research Centre on Equines, Hisar 125001, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7025-1567","authenticated-orcid":false,"given":"Harish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100907","DOI":"10.1016\/j.fbio.2021.100907","article-title":"Nutritional Attributes of Bovine Colostrum Components in Human Health and Disease: A Comprehensive Review","volume":"40","author":"Mehra","year":"2021","journal-title":"Food Biosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"01100","DOI":"10.3389\/fphar.2020.01100","article-title":"Therapeutic Applications of Human and Bovine Colostrum in the Treatment of Gastrointestinal Diseases and Distinctive Cancer Types: The Current Evidence","volume":"11","author":"Yadav","year":"2020","journal-title":"Front. 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