{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:19:16Z","timestamp":1774379956563,"version":"3.50.1"},"reference-count":50,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (Lisbon, Portugal)","doi-asserted-by":"publisher","award":["UID\/AGR\/04129\/2020 (LEAF)"],"award-info":[{"award-number":["UID\/AGR\/04129\/2020 (LEAF)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (Lisbon, Portugal)","doi-asserted-by":"publisher","award":["PTDC\/BAA-AGR\/28608\/2017"],"award-info":[{"award-number":["PTDC\/BAA-AGR\/28608\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (Lisbon, Portugal)","doi-asserted-by":"publisher","award":["SFRH\/BD\/132832\/2017"],"award-info":[{"award-number":["SFRH\/BD\/132832\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Food fortification with bioactive compounds may constitute a way to ameliorate inflammatory bowel diseases (IBDs). Lupin seeds contain an oligomer named deflamin that can reduce IBD\u2019s symptoms via MMP-9 inhibition. Here, our goal was to develop a lupin protein concentrate (LPC) enriched in deflamin and to test its application as a food additive to be used as a functional food against colitis. The nutritional profile of the LPC was evaluated, and its efficacy in vivo was tested, either alone or as added to wheat cookies. The LPC presented high protein and carbohydrate contents (20.09 g\/100 g and 62.05\/100 g, respectively), as well as antioxidant activity (FRAP: 351.19 mg AAE\/10 mg and DPPH: 273.9 mg AAE\/10 mg). It was also effective against TNBS-induced colitis in a dose dependent-manner, reducing DAI scores by more than 50% and concomitantly inhibiting MMP-9 activity. When added to cookies, the LPC activities were maintained after baking, and a 4-day diet with LPC cookies induced a significant protective effect against acetic acid-induced colitis, overall bringing lesions, oxidative stress and DNA damage levels to values significantly similar to controls (p &lt; 0.001). The results show that the LPC is an efficient way to deliver deflamin in IBD-targeted diets.<\/jats:p>","DOI":"10.3390\/nu14102102","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T23:14:26Z","timestamp":1652915666000},"page":"2102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Lupin Protein Concentrate as a Novel Functional Food Additive That Can Reduce Colitis-Induced Inflammation and Oxidative Stress"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-852X","authenticated-orcid":false,"given":"Joana","family":"Mota","sequence":"first","affiliation":[{"name":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisbon, Portugal"},{"name":"Faculty of Veterinary Medicine, Lus\u00f3fona University, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6917-4477","authenticated-orcid":false,"given":"Sandra","family":"Casimiro","sequence":"additional","affiliation":[{"name":"Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina de Lisboa, Universidade de Lisboa, 1649-028 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5940-3750","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Fernandes","sequence":"additional","affiliation":[{"name":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisbon, Portugal"}]},{"given":"Renata M.","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Hepatology and Gastroenterology, Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre 90040-060, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3015-0192","authenticated-orcid":false,"given":"Eliz\u00e2ngela","family":"Schemitt","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Hepatology and Gastroenterology, Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre 90040-060, Brazil"}]},{"given":"Jaqueline","family":"Picada","sequence":"additional","affiliation":[{"name":"Genetic Toxicologic Laboratory, Lutheran University of Brazil (ULBRA), Canoas 92425-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4782-7318","authenticated-orcid":false,"given":"Lu\u00eds","family":"Costa","sequence":"additional","affiliation":[{"name":"Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina de Lisboa, Universidade de Lisboa, 1649-028 Lisbon, Portugal"},{"name":"Oncology Division, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte, 1649-028 Lisbon, Portugal"}]},{"given":"Norma","family":"Marroni","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Hepatology and Gastroenterology, Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre 90040-060, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5266-1685","authenticated-orcid":false,"given":"Anabela","family":"Raymundo","sequence":"additional","affiliation":[{"name":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8251-6286","authenticated-orcid":false,"given":"Ana","family":"Lima","sequence":"additional","affiliation":[{"name":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisbon, Portugal"},{"name":"Faculty of Veterinary Medicine, Lus\u00f3fona University, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-7564","authenticated-orcid":false,"given":"Ricardo Boavida","family":"Ferreira","sequence":"additional","affiliation":[{"name":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.tifs.2018.06.011","article-title":"Advances in nutraceutical delivery systems: From formulation design for bioavailability enhancement to efficacy and safety evaluation","volume":"78","author":"Martins","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00535-018-1439-1","article-title":"Evidence-based clinical practice guidelines for inflammatory bowel disease","volume":"53","author":"Matsuoka","year":"2018","journal-title":"J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.3748\/wjg.v25.i30.4181","article-title":"Beneficial effects of nutritional supplements on intestinal epithelial barrier functions in experimental colitis models in vivo","volume":"25","author":"Schnoor","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.dld.2021.03.002","article-title":"Quality of life in patients with moderate to severe ulcerative colitis and the impact of treatment: A narrative review","volume":"53","author":"Armuzzi","year":"2021","journal-title":"Dig. Liver Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"otz054","DOI":"10.1093\/crocol\/otz054","article-title":"Impact of diet on risk of IBD","volume":"2","author":"Ananthakrishnan","year":"2020","journal-title":"Crohn\u2019s Colitis 360"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e2000514","DOI":"10.1002\/mnfr.202000514","article-title":"Diet and Inflammatory Bowel Disease: What Quality Standards Should Be Applied in Clinical and Laboratory Studies?","volume":"65","author":"Rogler","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.3748\/wjg.v24.i25.2673","article-title":"Diets, functional foods, and nutraceuticals as alternative therapies for inflammatory bowel disease: Present status and future trends","volume":"24","author":"Mijan","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_8","first-page":"2894169","article-title":"The influence of nutrients on inflammatory bowel diseases","volume":"2020","author":"Filip","year":"2020","journal-title":"J. Nutr. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lean, Q.Y., Eri, R.D., Fitton, J.H., Patel, R.P., and Gueven, N. (2015). Fucoidan Extracts Ameliorate Acute Colitis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0128453"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"La Manna, S., Di Natale, C., Florio, D., and Marasco, D. (2018). Peptides as therapeutic agents for inflammatory-related diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092714"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jnutbio.2017.02.005","article-title":"Pomegranate polyphenolics reduce inflammation and ulceration in intestinal colitis-involvement of the miR-145\/p70S6K1\/HIF1alpha axis in vivo and in vitro","volume":"43","author":"Kim","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1021\/acs.jafc.7b01323","article-title":"In vivo study of the efficacy of the essential oil of Zanthoxylum bungeanum pericarp in dextran sulfate sodium-induced murine experimental colitis","volume":"65","author":"Zhang","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1007\/s13197-018-3339-z","article-title":"Influence of protein source on characteristics and quality of gluten-free cookies","volume":"55","year":"2018","journal-title":"J. Food Sci. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Mota, J., Direito, R., Rocha, J., Fernandes, J., Sepodes, B., Figueira, M.E., Raymundo, A., Lima, A., and Ferreira, R.B. (2021). Lupinus albus Protein Components Inhibit MMP-2 and MMP-9 Gelatinolytic Activity In Vitro and In Vivo. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222413286"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Derkacz, A., Olczyk, P., Olczyk, K., and Komosinska-Vassev, K. (2021). The Role of Extracellular Matrix Components in Inflammatory Bowel Diseases. J. Clin. Med., 10.","DOI":"10.3390\/jcm10051122"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Mota, J., Lima, A., Ferreira, R.B., and Raymundo, A. (2021). Technological Potential of a Lupin Protein Concentrate as a Nutraceutical Delivery System in Baked Cookies. Foods, 10.","DOI":"10.3390\/foods10081929"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Okagu, I.U., Ndefo, J.C., Aham, E.C., Obeme-Nmom, J.I., Agboinghale, P.E., Aguchem, R.N., Nechi, R.N., and Lammi, C. (2021). Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits. Nutrients, 13.","DOI":"10.3390\/nu13093266"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Alemany-Cosme, E., S\u00e1ez-Gonz\u00e1lez, E., Moret, I., Mateos, B., Iborra, M., Nos, P., Sandoval, J., and Beltr\u00e1n, B. (2021). Oxidative stress in the pathogenesis of Crohn\u2019s disease and the interconnection with immunological response, microbiota, external environmental factors, and epigenetics. Antioxidants, 10.","DOI":"10.3390\/antiox10010064"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Vona, R., Pallotta, L., Cappelletti, M., Severi, C., and Matarrese, P. (2021). The Impact of Oxidative Stress in Human Pathology: Focus on Gastrointestinal Disorders. Antioxidants, 10.","DOI":"10.3390\/antiox10020201"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"God\u00ednez-M\u00e9ndez, L.A., Gurrola-D\u00edaz, C.M., Zepeda-Nu\u00f1o, J.S., Vega-Maga\u00f1a, N., Lopez-Roa, R.I., \u00cd\u00f1iguez-Guti\u00e9rrez, L., Garc\u00eda-L\u00f3pez, P.M., Fafutis-Morris, M., and Delgado-Rizo, V. (2021). In Vivo Healthy Benefits of Galacto-Oligosaccharides from Lupinus albus (LAGOS) in Butyrate Production through Intestinal Microbiota. Biomolecules, 11.","DOI":"10.3390\/biom11111658"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Batista, A.P., Niccolai, A., Bursic, I., Sousa, I., Raymundo, A., Rodolfi, L., Biondi, N., and Tredici, M.R. (2019). Microalgae as Functional Ingredients in Savory Food Products: Application to Wheat Crackers. Foods, 8.","DOI":"10.3390\/foods8120611"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1053\/j.gastro.2005.09.017","article-title":"Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: Central role of epithelial-derived MMP","volume":"129","author":"Castaneda","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/0253-7613.150311","article-title":"Protective effect of simvastatin and rosuvastatin on trinitrobenzene sulfonic acid-induced colitis in rats","volume":"47","author":"Maheshwari","year":"2015","journal-title":"Indian J. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.foodchem.2015.10.063","article-title":"Legume seeds and colorectal cancer revisited: Protease inhibitors reduce MMP-9 activity and colon cancer cell migration","volume":"197","author":"Lima","year":"2016","journal-title":"Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Mota, J., Lima, A., Ferreira, R.B., and Raymundo, A. (2020). Lupin Seed Protein Extract Can Efficiently Enrich the Physical Properties of Cookies Prepared with Alternative Flours. Foods, 9.","DOI":"10.3390\/foods9081064"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/ptr.5142","article-title":"Boswellia serrata has beneficial anti-inflammatory and antioxidant properties in a model of experimental colitis","volume":"28","author":"Hartmann","year":"2014","journal-title":"Phytother. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Fernandes, J.C., Schemitt, E.G., Da Silva, J., Marroni, N.P., Lima, A., and Ferreira, R.B. (2021). Combination of trans-Resveratrol and \u03b5-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression. Nutrients, 13.","DOI":"10.3390\/nu13113677"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1742-7843.2007.00181.x","article-title":"N-Acetylcysteine effects on genotoxic and oxidative stress parameters in cirrhotic rats with hepatopulmonary syndrome","volume":"102","author":"Vercelino","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1177\/002215540104900912","article-title":"A silver staining method for single-cell gel assay","volume":"49","author":"Nadin","year":"2001","journal-title":"J. Histochem. Cytochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s43014-020-0020-5","article-title":"Plant food anti-nutritional factors and their reduction strategies: An overview","volume":"2","author":"Samtiya","year":"2020","journal-title":"J. Food Process. Preserv."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jfca.2011.10.002","article-title":"Antioxidant activity and phenolic content in three lupin species","volume":"25","author":"Siger","year":"2012","journal-title":"J. Food Compos. Anal."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jnutbio.2017.03.002","article-title":"Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities","volume":"46","author":"Direito","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"109351","DOI":"10.1016\/j.biopha.2019.109351","article-title":"Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice","volume":"118","author":"Rocha","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Direito, R., Rocha, J., Lima, A., Gon\u00e7alves, M.M., Duarte, M.P., Mateus, V., Sousa, C., Fernandes, A., Pinto, R., and Ferreira, R.B. (2019). Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice. Medicines, 6.","DOI":"10.3390\/medicines6020065"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/jmf.2019.0082","article-title":"Study on Biological Activity of Bread Enriched with Natural Polyphenols in Terms of Growth Inhibition of Tumor Intestine Cells","volume":"23","author":"Szwajgier","year":"2020","journal-title":"J. Med. Food"},{"key":"ref_37","first-page":"608053","article-title":"Anticancer and antioxidant activity of bread enriched with broccoli sprouts","volume":"2014","author":"Dziki","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_38","first-page":"1341","article-title":"Animal models of ulcerative colitis and their application in drug research","volume":"7","author":"Low","year":"2013","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4196\/kjpp.2014.18.4.279","article-title":"A review on chemical-induced inflammatory bowel disease models in rodents","volume":"18","author":"Randhawa","year":"2014","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"736837","DOI":"10.1155\/2012\/736837","article-title":"Glutathione homeostasis and functions: Potential targets for medical interventions","volume":"2012","author":"Lushchak","year":"2012","journal-title":"J. Amino Acids"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.redox.2015.10.006","article-title":"Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?","volume":"6","author":"Moura","year":"2015","journal-title":"Redox Biol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Dzi\u0105bowska-Grabias, K., Sztanke, M., Zaj\u0105c, P., Celejewski, M., Kurek, K., Szkutnicki, S., Korga, P., Bulikowski, W., and Sztanke, K. (2021). Antioxidant Therapy in Inflammatory Bowel Diseases. Antioxidants, 10.","DOI":"10.3390\/antiox10030412"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s10620-010-1364-5","article-title":"Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats","volume":"56","author":"Tahan","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s13197-011-0269-4","article-title":"Role of nutraceuticals in human health","volume":"49","author":"Das","year":"2012","journal-title":"J. Food Sci. Technol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Shifrin, H., Nadler-Milbauer, M., Shoham, S., and Weinstock, M. (2013). Rivastigmine alleviates experimentally induced colitis in mice and rats by acting at central and peripheral sites to modulate imunne responses. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057668"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1503\/cjs.013610","article-title":"Vitamin E has a dual effect of anti-inflammatory and antioxidant activities in acetic acid-induced ulcerative colitis in rats","volume":"54","author":"Tahan","year":"2011","journal-title":"Can. J. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/ajcn\/84.5.975","article-title":"Lupin-enriched bread increases satiety and reduces energy intake acutely","volume":"84","author":"Lee","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1039\/C3FO60583C","article-title":"Pasta supplemented with isolated lupin protein fractions reduces body weight gain and food intake of rats and decreases plasma glucose concentration upon glucose overload trial","volume":"5","author":"Capraro","year":"2014","journal-title":"Food Funct."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.fitote.2005.11.008","article-title":"Grain legume proteins and nutraceutical properties","volume":"77","author":"Duranti","year":"2006","journal-title":"Fitoterapia"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.lwt.2017.08.015","article-title":"Functional and textural properties of a dehulled oat (Avena sativa L.) and pea (Pisum sativum) protein isolate cracker","volume":"86","author":"Enriquez","year":"2017","journal-title":"LWT"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/10\/2102\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:13:57Z","timestamp":1760138037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/10\/2102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,18]]},"references-count":50,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["nu14102102"],"URL":"https:\/\/doi.org\/10.3390\/nu14102102","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,18]]}}}