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Ministry of Science and Innovation","award":["UIDBP\/4539\/2020 (CIBB)"],"award-info":[{"award-number":["UIDBP\/4539\/2020 (CIBB)"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["POCI-01-0145-FEDER-031712"],"award-info":[{"award-number":["POCI-01-0145-FEDER-031712"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["LISBOA\u201401\u20130145\u2014FEDER\u2014007344"],"award-info":[{"award-number":["LISBOA\u201401\u20130145\u2014FEDER\u2014007344"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["COFAC\/ILIND\/CBIOS\/2\/2021"],"award-info":[{"award-number":["COFAC\/ILIND\/CBIOS\/2\/2021"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["CEEC\/04567\/CBIOS\/2020"],"award-info":[{"award-number":["CEEC\/04567\/CBIOS\/2020"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["2020.04126.CEECIND\/CP1596\/CT0006"],"award-info":[{"award-number":["2020.04126.CEECIND\/CP1596\/CT0006"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["LA\/P\/0008\/2020"],"award-info":[{"award-number":["LA\/P\/0008\/2020"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["PID2020-114102RB-I00"],"award-info":[{"award-number":["PID2020-114102RB-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(Poly)phenols have anti-diabetic properties that are mediated through the regulation of the main biomarkers associated with type 2 diabetes mellitus (T2DM) (fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), insulin resistance (IR)), as well as the modulation of other metabolic, inflammatory and oxidative stress pathways. A wide range of human and pre-clinical studies supports these effects for different plant products containing mixed (poly)phenols (e.g., berries, cocoa, tea) and for some single compounds (e.g., resveratrol). We went through some of the latest human intervention trials and pre-clinical studies looking at (poly)phenols against T2DM to update the current evidence and to examine the progress in this field to achieve consistent proof of the anti-diabetic benefits of these compounds. Overall, the reported effects remain small and highly variable, and the accumulated data are still limited and contradictory, as shown by recent meta-analyses. We found newly published studies with better experimental strategies, but there were also examples of studies that still need to be improved. Herein, we highlight some of the main aspects that still need to be considered in future studies and reinforce the messages that need to be taken on board to achieve consistent evidence of the anti-diabetic effects of (poly)phenols.<\/jats:p>","DOI":"10.3390\/nu14173563","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:13:56Z","timestamp":1661904836000},"page":"3563","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Updated Information of the Effects of (Poly)phenols against Type-2 Diabetes Mellitus in Humans: Reinforcing the Recommendations for Future Research"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0552-8480","authenticated-orcid":false,"given":"Regina","family":"Menezes","sequence":"first","affiliation":[{"name":"CBIOS\u2014Universidade Lus\u00f3fon\u00e1s, Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisboa, Portugal"},{"name":"NOVA Medical School\u2014Faculdade de Ci\u00eancias M\u00e9dicas (NMS\u2014FCM), Universidade Nova de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria 130, 1169-056 Lisboa, Portugal"},{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, 2781-901 Oeiras, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3422-290X","authenticated-orcid":false,"given":"Paulo","family":"Matafome","sequence":"additional","affiliation":[{"name":"Coimbra Institute of Clinical and Biomedical Research (iCBR) and Institute of Physiology, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Instituto Polit\u00e9cnico de Coimbra, Coimbra Health School (ESTeSC), Department of Complementary Sciences, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9114-9967","authenticated-orcid":false,"given":"Marisa","family":"Freitas","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4125-853X","authenticated-orcid":false,"given":"Mar\u00eda-Teresa","family":"Garc\u00eda-Conesa","sequence":"additional","affiliation":[{"name":"Research Group on Quality, Safety and Bioactivity of Plant Foods, Centro de Edafolog\u00eda y Biolog\u00eda Aplicada del Segura (CEBAS), Spanish National Research Council (CSIC), Campus de Espinardo, 30100 Murcia, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"ref_1","unstructured":"International Diabetes Federation (IDF) (2022, August 09). 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