{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:32:49Z","timestamp":1773160369459,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Science and Technology (FCT)","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}]},{"name":"Foundation for Science and Technology (FCT)","award":["SFRH\/BD\/139137\/2018"],"award-info":[{"award-number":["SFRH\/BD\/139137\/2018"]}]},{"name":"Foundation for Science and Technology (FCT)","award":["2020.04947.BD"],"award-info":[{"award-number":["2020.04947.BD"]}]},{"name":"Foundation for Science and Technology (FCT)","award":["101003373"],"award-info":[{"award-number":["101003373"]}]},{"name":"European Regional Development Fund (ERDF)","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["SFRH\/BD\/139137\/2018"],"award-info":[{"award-number":["SFRH\/BD\/139137\/2018"]}]},{"name":"European Regional Development Fund (ERDF)","award":["2020.04947.BD"],"award-info":[{"award-number":["2020.04947.BD"]}]},{"name":"European Regional Development Fund (ERDF)","award":["101003373"],"award-info":[{"award-number":["101003373"]}]},{"DOI":"10.13039\/501100001871","name":"FCT through PhD fellowships","doi-asserted-by":"publisher","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT through PhD fellowships","doi-asserted-by":"publisher","award":["SFRH\/BD\/139137\/2018"],"award-info":[{"award-number":["SFRH\/BD\/139137\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT through PhD fellowships","doi-asserted-by":"publisher","award":["2020.04947.BD"],"award-info":[{"award-number":["2020.04947.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT through PhD fellowships","doi-asserted-by":"publisher","award":["101003373"],"award-info":[{"award-number":["101003373"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marie Sklodowska-Curie","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}]},{"name":"Marie Sklodowska-Curie","award":["SFRH\/BD\/139137\/2018"],"award-info":[{"award-number":["SFRH\/BD\/139137\/2018"]}]},{"name":"Marie Sklodowska-Curie","award":["2020.04947.BD"],"award-info":[{"award-number":["2020.04947.BD"]}]},{"name":"Marie Sklodowska-Curie","award":["101003373"],"award-info":[{"award-number":["101003373"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The bioactivity of natural by-products in food and pharmaceutical applications is the subject of numerous studies. Cherry production and processing generates large amounts of biowaste, most of which is not used. The recovery of these by-products is essential for promoting the circular economy and to improving sustainability in the food industry. In this work, we explored the anti-inflammatory and antimicrobial potential of two different extracts from stems, leaves, and flowers of Portuguese cherries. The anti-inflammatory potential was studied on lipopolysaccharide (LPS)-stimulated mouse macrophages (RAW 264.7) by evaluating the effect of by-products on cellular viability and nitric oxide (NO) production. Disc diffusion and minimum inhibitory concentration (MIC) were used to determine antimicrobial activity. The cherry by-products had no cytotoxic effect on RAW 264.7 cells, and were able to inhibit nitrite production in a dose-dependent manner. Moreover, all aqueous infusions showed good antioxidant activity against NO radicals. Moreover, leaf extracts showed the best activity against most of the strains studied. The results revealed, for the first time, interesting anti-inflammatory and antimicrobial properties of cherry by-products. This could potentially be of interest for their therapeutic use in the treatment of inflammation-related diseases or in controlling the growth of microorganisms.<\/jats:p>","DOI":"10.3390\/nu14214576","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T06:01:28Z","timestamp":1667282488000},"page":"4576","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Anti-Inflammatory and Antimicrobial Activities of Portuguese Prunus avium L. (Sweet Cherry) By-Products Extracts"],"prefix":"10.3390","volume":"14","author":[{"given":"Ana R.","family":"Nunes","sequence":"first","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"CNC\u2014Centre for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-4400","authenticated-orcid":false,"given":"Jos\u00e9 D.","family":"Flores-F\u00e9lix","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7795-795X","authenticated-orcid":false,"given":"Ana C.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3854-6549","authenticated-orcid":false,"given":"Am\u00edlcar","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"CIBIT\u2014Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-0714","authenticated-orcid":false,"given":"Gilberto","family":"Alves","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5264-3516","authenticated-orcid":false,"given":"Lu\u00eds R.","family":"Silva","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"CPIRN-UDI-IPG\u2014Research Unit for Inland Development, Center for Potential and Innovation of Natural Resources, Polytechnic Institute of Guarda, 6300-554 Guarda, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s11130-019-00750-w","article-title":"Herbal Teas and their Health Benefits: A Scoping Review","volume":"74","author":"Poswal","year":"2019","journal-title":"Plant Foods Hum. 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