{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:25:00Z","timestamp":1777422300019,"version":"3.51.4"},"reference-count":121,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Individual Call to Scientific Employment Stimulus\u2014Second Edition","doi-asserted-by":"publisher","award":["CEECIND\/01070\/2018"],"award-info":[{"award-number":["CEECIND\/01070\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Individual Call to Scientific Employment Stimulus\u2014Second Edition","doi-asserted-by":"publisher","award":["SFRH\/BD\/145203\/2019"],"award-info":[{"award-number":["SFRH\/BD\/145203\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Individual Call to Scientific Employment Stimulus\u2014Second Edition","doi-asserted-by":"publisher","award":["UI\/BD\/152306\/2021"],"award-info":[{"award-number":["UI\/BD\/152306\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["CEECIND\/01070\/2018"],"award-info":[{"award-number":["CEECIND\/01070\/2018"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["SFRH\/BD\/145203\/2019"],"award-info":[{"award-number":["SFRH\/BD\/145203\/2019"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["UI\/BD\/152306\/2021"],"award-info":[{"award-number":["UI\/BD\/152306\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Heart failure (HF) is a debilitating disease with a significant clinical and economic impact worldwide. Multiple factors seem to increase the risk of developing HF, such as hypertension, obesity and diabetes. Since chronic inflammation plays a significant role in HF pathophysiology and gut dysbiosis is associated with low-grade chronic inflammation, the risk of cardiovascular diseases is likely modulated by the gut microbiome (GM). Considerable progress has been made in HF management. However, there is a need to find new strategies to reduce mortality and increase the quality of life, mainly of HFpEF patients, since its prevalence continues to rise. Recent studies validate that lifestyle changes, such as diet modulation, represent a potential therapeutic approach to improve several cardiometabolic diseases, although their effects on the GM and its indirect cardiac impact still warrant further research. Hence, in this paper, we aim to clarify the link between HF and the human microbiome.<\/jats:p>","DOI":"10.3390\/nu15051223","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T06:55:16Z","timestamp":1677567316000},"page":"1223","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Diet-Induced Microbiome\u2019s Impact on Heart Failure: A Double-Edged Sword"],"prefix":"10.3390","volume":"15","author":[{"given":"Alexandre","family":"Rodrigues","sequence":"first","affiliation":[{"name":"INEB-Institute of Biomedical Engineering, University of Porto, 4200-135 Porto, Portugal"},{"name":"i3S-Institute for Research & Innovation in Health, University of Porto, 4200-135 Porto, Portugal"},{"name":"Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5386-8378","authenticated-orcid":false,"given":"Alexandre","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal"},{"name":"UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Juliana","family":"Morais","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal"},{"name":"Cintesis@RISE, Center for Health Technology and Services Research, 4200-450 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7382-4834","authenticated-orcid":false,"given":"Ricardo","family":"Araujo","sequence":"additional","affiliation":[{"name":"INEB-Institute of Biomedical Engineering, University of Porto, 4200-135 Porto, Portugal"},{"name":"i3S-Institute for Research & Innovation in Health, University of Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1937-3782","authenticated-orcid":false,"given":"In\u00eas","family":"Falc\u00e3o-Pires","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal"},{"name":"UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrcardio.2010.165","article-title":"Epidemiology and risk profile of heart failure","volume":"8","author":"Bui","year":"2011","journal-title":"Nat. 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