{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:58:10Z","timestamp":1775149090982,"version":"3.50.1"},"reference-count":61,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Science and Technology to ISAMB","award":["UIDB\/04295\/2020"],"award-info":[{"award-number":["UIDB\/04295\/2020"]}]},{"name":"Foundation for Science and Technology to ISAMB","award":["UIDP\/04295\/2020"],"award-info":[{"award-number":["UIDP\/04295\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The gene TAS2R38 single nucleotide polymorphisms (SNPs-P49A, A262V and V296I) can condition bitter tasting by PAV (proline\u2013alanine\u2013valine) and non-bitter-tasting by AVI (alanine\u2013valine\u2013isoleucine) homozygosity. We evaluated this polymorphisms association with thyroid function, metabolism and anthropometry parameters determined by: Endpoint analysis (SNPs); DXA (fat mass-%, total fat mass\u2014kg, lean mass\u2014kg); Standard methods (lipid metabolism parameters, HbA1c-%, glycemia\u2014mg\/dL, insulinemia\u2014\u00b5IU\/mL, HOMA-IR, uricemia\u2014mg\/dL, calcemia\u2014mg\/dL and BMI\u2014kg\/m2); ELISA (leptinemia\u2014ng\/mL); Spectrophotometry (Angiotensin Converting Enzyme activity\u2014UI\/L). Statistics: SPSS program; OR [IC95%]; p &lt; 0.05. Sample: 114 hypothyroid, 49 hyperthyroid, and 179 controls. An association between A262V-valine\u2013valine and hypothyroidism\/hyperthyroidism was verified (OR = 2.841; IC95% [1.726\u20134.676]), p &lt; 0.001\/OR = 8.915; IC95% [4.286\u201318.543]), p &lt; 0.001). Protector effect from thyroid dysfunction: A262V-alanine\u2013valine (OR = 0.467; IC95% [0.289\u20130.757], p = 0.002\/OR = 0.132; IC95% [0.056\u20130.309], p &lt; 0.001) and PAV (OR = 0.456; IC95% [0.282\u20130.737], p = 0.001\/OR = 0.101; IC95% [0.041\u20130.250], p &lt; 0.001). Higher parameter values associated with genotypes were: fat-mass-% (V296I-valine\u2013isoleucine), lean-mass (P49A-proline\u2013proline; PVI), leptin (AVI), HbA1c (A262V-alanine\u2013valine) and lower values in lean-Mass (AVI; PVV), leptin (A262V-alanine\u2013alanine), HbA1c (PVV), uricemia (V296I-valine\u2013isoleucine), glycemia (A262V-alanine\u2013alanine; AAV) and plasma triglycerides (PVV). In conclusion, TAS2R38 influences thyroid function, body composition and metabolism. Bitter taste perception (PAV) and the genotype A262V-alanine\u2013valine can protect from thyroid dysfunction. AVV, PVV and genotype A262V-valine\u2013valine may confer higher predisposition for thyroid dysfunction, particularly PVV for hyperthyroidism.<\/jats:p>","DOI":"10.3390\/nu15092214","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T02:03:31Z","timestamp":1683511411000},"page":"2214","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of the TAS2R38 Gene Single Nucleotide Polymorphisms in Metabolism and Anthropometry in Thyroid Dysfunction"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7722-0268","authenticated-orcid":false,"given":"Marta Mendes","family":"Costa","sequence":"first","affiliation":[{"name":"Ecogenetics and Human Health Unity, Institute for Environmental Health (ISAMB), Genetics Laboratory, Associate Laboratory TERRA, Faculty of Medicine, Lisbon University, 1649-028 Lisbon, Portugal"}]},{"given":"Alda Pereira","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Ecogenetics and Human Health Unity, Institute for Environmental Health (ISAMB), Genetics Laboratory, Associate Laboratory TERRA, Faculty of Medicine, Lisbon University, 1649-028 Lisbon, Portugal"},{"name":"Faculty of Medicine, University Clinic for General and Family Medicine, Lisbon University,1649-028 Lisbon, Portugal"}]},{"given":"Carolina","family":"Santos","sequence":"additional","affiliation":[{"name":"Ecogenetics and Human Health Unity, Institute for Environmental Health (ISAMB), Genetics Laboratory, Associate Laboratory TERRA, Faculty of Medicine, Lisbon University, 1649-028 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3527-3274","authenticated-orcid":false,"given":"Joana","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Ecogenetics and Human Health Unity, Institute for Environmental Health (ISAMB), Genetics Laboratory, Associate Laboratory TERRA, Faculty of Medicine, Lisbon University, 1649-028 Lisbon, Portugal"},{"name":"Institute for Scientific Research Bento Rocha Cabral, Cal\u00e7ada Bento da Rocha Cabral 14, 1250-012 Lisbon, Portugal"}]},{"given":"M\u00e1rio Rui","family":"Mascarenhas","sequence":"additional","affiliation":[{"name":"Ecogenetics and Human Health Unity, Institute for Environmental Health (ISAMB), Genetics Laboratory, Associate Laboratory TERRA, Faculty of Medicine, Lisbon University, 1649-028 Lisbon, Portugal"},{"name":"Clinic of Endocrinology (CEDML), Diabetes and Metabolism of Lisbon Lda, 1050-017 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5773-5687","authenticated-orcid":false,"given":"Manuel","family":"Bicho","sequence":"additional","affiliation":[{"name":"Ecogenetics and Human Health Unity, Institute for Environmental Health (ISAMB), Genetics Laboratory, Associate Laboratory TERRA, Faculty of Medicine, Lisbon University, 1649-028 Lisbon, Portugal"},{"name":"Institute for Scientific Research Bento Rocha Cabral, Cal\u00e7ada Bento da Rocha Cabral 14, 1250-012 Lisbon, Portugal"}]},{"given":"Ana Paula","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Ecogenetics and Human Health Unity, Institute for Environmental Health (ISAMB), Genetics Laboratory, Associate Laboratory TERRA, Faculty of Medicine, Lisbon University, 1649-028 Lisbon, Portugal"},{"name":"Clinic of Endocrinology (CEDML), Diabetes and Metabolism of Lisbon Lda, 1050-017 Lisbon, Portugal"},{"name":"Faculty of Medicine, University Clinic of Endocrinology, Lisbon University, 1649-028 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.3389\/fgene.2019.01272","article-title":"Genetic background of taste perception, taste preferences, and its nutritional implications: A systematic review","volume":"10","author":"Llanaj","year":"2019","journal-title":"Front. 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