{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:03:16Z","timestamp":1778922196519,"version":"3.51.4"},"reference-count":283,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Anthocyanins (ACNs) have attracted considerable attention for their potential to modulate the immune system. Research has revealed their antioxidant and anti-inflammatory properties, which play a crucial role in immune regulation by influencing key immune cells, such as lymphocytes, macrophages, and dendritic cells. Moreover, ACNs contribute towards maintaining a balance between proinflammatory and anti-inflammatory cytokines, thus promoting immune health. Beyond their direct effects on immune cells, ACNs significantly impact gut health and the microbiota, essential factors in immune regulation. Emerging evidence suggests that they positively influence the composition of the gut microbiome, enhancing their immunomodulatory effects. Furthermore, these compounds synergize with other bioactive substances, such as vitamins and minerals, further enhancing their potential as immune-supporting dietary supplements. However, detailed clinical studies must fully validate these findings and determine safe dosages across varied populations. Incorporating these natural compounds into functional foods or supplements could revolutionize the management of immune-related conditions. Personalized nutrition and healthcare strategies may be developed to enhance overall well-being and immune resilience by fully understanding the mechanisms underlying the actions of their components. Recent advancements in delivery methods have focused on improving the bioavailability and effectiveness of ACNs, providing promising avenues for future applications.<\/jats:p>","DOI":"10.3390\/nu15194152","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T08:55:01Z","timestamp":1695718501000},"page":"4152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Anthocyanins as Immunomodulatory Dietary Supplements: A Nutraceutical Perspective and Micro-\/Nano-Strategies for Enhanced Bioavailability"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0228-8904","authenticated-orcid":false,"given":"Thadiyan Parambil","family":"Ijinu","sequence":"first","affiliation":[{"name":"Natur\u00e6 Scientific, Kerala University-Business Innovation and Incubation Centre, Kariavattom Campus, University of Kerala, Thiruvananthapuram 695581, India"},{"name":"The National Society of Ethnopharmacology, VRA-179, Mannamoola, Peroorkada P.O., Thiruvananthapuram 695005, India"}]},{"given":"Lorenza Francesca","family":"De Lellis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy"}]},{"given":"Santny","family":"Shanmugarama","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3030-5799","authenticated-orcid":false,"given":"Rosa","family":"P\u00e9rez-Gregorio","sequence":"additional","affiliation":[{"name":"Food and Health Omics Group, Institute of Agroecology and Food, Faculty of Sciences, University of Vigo, 32004 Ourense, Spain"},{"name":"LAQV-REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"},{"name":"Department of Analytical and Food Chemistry, Galicia Sur Health Research Institute (IISGS), SERGAS-UVIGO, 32002 Ourense, Spain"}]},{"given":"Parameswaran","family":"Sasikumar","sequence":"additional","affiliation":[{"name":"Drug Testing Laboratory, Government Ayurveda College, Thiruvananthapuram 695001, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9437-676X","authenticated-orcid":false,"given":"Hammad","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy"}]},{"given":"Daniele Giuseppe","family":"Buccato","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8084-9976","authenticated-orcid":false,"given":"Alessandro","family":"Di Minno","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy"},{"name":"CEINGE-Biotecnologie Avanzate, Via Gaetano Salvatore 486, 80145 Naples, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2877-9445","authenticated-orcid":false,"given":"Alessandra","family":"Baldi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Napoli Federico II, Via D. 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Montesano 49, 80131 Naples, Italy"},{"name":"International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S1470-2045(20)30238-2","article-title":"Managing patients with cancer during the COVID-19 pandemic: Frontline experience from Wuhan","volume":"21","author":"Mei","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3109\/08820139.2015.1099409","article-title":"An overview of organ-specific autoimmune diseases including immunotherapy","volume":"44","author":"Mastrandrea","year":"2015","journal-title":"Immunol. Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.clim.2019.06.006","article-title":"Potential therapeutic applications of exosomes in different autoimmune diseases","volume":"205","author":"Xu","year":"2019","journal-title":"Clin. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Rusek, P., Wala, M., Druszczy\u0144ska, M., and Fol, M. (2018). Infectious agents as stimuli of trained innate immunity. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020456"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1136\/annrheumdis-2021-220781","article-title":"SARS-CoV-2 vaccination in rituximab-treated patients: B cells promote humoral immune responses in the presence of T-cell-mediated immunity","volume":"80","author":"Mrak","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Wang, Y., Jia, A., Bi, Y., Wang, Y., Yang, Q., Cao, Y., Li, Y., and Liu, G. (2020). Targeting myeloid-derived suppressor cells in cancer immunotherapy. Cancers, 12.","DOI":"10.3390\/cancers12092626"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","article-title":"IFN\u03b3: Signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy","volume":"18","author":"Ivashkiv","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.immuni.2019.03.020","article-title":"IL-10 family cytokines IL-10 and IL-22: From basic science to clinical translation","volume":"50","author":"Ouyang","year":"2019","journal-title":"Immunity"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.immuni.2019.12.018","article-title":"Tumor immunology and tumor evolution: Intertwined histories","volume":"52","author":"Galon","year":"2020","journal-title":"Immunity"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41580-019-0129-z","article-title":"PI3K isoforms in cell signalling and vesicle trafficking","volume":"20","author":"Bilanges","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.semcancer.2017.09.002","article-title":"MAPK signalling pathway in cancers: Olive products as cancer preventive and therapeutic agents","volume":"56","author":"Peluso","year":"2019","journal-title":"Semin. Cancer Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41571-019-0293-2","article-title":"Targeting signalling pathways and the immune microenvironment of cancer stem cells\u2014A clinical update","volume":"17","author":"Clara","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3389\/fmed.2019.00165","article-title":"Boosting the immune system, from science to myth: Analysis the infosphere with google","volume":"6","author":"Macedo","year":"2019","journal-title":"Front. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13223-020-00474-6","article-title":"\u201cImmune boosting\u201d in the time of COVID: Selling immunity on instagram","volume":"16","author":"Wagner","year":"2020","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_15","first-page":"1","article-title":"Trends in the use of complementary health approaches among adults: United States, 2002-2012","volume":"79","author":"Clarke","year":"2015","journal-title":"Natl. Health Stat. Report."},{"key":"ref_16","unstructured":"(2023, June 02). Grand View Research, Dietary Supplements Market Size, Share & Trend Analysis Report by Ingredient (Botanicals, Vitamins, Minerals, Amino Acids, Enzymes), by Product, by Application, by End-use, and Segment Forecasts, 2018\u20132024. Available online: https:\/\/web.archive.org\/web\/20190115112358\/https:\/\/www.grandviewresearch.com\/industry-analysis\/dietary-supplements-market."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"106076","DOI":"10.1016\/j.phrs.2022.106076","article-title":"Future directions for the discovery of natural product-derived immunomodulating drugs: An IUPHAR positional review","volume":"177","author":"Wainwright","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"637553","DOI":"10.3389\/fimmu.2021.637553","article-title":"Medicinal plants and isolated molecules demonstrating immunomodulation activity as potential alternative therapies for viral diseases including COVID-19","volume":"12","author":"Alhazmi","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.1038\/s41586-019-1758-2","article-title":"Publisher correction: Harnessing innate immunity in cancer therapy","volume":"576","author":"Demaria","year":"2019","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Di Sotto, A., Vitalone, A., and Di Giacomo, S. (2020). Plant-derived nutraceuticals and immune system modulation: An evidence-based overview. Vaccines, 8.","DOI":"10.3390\/vaccines8030468"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/fft2.129","article-title":"Immunomodulatory potential of phytochemicals and other bioactive compounds of fruits: A Review","volume":"3","author":"Maheshwari","year":"2022","journal-title":"Food Front."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.3389\/fpls.2018.01178","article-title":"Corrigendum: Plant-derived immunomodulators: An insight on their preclinical evaluation and clinical trials","volume":"9","author":"Jantan","year":"2018","journal-title":"Front. Plant Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Gupta, R.C., Srivastava, A., and Lall, R. (2019). Nutraceuticals in Veterinary Medicine, Springer International Publishing.","DOI":"10.1007\/978-3-030-04624-8"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-022-00724-0","article-title":"Immunomodulatory functional foods and their molecular mechanisms","volume":"54","author":"Kim","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/ptr.5642","article-title":"Chemistry, pharmacology and health benefits of anthocyanins: Anthocyanins and human health","volume":"30","author":"Smeriglio","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.clnu.2020.09.041","article-title":"Anthocyanins attenuate vascular and inflammatory responses to a high fat high energy meal challenge in overweight older adults: A cross-over, randomized, double-blind clinical trial","volume":"40","author":"Chang","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_27","unstructured":"M\u00e9rillon, J.-M., and Ramawat, K.G. (2018). Reference Series in Phytochemistry, Springer International Publishing."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1080\/87559129.2022.2029479","article-title":"Anthocyanins and proanthocyanidins: Chemical structures, food sources, bioactivities, and product development","volume":"39","author":"Qi","year":"2022","journal-title":"Food Rev. Int."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Koz\u0142owska, A., and Dzier\u017canowski, T. (2021). Targeting inflammation by anthocyanins as the novel therapeutic potential for chronic diseases: An update. Molecules, 26.","DOI":"10.3390\/molecules26144380"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3945\/an.115.009233","article-title":"Anthocyanins","volume":"6","author":"Wallace","year":"2015","journal-title":"Adv. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Riaz, M., Zia-Ul-Haq, M., and Saad, B. (2016). Anthocyanins and Human Health: Biomolecular and Therapeutic Aspects, Springer International Publishing.","DOI":"10.1007\/978-3-319-26456-1"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Lee, Y.-M., Yoon, Y., Yoon, H., Park, H.-M., Song, S., and Yeum, K.-J. (2017). Dietary anthocyanins against obesity and inflammation. Nutrients, 9.","DOI":"10.3390\/nu9101089"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Tena, N., Mart\u00edn, J., and Asuero, A.G. (2020). State of the art of anthocyanins: Antioxidant activity, sources, bioavailability, and therapeutic effect in human health. Antioxidants, 9.","DOI":"10.3390\/antiox9050451"},{"key":"ref_34","unstructured":"Nabavi, S.M., Suntar, I., Barreca, D., and Khan, H. (2020). Phytonutrients in Food: From Traditional to Rational Usage, Woodhead Publishing."},{"key":"ref_35","first-page":"53","article-title":"The biology and structural distribution of surface flavonoids","volume":"2","author":"Onyilagha","year":"2004","journal-title":"Recent Res. Dev. Plant Sci."},{"key":"ref_36","unstructured":"Goodwin, T.W. (1988). Plant Pigments, Academic Press."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-313X.2008.03447.x","article-title":"Biosynthesis of plant pigments: Anthocyanins, betalains and carotenoids","volume":"54","author":"Tanaka","year":"2008","journal-title":"Plant J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"18747","DOI":"10.3390\/molecules191118747","article-title":"The role of acyl-glucose in anthocyanin modifications","volume":"19","author":"Sasaki","year":"2014","journal-title":"Molecules"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1111\/1541-4337.12836","article-title":"Acylated anthocyanins: A review on their bioavailability and effects on postprandial carbohydrate metabolism and inflammation","volume":"20","author":"Jokioja","year":"2021","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.foodchem.2016.07.073","article-title":"Stability-increasing effects of anthocyanin glycosyl acylation","volume":"214","author":"Zhao","year":"2017","journal-title":"Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Alappat, B., and Alappat, J. (2020). Anthocyanin pigments: Beyond aesthetics. Molecules, 25.","DOI":"10.3390\/molecules25235500"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.nut.2013.04.007","article-title":"Edible berries: Bioactive components and their effect on human health","volume":"30","author":"Nile","year":"2014","journal-title":"Nutrition"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jnutbio.2019.03.009","article-title":"Synergistic anti-inflammatory effects and mechanisms of combined phytochemicals","volume":"69","author":"Zhang","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1017\/S0007114511001437","article-title":"Estimation of the intake of anthocyanidins and their food sources in the European Prospective Investigation into Cancer and Nutrition (EPIC) study","volume":"106","author":"Knaze","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jff.2016.09.016","article-title":"Cyanidin-3- O -Galactoside in ripe pistachio (Pistachia vera L. Variety Bronte) Hulls: Identification and evaluation of its antioxidant and cytoprotective activities","volume":"27","author":"Bellocco","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1369-703X(02)00221-8","article-title":"Acylated anthocyanins from edible sources and their applications in food systems","volume":"14","author":"Giusti","year":"2003","journal-title":"Biochem. Eng. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fchem.2018.00052","article-title":"Anthocyanin biosynthesis and degradation mechanisms in solanaceous vegetables: A review","volume":"6","author":"Liu","year":"2018","journal-title":"Front. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1361779","DOI":"10.1080\/16546628.2017.1361779","article-title":"Anthocyanidins and anthocyanins: Colored pigments as food, pharmaceutical ingredients, and the potential health benefits","volume":"61","author":"Khoo","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/87559129.2020.1717523","article-title":"Immunomodulatory; Anti-inflammatory\/antioxidant effects of polyphenols: A comparative review on the parental compounds and their metabolites","volume":"37","author":"Sobhani","year":"2021","journal-title":"Food Rev. Int."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Ma, Z., Du, B., Li, J., Yang, Y., and Zhu, F. (2021). An insight into anti-inflammatory activities and inflammation related diseases of anthocyanins: A review of both in vivo and in vitro investigations. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011076"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"110922","DOI":"10.1016\/j.fct.2019.110922","article-title":"Impact of dietary anthocyanins on systemic and vascular inflammation: Systematic review and meta-analysis on randomised clinical trials","volume":"135","author":"Fallah","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"114917","DOI":"10.1016\/j.taap.2020.114917","article-title":"Cyanidin prevents the hyperproliferative potential of fibroblast-like synoviocytes and disease progression via targeting IL-17A cytokine signalling in rheumatoid arthritis","volume":"391","author":"Samarpita","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Hair, R., Sakaki, J.R., and Chun, O.K. (2021). Anthocyanins, microbiome and health benefits in aging. Molecules, 26.","DOI":"10.3390\/molecules26030537"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Verediano, T.A., Stampini Duarte Martino, H., Dias Paes, M.C., and Tako, E. (2021). Effects of anthocyanin on intestinal health: A systematic review. Nutrients, 13.","DOI":"10.3390\/nu13041331"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1021\/acs.jafc.2c05879","article-title":"Anthocyanins as promising molecules affecting energy homeostasis, inflammation, and gut microbiota in type 2 diabetes with special reference to impact of acylation","volume":"71","author":"Chen","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1038\/s41598-023-28764-0","article-title":"Effect of anthocyanins on gut health markers, firmicutes-bacteroidetes ratio and short-chain fatty acids: A systematic review via meta-analysis","volume":"13","author":"Kapoor","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Liang, A., Leonard, W., Beasley, J.T., Fang, Z., Zhang, P., and Ranadheera, C.S. (Crit. Rev. Food Sci. Nutr., 2023). Anthocyanins-gut microbiota-health axis: A review, Crit. Rev. Food Sci. Nutr., ahead of print.","DOI":"10.1080\/10408398.2023.2187212"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2174\/138161282006140220120344","article-title":"Potential use of dietary natural products, especially polyphenols, for improving type-1 allergic symptoms","volume":"20","author":"Kumazawa","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1801S","DOI":"10.3945\/jn.109.108324","article-title":"Grape consumption supports immunity in animals and humans","volume":"139","author":"Percival","year":"2009","journal-title":"J. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1177\/0022034515604620","article-title":"Dual role of cyanidin-3-glucoside on the differentiation of bone cells","volume":"94","author":"Park","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ptr.5565","article-title":"Protocatechuic acid attenuates osteoclastogenesis by downregulating JNK\/c-Fos\/NFATc1 signaling and prevents inflammatory bone loss in mice: PCA attenuates osteoclastogenesis","volume":"30","author":"Park","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s12013-013-9728-z","article-title":"Delphinidin activates NFAT and induces IL-2 production through SOCE in T cells","volume":"68","author":"Jara","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/carcin\/bgg184","article-title":"Anthocyanidins inhibit activator protein 1 activity and cell transformation: Structure-activity relationship and molecular mechanisms","volume":"25","author":"Hou","year":"2003","journal-title":"Carcinogenesis"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.bcp.2005.05.003","article-title":"Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: Structure\u2013activity relationship and molecular mechanisms involved","volume":"70","author":"Hou","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kiselova-Kaneva, Y., Nashar, M., Roussev, B., Salim, A., Hristova, M., Olczyk, P., Komosinska-Vassev, K., Dincheva, I., Badjakov, I., and Galunska, B. (2023). Sambucus Ebulus (Elderberry) fruits modulate inflammation and complement system activity in humans. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108714"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.3390\/nu14132738","article-title":"Cyanidin-3-O-glucoside and peonidin-3-o-glucoside-rich fraction of black rice germ and bran suppresses inflammatory responses from SARS-CoV-2 spike glycoprotein S1-induction in vitro in A549 lung cells and THP-1 macrophages via inhibition of the NLRP3 inflammasome pathway","volume":"14","author":"Semmarath","year":"2022","journal-title":"Nutrients"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Li, J., Zou, C., and Liu, Y. (2022). Amelioration of ovalbumin-induced food allergy in mice by targeted rectal and colonic delivery of cyanidin-3-o-glucoside. Foods, 11.","DOI":"10.3390\/foods11111542"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Amer, S.A., Al-Khalaifah, H.S., Gouda, A., Osman, A., Goda, N.I.A., Mohammed, H.A., Darwish, M.I.M., Hassan, A.M., and Mohamed, S.K.A. (2022). Potential effects of anthocyanin-rich roselle (Hibiscus sabdariffa L.) extract on the growth, intestinal histomorphology, blood biochemical parameters, and the immune status of broiler chickens. Antioxidants, 11.","DOI":"10.3390\/antiox11030544"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Trinei, M., Carpi, A., Menabo\u2019, R., Storto, M., Fornari, M., Marinelli, A., Minardi, S., Riboni, M., Casciaro, F., and DiLisa, F. (2022). Dietary intake of cyanidin-3-glucoside induces a long-lasting cardioprotection from ischemia\/reperfusion injury by altering the microbiota. J. Nutr. Biochem., 101.","DOI":"10.1016\/j.jnutbio.2021.108921"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Jaiswal, V., Park, M., and Lee, H.-J. (2021). Comparative transcriptome analysis of the expression of antioxidant and immunity genes in the spleen of a cyanidin 3-o-glucoside-treated Alzheimer\u2019s mouse model. Antioxidants, 10.","DOI":"10.3390\/antiox10091435"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/fsn3.2119","article-title":"Boysenberry and apple juice concentrate reduced acute lung inflammation and increased M2 macrophage-associated cytokines in an acute mouse model of allergic airways disease","volume":"9","author":"Shaw","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"623971","DOI":"10.3389\/fchem.2020.623971","article-title":"Identification of small molecule inhibitors of the deubiquitinating activity of the SARS-CoV-2 papain-like protease: In silico molecular docking studies and in vitro enzymatic activity assay","volume":"8","author":"Pitsillou","year":"2020","journal-title":"Front. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"107851","DOI":"10.1016\/j.jmgm.2021.107851","article-title":"Interaction of small molecules with the SARS-CoV-2 papain-like protease: In silico studies and in vitro validation of protease activity inhibition using an enzymatic inhibition assay","volume":"104","author":"Pitsillou","year":"2021","journal-title":"J. Mol. Graph. Model."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"8560","DOI":"10.1039\/D0FO01778G","article-title":"Effects of cyanidin 3-o-glucoside and hydrochlorothiazide on T-cell phenotypes and function in spontaneously hypertensive rats","volume":"11","author":"Aloud","year":"2020","journal-title":"Food Funct."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13075-019-2001-0","article-title":"Potential therapeutic effects of cyanidin-3-o-glucoside on rheumatoid arthritis by relieving inhibition of CD38+ NK cells on Treg cell differentiation","volume":"21","author":"Wang","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11560","DOI":"10.1038\/s41598-019-47903-0","article-title":"Anthocyanins, delphinidin-3-o-glucoside and cyanidin-3-o-glucoside, inhibit immune checkpoints in human colorectal cancer cells in vitro and in silico","volume":"9","author":"Mazewski","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Cremonini, E., Daveri, E., Mastaloudis, A., Adamo, A.M., Mills, D., Kalanetra, K., Hester, S.N., Wood, S.M., Fraga, C.G., and Oteiza, P.I. (2019). Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis. Redox Biol., 26.","DOI":"10.1016\/j.redox.2019.101269"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.biopha.2018.05.057","article-title":"Anti-tumor properties of anthocyanins from Lonicera caerulea \u2018Beilei\u2019 fruit on human hepatocellular carcinoma: In vitro and in vivo study","volume":"104","author":"Zhou","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3454023","DOI":"10.1155\/2017\/3454023","article-title":"Cyanidin-3-o-glucoside modulates the in vitro inflammatory crosstalk between intestinal epithelial and endothelial cells","volume":"2017","author":"Ferrari","year":"2017","journal-title":"Mediators Inflamm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.lfs.2015.01.037","article-title":"Inhibition of microglial activation by elderberry extracts and its phenolic components","volume":"128","author":"Simonyi","year":"2015","journal-title":"Life Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/09168451.2014.912115","article-title":"Cyanidin-3-glucoside suppresses Th2 cytokines and GATA-3 transcription factor in EL-4 T cells","volume":"78","author":"Pyo","year":"2014","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s00262-014-1564-5","article-title":"Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak\/STAT signaling","volume":"63","author":"Mace","year":"2014","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/ejh.12071","article-title":"Can anthocyanins improve maintenance therapy of Ph(+) acute lymphoblastic leukaemia?","volume":"90","author":"Schmidt","year":"2013","journal-title":"Eur. J. Haematol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0955-2863(02)00255-3","article-title":"Fruit juice consumption modulates antioxidative status, immune status and DNA damage","volume":"14","author":"Bub","year":"2003","journal-title":"J. Nutr. Biochem."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Ryyti, R., H\u00e4m\u00e4l\u00e4inen, M., Lepp\u00e4nen, T., Peltola, R., and Moilanen, E. (2022). Phenolic compounds known to be present in lingonberry (Vaccinium Vitis-Idaea L.) enhance macrophage polarization towards the anti-inflammatory M2 phenotype. Biomedicines, 10.","DOI":"10.3390\/biomedicines10123045"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"111853","DOI":"10.1016\/j.nut.2022.111853","article-title":"Delphinidin-3-O-glucoside in vitro suppresses NF-\u039aB and changes the secretome of mesenchymal stem cells affecting macrophage activation","volume":"105","author":"Neves","year":"2023","journal-title":"Nutrition"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/carcin\/bgaa008","article-title":"Reduction of colitis-associated colon carcinogenesis by a black lentil water extract through inhibition of inflammatory and immunomodulatory cytokines","volume":"41","author":"Mazewski","year":"2020","journal-title":"Carcinogenesis"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/1750-3841.14490","article-title":"Delphinidin chloride and its hydrolytic metabolite gallic acid promote differentiation of regulatory T cells and have an anti-inflammatory effect on the allograft model","volume":"84","author":"Hyun","year":"2019","journal-title":"J. Food Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"9378","DOI":"10.1038\/s41598-017-09933-4","article-title":"Estrogen receptor \u03b1\/HDAC\/NFAT axis for delphinidin effects on proliferation and differentiation of T lymphocytes from patients with cardiovascular risks","volume":"7","author":"Dayoub","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/ars.2016.6769","article-title":"Dual inhibition of PI3K\/Akt and MTOR by the dietary antioxidant, delphinidin, ameliorates psoriatic features in vitro and in an imiquimod-induced psoriasis-like disease in mice","volume":"26","author":"Chamcheu","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"9970","DOI":"10.18632\/oncotarget.3667","article-title":"Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage","volume":"6","author":"Ko","year":"2015","journal-title":"Oncotarget"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.bbrc.2011.06.029","article-title":"Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-\u039aB acetylation in fibroblast-like synoviocyte MH7A cells","volume":"410","author":"Seong","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"154951","DOI":"10.1016\/j.cyto.2019.154951","article-title":"EFLA 945 restricts AIM2 inflammasome activation by preventing DNA entry for psoriasis treatment","volume":"127","author":"Chung","year":"2020","journal-title":"Cytokine"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Iban-Arias, R., Sebastian-Valverde, M., Wu, H., Lyu, W., Wu, Q., Simon, J., and Pasinetti, G.M. (2022). Role of polyphenol-derived phenolic acid in mitigation of inflammasome-mediated anxiety and depression. Biomedicines, 10.","DOI":"10.3390\/biomedicines10061264"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41467-017-02794-5","article-title":"Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1038\/533S104a","article-title":"Microbiome: Bacterial broadband","volume":"533","author":"Eisenstein","year":"2016","journal-title":"Nature"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Sender, R., Fuchs, S., and Milo, R. (2016). Revised estimates for the number of human and bacteria cells in the body. PLoS Biol., 14.","DOI":"10.1101\/036103"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1017\/S0007114510003946","article-title":"Colonic metabolites of berry polyphenols: The missing link to biological activity?","volume":"104","author":"Williamson","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"9517","DOI":"10.1021\/jf402506c","article-title":"Impact of polyphenols and polyphenol-rich dietary sources on gut microbiota composition","volume":"61","author":"Etxeberria","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1017\/S0007114512003376","article-title":"Contribution of gut bacteria to the metabolism of cyanidin 3-glucoside in human microbiota-associated rats","volume":"109","author":"Hanske","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jnutbio.2018.04.001","article-title":"Impact of tart cherries polyphenols on the human gut microbiota and phenolic metabolites in vitro and in vivo","volume":"59","author":"Pottgen","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1021\/acs.jafc.9b00247","article-title":"Differential catabolism of an anthocyanin-rich elderberry extract by three gut microbiota bacterial species","volume":"68","author":"Bresciani","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions: Metabolism of nutrients and other food components","volume":"57","author":"Rowland","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Eker, M.E., Aaby, K., Budic-Leto, I., Rimac Brn\u010di\u0107, S., El, S.N., Karakaya, S., Simsek, S., Manach, C., Wiczkowski, W., and de Pascual-Teresa, S. (2019). A review of factors affecting anthocyanin bioavailability: Possible implications for the inter-individual variability. Foods, 9.","DOI":"10.3390\/foods9010002"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tifs.2018.11.025","article-title":"Digestion and absorption of red grape and wine anthocyanins through the gastrointestinal tract","volume":"83","author":"Han","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1080\/10408398.2018.1533517","article-title":"Metabolism of anthocyanins and consequent effects on the gut microbiota","volume":"59","author":"Tian","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.foodchem.2017.06.054","article-title":"Biotransformation and metabolism of three mulberry anthocyanin monomers by rat gut microflora","volume":"237","author":"Chen","year":"2017","journal-title":"Food Chem."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Makarewicz, M., Dro\u017cd\u017c, I., Tarko, T., and Duda-Chodak, A. (2021). The interactions between polyphenols and microorganisms, especially gut microbiota. Antioxidants, 10.","DOI":"10.3390\/antiox10020188"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jff.2013.05.010","article-title":"Bioavailability of anthocyanins and derivatives","volume":"7","author":"Fernandes","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00394-005-0557-8","article-title":"Stability and biotransformation of various dietary anthocyanins in vitro","volume":"45","author":"Fleschhut","year":"2006","journal-title":"Eur. J. Nutr."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Zhao, R., and Shen, G.X. (2023). Impact of anthocyanin component and metabolite of saskatoon berry on gut microbiome and relationship with fecal short chain fatty acids in diet-induced insulin resistant mice. J. Nutr. Biochem., 111.","DOI":"10.1016\/j.jnutbio.2022.109201"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"50","DOI":"10.15430\/JCP.2022.27.1.50","article-title":"Protocatechuic acid, a gut bacterial metabolite of black raspberries, inhibits adenoma development and alters gut microbiome profiles in Apcmin\/+ mice","volume":"27","author":"Dong","year":"2022","journal-title":"J. Cancer Prev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1039\/D1FO02983E","article-title":"Food-derived cyanidin-3-o-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice","volume":"13","author":"Chen","year":"2022","journal-title":"Food Funct."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"11503","DOI":"10.1039\/D1FO02454J","article-title":"Anti-inflammatory effects of purple sweet potato anthocyanin extract in DSS-induced colitis: Modulation of commensal bacteria and attenuated bacterial intestinal infection","volume":"12","author":"Mu","year":"2021","journal-title":"Food Funct."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Liu, X., Wang, L., Jing, N., Jiang, G., and Liu, Z. (2020). Biostimulating gut microbiome with bilberry anthocyanin combo to enhance anti-PD-L1 efficiency against murine colon cancer. Microorganisms, 8.","DOI":"10.3390\/microorganisms8020175"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Nakano, H., Wu, S., Sakao, K., Hara, T., He, J., Garcia, S., Shetty, K., and Hou, D.-X. (2020). Bilberry anthocyanins ameliorate NAFLD by improving dyslipidemia and gut microbiome dysbiosis. Nutrients, 12.","DOI":"10.3390\/nu12113252"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1900455","DOI":"10.1002\/mnfr.201900455","article-title":"Malvidin 3--glucoside modulated gut microbial dysbiosis and global metabolome disrupted in a murine colitis model induced by dextran sulfate sodium","volume":"63","author":"Liu","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Tan, J., Li, Y., Hou, D.-X., and Wu, S. (2019). The effects and mechanisms of cyanidin-3-glucoside and its phenolic metabolites in maintaining intestinal integrity. Antioxidants, 8.","DOI":"10.3390\/antiox8100479"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Overall, J., Bonney, S., Wilson, M., Beermann, A., Grace, M., Esposito, D., Lila, M., and Komarnytsky, S. (2017). Metabolic effects of berries with structurally diverse anthocyanins. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18020422"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1021\/acs.jafc.5b00963","article-title":"Black currant anthocyanins attenuate weight gain and improve glucose metabolism in diet-induced obese mice with intact, but not disrupted, gut microbiome","volume":"63","author":"Esposito","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1021\/jf3002153","article-title":"Metabolism of anthocyanins by human gut microflora and their influence on gut bacterial growth","volume":"60","author":"Hidalgo","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1021\/jf960421t","article-title":"Oxygen radical absorbing capacity of anthocyanins","volume":"45","author":"Wang","year":"1997","journal-title":"J. Agric. Food Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1021\/jf0204811","article-title":"Colour and antioxidant properties of cyanidin-based anthocyanin pigments","volume":"50","author":"Stintzing","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1021\/jf00044a005","article-title":"Antioxidative activity of monoacylated anthocyanins isolated from Muscat Bailey a grape","volume":"42","author":"Tamura","year":"1994","journal-title":"J. Agric. Food Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0006-2952(96)00421-2","article-title":"Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L.","volume":"52","author":"Tsuda","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/ejlt.200600166","article-title":"Inhibition of lipid peroxidation by anthocyanins, anthocyanidins and their phenolic degradation products","volume":"109","author":"Brown","year":"2007","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"770","DOI":"10.2174\/156652411798062395","article-title":"Nutritional antioxidants and adaptive cell responses: An update","volume":"11","author":"Speciale","year":"2011","journal-title":"Curr. Mol. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1002\/mnfr.201300102","article-title":"Cyanidin-3-O-glucoside counters the response to TNF-alpha of endothelial cells by activating Nrf2 pathway","volume":"57","author":"Speciale","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/nutrit\/nuu066","article-title":"Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-B and mitogen-activated protein kinase signaling cascades","volume":"73","author":"Vendrame","year":"2015","journal-title":"Nutr. Rev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1021\/jf203989k","article-title":"Anthocyanin-rich A\u00e7ai (Euterpe oleracea Mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells","volume":"60","author":"Poulose","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Hassimotto, N.M.A., Moreira, V., do Nascimento, N.G., Souto, P.C.M.d.C., Teixeira, C., and Lajolo, F.M. (2013). Inhibition of carrageenan-induced acute inflammation in mice by oral administration of anthocyanin mixture from wild mulberry and cyanidin-3-glucoside. Biomed Res. Int., 2013.","DOI":"10.1155\/2013\/146716"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Cui, H.-X., Chen, J.-H., Li, J.-W., Cheng, F.-R., and Yuan, K. (2018). Protection of anthocyanin from Myrica rubra against cerebral ischemia-reperfusion injury via modulation of the TLR4\/NF-\u039aB and NLRP3 pathways. Molecules, 23.","DOI":"10.3390\/molecules23071788"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2017.06.027","article-title":"Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1\/TXNIP complex in cerebral ischemia reperfusion injury","volume":"336","author":"Hou","year":"2018","journal-title":"Behav. Brain Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.2174\/1381612823666170519151801","article-title":"Anthocyanins: Multi-target agents for prevention and therapy of chronic diseases","volume":"23","author":"Putta","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"105642","DOI":"10.1016\/j.jff.2023.105642","article-title":"Hepatoprotective effect of cyanidin-3-o-glucoside\u2013lauric acid ester against H2O2-induced oxidative damage in LO2 cells","volume":"107","author":"Zhou","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"109964","DOI":"10.1016\/j.foodres.2020.109964","article-title":"Beneficial effects of anthocyanin-rich peels of Myrtaceae fruits on chemically-induced liver fibrosis and carcinogenesis in mice","volume":"139","author":"Romualdo","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Zuo, A., Wang, S., Liu, L., Yao, Y., and Guo, J. (2019). Understanding the effect of anthocyanin extracted from Lonicera Caerulea L. on alcoholic hepatosteatosis. Biomed. Pharmacother., 117.","DOI":"10.1016\/j.biopha.2019.109087"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Popovi\u0107, D., Koci\u0107, G., Kati\u0107, V., Zarubica, A., Veli\u010dkovi\u0107, L.J., Ni\u010dkovi\u0107, V.P., Jovi\u0107, A., Veljkovi\u0107, A., Petrovi\u0107, V., and Raki\u0107, V. (2019). Anthocyanins protect hepatocytes against CCl4-induced acute liver injury in rats by inhibiting pro-inflammatory mediators, polyamine catabolism, lipocalin-2, and excessive proliferation of Kupffer cells. Antioxidants, 8.","DOI":"10.3390\/antiox8100451"},{"key":"ref_140","first-page":"75","article-title":"Modern treatment approaches in psychoses. pharmacogenetic, neuroimagistic and clinical implications","volume":"65","author":"Nussbaum","year":"2017","journal-title":"Farmacia"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Singh, A., Kukreti, R., Saso, L., and Kukreti, S. (2019). Oxidative stress: A key modulator in neurodegenerative diseases. Molecules, 24.","DOI":"10.3390\/molecules24081583"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.it.2015.08.002","article-title":"Immune surveillance of the CNS following infection and injury","volume":"36","author":"Russo","year":"2015","journal-title":"Trends Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neulet.2011.05.048","article-title":"Neuroprotective effect of cyanidin-3-o-glucoside anthocyanin in mice with focal cerebral ischemia","volume":"500","author":"Min","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.fct.2018.05.066","article-title":"Regulation of redox status in neuronal SH-SY5Y cells by blueberry (Vaccinium myrtillus L.) juice, cranberry (Vaccinium macrocarpon A.) juice and cyanidin","volume":"118","author":"Smith","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jnutbio.2018.02.014","article-title":"Anthocyanins as a potential pharmacological agent to manage memory deficit, oxidative stress and alterations in ion pump activity induced by experimental sporadic dementia of Alzheimer\u2019s type","volume":"56","author":"Pacheco","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Amin, F.U., Shah, S.A., Badshah, H., Khan, M., and Kim, M.O. (2017). Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via P38\/JNK pathway against A\u03b21\u201342-induced oxidative stress. J. Nanobiotechnology, 15.","DOI":"10.1186\/s12951-016-0227-4"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1016\/j.nano.2017.06.022","article-title":"Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against A\u03b21-42-induced neuroinflammation and neurodegeneration via the NF-KB\/JNK\/GSK3\u03b2 signaling pathway","volume":"13","author":"Kim","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1021\/jf8032039","article-title":"Anthocyanin content, lipid peroxidation and cyclooxygenase enzyme inhibitory activities of sweet and sour cherries","volume":"57","author":"Mulabagal","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/1028415031000111282","article-title":"Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model","volume":"6","author":"Joseph","year":"2003","journal-title":"Nutr. Neurosci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1212\/WNL.0b013e31824f7fc4","article-title":"Habitual intake of dietary flavonoids and risk of Parkinson disease","volume":"78","author":"Gao","year":"2012","journal-title":"Neurology"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1017\/S0007114509992364","article-title":"Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment","volume":"103","author":"Krikorian","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1021\/jf9029332","article-title":"Blueberry supplementation improves memory in older adults","volume":"58","author":"Krikorian","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Ockermann, P., Headley, L., Lizio, R., and Hansmann, J. (2021). A Review of the properties of anthocyanins and their influence on factors affecting cardiometabolic and cognitive health. Nutrients, 13.","DOI":"10.3390\/nu13082831"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"6759","DOI":"10.1021\/jf201079h","article-title":"Anthocyanin extract from black rice significantly ameliorates platelet hyperactivity and hypertriglyceridemia in dyslipidemic rats induced by high fat diets","volume":"59","author":"Yang","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Conesa, M.-T., Chambers, K., Combet, E., Pinto, P., Garcia-Aloy, M., Andr\u00e9s-Lacueva, C., de Pascual-Teresa, S., Mena, P., Konic Ristic, A., and Hollands, W. (2018). Meta-analysis of the effects of foods and derived products containing ellagitannins and anthocyanins on cardiometabolic biomarkers: Analysis of factors influencing variability of the individual responses. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030694"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1039\/C7FO01551H","article-title":"Association between berries intake and cardiovascular diseases risk factors: A systematic review with meta-analysis and trial sequential analysis of randomized controlled trials","volume":"9","author":"Domingues","year":"2018","journal-title":"Food Funct."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/CIRCULATIONAHA.112.122408","article-title":"High Anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women","volume":"127","author":"Cassidy","year":"2013","journal-title":"Circulation"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3945\/ajcn.116.133132","article-title":"Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men","volume":"104","author":"Cassidy","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Joo, H., Choi, S., Lee, Y., Lee, E., Park, M., Park, K., Kim, C.-S., Lim, Y., Park, J.-T., and Jeon, B. (2018). Anthocyanin-rich extract from Red Chinese Cabbage alleviates vascular inflammation in endothelial cells and APO E\u2212\/\u2212 Mice. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030816"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"12722","DOI":"10.1021\/jf103427j","article-title":"Protocatechuic acid, a metabolite of anthocyanins, inhibits monocyte adhesion and reduces atherosclerosis in apolipoprotein E-deficient mice","volume":"58","author":"Wang","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.3945\/jn.110.123927","article-title":"Dietary blueberries attenuate atherosclerosis in apolipoprotein E-deficient mice by upregulating antioxidant enzyme expression","volume":"140","author":"Wu","year":"2010","journal-title":"J. Nutr."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.numecd.2017.02.002","article-title":"Dietary cyanidin 3-glucoside from purple corn ameliorates doxorubicin-induced cardiotoxicity in mice","volume":"27","author":"Petroni","year":"2017","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.fct.2017.11.032","article-title":"Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage","volume":"111","author":"Skates","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Bognar, E., Sarszegi, Z., Szabo, A., Debreceni, B., Kalman, N., Tucsek, Z., Sumegi, B., and Gallyas, F. (2013). Antioxidant and anti-inflammatory effects in RAW264.7 macrophages of malvidin, a major red wine polyphenol. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065355"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physiol.00050.2013","article-title":"AMPK: Regulating energy balance at the cellular and whole body levels","volume":"29","author":"Hardie","year":"2014","journal-title":"Physiology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"e12996","DOI":"10.1111\/eci.12996","article-title":"Hypothalamic AMPK and energy balance","volume":"48","year":"2018","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s12263-015-0455-5","article-title":"Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid and glucose metabolism in estrogen-deficient rats by AMPK activation","volume":"10","author":"Park","year":"2015","journal-title":"Genes Nutr."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/09637486.2016.1146235","article-title":"Anti-obesity effects of artificial planting blueberry (Vaccinium ashei) anthocyanin in high-fat diet-treated mice","volume":"67","author":"Wu","year":"2016","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/biof.1365","article-title":"Contribution of anthocyanin-rich foods in obesity control through gut microbiota interactions: Anthocyanin-rich foods in obesity control","volume":"43","author":"Jamar","year":"2017","journal-title":"Biofactors"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1021\/jf1035405","article-title":"Anthocyanins from Chinese Bayberry extract protect \u03b2 cells from oxidative stress-mediated injury via HO-1 upregulation","volume":"59","author":"Zhang","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.nutres.2010.06.016","article-title":"Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome","volume":"30","author":"Basu","year":"2010","journal-title":"Nutr. Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1021\/jf071993o","article-title":"Whole berries versus berry anthocyanins: Interactions with dietary fat levels in the C57BL\/6J mouse model of obesity","volume":"56","author":"Prior","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.jnutbio.2012.12.010","article-title":"Wild blueberry (Vaccinium angustifolium) consumption improves inflammatory status in the obese zucker rat model of the metabolic syndrome","volume":"24","author":"Vendrame","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12967-019-1972-6","article-title":"Purple corn extract induces long-lasting reprogramming and M2 phenotypic switch of adipose tissue macrophages in obese mice","volume":"17","author":"Tomay","year":"2019","journal-title":"J. Transl. Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/1541-4337.12024","article-title":"The case for anthocyanin consumption to promote human health: A review","volume":"12","author":"Pojer","year":"2013","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/bph.13627","article-title":"Effects of anthocyanins on the prevention and treatment of cancer","volume":"174","author":"Lin","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12015-007-0004-8","article-title":"Signaling pathways in cancer and embryonic stem cells","volume":"3","author":"Dreesen","year":"2007","journal-title":"Stem Cell Rev."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.canlet.2012.05.029","article-title":"Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells","volume":"325","author":"Kausar","year":"2012","journal-title":"Cancer Lett."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.taap.2014.06.028","article-title":"Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-\u039aB signaling pathways in SKH-1 hairless mice skin","volume":"280","author":"Pratheeshkumar","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5009\/gnl16068","article-title":"A\u00e7a\u00ed berries inhibit colon tumorigenesis in azoxymethane\/dextran sulfate sodium-treated mice","volume":"11","author":"Choi","year":"2017","journal-title":"Gut Liver"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.fct.2018.08.078","article-title":"Lyophilized A\u00e7a\u00ed pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells","volume":"121","author":"Fragoso","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.kjms.2017.11.004","article-title":"Mulberry anthocyanins improves thyroid cancer progression mainly by inducing apoptosis and autophagy cell death","volume":"34","author":"Long","year":"2018","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.3389\/fphar.2020.01300","article-title":"The therapeutic potential of anthocyanins: Current approaches based on their molecular mechanism of action","volume":"11","author":"Salehi","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000475524","article-title":"Anthocyanins prevent colorectal cancer development in a mouse model","volume":"95","author":"Lippert","year":"2017","journal-title":"Digestion"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Chen, J., Zhu, Y., Zhang, W., Peng, X., Zhou, J., Li, F., Han, B., Liu, X., Ou, Y., and Yu, X. (2018). Delphinidin induced protective autophagy via MTOR pathway suppression and AMPK pathway activation in HER-2 positive breast cancer cells. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4231-y"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Nomi, Y., Iwasaki-Kurashige, K., and Matsumoto, H. (2019). Therapeutic effects of anthocyanins for vision and eye health. Molecules, 24.","DOI":"10.3390\/molecules24183311"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/labinvest.2011.132","article-title":"Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: Cellular and molecular mechanism","volume":"92","author":"Miyake","year":"2012","journal-title":"Lab. Investig."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1089\/jmf.2012.2241","article-title":"Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma","volume":"15","author":"Shim","year":"2012","journal-title":"J. Med. Food"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000335961","article-title":"Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma","volume":"228","author":"Ohguro","year":"2012","journal-title":"Ophthalmologica"},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Thiraphatthanavong, P., Wattanathorn, J., Muchimapura, S., Wipawee, T.-M., Wannanon, P., Terdthai, T.-U., Suriharn, B., and Lertrat, K. (2014). Preventive effect of Zea mays L. (Purple Waxy Corn) on experimental diabetic cataract. Biomed Res. Int., 2014.","DOI":"10.1155\/2014\/507435"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.exer.2012.02.010","article-title":"Anthocyanins from the seed coat of black soybean reduce retinal degeneration induced by N-methyl-N-nitrosourea","volume":"97","author":"Paik","year":"2012","journal-title":"Exp. Eye Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1002\/jsfa.7628","article-title":"Determination of polyphenolic profile, antioxidant activity and antibacterial properties of maqui [Aristotelia chilensis (Molina) Stuntz] a chilean blackberry","volume":"96","author":"Genskowsky","year":"2016","journal-title":"J. Sci. Food Agric."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ijfoodmicro.2012.07.001","article-title":"Antimicrobial assays of natural extracts and their inhibitory effect against Listeria innocua and fish spoilage bacteria, after incorporation into biopolymer edible films","volume":"158","author":"Iturriaga","year":"2012","journal-title":"Int. J. Food Microbiol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.foodcont.2011.02.024","article-title":"Antimicrobial effect of cranberry juice and extracts","volume":"22","author":"Caillet","year":"2011","journal-title":"Food Control"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1046\/j.1365-2672.2001.01271.x","article-title":"Antimicrobial properties of phenolic compounds from berries","volume":"90","author":"Nohynek","year":"2001","journal-title":"J. Appl. Microbiol."},{"key":"ref_196","first-page":"149","article-title":"Anthocyanins as antimicrobial agents of natural plant origin","volume":"6","author":"Cisowska","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"111574","DOI":"10.1016\/j.fct.2020.111574","article-title":"An overview of the health benefits of Prunus species with special reference to metabolic syndrome risk factors","volume":"144","author":"Ullah","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1080\/10408398.2012.755149","article-title":"The health potential of fruits and vegetables phytochemicals: Notable examples","volume":"56","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.appet.2014.04.012","article-title":"Promoting consumption of fruit and vegetables for better health. Have campaigns delivered on the goals?","volume":"79","author":"Rekhy","year":"2014","journal-title":"Appetite"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Ullah, H., Sommella, E., Santarcangelo, C., D\u2019Avino, D., Rossi, A., Dacrema, M., Minno, A.D., Di Matteo, G., Mannina, L., and Campiglia, P. (2022). Hydroethanolic extract of Prunus domestica L.: Metabolite profiling and in vitro modulation of molecular mechanisms associated to cardiometabolic diseases. Nutrients, 14.","DOI":"10.3390\/nu14020340"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Mandalari, G., Vardakou, M., Faulks, R., Bisignano, C., Martorana, M., Smeriglio, A., and Trombetta, D. (2016). Food matrix effects of polyphenol bioaccessibility from almond skin during simulated human digestion. Nutrients, 8.","DOI":"10.3390\/nu8090568"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Manolescu, B.N., Oprea, E., Mititelu, M., Ruta, L.L., and Farcasanu, I.C. (2019). Dietary anthocyanins and stroke: A review of pharmacokinetic and pharmacodynamic studies. Nutrients, 11.","DOI":"10.3390\/nu11071479"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1021\/acs.langmuir.5b01122","article-title":"New anthocyanin\u2013human salivary protein complexes","volume":"31","author":"Soares","year":"2015","journal-title":"Langmuir"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1039\/C3FO60702J","article-title":"A standardised static in vitro digestion method suitable for food\u2014An international consensus","volume":"5","author":"Minekus","year":"2014","journal-title":"Food Funct."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1039\/C7FO00885F","article-title":"The effect of dietary factors on strawberry anthocyanins oral bioavailability","volume":"8","author":"Xiao","year":"2017","journal-title":"Food Funct."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.foodchem.2012.04.110","article-title":"Susceptibility of anthocyanins to ex vivo degradation in human saliva","volume":"135","author":"Kamonpatana","year":"2012","journal-title":"Food Chem."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"6903","DOI":"10.1021\/jf405180k","article-title":"Anthocyanin structure determines susceptibility to microbial degradation and bioavailability to the buccal mucosa","volume":"62","author":"Kamonpatana","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev-food-041715-033346","article-title":"Unraveling anthocyanin bioavailability for human health","volume":"7","author":"Lila","year":"2016","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1034\/j.1601-0825.2002.02851.x","article-title":"Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion","volume":"8","author":"Pedersen","year":"2002","journal-title":"Oral Dis."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Henriques, J.F., Serra, D., Dinis, T.C.P., and Almeida, L.M. (2020). The anti-neuroinflammatory role of anthocyanins and their metabolites for the prevention and treatment of brain disorders. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228653"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1207\/s15327914nc5401_2","article-title":"Intact anthocyanins and metabolites in rat urine and plasma after 3 months of anthocyanin supplementation","volume":"54","author":"He","year":"2006","journal-title":"Nutr. Cancer"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/mnfr.200700024","article-title":"The bioavailability of raspberry anthocyanins and ellagitannins in rats","volume":"51","author":"Borges","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/mnfr.201100566","article-title":"Gastrointestinal stability and bioavailability of (poly)phenolic compounds following ingestion of concord grape juice by humans","volume":"56","author":"Stalmach","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41598-018-37283-2","article-title":"GLUT1 and GLUT3 involvement in anthocyanin gastric transport- nanobased targeted approach","volume":"9","author":"Oliveira","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0006-291X(02)00927-0","article-title":"The interaction of anthocyanins with bilitranslocase","volume":"296","author":"Passamonti","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1021\/acs.jafc.8b06737","article-title":"Anthocyanins: From sources and bioavailability to cardiovascular-health benefits and molecular mechanisms of action","volume":"67","author":"Krga","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1093\/jn\/133.12.4178","article-title":"Anthocyanins are efficiently absorbed from the stomach in anesthetized rats","volume":"133","author":"Felgines","year":"2003","journal-title":"J. Nutr."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"11","DOI":"10.31665\/JFB.2018.4162","article-title":"Bioaccessibility and bioavailability of phenolic compounds","volume":"4","author":"Shahidi","year":"2018","journal-title":"J. Food Bioact."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1389200214666131211160308","article-title":"The metabolism of anthocyanins","volume":"15","author":"Hribar","year":"2014","journal-title":"Curr. Drug Metab."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3945\/ajcn.116.136051","article-title":"The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids","volume":"105","author":"Cassidy","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2174\/138920009788498950","article-title":"Bioavailability of flavonoids: A review of their membrane transport and the function of bilitranslocase in animal and plant organisms","volume":"10","author":"Passamonti","year":"2009","journal-title":"Curr. Drug Metab."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.3390\/nu6104165","article-title":"The role of sodium-dependent glucose transporter 1 and glucose transporter 2 in the absorption of cyanidin-3-O-\u03b2-glucoside in Caco-2 cells","volume":"6","author":"Zou","year":"2014","journal-title":"Nutrients"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"21555","DOI":"10.3390\/ijms160921555","article-title":"Anthocyanin absorption and metabolism by human intestinal Caco-2 cells\u2014A review","volume":"16","author":"Kamiloglu","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"562","DOI":"10.2174\/1570159X14666161026151545","article-title":"Polyphenols beyond barriers: A glimpse into the brain","volume":"15","author":"Figueira","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/mnfr.200900007","article-title":"Absorption of anthocyanins through intestinal epithelial cells\u2014Putative involvement of GLUT2","volume":"53","author":"Faria","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Alzaid, F., Cheung, H.-M., Preedy, V.R., and Sharp, P.A. (2013). Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078932"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"12183","DOI":"10.1021\/jf404439b","article-title":"Overview of metabolism and bioavailability enhancement of polyphenols","volume":"61","author":"Lewandowska","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3945\/ajcn.112.049247","article-title":"Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: A 13C-tracer study","volume":"97","author":"Czank","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1017\/S0007114510000061","article-title":"Radiolabelled cyanidin 3-o-glucoside is poorly absorbed in the mouse","volume":"103","author":"Felgines","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1039\/C7FO01074E","article-title":"Human anthocyanin bioavailability: Effect of intake duration and dosing","volume":"8","author":"Kalt","year":"2017","journal-title":"Food Funct."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/jsfa.1645","article-title":"LC-MS identification of anthocyanins in boysenberry extract and anthocyanin metabolites in human urine following dosing","volume":"84","author":"Cooney","year":"2004","journal-title":"J. Sci. Food Agric."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"7721","DOI":"10.1021\/jf051092k","article-title":"Blackberry anthocyanins are mainly recovered from urine as methylated and glucuronidated conjugates in humans","volume":"53","author":"Felgines","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1021\/acs.jafc.6b05455","article-title":"Flavonoid metabolites in human urine during blueberry anthocyanin intake","volume":"65","author":"Kalt","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"22815","DOI":"10.1038\/srep22815","article-title":"Determination of cyanidin 3-glucoside in rat brain, liver and kidneys by UPLC\/MS-MS and its application to a short-term pharmacokinetic study","volume":"6","author":"Fornasaro","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1021\/jf071998l","article-title":"Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs","volume":"56","author":"Kalt","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1021\/jf903529m","article-title":"Xenobiotic metabolism and berry flavonoid transport across the blood-brain barrier","volume":"58","author":"Milbury","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1002\/mnfr.201500224","article-title":"Plasma bioavailability and regional brain distribution of polyphenols from apple\/grape seed and bilberry extracts in a young swine model","volume":"59","author":"Chen","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"9856","DOI":"10.1021\/jf903424k","article-title":"Correction to distribution and excretion of bilberry anthocyanins in mice","volume":"57","author":"Sakakibara","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1021\/jf0110755","article-title":"Enzymatic synthesis of [3\u2018-O-methyl-3H]malvidin-3-glucoside from petunidin-3-glucoside","volume":"50","author":"Zimman","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1124\/dmd.106.011122","article-title":"Methylated flavonoids have greatly improved intestinal absorption and metabolic stability","volume":"34","author":"Wen","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1079\/BJN20051596","article-title":"Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats","volume":"95","author":"Marks","year":"2006","journal-title":"Br. J. Nutr."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1021\/jf052108+","article-title":"Fate of anthocyanins and antioxidant capacity in contents of the gastrointestinal tract of weanling pigs following black raspberry consumption","volume":"54","author":"Wu","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/jn\/138.5.897","article-title":"Anthocyanin excretion by humans increases linearly with increasing strawberry dose","volume":"138","author":"Carkeet","year":"2008","journal-title":"J. Nutr."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/jssc.200500072","article-title":"Estimation of partition coefficients by MEKC part 2: Anthocyanins","volume":"28","author":"Lemr","year":"2005","journal-title":"J. Sep. Sci."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/ajcn\/73.5.920","article-title":"Anthocyanins are absorbed in glycated forms in elderly women: A pharmacokinetic study","volume":"73","author":"Cao","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1021\/acs.jafc.6b00805","article-title":"Pharmacokinetic characterization and bioavailability of strawberry anthocyanins relative to meal intake","volume":"64","author":"Sandhu","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jpba.2017.04.042","article-title":"Pharmacokinetic profile of bilberry anthocyanins in rats and the role of glucose transporters: LC\u2013MS\/MS and computational studies","volume":"144","author":"Baron","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1079\/BJN20041126","article-title":"Anthocyanin metabolites in human urine and serum","volume":"91","author":"Kay","year":"2004","journal-title":"Br. J. Nutr."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1079\/NRR2005116","article-title":"Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans","volume":"19","author":"Kay","year":"2006","journal-title":"Nutr. Res. Rev."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/jn\/133.5.1296","article-title":"Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humans","volume":"133","author":"Felgines","year":"2003","journal-title":"J. Nutr."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1093\/jn\/135.11.2582","article-title":"Anthocyanins exist in the circulation primarily as metabolites in adult men","volume":"135","author":"Kay","year":"2005","journal-title":"J. Nutr."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.foodchem.2016.05.122","article-title":"Bioavailability of anthocyanins and colonic polyphenol metabolites following consumption of aronia berry extract","volume":"211","author":"Xie","year":"2016","journal-title":"Food Chem."},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Li, A., Xiao, R., He, S., An, X., He, Y., Wang, C., Yin, S., Wang, B., Shi, X., and He, J. (2019). Research advances of purple sweet potato anthocyanins: Extraction, identification, stability, bioactivity, application, and biotransformation. Molecules, 24.","DOI":"10.3390\/molecules24213816"},{"key":"ref_254","first-page":"100488","article-title":"Biopolymer-based encapsulation of anthocyanins as reinforced natural colorants for food applications","volume":"11","author":"Jiang","year":"2023","journal-title":"J. Agric. Food Res."},{"key":"ref_255","first-page":"100346","article-title":"Nanocarriers based on polysaccharides for improving the stability and bioavailability of anthocyanins: A review","volume":"6","author":"Yuan","year":"2023","journal-title":"Carbohydr. Polym. Technol. Appl."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ijbiomac.2020.01.197","article-title":"Improvement of thermal stability and antioxidant activity of anthocyanins of Echium amoenum petal using maltodextrin\/modified starch combination as wall material","volume":"148","author":"Mehran","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1039\/D0RA08162K","article-title":"Preparing, optimising, and evaluating chitosan nanocapsules to improve the stability of anthocyanins from Aronia melanocarpa","volume":"11","author":"Wang","year":"2021","journal-title":"RSC Adv."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"114335","DOI":"10.1016\/j.lwt.2022.114335","article-title":"Stability and antioxidant activity of chitosan\/\u03b2-lactoglobulin on anthocyanins from Aronia melanocarpa","volume":"173","author":"Chen","year":"2023","journal-title":"Lebenson. Wiss. Technol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.foodchem.2017.10.109","article-title":"Blackberry anthocyanins: \u03b2-cyclodextrin fortification for thermal and gastrointestinal stabilization","volume":"245","author":"Fernandes","year":"2018","journal-title":"Food Chem."},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Vukoja, J., Buljeta, I., Pichler, A., \u0160imunovi\u0107, J., and Kopjar, M. (2021). Formulation and stability of cellulose-based delivery systems of raspberry phenolics. Processes, 9.","DOI":"10.3390\/pr9010090"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1080\/21691401.2017.1339050","article-title":"Stability enhancement of mulberry-extracted anthocyanin using alginate\/chitosan microencapsulation for food supplement application","volume":"46","author":"Kanokpanont","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ijbiomac.2017.11.122","article-title":"Microencapsulation of saffron anthocyanins using \u03b2 glucan and \u03b2 cyclodextrin: Microcapsule characterization, release behaviour & antioxidant potential during in-vitro digestion","volume":"109","author":"Ahmad","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.foodchem.2014.07.059","article-title":"In vitro release properties of encapsulated blueberry (Vaccinium ashei) extracts","volume":"168","author":"Flores","year":"2015","journal-title":"Food Chem."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10847-016-0624-1","article-title":"Physicochemical characterization and biological activities of the ethanol extract of Bryophyllum pinnatum (Lam.) Oken incorporated in \u03b2-cyclodextrin","volume":"85","author":"Lanna","year":"2016","journal-title":"J. Incl. Phenom. Macrocycl. Chem."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.foodchem.2019.05.086","article-title":"Effect of wall materials on some physicochemical properties and release characteristics of encapsulated black rice anthocyanin microcapsules","volume":"294","author":"Norkaew","year":"2019","journal-title":"Food Chem."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.lwt.2018.04.083","article-title":"Functional evaluation of microencapsulated anthocyanins from sour cherries skins extract in whey proteins isolate","volume":"95","author":"Oancea","year":"2018","journal-title":"Lebenson. Wiss. Technol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.foodchem.2017.12.058","article-title":"Encapsulation of anthocyanins from bilberries\u2014Effects on bioavailability and intestinal accessibility in humans","volume":"248","author":"Mueller","year":"2018","journal-title":"Food Chem."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"103111","DOI":"10.1016\/j.ifset.2022.103111","article-title":"Bioavailability of blackberry pomace microcapsules by using different techniques: An approach for yogurt application","volume":"81","author":"Romanini","year":"2022","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jff.2015.04.022","article-title":"In vitro fermentation of anthocyanins encapsulated with cyclodextrins: Release, metabolism and influence on gut microbiota growth","volume":"16","author":"Flores","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.foodres.2018.08.045","article-title":"Nanocomplexes composed of chitosan derivatives and \u03b2-lactoglobulin as a carrier for anthocyanins: Preparation, stability and bioavailability in vitro","volume":"116","author":"Ge","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1021\/jf2047515","article-title":"Preparation and comparative release characteristics of three anthocyanin encapsulation systems","volume":"60","author":"Oidtmann","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.idairyj.2011.04.003","article-title":"Whey protein gels for the entrapment of bioactive anthocyanins from bilberry extract","volume":"21","author":"Betz","year":"2011","journal-title":"Int. Dairy J."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"110552","DOI":"10.1016\/j.jfoodeng.2021.110552","article-title":"Synthesis of porous starch microgels for the encapsulation, delivery and stabilization of anthocyanins","volume":"302","author":"Ji","year":"2021","journal-title":"J. Food Eng."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1002\/jsfa.11175","article-title":"Nanoencapsulation in low\u2014molecular\u2014weight chitosan improves in vivo antioxidant potential of black carrot anthocyanin","volume":"101","author":"Chatterjee","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"106114","DOI":"10.1016\/j.foodhyd.2020.106114","article-title":"Facile synthesis of nano-nanocarriers from chitosan and pectin with improved stability and biocompatibility for anthocyanins delivery: An in vitro and in vivo study","volume":"109","author":"Zhao","year":"2020","journal-title":"Food Hydrocoll."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.carbpol.2016.11.005","article-title":"Chitosan-cellulose nanocrystal microencapsulation to improve encapsulation efficiency and stability of entrapped fruit anthocyanins","volume":"157","author":"Wang","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.powtec.2017.01.070","article-title":"Influence of spray drying on water solubility index, apparent density, and anthocyanin content of pomegranate juice powder","volume":"311","author":"Jafari","year":"2017","journal-title":"Powder Technol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.tifs.2018.02.001","article-title":"Lipid nano scale cargos for the protection and delivery of food bioactive ingredients and nutraceuticals","volume":"74","author":"Akhavan","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1080\/10408398.2018.1484687","article-title":"A Systematic review on nanoencapsulation of food bioactive ingredients and nutraceuticals by various nanocarriers","volume":"59","author":"Assadpour","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_280","unstructured":"Jafari, S.M. (2017). Nanoencapsulation Technologies for the Food and Nutraceutical Industries, Academic Press."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.foodchem.2015.12.061","article-title":"Preservation of anthocyanins in solid lipid nanoparticles: Optimization of a microemulsion dilution method using the placket\u2013burman and box\u2013behnken designs","volume":"199","author":"Ravanfar","year":"2016","journal-title":"Food Chem."},{"key":"ref_282","first-page":"234","article-title":"Encapsulation of mangosteen extract in virgin coconut oil based nanoemulsions: Preparation and characterization for topical formulation","volume":"929","author":"Mulia","year":"2018","journal-title":"Mater. Sci. For."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.foodchem.2016.09.207","article-title":"Nanoliposomal carriers for improvement the bioavailability of high\u2014Valued phenolic compounds of pistachio green hull extract","volume":"220","author":"Rafiee","year":"2017","journal-title":"Food Chem."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/19\/4152\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:58:39Z","timestamp":1760129919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/19\/4152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,26]]},"references-count":283,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["nu15194152"],"URL":"https:\/\/doi.org\/10.3390\/nu15194152","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,26]]}}}