{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:57:50Z","timestamp":1762325870102,"version":"build-2065373602"},"reference-count":85,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Sodium, although essential for life, is a key factor in changes in vascular function and cardiovascular disease when consumed in excess. Sarcocornia spp., a halophyte plant with many nutritional benefits, presents itself as a promising substitute for the consumption of purified salt. Matrix metalloproteinases (MMPs) 2 and 9 are widely studied due to their action in physiological processes and as biomarkers at the diagnostic level due to their increased expression in inflammatory processes. This study aimed to evaluate whether replacing salt with Sarcocornia\u00a0perennis (S. perennis) powder in healthy young people leads to an improvement in biochemical profiles and the attenuation of MMP-2 and MMP-9 activity. In the present study, 30 participants were randomized into a control group that consumed salt and an intervention group that replaced salt with powdered S. perennis. The evaluation of the biochemical parameters was carried out by the spectrophotometry method, and the evaluation of MMP activity was carried out by zymography. A significant decrease was observed in the intervention group in total cholesterol, high-density lipoprotein cholesterol (HDL-c), and creatinine (p-value \u2264 0.05), along with lower but not significantly different mean values of triglycerides. Regarding MMP activity after the intervention, a lower mean value was observed for MMP-9 activity, with there being higher mean values for MMP-2 activity, both with p-values \u2265 0.05. The results confirmed that the consumption of S. perennis is a beneficial choice for health regarding the lipid profile. The evaluation of MMP activity indicated the potential of S. perennis in the regulation of MMP-9 activity in healthy individuals, along with the need for the further study of these proteases in individuals with pathologies.<\/jats:p>","DOI":"10.3390\/nu16070929","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T14:00:23Z","timestamp":1711375223000},"page":"929","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessing Sarcocornia as a Salt Substitute: Effects on Lipid Profile and Gelatinase Activity"],"prefix":"10.3390","volume":"16","author":[{"given":"Beatriz","family":"Lou\u00e7ano","sequence":"first","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"}]},{"given":"Sara","family":"Maletti","sequence":"additional","affiliation":[{"name":"Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, Faculty of Medicine and Surgery, University of Modena and Reggio Emilia, Policlinico, via del Pozzo, 7141124 Modena, Italy"}]},{"given":"Helena","family":"Tim\u00f3teo","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9829-1592","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Medical Sciences, Socials and Humans, Rua 5 de Outubro, 3046-854 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9559-2165","authenticated-orcid":false,"given":"N\u00e1dia","family":"Os\u00f3rio","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"},{"name":"LABINSA\u00daDE-Research Laboratory for Applied Health Sciences, Polytechnic Institute of Coimbra, Coimbra Health School, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"},{"name":"Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"given":"Maria Jo\u00e3o","family":"Barroca","sequence":"additional","affiliation":[{"name":"Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"},{"name":"Polytechnic Institute of Coimbra, Agriculture School of Coimbra, Bencanta, 3040-360 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-7980","authenticated-orcid":false,"given":"Aida Moreira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"},{"name":"Polytechnic Institute of Coimbra, Agriculture School of Coimbra, Bencanta, 3040-360 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9119-7774","authenticated-orcid":false,"given":"Telmo","family":"Pereira","sequence":"additional","affiliation":[{"name":"LABINSA\u00daDE-Research Laboratory for Applied Health Sciences, Polytechnic Institute of Coimbra, Coimbra Health School, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"},{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Clinical Physiology, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"},{"name":"Faculty of Sport Science and Physical Education, University of Coimbra, CIDAF\u2014Research Unit for Sport and Physical Activity, 3000-456 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7844-0506","authenticated-orcid":false,"given":"Armando","family":"Caseiro","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"},{"name":"LABINSA\u00daDE-Research Laboratory for Applied Health Sciences, Polytechnic Institute of Coimbra, Coimbra Health School, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal"},{"name":"Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"},{"name":"Faculty of Sport Science and Physical Education, University of Coimbra, CIDAF\u2014Research Unit for Sport and Physical Activity, 3000-456 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bernal, A., Zafra, M.A., Sim\u00f3n, M.J., and Mah\u00eda, J. (2023). Sodium Homeostasis, a Balance Necessary for Life. Nutrients, 15.","DOI":"10.3390\/nu15020395"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Baumer-Harrison, C., Breza, J.M., Sumners, C., Krause, E.G., and de Kloet, A.D. (2023). Sodium Intake and Disease: Another Relationship to Consider. 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