{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:22:35Z","timestamp":1773904955444,"version":"3.50.1"},"reference-count":55,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/15196-4"],"award-info":[{"award-number":["2021\/15196-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/24069-3"],"award-info":[{"award-number":["2018\/24069-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["UIDB\/00408\/2020"],"award-info":[{"award-number":["UIDB\/00408\/2020"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["UIDP\/00408\/2020"],"award-info":[{"award-number":["UIDP\/00408\/2020"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"LASIGE Research Unit","award":["2021\/15196-4"],"award-info":[{"award-number":["2021\/15196-4"]}]},{"name":"LASIGE Research Unit","award":["2018\/24069-3"],"award-info":[{"award-number":["2018\/24069-3"]}]},{"name":"LASIGE Research Unit","award":["UIDB\/00408\/2020"],"award-info":[{"award-number":["UIDB\/00408\/2020"]}]},{"name":"LASIGE Research Unit","award":["UIDP\/00408\/2020"],"award-info":[{"award-number":["UIDP\/00408\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Blood selenium (Se) concentrations differ substantially by population and could be influenced by genetic variants, increasing Se deficiency-related diseases. We conducted a genome-wide association study (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with serum Se deficiency in 382 adults with admixed ancestry. Genotyping arrays were combined to yield 90,937 SNPs. R packages were applied to quality control and imputation. We also performed the ancestral proportion analysis. The Search Tool for the Retrieval of Interacting Genes was used to interrogate known protein\u2013protein interaction networks (PPIs). Our ancestral proportion analysis estimated 71% of the genome was from Caucasians, 22% was from Africans, and 8% was from East Asians. We identified the SNP rs1561573 in the TraB domain containing 2B (TRABD2B), rs425664 in MAF bZIP transcription factor (MAF), rs10444656 in spermatogenesis-associated 13 (SPATA13), and rs6592284 in heat shock protein nuclear import factor (HIKESHI) genes. The PPI analysis showed functional associations of Se deficiency, thyroid hormone metabolism, NRF2-ARE and the Wnt pathway, and heat stress. Our findings show evidence of a genetic association between Se deficiency and metabolic pathways indirectly linked to Se regulation, reinforcing the complex relationship between Se intake and the endogenous factors affecting the Se requirements for optimal health.<\/jats:p>","DOI":"10.3390\/nu16111627","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T05:14:02Z","timestamp":1716786842000},"page":"1627","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genome-Wide Admixture and Association Study of Serum Selenium Deficiency to Identify Genetic Variants Indirectly Linked to Selenium Regulation in Brazilian Adults"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7498-6165","authenticated-orcid":false,"given":"Ligia","family":"Moriguchi Watanabe","sequence":"first","affiliation":[{"name":"Division of Nutrition and Metabolism, Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2014FMRP\/USP, S\u00e3o Paulo 14049-900, Brazil"},{"name":"Departamento de Estat\u00edstica e Investiga\u00e7\u00e3o Operacional (DEIO) e Centro de Estat\u00edstica e Aplica\u00e7\u00f5es (CEAUL), Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-720X","authenticated-orcid":false,"given":"Lisete","family":"Sousa","sequence":"additional","affiliation":[{"name":"Departamento de Estat\u00edstica e Investiga\u00e7\u00e3o Operacional (DEIO) e Centro de Estat\u00edstica e Aplica\u00e7\u00f5es (CEAUL), Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-1496","authenticated-orcid":false,"given":"Francisco M.","family":"Couto","sequence":"additional","affiliation":[{"name":"LASIGE, Departamento de Inform\u00e1tica, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9589-8586","authenticated-orcid":false,"given":"Nat\u00e1lia Yumi","family":"Noronha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2014FMRP\/USP, S\u00e3o Paulo 14049-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3645-3709","authenticated-orcid":false,"given":"Marcela Augusta","family":"de Souza Pinhel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2014FMRP\/USP, S\u00e3o Paulo 14049-900, Brazil"}]},{"given":"Gleyson Francisco","family":"da Silva Carvalho","sequence":"additional","affiliation":[{"name":"Department of Pathology, S\u00e3o Paulo Medical School, University of S\u00e3o Paulo\u2014FMUSP, S\u00e3o Paulo 01246-903, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-4709","authenticated-orcid":false,"given":"Guilherme","family":"da Silva Rodrigues","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo 14040-900, Brazil"}]},{"given":"Carlos Roberto","family":"Bueno J\u00fanior","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo 14040-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2236-3956","authenticated-orcid":false,"given":"Leslie Domenici","family":"Kulikowski","sequence":"additional","affiliation":[{"name":"Department of Pathology, S\u00e3o Paulo Medical School, University of S\u00e3o Paulo\u2014FMUSP, S\u00e3o Paulo 01246-903, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2498-0619","authenticated-orcid":false,"given":"Fernando","family":"Barbosa J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses and Bromatology, Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo\u2014FCFRP\/USP, S\u00e3o Paulo 14040-900, Brazil"}]},{"given":"Carla Barbosa","family":"Nonino","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism, Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2014FMRP\/USP, S\u00e3o Paulo 14049-900, Brazil"},{"name":"Department of Internal Medicine, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2014FMRP\/USP, S\u00e3o Paulo 14049-900, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kieliszek, M. 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