{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T16:48:53Z","timestamp":1774889333499,"version":"3.50.1"},"reference-count":65,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Cardiovascular diseases (CVDs) are the leading cause of death worldwide. This study focused on evaluating the impact of a Mediterranean-type diet combined with physical exercise on CVD risk factors of high-risk individuals. A randomized clinical trial (RCT) recruited individuals (\u226550 years old) with no history of acute myocardial infarction, but with high CVD risk criteria according to the SCORE2\/SCORE2 OP. Anthropometric and biochemical parameters were assessed at baseline and after 12 weeks of diet and exercise intervention. Participants were randomly assigned into 3 groups: no intervention group (Group 1a), physical exercise group (Group 1b), and physical exercise (\u00b12 h\/week) plus diet group (Group 2). Briefly, the dietary intervention was based on the principles of an isocaloric Mediterranean diet (MD), with seven main meals\/week centered on plant-based foods (legumes and pulses). The combined effect of exercise and the diet showed significant decrease in WC (p = 0.002), BST (p &lt; 0.001), visceral fat (p &lt; 0.001), and TG (p = 0.029), compared with control groups. The intervention significantly increased legume intake (p &lt; 0.001), as well as adherence to the MD, which associates with WC decrease (p = 0.024) and visceral fat (p = 0.017). A combined intervention of exercise and diet should be endorsed as an efficient modifier of cardiometabolic parameters.<\/jats:p>","DOI":"10.3390\/nu16152443","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T14:39:08Z","timestamp":1722004748000},"page":"2443","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of a Mediterranean-Inspired Diet on Cardiovascular Disease Risk Factors: A Randomized Clinical Trial"],"prefix":"10.3390","volume":"16","author":[{"given":"Ana Rita","family":"Barbosa","sequence":"first","affiliation":[{"name":"Comprehensive Health Research Centre\u2014CHRC, Universidade de \u00c9vora, Col\u00e9gio Lu\u00eds Ant\u00f3nio Verney, Gab:269-a, Rua Rom\u00e3o Ramalho 59, 7002-554 \u00c9vora, Portugal"},{"name":"Algarve Biomedical Center Research Institute, Universidade do Algarve, FMCB Ed. Campus de Gambelas, 8005-139 Faro, Portugal"}]},{"given":"Sandra","family":"Pais","sequence":"additional","affiliation":[{"name":"Comprehensive Health Research Centre\u2014CHRC, Universidade de \u00c9vora, Col\u00e9gio Lu\u00eds Ant\u00f3nio Verney, Gab:269-a, Rua Rom\u00e3o Ramalho 59, 7002-554 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-4772","authenticated-orcid":false,"given":"Ana","family":"Marreiros","sequence":"additional","affiliation":[{"name":"Algarve Biomedical Center Research Institute, Universidade do Algarve, FMCB Ed. Campus de Gambelas, 8005-139 Faro, Portugal"},{"name":"Faculty of Medicine and Biomedical Sciences, Universidade do Algarve, FMCB Ed. Campus de Gambelas, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5040-735X","authenticated-orcid":false,"given":"Marta","family":"Correia","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"ref_1","unstructured":"(2023). World Health Statistics 2023: Monitoring health for the SDGs, Sustainable Development Goals, World Health Organization. Available online: https:\/\/www.who.int\/publications\/book-orders."},{"key":"ref_2","unstructured":"Institute for Health Metrics and Evaluation (IHME) (2024, March 04). Global Burden of Diseases (GBD) Compare. 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