{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T23:16:29Z","timestamp":1773962189149,"version":"3.50.1"},"reference-count":81,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","award":["APQ-01494-21"],"award-info":[{"award-number":["APQ-01494-21"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["APQ-01494-21"],"award-info":[{"award-number":["APQ-01494-21"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["APQ-01494-21"],"award-info":[{"award-number":["APQ-01494-21"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Insects like Gryllus assimilis have an excellent nutritional profile, including iron. However, the bioavailability of this iron and its effects on intestinal health and oxidative balance remain unclear. To enhance acceptance, insects can be used in powder form and combined with common flours. Objective: This study evaluates the effects of Gryllus assimilis powder, alone or with soy flour, on iron bioavailability, intestinal health, and oxidative balance in rodents. Methods: Using the hemoglobin depletion\/repletion method, 32 male Wistar rats were divided into four groups: A (standard diet + ferrous sulfate), B (diet + Gryllus assimilis + soy flour), C (diet + Gryllus assimilis), and D (diet + soy flour). Hemoglobin levels, regeneration efficiency, biological value, serum markers, intestinal health, and oxidative balance were assessed. Results: Food intake, weight gain, and bioavailability measures showed no differences. However, the Gryllus + soy group showed higher weekly and final hemoglobin levels than Gryllus alone. This combination also improved acetic acid levels, fecal moisture, and oxidative balance, increasing superoxide dismutase activity while reducing peroxidation products compared to Gryllus alone. Conclusion: These findings highlight the potential benefits of combining Gryllus assimilis with soy flour for iron bioavailability and overall health.<\/jats:p>","DOI":"10.3390\/nu17030437","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T09:42:23Z","timestamp":1737970943000},"page":"437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Soybean Flour Fortified with Gryllus assimilis Powder to Increase Iron Bioavailability Improves Gut Health and Oxidative Balance In Vivo"],"prefix":"10.3390","volume":"17","author":[{"given":"Michele L\u00edlian da Fonseca","family":"Barnab\u00e9","sequence":"first","affiliation":[{"name":"Laboratory of Vitamin Analysis, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"given":"Laura C\u00e9lia de Oliveira Souza","family":"Vicente","sequence":"additional","affiliation":[{"name":"Laboratory of Vitamin Analysis, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"given":"Karina Vitoria Cipriana","family":"Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Vitamin Analysis, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"given":"Gabrieli Fernandes","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Laboratory of Vitamin Analysis, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"given":"Elias","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Vitamin Analysis, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0206-633X","authenticated-orcid":false,"given":"L\u00edvya Alves","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Vitamin Analysis, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-0348","authenticated-orcid":false,"given":"Kelly Aparecida","family":"Dias","sequence":"additional","affiliation":[{"name":"Laboratory of Vitamin Analysis, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5635-0806","authenticated-orcid":false,"given":"Stephanie Michelin Santana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Vitamin Analysis, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0298-0543","authenticated-orcid":false,"given":"Vinicius Parzanini Brilhante de S\u00e3o","family":"Jos\u00e9","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Nutrition, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"given":"Manoela Maciel dos Santos","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-4578","authenticated-orcid":false,"given":"Ricardo C.","family":"Calhelha","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Alameda Santa Apol\u00f3nia, 5300-252 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-252 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3012-1327","authenticated-orcid":false,"given":"Luciano Bernardes","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"},{"name":"Department of Sports, Instituto Polit\u00e9cnico de Bragan\u00e7a, 5300-252 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5713-3994","authenticated-orcid":false,"given":"L\u00facia","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Alameda Santa Apol\u00f3nia, 5300-252 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-252 Bragan\u00e7a, Portugal"},{"name":"Facultade de Ciencias, Universidad de Vigo, 32004 Ourense, Spain"}]},{"given":"Izabela Maria Montezano de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laboratory of Food Analysis, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"given":"B\u00e1rbara Pereira da","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Nutrition, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"given":"H\u00e9rcia Stampini Duarte","family":"Martino","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Nutrition, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5831-3590","authenticated-orcid":false,"given":"Reggiani Vilela","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-5694","authenticated-orcid":false,"given":"Ceres","family":"Mattos Della Lucia","sequence":"additional","affiliation":[{"name":"Laboratory of Vitamin Analysis, Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,25]]},"reference":[{"key":"ref_1","unstructured":"Skalnaya, M.G., and Skalny, A.V. 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