{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:22:15Z","timestamp":1775215335709,"version":"3.50.1"},"reference-count":156,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Milk is a highly complex food that contains all the nutrients necessary for the development of mammalian offspring. For millennia, humans have included milk and milk products as major components of their diet. However, the effect of the consumption of dairy products on health has been a concern in recent years in terms of myths and realities. This review briefly describes the composition of bovine milk, the positive and negative effects that have been related to dairy products, and those aspects where the scientific evidence is still inconclusive. In addition to being nutritional, dairy products are a source of bioactive peptides, prebiotics and probiotics, fatty acids such as CLA, and fat globule membranes or have a protective effect against certain diseases. Negative effects include milk protein allergy or lactose intolerance. The effects of dairy products on certain cancers, such as prostate cancer, and their role in type II diabetes mellitus or weight gain are still inconclusive. Although the role of dairy products in cardiovascular risk is still inconclusive, recent meta-analyses have shown that dairy products may have a protective effect.<\/jats:p>","DOI":"10.3390\/nu17040646","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T08:05:42Z","timestamp":1739347542000},"page":"646","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Role of Dairy in Human Nutrition: Myths and Realities"],"prefix":"10.3390","volume":"17","author":[{"given":"Laura","family":"Sanjuli\u00e1n","sequence":"first","affiliation":[{"name":"Food Hygiene, Inspection and Control Laboratory (Lhica), Department of Analytical Chemistry, Nutrition and Bromatology, School of Veterinary Science, Campus Terra, University of Santiago de Compostela, 27002 Lugo, Spain"}]},{"given":"Salvador","family":"Fern\u00e1ndez-Rico","sequence":"additional","affiliation":[{"name":"Food Hygiene, Inspection and Control Laboratory (Lhica), Department of Analytical Chemistry, Nutrition and Bromatology, School of Veterinary Science, Campus Terra, University of Santiago de Compostela, 27002 Lugo, Spain"}]},{"given":"Nerea","family":"Gonz\u00e1lez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Food Hygiene, Inspection and Control Laboratory (Lhica), Department of Analytical Chemistry, Nutrition and Bromatology, School of Veterinary Science, Campus Terra, University of Santiago de Compostela, 27002 Lugo, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9324-1342","authenticated-orcid":false,"given":"Alberto","family":"Cepeda","sequence":"additional","affiliation":[{"name":"Food Hygiene, Inspection and Control Laboratory (Lhica), Department of Analytical Chemistry, Nutrition and Bromatology, School of Veterinary Science, Campus Terra, University of Santiago de Compostela, 27002 Lugo, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7992-1491","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Miranda","sequence":"additional","affiliation":[{"name":"Food Hygiene, Inspection and Control Laboratory (Lhica), Department of Analytical Chemistry, Nutrition and Bromatology, School of Veterinary Science, Campus Terra, University of Santiago de Compostela, 27002 Lugo, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8676-8816","authenticated-orcid":false,"given":"Cristina","family":"Fente","sequence":"additional","affiliation":[{"name":"Food Hygiene, Inspection and Control Laboratory (Lhica), Department of Analytical Chemistry, Nutrition and Bromatology, School of Veterinary Science, Campus Terra, University of Santiago de Compostela, 27002 Lugo, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7283-9372","authenticated-orcid":false,"given":"Alexandre","family":"Lamas","sequence":"additional","affiliation":[{"name":"Food Hygiene, Inspection and Control Laboratory (Lhica), Department of Analytical Chemistry, Nutrition and Bromatology, School of Veterinary Science, Campus Terra, University of Santiago de Compostela, 27002 Lugo, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-9931","authenticated-orcid":false,"given":"Patricia","family":"Regal","sequence":"additional","affiliation":[{"name":"Food Hygiene, Inspection and Control Laboratory (Lhica), Department of Analytical Chemistry, Nutrition and Bromatology, School of Veterinary Science, Campus Terra, University of Santiago de Compostela, 27002 Lugo, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"ref_1","unstructured":"(1999). Food and Agriculture Administration Codex General Standard for the Use of Dairy Terms (Standard No. CODEX STAN 206-1999)."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1007\/s10661-011-2241-1","article-title":"Cadmium and Lead in Bovine Milk in the Mining Area of the Caudal River (Spain)","volume":"184","author":"Prieto","year":"2012","journal-title":"Environ. Monit. Assess."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Autio, M., Sekki, S., Autio, J., Peltonen, K., and Niva, M. (2023). Toward De-Dairyfication of the Diet?\u2014Consumers Downshifting Milk, yet Justifying Their Dairy Pleasures. Front. Sustain., 4.","DOI":"10.3389\/frsus.2023.975679"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.nut.2016.07.019","article-title":"Consumption of Milk and Dairy Products: Facts and Figures","volume":"33","author":"Zingone","year":"2017","journal-title":"Nutrition"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.nut.2013.10.011","article-title":"Milk Nutritional Composition and Its Role in Human Health","volume":"30","author":"Pereira","year":"2014","journal-title":"Nutrition"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e609","DOI":"10.3399\/bjgp16X686521","article-title":"Differentiating Milk Allergy (IgE and Non-IgE Mediated) from Lactose Intolerance: Understanding the Underlying Mechanisms and Presentations","volume":"66","author":"Walsh","year":"2016","journal-title":"Br. J. Gen. Pract."},{"key":"ref_7","first-page":"2039","article-title":"[Scientific Evidence about the Role of Yogurt and Other Fermented Milks in the Healthy Diet for the Spanish Population]","volume":"28","author":"Baladia","year":"2013","journal-title":"Nutr. Hosp."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.idairyj.2010.12.011","article-title":"Milk Intelligence: Mining Milk for Bioactive Substances Associated with Human Health","volume":"21","author":"Mills","year":"2011","journal-title":"Int. Dairy J."},{"key":"ref_9","first-page":"8","article-title":"Milk Nutritional Composition and Its Role in Human Health","volume":"9","author":"Lambrini","year":"2020","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"103648","DOI":"10.1016\/j.jprot.2020.103648","article-title":"BoMiProt: A Database of Bovine Milk Proteins","volume":"215","author":"Maity","year":"2020","journal-title":"J. Proteom."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1080\/10408398.2016.1160361","article-title":"Effect of Processing on Nutritive Values of Milk Protein","volume":"57","author":"Borad","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3945\/an.113.005025","article-title":"Milk, Dairy Products, and Their Functional Effects in Humans: A Narrative Review of Recent Evidence","volume":"5","author":"Visioli","year":"2014","journal-title":"Adv. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/10408690590957098","article-title":"Composition, Structure and Absorption of Milk Lipids: A Source of Energy, Fat-Soluble Nutrients and Bioactive Molecules","volume":"46","author":"German","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"105370","DOI":"10.1016\/j.idairyj.2022.105370","article-title":"Bovine Milk Fatty Acid and Triacylglycerol Composition and Structure Differ between Early and Late Lactation Influencing Milk Fat Solid Fat Content","volume":"131","author":"Yener","year":"2022","journal-title":"Int. Dairy J."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Jiang, X., Zhao, Z., Chen, X., Miao, F., Li, J., Yu, H., Jiang, P., and Lin, Z. (2024). Effects of Genetic Polymorphism in the IFI27 Gene on Milk Fat Traits and Relevance to Lipid Metabolism in Bovine Mammary Epithelial Cells. Animals, 14.","DOI":"10.3390\/ani14223284"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/jpn.13816","article-title":"Milk Production and Milk Fatty Acid Profile as a Response to Feeding Dairy Cows with Flax Products during the Persistence Period","volume":"107","author":"Shams","year":"2023","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.aninu.2024.06.009","article-title":"Variations in the Milk Lipidomic Profile of Lactating Dairy Cows Fed the Diets Containing Alfalfa Hay versus Alfalfa Silage","volume":"19","author":"Liu","year":"2024","journal-title":"Anim. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zou, Y., Chen, Y., Meng, Q., Wang, Y., and Zhang, Y. (2024). Cow Milk Fatty Acid and Protein Composition in Different Breeds and Regions in China. Molecules, 29.","DOI":"10.20944\/preprints202409.1849.v1"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Stergiadis, S., N\u00f8rskov, N.P., Purup, S., Givens, I., and Lee, M.R.F. (2019). Comparative Nutrient Profiling of Retail Goat and Cow Milk. Nutrients, 11.","DOI":"10.3390\/nu11102282"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s41586-023-06749-3","article-title":"Trans-Vaccenic Acid Reprograms CD8+ T Cells and Anti-Tumor Immunity","volume":"623","author":"Fan","year":"2023","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12944-019-0993-8","article-title":"Trans-Vaccenic Acid Inhibits Proliferation and Induces Apoptosis of Human Nasopharyngeal Carcinoma Cells via a Mitochondrial-Mediated Apoptosis Pathway","volume":"18","author":"Song","year":"2019","journal-title":"Lipids Health Dis."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Morenga, L.T., and Montez, J.M. (2017). Health Effects of Saturated and Trans-Fatty Acid Intake in Children and Adolescents: Systematic Review and Meta-Analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186672"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Sanjulian, L., Lamas, A., Barreiro, R., Mart\u00ednez, I., Garc\u00eda-Alonso, L., Cepeda, A., Fente, C., and Regal, P. (2024). Investigating the Dietary Impact on Trans-Vaccenic Acid (Trans-C18: 1 n-7) and Other Beneficial Fatty Acids in Breast Milk and Infant Formulas. Foods, 13.","DOI":"10.3390\/foods13142164"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9827369","DOI":"10.1155\/2016\/9827369","article-title":"Isolation and Analysis of Phospholipids in Dairy Foods","volume":"2016","author":"Pimentel","year":"2016","journal-title":"J. Anal. Methods Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3168\/jds.S0022-0302(07)71554-0","article-title":"Factors Affecting the Concentration of Sphingomyelin in Bovine Milk","volume":"90","author":"Graves","year":"2007","journal-title":"J. Dairy Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Nilsson, \u00c5., Duan, R.D., and Ohlsson, L. (2021). Digestion and Absorption of Milk Phospholipids in Newborns and Adults. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.724006"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.3390\/ijms14022808","article-title":"Phospholipids in Milk Fat: Composition, Biological and Technological Significance, and Analytical Strategies","volume":"14","author":"Contarini","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8239","DOI":"10.3168\/jds.2023-23378","article-title":"Sterol, Tocopherol, and Bioactive Fatty Acid Differences between Conventional, High-Quality, and Organic Cow Milk","volume":"106","author":"Martini","year":"2023","journal-title":"J. Dairy Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.3168\/jds.2018-15067","article-title":"Modification of the Sterol Profile in Milk through Feeding","volume":"102","author":"Duong","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fox, P.F., Uniacke-Lowe, T., McSweeney, P.L.H., and O\u2019Mahony, J.A. (2015). Dairy Chemistry and Biochemistry, Springer.","DOI":"10.1007\/978-3-319-14892-2"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.3168\/jds.2018-15955","article-title":"Invited Review: Milk Lactose\u2014Current Status and Future Challenges in Dairy Cattle","volume":"102","author":"Costa","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e70018","DOI":"10.1111\/1541-4337.70018","article-title":"Is It Possible to Obtain Substitutes for Human Milk Oligosaccharides from Bovine Milk, Goat Milk, or Other Mammal Milks?","volume":"23","author":"Jiang","year":"2024","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Robinson, R.C. (2019). Structures and Metabolic Properties of Bovine Milk Oligosaccharides and Their Potential in the Development of Novel Therapeutics. Front. Nutr., 6.","DOI":"10.3389\/fnut.2019.00050"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1017\/S0007114500002270","article-title":"Oligosaccharides and Glycoconjugates in Bovine Milk and Colostrum","volume":"84","author":"Gopal","year":"2000","journal-title":"Br. J. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.1021\/jf300015j","article-title":"Natural Variability in Bovine Milk Oligosaccharides from Danish Jersey and Holstein-Friesian Breeds","volume":"60","author":"Sundekilde","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/ajcn\/78.5.1024","article-title":"Brain Ganglioside and Glycoprotein Sialic Acid in Breastfed Compared with Formula-Fed Infants","volume":"78","author":"Wang","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/S0378-3782(01)00202-X","article-title":"Oligosaccharides: Application in Infant Food","volume":"65","year":"2001","journal-title":"Early Hum. Dev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"847S","DOI":"10.1093\/jn\/137.3.847S","article-title":"Oligosaccharides from Milk","volume":"137","author":"Boehm","year":"2007","journal-title":"J. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority (2017). Dietary Reference Values for Nutrients Summary Report. EFSA Support. Publ., 14, e15121E.","DOI":"10.2903\/sp.efsa.2017.e15121"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1476-511X-6-25","article-title":"Bovine Milk in Human Nutrition\u2014A Review","volume":"6","author":"Haug","year":"2007","journal-title":"Lipids Health Dis."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Linehan, K., Patangia, D.V., Roos, R.P., and Stanton, C. (2024). Production, composition and nutritional properties of organic milk: A Critical review. Foods, 13.","DOI":"10.3390\/foods13040550"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2527\/af.2014-0008","article-title":"Nutritional Interest of Milk and Dairy Products: Some Scientific Data to Fuel the Debate","volume":"4","author":"Chouinard","year":"2014","journal-title":"Anim. Front."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/07315724.2017.1299651","article-title":"Calcium Bioavailability from Mineral Waters with Different Mineralization in Comparison to Milk and a Supplement","volume":"36","author":"Greupner","year":"2017","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_44","first-page":"1","article-title":"Milk and Milk Products: Food Sources of Calcium","volume":"31","author":"Rovira","year":"2015","journal-title":"Nutr. Hosp."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Rangel-Galv\u00e1n, M., Rangel-Galv\u00e1n, V., and Rangel-Huerta, A. (2023). T-Type Calcium Channel Modulation by Hydrogen Sulfide in Neuropathic Pain Conditions. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1212800"},{"key":"ref_46","first-page":"341","article-title":"Calcium, Essential for Health","volume":"33","year":"2016","journal-title":"Nutr. Hosp."},{"key":"ref_47","first-page":"247","article-title":"The Physiological Importance of the Casein Phosphopeptide Calcium Salts. II. Peroral Calcium Dosage of Infants","volume":"55","author":"Mellander","year":"1950","journal-title":"Acta Soc. Med. Ups."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/bcp.13002","article-title":"Milk-Derived Bioactive Peptides and Their Health Promoting Effects: A Potential Role in Atherosclerosis","volume":"83","author":"Marcone","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Rangel, A.H.d.N., Bezerra, D.A.F.V.d.A., Sales, D.C., Ara\u00fajo, E.d.O.M., Lucena, L.M.d., Porto, A.L.F., V\u00e9ras, \u00cd.V.U.M., Lacerda, A.F., Ribeiro, C.V.D.M., and Anaya, K. (2023). An Overview of the Occurrence of Bioactive Peptides in Different Types of Cheeses. Foods, 12.","DOI":"10.3390\/foods12234261"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.sjbs.2015.06.005","article-title":"Milk Derived Bioactive Peptides and Their Impact on Human Health\u2014A Review","volume":"23","author":"Mohanty","year":"2016","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/10408398.2015.1136590","article-title":"Therapeutic Potential of Dairy Bioactive Peptides: A Contemporary Perspective","volume":"58","author":"Sultan","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1097\/00004872-201106001-00068","article-title":"Blood pressure lowering effect of dietary integration with grana padano cheese in hypertensive patients","volume":"29","author":"Crippa","year":"2011","journal-title":"J. Hypertens."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/nutrit\/nuab097","article-title":"Dairy Bioactive Proteins and Peptides: A Narrative Review","volume":"79","author":"Auestad","year":"2021","journal-title":"Nutr. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2147\/CEG.S32368","article-title":"Lactose Intolerance: Diagnosis, Genetic, and Clinical Factors","volume":"5","author":"Mattar","year":"2012","journal-title":"Clin. Exp. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/glycob\/cwt007","article-title":"Annotation and Structural Elucidation of Bovine Milk Oligosaccharides and Determination of Novel Fucosylated Structures","volume":"23","author":"Aldredge","year":"2013","journal-title":"Glycobiology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/1758-2229.13083","article-title":"O-Acetylesterase Activity of Bifidobacterium Bifidum Sialidase Facilities the Liberation of Sialic Acid and Encourages the Proliferation of Sialic Acid Scavenging Bifidobacterium Breve","volume":"14","author":"Yokoi","year":"2022","journal-title":"Environ. Microbiol. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1128\/AEM.06762-11","article-title":"Bifidobacterium Longum Subsp. Infantis ATCC 15697 \u03b1-Fucosidases Are Active on Fucosylated Human Milk Oligosaccharides","volume":"78","author":"Sela","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Garrido, D., Ruiz-Moyano, S., Kirmiz, N., Davis, J.C., Totten, S.M., Lemay, D.G., Ugalde, J.A., German, J.B., Lebrilla, C.B., and Mills, D.A. (2016). A Novel Gene Cluster Allows Preferential Utilization of Fucosylated Milk Oligosaccharides in Bifidobacterium Longum Subsp. Longum SC596. Sci. Rep., 6.","DOI":"10.1038\/srep35045"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2220\/biomedres.35.303","article-title":"Oral Administration of Bifidobacterium Spp. Improves Insulin Resistance, Induces Adiponectin, and Prevents Inflammatory Adipokine Expressions","volume":"35","author":"Le","year":"2014","journal-title":"Biomed. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jnutbio.2018.04.007","article-title":"Synbiotics Bifidobacterium Infantis and Milk Oligosaccharides Are Effective in Reversing Cancer-Prone Nonalcoholic Steatohepatitis Using Western Diet-Fed FXR Knockout Mouse Models","volume":"57","author":"Jena","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.3168\/jds.2016-11890","article-title":"Bovine Milk Oligosaccharides Decrease Gut Permeability and Improve Inflammation and Microbial Dysbiosis in Diet-Induced Obese Mice","volume":"100","author":"Boudry","year":"2017","journal-title":"J. Dairy Sci."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Wang, M., Monaco, M.H., Hauser, J., Yan, J., Dilger, R.N., and Donovan, S.M. (2021). Bovine Milk Oligosaccharides and Human Milk Oligosaccharides Modulate the Gut Microbiota Composition and Volatile Fatty Acid Concentrations in a Preclinical Neonatal Model. Microorganisms, 9.","DOI":"10.3390\/microorganisms9050884"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Leeuwendaal, N.K., Stanton, C., O\u2019toole, P.W., and Beresford, T.P. (2022). Fermented Foods, Health and the Gut Microbiome. Nutrients, 14.","DOI":"10.3390\/nu14071527"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Abd El-Salam, M.H., El-Shibiny, S., Assem, F.M., El-Sayyad, G.S., Hasanien, Y.A., Elfadil, D., and Soliman, T.N. (2025). Impact of Fermented Milk On Gut Microbiota And Human Health: A Comprehensive Review. Curr. Microbiol., 82.","DOI":"10.1007\/s00284-025-04061-z"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3920\/BM2015.0103","article-title":"Oral Administration of Kefiran Exerts a Bifidogenic Effect on BALB\/c Mice Intestinal Microbiota","volume":"7","author":"Hamet","year":"2016","journal-title":"Benef. Microbes"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"361604","DOI":"10.1155\/2015\/361604","article-title":"Impact of Kefir Derived Lactobacillus Kefiri on the Mucosal Immune Response and Gut Microbiota","volume":"2015","author":"Carasi","year":"2015","journal-title":"J. Immunol. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.biochi.2017.08.006","article-title":"Production of Trans and Conjugated Fatty Acids in Dairy Ruminants and Their Putative Effects on Human Health: A Review","volume":"141","author":"Ferlay","year":"2017","journal-title":"Biochimie"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/1471-0307.12359","article-title":"Natural Antioxidants in Milk and Dairy Products","volume":"70","author":"Hanna","year":"2017","journal-title":"Int. J. Dairy Technol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Ivanova, M. (2021). Conjugated linoleic acid-enriched dairy products: A review. J. Microbiol. Biotechnol. Food Sci., 10.","DOI":"10.15414\/jmbfs.3609"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Pipoyan, D., Stepanyan, S., Stepanyan, S., Beglaryan, M., Costantini, L., Molinari, R., and Merendino, N. (2021). The Effect of Trans Fatty Acids on Human Health: Regulation and Consumption Patterns. Foods, 10.","DOI":"10.3390\/foods10102452"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"113158","DOI":"10.1016\/j.foodres.2023.113158","article-title":"Conjugated Linoleic Acid (CLA) as a Functional Food: Is It Beneficial or Not?","volume":"172","author":"Badawy","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"175162","DOI":"10.1016\/j.ejphar.2022.175162","article-title":"The Effects of Conjugated Linoleic Acid Supplementation on Blood Pressure and Endothelial Function in Adults: A Systematic Review and Dose-Response Meta-Analysis","volume":"931","author":"Asbaghi","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12937-023-00876-3","article-title":"The Effects of Conjugated Linoleic Acid Supplementation on Glycemic Control, Adipokines, Cytokines, Malondialdehyde and Liver Function Enzymes in Patients at Risk of Cardiovascular Disease: A GRADE-Assessed Systematic Review and Dose\u2013Response Meta-Analysis","volume":"22","author":"Ghodoosi","year":"2023","journal-title":"Nutr. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/nutrit\/nuac060","article-title":"Effects of Conjugated Linoleic Acid and Exercise on Body Composition and Obesity: A Systematic Review and Meta-Analysis","volume":"81","author":"Liang","year":"2023","journal-title":"Nutr. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12944-015-0010-9","article-title":"Effect of Conjugated Linoleic Acid on Blood Pressure: A Meta-Analysis of Randomized, Double-Blind Placebo-Controlled Trials","volume":"14","author":"Yang","year":"2015","journal-title":"Lipids Health Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4081\/reumatismo.2016.870","article-title":"Guidelines for the Diagnosis, Prevention and Management of Osteoporosis","volume":"68","author":"Rossini","year":"2016","journal-title":"Reumatismo"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Polzonetti, V., Pucciarelli, S., Vincenzetti, S., and Polidori, P. (2020). Dietary Intake of Vitamin d from Dairy Products Reduces the Risk of Osteoporosis. Nutrients, 12.","DOI":"10.20944\/preprints202002.0465.v2"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-015-0062-x","article-title":"Effects of Dairy Products Consumption on Health: Benefits and Beliefs\u2014A Commentary from the Belgian Bone Club and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases","volume":"98","author":"Rozenberg","year":"2016","journal-title":"Calcif. Tissue Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1093\/advances\/nmy097","article-title":"Effects of Milk and Dairy Products on the Prevention of Osteoporosis and Osteoporotic Fractures in Europeans and Non-Hispanic Whites from North America: A Systematic Review and Updated Meta-Analysis","volume":"10","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Cruz-Pierard, S.M., Nestares, T., and Amaro-Gahete, F.J. (2022). Vitamin D and Calcium as Key Potential Factors Related to Colorectal Cancer Prevention and Treatment: A Systematic Review. Nutrients, 14.","DOI":"10.3390\/nu14224934"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1053\/j.gastro.2014.12.035","article-title":"Nutrients, Foods, and Colorectal Cancer Prevention","volume":"148","author":"Song","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10552-021-01512-3","article-title":"The Role of Calcium and Vitamin D Dietary Intake on Risk of Colorectal Cancer: Systematic Review and Meta-Analysis of Case\u2013Control Studies","volume":"33","author":"Molina","year":"2022","journal-title":"Cancer Causes Control"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"S190","DOI":"10.1093\/advances\/nmy114","article-title":"Association between Dairy Product Consumption and Colorectal Cancer Risk in Adults: A Systematic Review and Meta-Analysis of Epidemiologic Studies","volume":"10","author":"Babio","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bone.2008.02.022","article-title":"Impact of Dairy Products and Dietary Calcium on Bone-Mineral Content in Children: Results of a Meta-Analysis","volume":"43","author":"Huncharek","year":"2008","journal-title":"Bone"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1080\/10408398.2011.629353","article-title":"Colorectal Cancer and Nonfermented Milk, Solid Cheese, and Fermented Milk Consumption: A Systematic Review and Meta-Analysis of Prospective Studies","volume":"54","author":"Ralston","year":"2014","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.clinthera.2010.04.024","article-title":"Supplemental Calcium in the Chemoprevention of Colorectal Cancer: A Systematic Review and Meta-Analysis","volume":"32","author":"Carroll","year":"2010","journal-title":"Clin. Ther."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnu.2022.11.006","article-title":"Milk Consumption and Risk of Twelve Cancers: A Large-Scale Observational and Mendelian Randomization Study","volume":"42","author":"Lumsden","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.18520\/cs\/v118\/i9\/1375-1378","article-title":"Cow milk protein allergy and lactose intolerance","volume":"118","author":"Prasad","year":"2020","journal-title":"Curr. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e609","DOI":"10.1080\/10408398.2019.1590800","article-title":"Consumption of Milk and Dairy Products and Risk of Osteoporosis and Hip Fracture: A Systematic Review and Meta-Analysis","volume":"60","author":"Malmir","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Flom, J.D., and Sicherer, S.H. (2019). Epidemiology of Cow\u2019s Milk Allergy. Nutrients, 11.","DOI":"10.3390\/nu11051051"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.anai.2012.09.012","article-title":"The Prevalence and Characteristics of Food Allergy in Urban Minority Children","volume":"109","author":"Wang","year":"2012","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"104830","DOI":"10.1016\/j.tifs.2024.104830","article-title":"Recent Insights in Cow\u2019s Milk Protein Allergy: Clinical Relevance, Allergen Features, and Influences of Food Processing","volume":"156","author":"Zeng","year":"2025","journal-title":"Trends Food Sci. Technol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"100668","DOI":"10.1016\/j.waojou.2022.100668","article-title":"World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow\u2019s Milk Allergy (DRACMA) Guidelines Update\u2014III\u2014Cow\u2019s Milk Allergens and Mechanisms Triggering Immune Activation","volume":"15","author":"Jensen","year":"2022","journal-title":"World Allergy Organ. J."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Franco, C., Fente, C., S\u00e1nchez, C., Lamas, A., Cepeda, A., Leis, R., and Regal, P. (2022). Cow\u2019s Milk Antigens Content in Human Milk: A Scoping Review. Foods, 11.","DOI":"10.3390\/foods11121783"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Shkembi, B., and Huppertz, T. (2023). Glycemic Responses of Milk and Plant-Based Drinks: Food Matrix Effects. Foods, 12.","DOI":"10.3390\/foods12030453"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1017\/S0007114518000545","article-title":"Dairy Product Subgroups and Risk of Type 2 Diabetes","volume":"119","author":"Kawada","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00394-015-0855-8","article-title":"Dairy Product Consumption and Risk of Type 2 Diabetes in an Elderly Spanish Mediterranean Population at High Cardiovascular Risk","volume":"55","author":"Corella","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"14","DOI":"10.6065\/apem.2040074.037","article-title":"Dairy Consumption and Risk of Type-2 Diabetes: The Untold Story","volume":"26","author":"Gudi","year":"2021","journal-title":"Ann. Pediatr. Endocrinol. Metab."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1038\/ijo.2011.269","article-title":"Effect of Dairy Consumption on Weight and Body Composition in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials","volume":"36","author":"Abargouei","year":"2012","journal-title":"Int. J. Obes."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3945\/ajcn.112.037119","article-title":"Effects of Dairy Intake on Body Weight and Fat: A Meta-Analysis of Randomized Controlled Trials","volume":"96","author":"Chen","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1753-4887.2008.00032.x","article-title":"Dairy and Weight Loss Hypothesis: An Evaluation of the Clinical Trials","volume":"66","author":"Lanou","year":"2008","journal-title":"Nutr. Rev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/pubmed\/fdy064","article-title":"Association of Dairy Intake with Weight Change in Adolescents Undergoing Obesity Treatment","volume":"41","author":"Wrotniak","year":"2019","journal-title":"J. Public Health"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1017\/S002966511600001X","article-title":"New Perspectives on Dairy and Cardiovascular Health","volume":"75","author":"Lovegrove","year":"2016","journal-title":"Proc. Nutr. Soc."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3945\/an.112.002030","article-title":"Influence of Dairy Product and Milk Fat Consumption on Cardiovascular Disease Risk: A Review of the Evidence","volume":"3","author":"Huth","year":"2012","journal-title":"Adv. Nutr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41467-024-55585-0","article-title":"A Global Analysis of Dairy Consumption and Incident Cardiovascular Disease","volume":"16","author":"Zhuang","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"103772","DOI":"10.1016\/j.numecd.2024.10.010","article-title":"Milk and Yogurt Consumption and Its Association with Cardiometabolic Risk Factors in Patients with Type 2 Diabetes: The Fukuoka Diabetes Registry","volume":"35","author":"Yoshinari","year":"2025","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"386S","DOI":"10.3945\/ajcn.113.071597","article-title":"Meat, Dairy, and Cancer","volume":"100","author":"Abid","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"S212","DOI":"10.1093\/advances\/nmy119","article-title":"Milk and Dairy Product Consumption and Prostate Cancer Risk and Mortality: An Overview of Systematic Reviews and Meta-Analyses","volume":"10","author":"Bermejo","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/ajcn\/nqy037","article-title":"Calcium, Magnesium, and Whole-Milk Intakes and High-Aggressive Prostate Cancer in the North Carolina-Louisiana Prostate Cancer Project (PCaP)","volume":"107","author":"Steck","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s10552-019-01234-7","article-title":"Body Size and Dietary Risk Factors for Aggressive Prostate Cancer: A Case\u2013Control Study","volume":"30","author":"Pal","year":"2019","journal-title":"Cancer Causes Control"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1017\/S0007114522002380","article-title":"The Association between Dairy Products Consumption and Prostate Cancer Risk: A Systematic Review and Meta-Analysis","volume":"129","author":"Zhao","year":"2023","journal-title":"Br. J. Nutr."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1158\/0008-5472.CAN-15-1551","article-title":"A Meta-Analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk","volume":"76","author":"Travis","year":"2016","journal-title":"Cancer Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/aur.239","article-title":"Global Prevalence of Autism and Other Pervasive Developmental Disorders","volume":"5","author":"Elsabbagh","year":"2012","journal-title":"Autism Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/nutrit\/nuz092","article-title":"Nutritional Interventions for Autism Spectrum Disorder","volume":"78","author":"Karhu","year":"2020","journal-title":"Nutr. Rev."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Hartman, R.E., and Patel, D. (2020). Dietary Approaches to the Management of Autism Spectrum Disorders. Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management, Springer.","DOI":"10.1007\/978-3-030-30402-7_19"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s12519-018-0164-4","article-title":"Are Therapeutic Diets an Emerging Additional Choice in Autism Spectrum Disorder Management?","volume":"14","author":"Gogou","year":"2018","journal-title":"World J. Pediatr."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Sanctuary, M.R., Kain, J.N., Angkustsiri, K., and German, J.B. (2018). Dietary Considerations in Autism Spectrum Disorders: The Potential Role of Protein Digestion and Microbial Putrefaction in the Gut-Brain Axis. Front. Nutr., 5.","DOI":"10.3389\/fnut.2018.00040"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Rico, S., Mondrag\u00f3n, A.D.C., L\u00f3pez-Santamarina, A., Cardelle-Cobas, A., Regal, P., Lamas, A., Ibarra, I.S., Cepeda, A., and Miranda, J.M. (2022). A2 Milk: New Perspectives for Food Technology and Human Health. Foods, 11.","DOI":"10.3390\/foods11162387"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12937-016-0147-z","article-title":"Effects of Milk Containing Only A2 Beta Casein versus Milk Containing Both A1 and A2 Beta Casein Proteins on Gastrointestinal Physiology, Symptoms of Discomfort, and Cognitive Behavior of People with Self-Reported Intolerance to Traditional Cows\u2019 Milk","volume":"15","author":"Jianqin","year":"2015","journal-title":"Nutr. J."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/10408390591001144","article-title":"Health Implications of Milk Containing \u03b2-Casein with the A2 Genetic Variant","volume":"46","author":"Bell","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF03195213","article-title":"Polymorphism of Bovine Beta-Casein and Its Potential Effect on Human Health","volume":"48","author":"Kostyra","year":"2007","journal-title":"J. Appl. Genet."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.tifs.2017.05.007","article-title":"MiRNAs: The Hidden Bioactive Component of Milk","volume":"65","author":"Rani","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/1541-4337.12424","article-title":"Milk MicroRNAs in Health and Disease","volume":"18","author":"Benmoussa","year":"2019","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.3168\/jds.2014-9076","article-title":"Bovine Milk Exosomes Contain MicroRNA and MRNA and Are Taken up by Human Macrophages","volume":"98","author":"Izumi","year":"2015","journal-title":"J. Dairy Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-0034-1397344","article-title":"Overview of MicroRNA Biology","volume":"35","author":"Mohr","year":"2015","journal-title":"Semin. Liver Dis."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1139\/cjpp-2014-0392","article-title":"Gene Regulation by Dietary MicroRNAs","volume":"93","author":"Zempleni","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.3945\/jn.114.196436","article-title":"MicroRNAs Are Absorbed in Biologically Meaningful Amounts from Nutritionally Relevant Doses of Cow Milk and Affect Gene Expression in Peripheral Blood Mononuclear Cells, HEK-293 Kidney Cell Cultures, and Mouse Livers","volume":"144","author":"Baier","year":"2014","journal-title":"J. Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Herwijnen, M.J.C.v., Driedonks, T.A.P., Snoek, B.L., Kroon, A.M.T., Kleinjan, M., Jorritsma, R., Pieterse, C.M.J., Hoen, E.N.M.N., and Wauben, M.H.M. (2018). Abundantly Present MiRNAs in Milk-Derived Extracellular Vesicles Are Conserved Between Mammals. Front. Nutr., 5.","DOI":"10.3389\/fnut.2018.00081"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12263-017-0562-6","article-title":"Milk Exosomes: Beyond Dietary MicroRNAs","volume":"12","author":"Zempleni","year":"2017","journal-title":"Genes Nutr."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Alsaweed, M., Lai, C.T., Hartmann, P.E., Geddes, D.T., and Kakulas, F. (2016). Human Milk MiRNAs Primarily Originate from the Mammary Gland Resulting in Unique MiRNA Profiles of Fractionated Milk. Sci. Rep., 6.","DOI":"10.1038\/srep20680"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12986-017-0212-4","article-title":"Milk Disrupts P53 and DNMT1, the Guardians of the Genome: Implications for Acne Vulgaris and Prostate Cancer","volume":"14","author":"Melnik","year":"2017","journal-title":"Nutr. Metab."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12986-019-0412-1","article-title":"Milk Exosomal MiRNAs: Potential Drivers of AMPK-To-MTORC1 Switching in \u03b2-Cell de-Differentiation of Type 2 Diabetes Mellitus","volume":"16","author":"Melnik","year":"2019","journal-title":"Nutr. Metab."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s12192-018-0876-3","article-title":"Genome-Wide MicroRNA Profiling of Bovine Milk-Derived Exosomes Infected with Staphylococcus Aureus","volume":"23","author":"Cai","year":"2018","journal-title":"Cell Stress Chaperones"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.arr.2014.04.005","article-title":"MicroRNA Expression Altered by Diet: Can Food Be Medicinal?","volume":"17","author":"Palmer","year":"2014","journal-title":"Aging Res. Rev."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"14910","DOI":"10.1074\/jbc.C800074200","article-title":"The MiR-200 Family Inhibits Epithelial\u2013Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-Cadherin Transcriptional Repressors ZEB1 and ZEB2","volume":"283","author":"Korpal","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jaci.2016.04.039","article-title":"Milk: An Epigenetic Inducer of FoxP3 Expression","volume":"138","author":"Melnik","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3168\/jds.2019-16959","article-title":"Invited Review: MicroRNAs in Bovine Colostrum\u2014Focus on Their Origin and Potential Health Benefits for the Calf","volume":"103","author":"Goossens","year":"2020","journal-title":"J. Dairy Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3892\/or.2014.3036","article-title":"Diverse Roles of MiR-29 in Cancer (Review)","volume":"31","author":"Jiang","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1152\/physiolgenomics.00141.2011","article-title":"The MiR-29 Family: Genomics, Cell Biology, and Relevance to Renal and Cardiovascular Injury","volume":"44","author":"Kriegel","year":"2012","journal-title":"Physiol. Genom."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/hep.23380","article-title":"Effects of Microrna-29 on Apoptosis, Tumorigenicity, and Prognosis of Hepatocellular Carcinoma","volume":"51","author":"Xiong","year":"2010","journal-title":"Hepatology"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Lozano, C., Duroux-Richard, I., Firat, H., Schordan, E., and Apparailly, F. (2019). MicroRNAs: Key Regulators to Understand Osteoclast Differentiation?. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00375"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1002\/jcp.24306","article-title":"MiR-29b Negatively Regulates Human Osteoclastic Cell Differentiation and Function: Implications for the Treatment of Multiple Myeloma-Related Bone Disease","volume":"228","author":"Rossi","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s12967-015-0746-z","article-title":"Milk: An Epigenetic Amplifier of FTO-Mediated Transcription? Implications for Western Diseases","volume":"13","author":"Melnik","year":"2015","journal-title":"J. Transl. Med."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Walther, B., Guggisberg, D., Badertscher, R., Egger, L., Portmann, R., Dubois, S., Haldimann, M., Kopf-Bolanz, K., Rhyn, P., and Zoller, O. (2022). Comparison of Nutritional Composition between Plant-Based Drinks and Cow\u2019s Milk. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.988707"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1039\/D4FO00659C","article-title":"Milk Fat Globule Membrane and Their Polar Lipids: Reviewing Preclinical and Clinical Trials on Cognition","volume":"15","author":"Calvo","year":"2024","journal-title":"Food Funct."},{"key":"ref_146","unstructured":"Keenan, T.W., and Mather, I.H. (2009). Intracellular Origin of Milk Fat Globules and the Nature of the Milk Fat Globule Membrane. Advanced Dairy Chemistry, Springer."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"104786","DOI":"10.1016\/j.tifs.2024.104786","article-title":"The Compositions of Milk Fat Globule Membrane Determine the Interfacial Behavior, Digestive Properties, and Bioactivities: Natural Versus Processed Forms","volume":"154","author":"Ma","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.idairyj.2006.05.004","article-title":"Protein and Lipid Composition of Bovine Milk-Fat-Globule Membrane","volume":"17","author":"Fong","year":"2007","journal-title":"Int. Dairy J."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez, C., Franco, L., Regal, P., Lamas, A., Cepeda, A., and Fente, C. (2021). Breast Milk: A Source of Functional Compounds with Potential Application in Nutrition and Therapy. Nutrients, 13.","DOI":"10.3390\/nu13031026"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"113483","DOI":"10.1016\/j.jpeds.2023.113483","article-title":"Improved Neurodevelopmental Outcomes at 5.5 Years of Age in Children Who Received Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula Through 12 Months: A Randomized Controlled Trial","volume":"261","author":"Colombo","year":"2023","journal-title":"J. Pediatr."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jpeds.2019.08.030","article-title":"Improved Neurodevelopmental Outcomes Associated with Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula: A Randomized, Controlled Trial","volume":"215","author":"Li","year":"2019","journal-title":"J. Pediatr."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"105585","DOI":"10.1016\/j.jff.2023.105585","article-title":"The Effect of Supplementation with Milk Fat Globule Membranes on Psychological Health: A Randomized Clinical Trial in Healthy Adults with Moderate Stress","volume":"105","author":"Davies","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"105849","DOI":"10.1016\/j.jff.2023.105849","article-title":"Milk Fat Globule Membrane-Enriched Milk Improves Episodic Memory: A Randomized, Parallel, Double-Blind, Placebo-Controlled Trial in Older Adults","volume":"111","author":"Calvo","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Mondragon Portocarrero, A.D.C., Lopez-Santamarina, A., Lopez, P.R., Ortega, I.S.I., Duman, H., Karav, S., and Miranda, J.M. (2024). Substitutive Effects of Milk vs. Vegetable Milk on the Human Gut Microbiota and Implications for Human Health. Nutrients, 16.","DOI":"10.3390\/nu16183108"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jff.2018.05.038","article-title":"Milk Fat Globule Membrane Supplementation Modulates the Gut Microbiota and Attenuates Metabolic Endotoxemia in High-Fat Diet-Fed Mice","volume":"47","author":"Li","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Kosmerl, E., Rocha-Mendoza, D., Ortega-Anaya, J., Jim\u00e9nez-Flores, R., and Garc\u00eda-Cano, I. (2021). Improving Human Health with Milk Fat Globule Membrane, Lactic Acid Bacteria, and Bifidobacteria. 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