{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:33:15Z","timestamp":1775910795375,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting motor neurons in the brain and spinal cord, leading to muscle weakness, atrophy, and paralysis. Treatment focuses on symptom management, using medication, physiotherapy, and nutritional support. In this context, endoscopic gastrostomy (PEG) can provide adequate feeding, hopefully improving nutrition and preventing complications. Methods: We studied ALS patients undergoing PEG over three months post-procedure, using anthropometry ((BMI)\u2014body mass index; (MUAC)\u2014mid-upper arm circumference; (TSF)\u2014tricipital skinfold; (MAMC)\u2014mid-arm muscle circumference) and laboratory data (Albumin; Transferrin; total cholesterol and hemoglobin), evaluating survival, complications, and nutritional\/clinical status. Statistical analysis included Kaplan\u2013Meier survival estimation and Cox regression to assess nutritional markers associated with survival. Results: 150 ALS patients underwent gastrostomy, mostly older adults (mean age: 66.1 years; median: 67). Mean survival was 527 [95% CI: 432\u2013622] days, median 318 [95% CI: 236\u2013400]. ALS bulbar subtype, MUAC and MAMC positively impacted PEG-feeding survival time (p &lt; 0.05, Wald test). During the first three months of PEG feeding, each unit increase (cm) in MUAC and MAMC lowered death risk by 10% and 11%, respectively, highlighting the importance of nutrition care for survival. The bulbar subtype showed higher PEG feeding survival, with a 55.3% lower death hazard than the spinal subtype. There were no major PEG complications. Conclusions: ALS patients present a high risk of malnutrition. Patients that improved MAMC and MUAC in the first three PEG-fed months presented longer survival. Early PEG nutrition, even when some oral feeding is still possible, may reinforce the preventative role of enteral feeding in maintaining nutrition and potentially improving survival.<\/jats:p>","DOI":"10.3390\/nu17081292","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T05:59:00Z","timestamp":1744091940000},"page":"1292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nutrition and Survival of 150 Endoscopic Gastrostomy-Fed Patients with Amyotrophic Lateral Sclerosis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-6199","authenticated-orcid":false,"given":"Diogo","family":"Sousa-Catita","sequence":"first","affiliation":[{"name":"Aging Lab, Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, Caparica, 2829-511 Almada, Portugal"},{"name":"Resid\u00eancias Montepio, Servi\u00e7os de Sa\u00fade, SA.Rua Julieta Ferr\u00e3o N\u00b0 10\u20135\u00b0, 1600-131 Lisboa, Portugal"},{"name":"APELA\u2014Portuguese Association of Amyotrophic Lateral Sclerosis, 1900-221 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6584-1199","authenticated-orcid":false,"given":"Paulo","family":"Mascarenhas","sequence":"additional","affiliation":[{"name":"Aging Lab, Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, Caparica, 2829-511 Almada, Portugal"},{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, Caparica, 2829-511 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-124X","authenticated-orcid":false,"given":"C\u00e1tia","family":"Oliveira","sequence":"additional","affiliation":[{"name":"GENE\u2014Artificial NutritionTeam, Department of Gastroenterology Hospital Garcia de Orta, 2805-267 Almada, Portugal"}]},{"given":"Miguel","family":"Grunho","sequence":"additional","affiliation":[{"name":"Aging Lab, Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, Caparica, 2829-511 Almada, Portugal"},{"name":"Department of Neurology, Hospital Garcia de Orta, 2805-267 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-9107","authenticated-orcid":false,"given":"Carla A.","family":"Santos","sequence":"additional","affiliation":[{"name":"GENE\u2014Artificial NutritionTeam, Department of Gastroenterology Hospital Garcia de Orta, 2805-267 Almada, Portugal"}]},{"given":"Jo\u00e3o","family":"Cabrita","sequence":"additional","affiliation":[{"name":"APELA\u2014Portuguese Association of Amyotrophic Lateral Sclerosis, 1900-221 Lisboa, Portugal"}]},{"given":"Paula","family":"Correia","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital Garcia de Orta, 2805-267 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6477-7028","authenticated-orcid":false,"given":"Jorge","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Aging Lab, Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, Caparica, 2829-511 Almada, Portugal"},{"name":"GENE\u2014Artificial NutritionTeam, Department of Gastroenterology Hospital Garcia de Orta, 2805-267 Almada, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.clnu.2017.09.003","article-title":"ESPEN Guideline Clinical Nutrition in Neurology","volume":"37","author":"Burgos","year":"2018","journal-title":"Clin. 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