{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:34:43Z","timestamp":1760060083544,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006506","name":"Brazil\u2019s Ministry of Health","doi-asserted-by":"publisher","award":["TED 132\/2018"],"award-info":[{"award-number":["TED 132\/2018"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Health education plays a vital role in training health professionals and caregivers, supporting both prevention and the promotion of self-care. In this context, technology serves as a valuable ally by enabling continuous and flexible learning. Among the various domains of health education, nutrition stands out as a key element in the management of Amyotrophic Lateral Sclerosis (ALS), helping to prevent malnutrition and enhance patient well-being. Accordingly, this study aimed to evaluate the effectiveness of the teaching and learning processes within a learning pathway focused on food and nutrition in the context of ALS. Methods: This study adopted a longitudinal, quantitative design. The learning pathway, titled \u201cFood and Nutrition in ALS,\u201d consisted of four self-paced and self-instructional Massive Open Online Courses (MOOCs), offered through the Virtual Learning Environment of the Brazilian Health System (AVASUS). Participants included health professionals, caregivers, and patients from all five regions of Brazil. Participants had the autonomy to complete the courses in any order, with no prerequisites for enrollment. Results: Out of 14,263 participants enrolled nationwide, 182 were included in this study after signing the Informed Consent Form. Of these, 142 (78%) completed at least one course and participated in the educational intervention. A significant increase in knowledge was observed, with mean pre-test scores rising from 7.3 (SD = 1.8) to 9.6 (SD = 0.9) on the post-test across all courses (p &lt; 0.001). Conclusions: The self-instructional, technology-mediated continuing education model proved effective in improving participants\u2019 knowledge about nutrition in ALS. Future studies should explore knowledge retention, behavior change, and the impact of such interventions on clinical outcomes, especially in multidisciplinary care settings.<\/jats:p>","DOI":"10.3390\/nu17152562","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:25:11Z","timestamp":1754486711000},"page":"2562","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of a Learning Pathway on Food and Nutrition in Amyotrophic Lateral Sclerosis"],"prefix":"10.3390","volume":"17","author":[{"given":"Karla M\u00f4nica Dantas","family":"Coutinho","sequence":"first","affiliation":[{"name":"Health Sciences Graduate Program, Federal University of Rio Grande do Norte, Natal 59012-970, Brazil"},{"name":"Laboratory for Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2246-1073","authenticated-orcid":false,"given":"Humberto","family":"Rabelo","sequence":"additional","affiliation":[{"name":"Laboratory for Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"},{"name":"Center for Interdisciplinary Studies (CEIS20), University of Coimbra, 3000-457 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0805-1796","authenticated-orcid":false,"given":"Felipe","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laboratory for Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"},{"name":"Health Sciences Research Unit: Nursing (UICISA: E), Nursing School of Coimbra (ESEnfC), 3046-851 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2051-8611","authenticated-orcid":false,"given":"Karilany Dantas","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Laboratory for Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"},{"name":"Department of Biomedical Engineering, Federal University of Rio Grande do Norte, Natal 59078-900, Brazil"},{"name":"Health Innovation and Management Graduate Program, Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9216-8593","authenticated-orcid":false,"given":"Ricardo Alexsandro de Medeiros","family":"Valentim","sequence":"additional","affiliation":[{"name":"Laboratory for Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"},{"name":"Department of Biomedical Engineering, Federal University of Rio Grande do Norte, Natal 59078-900, Brazil"},{"name":"Health Innovation and Management Graduate Program, Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"}]},{"given":"Aline de Pinho","family":"Dias","sequence":"additional","affiliation":[{"name":"Laboratory for Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"},{"name":"Health Innovation and Management Graduate Program, Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8525-8155","authenticated-orcid":false,"given":"Jana\u00edna Luana Rodrigues da Silva","family":"Valentim","sequence":"additional","affiliation":[{"name":"Laboratory for Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-5298","authenticated-orcid":false,"given":"Natalia Ara\u00fajo do Nascimento","family":"Batista","sequence":"additional","affiliation":[{"name":"Laboratory for Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"},{"name":"Center for Global Studies (CEG), Universidade Aberta, 1269-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7943-2329","authenticated-orcid":false,"given":"Manoel Honorio","family":"Rom\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory for Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"}]},{"given":"Priscila Sanara da","family":"Cunha","sequence":"additional","affiliation":[{"name":"Laboratory for Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-8619","authenticated-orcid":false,"given":"Aliete","family":"Cunha-Oliveira","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Studies (CEIS20), University of Coimbra, 3000-457 Coimbra, Portugal"},{"name":"Health Sciences Research Unit: Nursing (UICISA: E), Nursing School of Coimbra (ESEnfC), 3046-851 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7506-1401","authenticated-orcid":false,"given":"Susana","family":"Henriques","sequence":"additional","affiliation":[{"name":"Center for Global Studies (CEG), Universidade Aberta, 1269-001 Lisbon, Portugal"}]},{"given":"Luciana Prot\u00e1sio","family":"de Melo","sequence":"additional","affiliation":[{"name":"Laboratory for Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-1678","authenticated-orcid":false,"given":"Sancha Helena de Lima","family":"Vale","sequence":"additional","affiliation":[{"name":"Health Sciences Graduate Program, Federal University of Rio Grande do Norte, Natal 59012-970, Brazil"},{"name":"Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-7048","authenticated-orcid":false,"given":"Lucia","family":"Leite-Lais","sequence":"additional","affiliation":[{"name":"Laboratory for Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"},{"name":"Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil"}]},{"given":"Kenio Costa","family":"de Lima","sequence":"additional","affiliation":[{"name":"Health Sciences Graduate Program, Federal University of Rio Grande do Norte, Natal 59012-970, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41582-023-00845-8","article-title":"Nutritional and Metabolic Factors in Amyotrophic Lateral Sclerosis","volume":"19","author":"Ludolph","year":"2023","journal-title":"Nat. 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