{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:39:05Z","timestamp":1761709145819,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"State of S\u00e3o Paulo Research Foundation- FAPESP","award":["2012\/17414-0"],"award-info":[{"award-number":["2012\/17414-0"]}]},{"name":"State of S\u00e3o Paulo Research Foundation-FAPESP","award":["2012\/16471-0"],"award-info":[{"award-number":["2012\/16471-0"]}]},{"name":"National Counsel of Technological and Scientific Development (CNPq)"},{"name":"\u201cPr\u00f3-reitoria de pesquisa\u201d (Prope-UNESP)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The aim of this study was to evaluate the effects of tomato supplementation on the normal rat heart and the role of oxidative stress in this scenario. Male Wistar rats were assigned to two groups: a control group (C; n = 16), in which animals received a control diet + 0.5 mL of corn oil\/kg body weight\/day, and a tomato group (T; n = 16), in which animals received a control diet supplemented with tomato +0.5 mL of corn oil\/kg body weight\/day. After three months, morphological, functional, and biochemical analyses were performed. Animals supplemented with tomato had a smaller left atrium diameter and myocyte cross-sectional area (CSA) compared to the control group (C group: 474 (415\u2013539); T group: 273 (258\u2013297) \u00b5m2; p = 0.004). Diastolic function was improved in rats supplemented with tomato. In addition, lipid hydroperoxide was lower (C group: 267 \u00b1 46.7; T group: 219 \u00b1 23.0 nmol\/g; p = 0.039) in the myocardium of rats supplemented with tomato. Tomato intake was also associated with up-regulation of miR-107 and miR-486 and down-regulation of miR-350 and miR-872. In conclusion, tomato supplementation induces changes in miRNA expression and reduces oxidative stress. In addition, these alterations may be responsible for CSA reduction and diastolic function improvement.<\/jats:p>","DOI":"10.3390\/nu7115493","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T01:57:02Z","timestamp":1448330222000},"page":"9640-9649","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Tomato (Lycopersicon esculentum) Supplementation Induces Changes in Cardiac miRNA Expression, Reduces Oxidative Stress and Left Ventricular Mass, and Improves Diastolic Function"],"prefix":"10.3390","volume":"7","author":[{"given":"Bruna","family":"Pereira","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Fernanda","family":"Arruda","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Patr\u00edcia","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Surgery and Orthopedics, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Tainara","family":"Felix","sequence":"additional","affiliation":[{"name":"Department of Surgery and Orthopedics, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Priscila","family":"Santos","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Bruna","family":"Rafacho","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Andrea","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Renan","family":"Claro","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Paula","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Bertha","family":"Polegato","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Katashi","family":"Okoshi","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Ana","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Chemistry and Biochemistry Department, Institute of Biosciences, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Sergio","family":"Paiva","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Leonardo","family":"Zornoff","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]},{"given":"Marcos","family":"Minicucci","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Botucatu Medical School, Univ Estadual Paulista (UNESP), Botucatu 18618-970, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2015,11,19]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization Cardiovascular Diseases. 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