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#311966"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","award":["491094227"],"award-info":[{"award-number":["491094227"]}]},{"name":"University of Veterinary Medicine Hannover, Foundation","award":["art. 185"],"award-info":[{"award-number":["art. 185"]}]},{"name":"University of Veterinary Medicine Hannover, Foundation","award":["6180-00001B"],"award-info":[{"award-number":["6180-00001B"]}]},{"name":"University of Veterinary Medicine Hannover, Foundation","award":["6180-00002B"],"award-info":[{"award-number":["6180-00002B"]}]},{"name":"University of Veterinary Medicine Hannover, Foundation","award":["FKZ 03F0767A"],"award-info":[{"award-number":["FKZ 03F0767A"]}]},{"name":"University of Veterinary Medicine Hannover, Foundation","award":["decision #311966"],"award-info":[{"award-number":["decision #311966"]}]},{"name":"University of Veterinary Medicine Hannover, Foundation","award":["491094227"],"award-info":[{"award-number":["491094227"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Antimicrobial-resistant bacteria pose a serious global health risk for humans and animals, while the role of wildlife in the dynamic transmission processes of antimicrobial resistance in environmental settings is still unclear. This study determines the occurrence of antimicrobial-resistant Escherichia coli in the free-living great cormorants (Phalacrocorax carbo) of the North and Baltic Sea coasts of Schleswig-Holstein, Germany. For this, resistant E.coli were isolated from cloacal or faecal swabs and their antimicrobial resistance pheno- and genotypes were investigated using disk diffusion tests and PCR assays. The isolates were further assigned to the four major phylogenetic groups, and their affiliation to avian pathogenic E. coli (APEC) was tested. Resistant E. coli were isolated from 66.7% of the 33 samples, and 48.9% of all the resistant isolates showed a multidrug resistance profile. No spatial differences were seen between the different sampling locations with regard to the occurrence of antimicrobial resistance or multidrug resistance. Most commonly, resistance percentages occurred against streptomycin, followed by tetracycline and sulfonamides. More than half of the isolates belonged to the phylogenetic group B1. Of all the isolates, 24.4% were classified as APEC isolates, of which almost 82% were identified as multidrug-resistant. These results add information on the dispersal of antimicrobial-resistant bacteria in wild birds in Germany, thereby allowing conclusions on the degree of environmental contamination and potential public health concerns.<\/jats:p>","DOI":"10.3390\/pathogens11080836","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T03:21:16Z","timestamp":1658978476000},"page":"836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High Rates of Multidrug-Resistant Escherichia coli in Great Cormorants (Phalacrocorax carbo) of the German Baltic and North Sea Coasts: Indication of Environmental Contamination and a Potential Public Health Risk"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7734-1466","authenticated-orcid":false,"given":"Stephanie","family":"Gross","sequence":"first","affiliation":[{"name":"Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hannover (TiHo) Foundation, 25761 B\u00fcsum, Germany"}]},{"given":"Anja","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute for Veterinary Food Science, Justus Liebig University Giessen, 35392 Giessen, Germany"}]},{"given":"Diana","family":"Seinige","sequence":"additional","affiliation":[{"name":"Office for Veterinary Affairs and Consumer Protection, Ministry of Lower Saxony for Food, Agriculture and Consumer Protection, 29221 Celle, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3910-1525","authenticated-orcid":false,"given":"Manuela","family":"Oliveira","sequence":"additional","affiliation":[{"name":"CIISA\u2014Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), Avenida da Universidade T\u00e9cnica, 1300-477 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2303-8533","authenticated-orcid":false,"given":"Dieter","family":"Steinhagen","sequence":"additional","affiliation":[{"name":"Fish Disease Research Unit, University of Veterinary Medicine Hannover, 30559 Hannover, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-3948","authenticated-orcid":false,"given":"Ursula","family":"Siebert","sequence":"additional","affiliation":[{"name":"Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hannover (TiHo) Foundation, 25761 B\u00fcsum, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8556-4080","authenticated-orcid":false,"given":"Corinna","family":"Kehrenberg","sequence":"additional","affiliation":[{"name":"Institute for Veterinary Food Science, Justus Liebig University Giessen, 35392 Giessen, Germany"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, May 05). Antimicrobial Resistance. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance."},{"key":"ref_2","unstructured":"Acar, J., Davies, J., and Buckley, M. (2009). Antibiotic Resistance: An Ecological Perspective on an Old Problem, American Society for Microbiology."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1111\/j.1462-2920.2009.01972.x","article-title":"The Role of Antibiotics and Antibiotic Resistance in Nature","volume":"11","author":"Aminov","year":"2009","journal-title":"Environ. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fmicb.2013.00047","article-title":"The Multifaceted Roles of Antibiotics and Antibiotic Resistance in Nature","volume":"4","author":"Sengupta","year":"2013","journal-title":"Front. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1473-3099(12)70317-1","article-title":"The Role of the Natural Environment in the Emergence of Antibiotic Resistance in Gram-Negative Bacteria","volume":"13","author":"Wellington","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11825","DOI":"10.1021\/acs.est.5b01888","article-title":"Fate of Extended-Spectrum \u03b2-Lactamase-Producing Escherichia coli from Faecal Sources in Surface Water and Probability of Human Exposure through Swimming","volume":"49","author":"Schijven","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.scitotenv.2019.03.428","article-title":"Hospital Effluent: A Reservoir for Carbapenemase-Producing Enterobacterales?","volume":"672","author":"Cahill","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Guenther, S., Aschenbrenner, K., Stamm, I., Bethe, A., Semmler, T., Stubbe, A., Stubbe, M., Batsajkhan, N., Glupczynski, Y., and Wieler, L.H. (2012). Comparable High Rates of Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli in Birds of Prey from Germany and Mongolia. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0053039"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0048-9697(98)00337-4","article-title":"Occurrence of Antibiotics in the Aquatic Environment","volume":"225","author":"Hirsch","year":"1999","journal-title":"Sci. Total Environ."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1021\/jf053041t","article-title":"Uptake of Veterinary Medicines from Soils into Plants","volume":"54","author":"Boxall","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1080\/09603123.2012.733934","article-title":"Occurrence of Antibiotics as Emerging Contaminant Substances in Aquatic Environment","volume":"23","author":"Miloradov","year":"2013","journal-title":"Int. J. Environ. Health Res."},{"key":"ref_12","first-page":"53","article-title":"Occurrence and fate of human pharmaceuticals in the environment","volume":"Volume 202","author":"Monteiro","year":"2010","journal-title":"Reviews of Environmental Contamination and Toxicology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fmicb.2014.00023","article-title":"Potential Impact of Antimicrobial Resistance in Wildlife, Environment and Human Health","volume":"5","author":"Radhouani","year":"2014","journal-title":"Front. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1126\/science.1149345","article-title":"A Global Map of Human Impact on Marine Ecosystems","volume":"319","author":"Halpern","year":"2008","journal-title":"Science"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"106466","DOI":"10.1016\/j.envint.2021.106466","article-title":"A Point Prevalence Survey of Antibiotic Resistance in the Irish Environment, 2018\u20132019","volume":"152","author":"Hooban","year":"2021","journal-title":"Environ. Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"30513","DOI":"10.2807\/1560-7917.ES.2017.22.15.30513","article-title":"Indistinguishable NDM-Producing Escherichia coli Isolated from Recreational Waters, Sewage, and a Clinical Specimen in Ireland, 2016 to 2017","volume":"22","author":"Mahon","year":"2017","journal-title":"Eurosurveillance"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Nappier, S.P., Liguori, K., Ichida, A.M., Stewart, J.R., and Jones, K.R. (2020). Antibiotic Resistance in Recreational Waters: State of the Science. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17218034"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"117711","DOI":"10.1016\/j.watres.2021.117711","article-title":"Evaluating the Potential for Exposure to Organisms of Public Health Concern in Naturally Occurring Bathing Waters in Europe: A Scoping Review","volume":"206","author":"Farrell","year":"2021","journal-title":"Water Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ecoenv.2013.01.016","article-title":"Detection and Fate of Antibiotic Resistant Bacteria in Wastewater Treatment Plants: A Review","volume":"91","author":"Bouki","year":"2013","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1007\/s11356-014-3474-7","article-title":"Antibiotic Resistance and Prevalence of Class 1 and 2 Integrons in Escherichia coli Isolated from Two Wastewater Treatment Plants, and Their Receiving Waters (Gulf of Gdansk, Baltic Sea, Poland)","volume":"22","author":"Kotlarska","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.2175\/106143007X183826","article-title":"The Effect of Wastewater Treatment on Antibiotic Resistance in Escherichia coli and Enterococcus sp","volume":"79","author":"Garcia","year":"2007","journal-title":"Water Environ. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1128\/AEM.01254-08","article-title":"Quantifying Nonspecific TEM \u03b2-Lactamase (BlaTEM) Genes in a Wastewater Stream","volume":"75","author":"Lachmayr","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2175\/106143008X304596","article-title":"Occurrence of Ciprofloxacin-, Trimethoprim-Sulfamethoxazole-, and Vancomycin-Resistant Bacteria in a Municipal Wastewater Treatment Plant","volume":"81","author":"Nagulapally","year":"2009","journal-title":"Water Environ. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1016\/j.scitotenv.2009.02.013","article-title":"Wastewater Treatment Contributes to Selective Increase of Antibiotic Resistance among Acinetobacter spp","volume":"407","author":"Zhang","year":"2009","journal-title":"Sci. Total Environ."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Quach-Cu, J., Herrera-Lynch, B., Marciniak, C., Adams, S., Simmerman, A., and Reinke, R. (2018). The Effect of Primary, Secondary, and Tertiary Wastewater Treatment Processes on Antibiotic Resistance Gene (ARG) Concentrations in Solid and Dissolved Wastewater Fractions. Water, 10.","DOI":"10.3390\/w10010037"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/j.1365-2672.2009.04515.x","article-title":"Methicillin-Resistant Staphylococcus aureus (MRSA) in Municipal Wastewater: An Uncharted Threat?","volume":"108","author":"Matussek","year":"2010","journal-title":"J. Appl. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fmicb.2012.00106","article-title":"Increased Levels of Multiresistant Bacteria and Resistance Genes after Wastewater Treatment and Their Dissemination into Lake Geneva, Switzerland","volume":"3","author":"Czekalski","year":"2012","journal-title":"Front. Microbiol."},{"key":"ref_28","first-page":"173","article-title":"Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer","volume":"7","author":"Penders","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e25950","DOI":"10.7554\/eLife.25950","article-title":"Inter-Species Population Dynamics Enhance Microbial Horizontal Gene Transfer and Spread of Antibiotic Resistance","volume":"6","author":"Cooper","year":"2017","journal-title":"Elife"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"115880","DOI":"10.1016\/j.watres.2020.115880","article-title":"The Role of the Natural Aquatic Environment in the Dissemination of Extended Spectrum Beta-Lactamase and Carbapenemase Encoding Genes: A Scoping Review","volume":"180","author":"Hooban","year":"2020","journal-title":"Water Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1139\/w05-028","article-title":"Occurrence of Antibiotic Resistance in Escherichia coli from Surface Waters and Fecal Pollution Sources near Hamilton, Ontario","volume":"51","author":"Edge","year":"2005","journal-title":"Can. J. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Yuan, Y., Liang, B., Jiang, B., Zhu, L., Wang, T., Li, Y., Liu, J., Guo, X., Ji, X., and Sun, Y. (2021). Migratory Wild Birds Carrying Multidrug-Resistant Escherichia coli as Potential Transmitters of Antimicrobial Resistance in China. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0261444"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e00839","DOI":"10.1002\/mbo3.839","article-title":"A Survey of Antimicrobial Resistance in Enterobacteriaceae Isolated from the Chesapeake Bay and Adjacent Upper Tributaries","volume":"8","author":"Riedel","year":"2019","journal-title":"MicrobiologyOpen"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrmicro818","article-title":"Pathogenic Escherichia coli","volume":"2","author":"Kaper","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fmicb.2013.00258","article-title":"Multidrug Resistant Commensal Escherichia coli in Animals and Its Impact for Public Health","volume":"4","author":"Szmolka","year":"2013","journal-title":"Front. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1128\/microbiolspec.ARBA-0026-2017","article-title":"Antimicrobial Resistance in Escherichia coli","volume":"6","author":"Poirel","year":"2018","journal-title":"Microbiol. Spectr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/ismej.2010.80","article-title":"Survival of Escherichia coli in the Environment: Fundamental and Public Health Aspects","volume":"5","author":"Semenov","year":"2011","journal-title":"ISME J."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Marcelino, V.R., Wille, M., Hurt, A.C., Gonz\u00e1lez-Acu\u00f1a, D., Klaassen, M., Schlub, T.E., Eden, J.-S., Shi, M., Iredell, J.R., and Sorrell, T.C. (2019). Meta-Transcriptomics Reveals a Diverse Antibiotic Resistance Gene Pool in Avian Microbiomes. BMC Biol., 17.","DOI":"10.1186\/s12915-019-0649-1"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fmicb.2011.00246","article-title":"Extended-Spectrum Beta-Lactamases Producing E. coli in Wildlife, yet Another Form of Environmental Pollution?","volume":"2","author":"Guenther","year":"2011","journal-title":"Front. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Khan, M.M., Kolenda, R., Schierack, P., Weinreich, J., R\u00f6diger, S., Schierack, J., Stubbe, M., Lkhagvasuren, D., Guenther, S., and Schaufler, K. (2021). Investigation of Commensal Escherichia coli Populations of Cormorant Hatchlings in the Absence of Anthropogenic Impacts in Remote Areas of West Mongolia. Microorganisms, 9.","DOI":"10.3390\/microorganisms9020372"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"139758","DOI":"10.1016\/j.scitotenv.2020.139758","article-title":"Migratory Birds-One Major Source of Environmental Antibiotic Resistance around Qinghai Lake, China","volume":"739","author":"Lin","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e00519-18","DOI":"10.1128\/AAC.00519-18","article-title":"Extensive Genetic Commonality among Wildlife, Wastewater, Community, and Nosocomial Isolates of Escherichia coli Sequence Type 131 (H 30R1 and H 30Rx Subclones) That Carry Bla CTX-M-27 or Bla CTX-M-15","volume":"62","author":"Jamborova","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1289\/ehp.1206316","article-title":"Human Health Risk Assessment (HHRA) for Environmental Development and Transfer of Antibiotic Resistance","volume":"121","author":"Ashbolt","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.vetmic.2009.12.016","article-title":"Antimicrobial Resistance Profiles of Escherichia coli from Common European Wild Bird Species","volume":"144","author":"Guenther","year":"2010","journal-title":"Vet. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1128\/AEM.00861-15","article-title":"Genetic Structure and Antimicrobial Resistance of Escherichia coli and Cryptic Clades in Birds with Diverse Human Associations","volume":"81","author":"Blyton","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1089\/vbz.2015.1935","article-title":"Virulence Genes and the Antimicrobial Susceptibility of Escherichia coli, Isolated from Wild Waterbirds, in The Netherlands and Poland","volume":"16","author":"Kuczkowski","year":"2016","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"656223","DOI":"10.3389\/fmicb.2021.656223","article-title":"Antimicrobial Resistance Glides in the Sky\u2014Free-Living Birds as a Reservoir of Resistant Escherichia coli With Zoonotic Potential","volume":"12","author":"Bomba","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_48","first-page":"4","article-title":"The Great Cormorant (Phalacrocorax Carbo) at Lower Lake Constance\/Germany: Dietary Composition and Impact on Commercial Fisheries","volume":"414","year":"2014","journal-title":"Knowl. Manag. Aquat. Ecosyst."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1080\/11250003.2015.1093661","article-title":"Selective Predators or Choosy Fishermen? Relation between Fish Harvest, Prey Availability and Great Cormorant (Phalacrocorax carbo sinensis) Diet","volume":"82","author":"Gagliardi","year":"2015","journal-title":"Ital. J. Zool."},{"key":"ref_50","first-page":"61","article-title":"Temporal Changes in the Diet of Great Cormorant (Phalacrocorax carbo sinensis) on the Southern Coast of Finland\u2014Comparison with Available Fish Data","volume":"16","author":"Lehikoinen","year":"2011","journal-title":"Boreal Environ. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.seares.2012.06.012","article-title":"Natural Born Indicators: Great Cormorant Phalacrocorax carbo (Aves: Phalacrocoracidae) as Monitors of River Discharge Influence on Estuarine Ichthyofauna","volume":"73","author":"Dias","year":"2012","journal-title":"J. Sea Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1093\/jac\/dks017","article-title":"Escherichia coli with Extended-Spectrum -Lactamase and Plasmid-Mediated Quinolone Resistance Genes in Great Cormorants and Mallards in Central Europe","volume":"67","author":"Tausova","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1292\/jvms.21-0108","article-title":"Prevalence of Antimicrobial Resistance in Bacteria Isolated from Great Cormorants (Phalacrocorax carbo hanedae) in Japan","volume":"83","author":"Odoi","year":"2021","journal-title":"J. Vet. Med. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ijantimicag.2012.11.005","article-title":"Higher-Generation Cephalosporin-Resistant Escherichia coli in Feral Birds in Switzerland","volume":"41","author":"Zurfluh","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/00063659709461062","article-title":"Seasonal Distribution and Timing of Migration of Cormorants Phalacrocorax carbo sinensis Breeding in Denmark","volume":"44","author":"Bregnballe","year":"1997","journal-title":"Bird Study"},{"key":"ref_56","first-page":"619","article-title":"Effects of Distance to Wintering Area on Arrival Date and Breeding Performance in Great Cormorants Phalacrocorax carbo","volume":"94","author":"Bregnballe","year":"2006","journal-title":"Ardea"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1128\/JCM.01468-12","article-title":"Improved Multiplex PCR Strategy for Rapid Assignment of the Four Major Escherichia coli Phylogenetic Groups","volume":"50","author":"Doumith","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"ref_58","unstructured":"(2018). CLSI Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals (Standard No. CLSI Standard VET01)."},{"key":"ref_59","unstructured":"(2020). CLSI Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals (Standard No. CLSI Supplement VET01S)."},{"key":"ref_60","unstructured":"(2022). CLSI Performance Standards for Antimicrobial Susceptibility Testing (Standard No. CLSI Supplement M100)."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13099-018-0268-3","article-title":"Characterization of Salmonella enterica Serovars Recovered from Meat Products Legally and Illegally Imported into the EU Reveals the Presence of Multiresistant and AmpC-Producing Isolates","volume":"10","author":"Jansen","year":"2018","journal-title":"Gut Pathog."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/jac\/dkh376","article-title":"Effect of Triclosan or a Phenolic Farm Disinfectant on the Selection of Antibiotic-Resistant Salmonella enterica","volume":"54","author":"Randall","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1574-6968.2001.tb10962.x","article-title":"Occurrence and Linkage of Genes Coding for Resistance to Sulfonamides, Streptomycin and Chloramphenicol in Bacteria of the Genera Pasteurella and Mannheimia","volume":"205","author":"Kehrenberg","year":"2001","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0378-1135(02)00263-8","article-title":"Antimicrobial Resistance and Resistance Gene Determinants in Clinical Escherichia coli from Different Animal Species in Switzerland","volume":"91","author":"Lanz","year":"2003","journal-title":"Vet. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0378-1135(00)00197-8","article-title":"Antimicrobial Susceptibility and Presence of Resistance Genes in Staphylococci from Poultry","volume":"74","author":"Aarestrup","year":"2000","journal-title":"Vet. Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","article-title":"Emergence of Plasmid-Mediated Colistin Resistance Mechanism MCR-1 in Animals and Human Beings in China: A Microbiological and Molecular Biological Study","volume":"16","author":"Liu","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"17-00672","DOI":"10.2807\/1560-7917.ES.2018.23.6.17-00672","article-title":"Multiplex PCR for Detection of Plasmid-Mediated Colistin Resistance Determinants, Mcr-1, Mcr-2, Mcr-3, Mcr-4 and Mcr-5 for Surveillance Purposes","volume":"23","author":"Rebelo","year":"2018","journal-title":"Eurosurveillance"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fmicb.2020.00080","article-title":"Development of a Novel Mcr-6 to Mcr-9 Multiplex PCR and Assessment of Mcr-1 to Mcr-9 Occurrence in Colistin-Resistant Salmonella enterica Isolates from Environment, Feed, Animals and Food (2011\u20132018) in Germany","volume":"11","author":"Borowiak","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1128\/AEM.66.10.4555-4558.2000","article-title":"Rapid and Simple Determination of the Escherichia coli Phylogenetic Group","volume":"66","author":"Clermont","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1128\/JCM.00816-08","article-title":"Identification of Minimal Predictors of Avian Pathogenic Escherichia coli Virulence for Use as a Rapid Diagnostic Tool","volume":"46","author":"Johnson","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1089\/fpd.2006.3.59","article-title":"Standardization of Pulsed-Field Gel Electrophoresis Protocols for the Subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet","volume":"3","author":"Ribot","year":"2006","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0147-9571(04)00059-1","article-title":"Bacterial Flora of Free-Living Double-Crested Cormorant (Phalacrocorax auritus) Chicks on Prince Edward Island, Canada, with Reference to Enteric Bacteria and Antibiotic Resistance","volume":"28","author":"Dobbin","year":"2005","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Nowaczek, A., Dec, M., St\u0119pie\u0144-Py\u015bniak, D., Urban-Chmiel, R., Marek, A., and R\u00f3\u017ca\u0144ski, P. (2021). Antibiotic Resistance and Virulence Profiles of Escherichia coli Strains Isolated from Wild Birds in Poland. Pathogens, 10.","DOI":"10.3390\/pathogens10081059"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1136\/vr.165.5.138","article-title":"Antimicrobial Resistance and Phylogenetic Groups in Isolates of Escherichia coli from Seagulls at the Berlengas Nature Reserve","volume":"165","author":"Radhouani","year":"2009","journal-title":"Vet. Rec."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3201\/eid2005.130325","article-title":"Extended-Spectrum \u03b2-Lactamases in Escherichia coli and Klebsiella pneumoniae in Gulls, Alaska, USA","volume":"20","author":"Bonnedahl","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/03079457.2014.897683","article-title":"Virulence Genes, Antibiotic Resistance and Integrons in Escherichia coli Strains Isolated from Synanthropic Birds from Spain","volume":"43","author":"Iglesias","year":"2014","journal-title":"Avian Pathol."},{"key":"ref_77","first-page":"21565","article-title":"Antibiotic Resistance Patterns in Escherichia coli from Gulls in Nine European Countries","volume":"4","author":"Stedt","year":"2014","journal-title":"Infect. Ecol. Epidemiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2672.2006.03241.x","article-title":"High Prevalence of Antimicrobial-Resistant Genes and Integrons in Escherichia coli Isolates from Black-Headed Gulls in the Czech Republic","volume":"103","author":"Dolejska","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"8126","DOI":"10.1128\/AEM.01446-10","article-title":"Antibiotic-Resistant Escherichia coli Bacteria, Including Strains with Genes Encoding the Extended-Spectrum Beta-Lactamase and QnrS, in Waterbirds on the Baltic Sea Coast of Poland","volume":"76","author":"Literak","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"482","DOI":"10.7589\/2018-05-139","article-title":"Multidrug-Resistant Escherichia coli and Tetracycline-Resistant Enterococcus faecalis in Wild Raptors of Alabama and Georgia, USA","volume":"55","author":"Hathcock","year":"2019","journal-title":"J. Wildl. Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s10393-017-1302-5","article-title":"Antibiotic-Resistant Escherichia coli in Migratory Birds Inhabiting Remote Alaska","volume":"15","author":"Ramey","year":"2018","journal-title":"Ecohealth"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3201\/eid1106.040717","article-title":"Free-Living Canada Geese and Antimicrobiai Resistance","volume":"11","author":"Cole","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"ref_83","first-page":"32334","article-title":"Increased Prevalence of Antibiotic-Resistant E. coli in Gulls Sampled in Southcentral Alaska Is Associated with Urban Environments","volume":"6","author":"Atterby","year":"2016","journal-title":"Infect. Ecol. Epidemiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/jac\/dkl122","article-title":"Effect of Human Vicinity on Antimicrobial Resistance and Integrons in Animal Faecal Escherichia coli","volume":"57","author":"Skurnik","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ijheh.2019.09.008","article-title":"Thinking Outside the Box: Association of Antimicrobial Resistance with Climate Warming in Europe\u2014A 30 Country Observational Study","volume":"223","author":"Kaba","year":"2020","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-Resistant, Extensively Drug-Resistant and Pandrug-Resistant Bacteria: An International Expert Proposal for Interim Standard Definitions for Acquired Resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_87","unstructured":"Schleswig-Holstein (2022, May 27). Schleswig-Holstein\u2014Zahlen Zur Bev\u00f6lkerung. Available online: https:\/\/www.schleswig-holstein.de\/DE\/LandLeute\/ZahlenFakten\/_documents\/bevoelkerung.html."},{"key":"ref_88","unstructured":"World Health Organization (2021). WHO Access, Watch, Reserve (AWaRe) Classification of Antibiotics for Evaluation and Monitoring of Use. 2021. Geneva: World Health Organization, WHO. (WHO\/MHP\/HPS\/EML\/2021.04); License: CC BY-NC-SA 3.0 IGO."},{"key":"ref_89","unstructured":"Bundesamt f\u00fcr Verbraucherschutz und Lebensmittelsicherheit (2016). Paul-Ehrlich-Gesellschaft f\u00fcr Chemotherapie e.V. GERMAP 2015\u2014Bericht \u00dcber Den Antibiotikaverbrauch Und Die Verbreitung von Antibiotikaresistenzen in Der Human- Und Veterin\u00e4rmedizin in Deutschland, Antiinfectives Intelligence."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1758-2229.2010.00148.x","article-title":"CTX-M-15-Type Extended-Spectrum Beta-Lactamases-Producing Escherichia coli from Wild Birds in Germany","volume":"2","author":"Guenther","year":"2010","journal-title":"Environ. Microbiol. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drup.2010.08.003","article-title":"Aminoglycoside Modifying Enzymes","volume":"13","author":"Ramirez","year":"2010","journal-title":"Drug Resist. Updat."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/nyas.12830","article-title":"Mechanisms of Drug Resistance: Quinolone Resistance","volume":"1354","author":"Hooper","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1099\/jmm.0.000551","article-title":"High Frequency of the Combined Presence of QRDR Mutations and PMQR Determinants in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli Isolates from Nosocomial and Community-Acquired Infections","volume":"66","author":"Royer","year":"2017","journal-title":"J. Med. Microbiol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Kotb, D.N., Mahdy, W.K., Mahmoud, M.S., and Khairy, R.M.M. (2019). Impact of Co-Existence of PMQR Genes and QRDR Mutations on Fluoroquinolones Resistance in Enterobacteriaceae Strains Isolated from Community and Hospital Acquired UTIs. BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-4606-y"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2147\/IDR.S199844","article-title":"Molecular Mechanisms Related to Colistin Resistance in Enterobacteriaceae","volume":"12","author":"Aghapour","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Blanco, P., Hernando-Amado, S., Reales-Calderon, J., Corona, F., Lira, F., Alcalde-Rico, M., Bernardini, A., Sanchez, M., and Martinez, J. (2016). Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants. Microorganisms, 4.","DOI":"10.3390\/microorganisms4010014"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jac\/dkg050","article-title":"The Importance of Efflux Pumps in Bacterial Antibiotic Resistance","volume":"51","author":"Webber","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1086\/514217","article-title":"Phylogenetic Analysis of Escherichia coli Strains Causing Neonatal Meningitis Suggests Horizontal Gene Transfer from a Predominant Pool of Highly Virulent B2 Group Strains","volume":"177","author":"Bingen","year":"1998","journal-title":"J. Infect. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1128\/JB.180.5.1159-1165.1998","article-title":"Chromosomal Regions Specific to Pathogenic Isolates of Escherichia coli Have a Phylogenetically Clustered Distribution","volume":"180","author":"Boyd","year":"1998","journal-title":"J. Bacteriol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1128\/IAI.67.2.546-553.1999","article-title":"The Link between Phylogeny and Virulence in Escherichia coli Extraintestinal Infection","volume":"67","author":"Picard","year":"1999","journal-title":"Infect. Immun."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1093\/molbev\/msm172","article-title":"Extraintestinal Virulence Is a Coincidental By-Product of Commensalism in B2 Phylogenetic Group Escherichia coli Strains","volume":"24","author":"Clermont","year":"2007","journal-title":"Mol. Biol. Evol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1099\/jmm.0.038364-0","article-title":"Wild Birds as Biological Indicators of Environmental Pollution: Antimicrobial Resistance Patterns of Escherichia coli and Enterococci Isolated from Common Buzzards (Buteo buteo)","volume":"61","author":"Radhouani","year":"2012","journal-title":"J. Med. Microbiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1128\/AEM.00275-07","article-title":"Relationship between Phylogenetic Groups, Genotypic Clusters, and Virulence Gene Profiles of Escherichia coli Strains from Diverse Human and Animal Sources","volume":"73","author":"Ishii","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mimet.2007.04.009","article-title":"Genotyping of Escherichia coli from Environmental and Animal Samples","volume":"70","author":"Higgins","year":"2007","journal-title":"J. Microbiol. 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