{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:22:58Z","timestamp":1769761378132,"version":"3.49.0"},"reference-count":70,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"LEAP-Agri (A Long-term EU-Africa Research and Innovation Partnership on Food and Innovation on Food and Nutrition Security and Sustainable Agriculture)","award":["220-MeTVAC"],"award-info":[{"award-number":["220-MeTVAC"]}]},{"name":"LEAP-Agri (A Long-term EU-Africa Research and Innovation Partnership on Food and Innovation on Food and Nutrition Security and Sustainable Agriculture)","award":["LEAPAgri\/0005\/2017"],"award-info":[{"award-number":["LEAPAgri\/0005\/2017"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, Portugal","doi-asserted-by":"publisher","award":["220-MeTVAC"],"award-info":[{"award-number":["220-MeTVAC"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, Portugal","doi-asserted-by":"publisher","award":["LEAPAgri\/0005\/2017"],"award-info":[{"award-number":["LEAPAgri\/0005\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The control of Tropical Theileriosis, a tick-borne disease with a strong impact on cattle breeding, can be facilitated using marker-assisted selection in breeding programs. Genome-wide association studies (GWAS) using high-density arrays are extremely important for the ongoing process of identifying genomic variants associated with resistance to Theileria annulata infection. In this work, single-nucleotide polymorphisms (SNPs) were analyzed in the Portuguese autochthonous cattle breeds Alentejana and Mertolenga. In total, 24 SNPs suggestive of significance (p \u2264 10\u22124) were identified for Alentejana cattle and 20 SNPs were identified for Mertolenga cattle. The genomic regions around these SNPs were further investigated for annotated genes and quantitative trait loci (QTLs) previously described by other authors. Regarding the Alentejana breed, the MAP3K1, CMTM7, SSFA2, and ATG13 genes are located near suggestive SNPs and appear as candidate genes for resistance to Tropical Theileriosis, considering its action in the immune response and resistance to other diseases. On the other hand, in the Mertolenga breed, the UOX gene is also a candidate gene due to its apparent link to the pathogenesis of the disease. These results may represent a first step toward the possibility of including genetic markers for resistance to Tropical Theileriosis in current breed selection programs.<\/jats:p>","DOI":"10.3390\/pathogens13010071","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T03:54:34Z","timestamp":1705031674000},"page":"71","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Genome-Wide Association Study for Resistance to Tropical Theileriosis in Two Bovine Portuguese Autochthonous Breeds"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9253-1508","authenticated-orcid":false,"given":"Diana","family":"Valente","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Vasco da Gama, Escola Universit\u00e1ria Vasco da Gama, 3020-210 Coimbra, Portugal"},{"name":"Escola de Ci\u00eancias Agr\u00e1rias e Veterin\u00e1rias, Universidade de Tr\u00e1s-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"},{"name":"Centro de Ci\u00eancia Animal e Veterin\u00e1ria, Universidade de Tr\u00e1s-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1370-6614","authenticated-orcid":false,"given":"Oct\u00e1vio","family":"Serra","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investiga\u00e7\u00e3o Agr\u00e1ria e Veterin\u00e1ria, I.P., Banco Portugu\u00eas de Germoplasma Vegetal, Quinta de S. Jos\u00e9, S. Pedro de Merelim, 4700-859 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9079-7380","authenticated-orcid":false,"given":"Nuno","family":"Carolino","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Vasco da Gama, Escola Universit\u00e1ria Vasco da Gama, 3020-210 Coimbra, Portugal"},{"name":"Instituto Nacional de Investiga\u00e7\u00e3o Agr\u00e1ria e Veterin\u00e1ria, Polo de Inova\u00e7\u00e3o da Fonte Boa\u2014Esta\u00e7\u00e3o Zoot\u00e9cnica Nacional, 2005-424 Santar\u00e9m, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, 1300-477 Lisboa, Portugal"},{"name":"Laborat\u00f3rio Associado para a Ci\u00eancia Animal e Veterin\u00e1ria, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, 1300-477 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-8335","authenticated-orcid":false,"given":"Jacinto","family":"Gomes","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, 1300-477 Lisboa, Portugal"},{"name":"Laborat\u00f3rio Associado para a Ci\u00eancia Animal e Veterin\u00e1ria, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, 1300-477 Lisboa, Portugal"},{"name":"Escola Superior Agr\u00e1ria de Elvas, Instituto Polit\u00e9cnico de Portalegre, 7350-092 Elvas, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7196-4179","authenticated-orcid":false,"given":"Ana Cl\u00e1udia","family":"Coelho","sequence":"additional","affiliation":[{"name":"Escola de Ci\u00eancias Agr\u00e1rias e Veterin\u00e1rias, Universidade de Tr\u00e1s-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"},{"name":"Centro de Ci\u00eancia Animal e Veterin\u00e1ria, Universidade de Tr\u00e1s-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal"},{"name":"Laborat\u00f3rio Associado para a Ci\u00eancia Animal e Veterin\u00e1ria, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa, 1300-477 Lisboa, Portugal"}]},{"given":"Pedro","family":"Espadinha","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o de Criadores de Bovinos da Ra\u00e7a Alentejana, Monforte Herdade da Coutada Real-Assumar, 7450-051 Assumar, Portugal"}]},{"given":"Jos\u00e9","family":"Pais","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o de Criadores de Bovinos Mertolengos, 7006-806 \u00c9vora, Portugal"}]},{"given":"In\u00eas","family":"Carolino","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Vasco da Gama, Escola Universit\u00e1ria Vasco da Gama, 3020-210 Coimbra, Portugal"},{"name":"Instituto Nacional de Investiga\u00e7\u00e3o Agr\u00e1ria e Veterin\u00e1ria, Polo de Inova\u00e7\u00e3o da Fonte Boa\u2014Esta\u00e7\u00e3o Zoot\u00e9cnica Nacional, 2005-424 Santar\u00e9m, Portugal"},{"name":"Instituto Superior de Agronomia, Universidade de Lisboa, 1349-017 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/tbed.13312","article-title":"Current status of tropical theileriosis in Northern Africa: A review of recent epidemiological investigations and implications for control","volume":"67","author":"Gharbi","year":"2020","journal-title":"Transbound. 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