{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:48:41Z","timestamp":1773737321556,"version":"3.50.1"},"reference-count":77,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Portuguese Foundation for Science and Technology (FCT)","doi-asserted-by":"publisher","award":["UIDB\/00772\/2020"],"award-info":[{"award-number":["UIDB\/00772\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese Foundation for Science and Technology (FCT)","doi-asserted-by":"publisher","award":["LA\/P\/0059\/2020"],"award-info":[{"award-number":["LA\/P\/0059\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>A cross-sectional study was conducted to gain insight into the epidemiology of canine ehrlichiosis and rickettsiosis in northern Portugal. Specific IgG antibodies to Ehrlichia canis were analysed using a commercial enzyme-linked immunosorbent assay (ELISA), and antibodies to Rickettsia conorii were analysed using a commercial indirect immunofluorescence antibody test (IFAT). A total of 113 dogs from two different shelters were sampled, and seroprevalence values of 0.9% (95% confidence (CI): 0.2\u20134.8%) for E. canis and 9.7 (95% CI: 5.5\u201316.6%) for R. conorii were found. Multiple logistic regression investigated risk factors for seropositivity. The odds ratios (ORs) of R. conorii seropositivity were higher for female dogs (OR = 6.429; 95% CI: 1.201\u201334.407). Dogs seropositive for co-infection (E. canis + R. conorii) were more frequently observed among females (OR = 7.606; CI 95%: 1.478\u201339.132) and in Shelter 2 (OR = 18.229; 95% CI: 2.190\u2013151.756). These findings show that shelter dogs in northern Portugal are exposed to E. canis and R. conorii, which can affect both canines and humans. It is imperative to adopt a One Health approach to educate the public about the hazards of canine zoonoses and develop legislation and procedures to control their spread and preserve public health.<\/jats:p>","DOI":"10.3390\/pathogens13020129","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:57:07Z","timestamp":1706504227000},"page":"129","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Ehrlichia canis and Rickettsia conorii Infections in Shelter Dogs: Seropositivity and Implications for Public Health"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6390-0194","authenticated-orcid":false,"given":"Paulo","family":"Afonso","sequence":"first","affiliation":[{"name":"CECAV\u2014Animal and Veterinary Research Centre, University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 5000-801 Vila Real, Portugal"},{"name":"Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-5674","authenticated-orcid":false,"given":"Ana Patr\u00edcia","family":"Lopes","sequence":"additional","affiliation":[{"name":"CECAV\u2014Animal and Veterinary Research Centre, University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 5000-801 Vila Real, Portugal"},{"name":"Department of Veterinary Sciences, University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-1669","authenticated-orcid":false,"given":"H\u00e9lder","family":"Quintas","sequence":"additional","affiliation":[{"name":"Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-7560","authenticated-orcid":false,"given":"Lu\u00eds","family":"Cardoso","sequence":"additional","affiliation":[{"name":"CECAV\u2014Animal and Veterinary Research Centre, University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 5000-801 Vila Real, Portugal"},{"name":"Department of Veterinary Sciences, University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7196-4179","authenticated-orcid":false,"given":"Ana Cl\u00e1udia","family":"Coelho","sequence":"additional","affiliation":[{"name":"CECAV\u2014Animal and Veterinary Research Centre, University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 5000-801 Vila Real, Portugal"},{"name":"Department of Veterinary Sciences, University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.vetpar.2009.03.028","article-title":"Emerging arthropod-borne diseases of companion animals in Europe","volume":"163","author":"Beugnet","year":"2009","journal-title":"Vet. Parasitol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pt.2009.01.003","article-title":"Managing canine vector-borne diseases of zoonotic concern: Part one","volume":"25","author":"Otranto","year":"2009","journal-title":"Trends Parasitol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.vetpar.2008.09.013","article-title":"Host surveys, ixodid tick biology and transmission scenarios as related to the tick-borne pathogen, Ehrlichia canis","volume":"158","author":"Stich","year":"2008","journal-title":"Vet. Parasitol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.pt.2010.01.007","article-title":"The increasing recognition of rickettsial pathogens in dogs and people","volume":"26","author":"Nicholson","year":"2010","journal-title":"Trends Parasitol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.vetpar.2012.09.034","article-title":"Seasonal dynamics of Ixodes ricinus on ground level and higher vegetation in a preserved wooded area in southern Europe","volume":"192","author":"Otranto","year":"2013","journal-title":"Vet. Parasitol."},{"key":"ref_6","first-page":"515","article-title":"Monocytic ehrlichiosis in dogs","volume":"14","author":"Bladowski","year":"2011","journal-title":"Pol. J. Vet. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S1471-4922(00)01856-0","article-title":"Tick-borne infectious diseases of dogs","volume":"17","author":"Shaw","year":"2001","journal-title":"Trends Parasitol."},{"key":"ref_8","first-page":"431","article-title":"Canine Monocytic ehrlichiosis: An update","volume":"19","author":"Harrus","year":"1997","journal-title":"Compend. Contin. Educ. Pract. Vet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr6502a1","article-title":"Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis\u2014United States","volume":"65","author":"Biggs","year":"2016","journal-title":"MMWR Recomm. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1128\/CMR.18.4.719-756.2005","article-title":"Tick-borne rickettsioses around the world: Emerging diseases challenging old concepts","volume":"18","author":"Parola","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1574-695X.2006.00138.x","article-title":"Spotted fever rickettsioses in southern and eastern Europe","volume":"49","author":"Brouqui","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.3201\/eid1409.071133","article-title":"Questions on Mediterranean spotted fever a century after its discovery","volume":"14","author":"Rovery","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1939-1676.2002.tb02374.x","article-title":"Consensus statement on ehrlichial disease of small animals from the infectious disease study group of the ACVIM","volume":"16","author":"Neer","year":"2002","journal-title":"J. Vet. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101353","DOI":"10.1016\/j.ttbdis.2019.101353","article-title":"Spatial and temporal trends of Mediterranean spotted fever in Spain, 2005\u20132015","volume":"11","author":"Herrador","year":"2020","journal-title":"Ticks Tick Borne Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13071-015-0824-3","article-title":"Acute febrile illness is associated with Rickettsia spp. infection in dogs","volume":"8","author":"Pennisi","year":"2015","journal-title":"Parasit. Vectors"},{"key":"ref_16","first-page":"239","article-title":"Rickettsial diseases and their serological diagnosis","volume":"46","year":"2000","journal-title":"Clin. Lab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1086\/425365","article-title":"Rickettsioses and the international traveler","volume":"39","author":"Ericsson","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/QCO.0000000000000298","article-title":"State of the art of diagnosis of rickettsial diseases","volume":"29","author":"Paris","year":"2016","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/zph.13015","article-title":"One Health zoonotic disease prioritization and systems mapping: An integration of two One Health tools","volume":"70","author":"Varela","year":"2023","journal-title":"Zoonoses Public Health"},{"key":"ref_20","unstructured":"Spindel, M. (2012). Shelter Medicine for Veterinarians and Staff, Wiley."},{"key":"ref_21","unstructured":"(2023, October 30). European Commission, Directorate-General for Health and Food Safety. TRACES\u20142022 Annual Report. Available online: https:\/\/op.europa.eu\/en\/publication-detail\/-\/publication\/ac12e9d7-6727-11ee-9220-01aa75ed71a1\/language-en\/format-PDF\/source-294184962."},{"key":"ref_22","unstructured":"Schrijver, R., Sikkema, R., Vries, H., Dewar, D., Bergevoet, R., Messori, S., D\u2019Albenzio, S., and Barnard, S. (2023, October 31). Study on the Welfare of Dogs and Cats Involved in Commercial Practices. Available online: https:\/\/food.ec.europa.eu\/system\/files\/2016-10\/aw_eu-strategy_study_dogs-cats-commercial-practices_en.pdf."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Migliore, S., Gargano, V., De Maria, C., Gambino, D., Gentile, A., Vitale Badaco, V., Schir\u00f2, G., Mira, F., Galluzzo, P., and Vicari, D. (2020). A cross sectional study on serological prevalence of Ehrlichia canis and Rickettsia conorii in different canine population of Sicily (South-Italy) during 2017\u20132019. Animals, 10.","DOI":"10.3390\/ani10122444"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s13071-023-05813-1","article-title":"Spatial and risk factor analyses of vector-borne pathogens among shelter dogs in the eastern United States","volume":"16","author":"Hazelrig","year":"2023","journal-title":"Parasit. Vectors"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13071-018-2724-9","article-title":"Does co-infection with vector-borne pathogens play a role in clinical canine leishmaniosis?","volume":"11","author":"Baxarias","year":"2018","journal-title":"Parasit. Vectors"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Patterson, G., Tanhauser, M., Schmidt, P., Spangler, D., Faulkner, C., Faulkner, V., Kish, D., Gruszynski, K., Naikare, H., and Coarsey, M.D. (2020). Serosurvey of arthropod-borne diseases among shelter dogs in the Cumberland Gap region of the United States. BMC Vet. Res., 16.","DOI":"10.1186\/s12917-020-02440-1"},{"key":"ref_27","unstructured":"INE (2022). Censos 2021. XVI Recenseamento Geral da Popula\u00e7\u00e3o. VI Recenseamento Geral da Habita\u00e7\u00e3o: Resultados Definitivos, INE."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Hosmer, D.W., and Lemeshow, S. (2000). Applied Logistic Regression, Wiley.","DOI":"10.1002\/0471722146"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1756-3305-5-62","article-title":"Prevalence of Dirofilaria immitis, Ehrlichia canis, Borrelia burgdorferi sensu lato, Anaplasma spp. and Leishmania infantum in apparently healthy and CVBD-suspect dogs in Portugal\u2014A national serological study","volume":"5","author":"Cardoso","year":"2012","journal-title":"Parasit. Vectors"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.tvjl.2008.10.009","article-title":"Molecular detection of Anaplasma platys and Ehrlichia canis in dogs from the north of Portugal","volume":"183","author":"Cardoso","year":"2010","journal-title":"Vet. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1756-3305-3-27","article-title":"Canine babesiosis in northern Portugal and molecular characterization of vector-borne co-Infections","volume":"3","author":"Cardoso","year":"2010","journal-title":"Parasit. Vectors"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13071-014-0613-4","article-title":"Diagnosis and incidence risk of clinical canine monocytic ehrlichiosis under field conditions in southern Europe","volume":"8","author":"Lebert","year":"2015","journal-title":"Parasit. Vectors"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.tvjl.2008.03.025","article-title":"Detection of Ehrlichia canis by polymerase chain reaction in dogs from Portugal","volume":"181","author":"Alexandre","year":"2009","journal-title":"Vet. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13071-015-0759-8","article-title":"Bacterial and protozoal agents of canine vector-borne diseases in the blood of domestic and stray dogs from southern Portugal","volume":"8","author":"Maia","year":"2015","journal-title":"Parasit. Vectors"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13071-015-0756-y","article-title":"First Report of Anaplasma platys infection in red foxes (Vulpes vulpes) and molecular detection of Ehrlichia canis and Leishmania infantum in foxes from Portugal","volume":"8","author":"Cardoso","year":"2015","journal-title":"Parasit. Vectors"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00436-009-1501-2","article-title":"Occurrence of Dirofilaria immitis and tick-borne infections caused by Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato and Ehrlichia canis in domestic dogs in France: Results of a countrywide serologic survey","volume":"105","author":"Pantchev","year":"2009","journal-title":"Parasitol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/1756-3305-7-285","article-title":"Survey of selected tick-borne diseases in dogs in Finland","volume":"7","author":"Kapiainen","year":"2014","journal-title":"Parasit. Vectors"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.vetpar.2011.04.020","article-title":"Canine vector-borne disease in travelled dogs in Germany\u2014A retrospective evaluation of laboratory data from the years 2004\u20132008","volume":"181","author":"Hamel","year":"2011","journal-title":"Vet Parasitol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1089\/vbz.2011.0915","article-title":"Seroprevalence and geographic distribution of Dirofilaria immitis and tick-borne infections (Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, and Ehrlichia canis) in dogs from Romania","volume":"12","author":"Mircean","year":"2012","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1089\/vbz.2007.0277","article-title":"Serological reactivity to Ehrlichia canis, Anaplasma phagocytophilum, Neorickettsia risticii, Borrelia burgdorferi and Rickettsia conorii in dogs from northwestern Spain","volume":"8","author":"Amusategui","year":"2008","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ttbdis.2012.10.026","article-title":"Prevalence of antibodies against Rickettsia conorii, Babesia canis, Ehrlichia canis, and Anaplasma phagocytophilum antigens in dogs from the Stretto di Messina area (Italy)","volume":"3","author":"Pennisi","year":"2012","journal-title":"Ticks Tick. Borne Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1515\/macvetrev-2016-0096","article-title":"Seroprevalence of Ehrlichia canis infection in stray dogs from Serbia","volume":"40","year":"2017","journal-title":"Maced. Vet. Rev."},{"key":"ref_43","first-page":"35","article-title":"Police dogs from Albania as indicators of exposure risk to Toxoplasma gondii, Neospora caninum and vector-borne pathogens of zoonotic and veterinary concern","volume":"1\u20132","author":"Rehbein","year":"2015","journal-title":"Vet. Parasitol. Reg. Stud. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/vr.148.21.665","article-title":"Seroprevalence of Ehrlichia canis antibodies among dogs in Turkey","volume":"148","author":"Batmaz","year":"2001","journal-title":"Vet. Rec."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1515\/fv-2017-0017","article-title":"Haematopathological changes in dogs affected with Ehrlichia canis in Lesvos","volume":"61","author":"Geromichalou","year":"2017","journal-title":"Folia Vet."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2478\/s11686-019-00098-w","article-title":"Seroprevalences of Rickettsia conorii, Ehrlichia canis and Coxiella burnetii in dogs from Montenegro","volume":"64","year":"2019","journal-title":"Acta Parasitol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s13071-016-1536-z","article-title":"Molecular investigation of tick-borne pathogens in dogs from Luanda, Angola","volume":"9","author":"Cardoso","year":"2016","journal-title":"Parasit. Vectors"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s13071-017-2216-3","article-title":"Serological and molecular detection of spotted fever group Rickettsia in a group of pet dogs from Luanda, Angola","volume":"10","author":"Barradas","year":"2017","journal-title":"Parasit. Vectors"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s13071-017-2237-y","article-title":"Molecular detection of vector-borne pathogens in dogs and cats from Qatar","volume":"10","author":"Alho","year":"2017","journal-title":"Parasit. Vectors"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1051\/vetres:2005054","article-title":"A serological study of exposure to arthropod-borne pathogens in dogs from northeastern Spain","volume":"37","author":"Llull","year":"2006","journal-title":"Vet. Res."},{"key":"ref_51","first-page":"145","article-title":"Dog tick-borne diseases in Sicily","volume":"48","author":"Torina","year":"2006","journal-title":"Parassitologia"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/BF01720305","article-title":"Prevalence of antibodies to Rickettsiae in the north-western part of Bosnia and Herzegovina","volume":"11","author":"Radulovic","year":"1995","journal-title":"Eur. J. Epidemiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2298\/VETGL1504219S","article-title":"Retrospective analysis of clinical and laboratory findings in hunting dogs with serologic reactions to tick-borne pathogens (Anaplasma phagocytophilum, Borrelia burgdorferi, Babesia canis, Ehrlichia canis, Ricketsia conorii)","volume":"69","author":"Savic","year":"2015","journal-title":"Vet. Glas."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s13071-021-04670-0","article-title":"Seroprevalence and associated risk factors for vector-borne pathogens in dogs from Egypt","volume":"14","author":"Selim","year":"2021","journal-title":"Parasit. Vectors"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1756-3305-3-33","article-title":"Experimental infection and co-infection of dogs with A naplasma platys and Ehrlichia canis: Hematologic, serologic and molecular findings","volume":"3","author":"Gaunt","year":"2010","journal-title":"Parasit. Vectors"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/vbz.2007.0236","article-title":"Serological and molecular prevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, and Ehrlichia species in dogs from Minnesota","volume":"8","author":"Beall","year":"2008","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1756-3305-6-97","article-title":"Are vector-borne pathogen co-infections complicating the clinical presentation in dogs?","volume":"6","author":"Otranto","year":"2013","journal-title":"Parasit. Vectors"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1136\/vr.141.14.360","article-title":"Canine monocytic ehrlichiosis: A retrospective study of 100 cases, and an epidemiological investigation of prognostic indicators for the Disease","volume":"141","author":"Harrus","year":"1997","journal-title":"Vet. Rec."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"255","DOI":"10.14202\/vetworld.2017.255-261","article-title":"Clinical and hematobiochemical response in canine monocytic ehrlichiosis seropositive dogs of Punjab","volume":"10","author":"Kottadamane","year":"2017","journal-title":"Vet. World"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.vetpar.2018.07.007","article-title":"Prevalence of canine heartworm infection in Mississippi animal shelters","volume":"259","author":"Donnett","year":"2018","journal-title":"Vet. Parasitol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/infdis\/151.2.377","article-title":"Persistence of antibodies to Rickettsia conorii after an acute attack of boutonneuse fever","volume":"151","author":"Mansueto","year":"1985","journal-title":"J. Infect. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.2460\/ajvr.2004.65.1200","article-title":"Comparison of results for serologic testing and a polymerase chain reaction assay to determine the prevalence of stray dogs in eastern Tennessee seropositive to Ehrlichia canis","volume":"65","author":"Seaman","year":"2004","journal-title":"Am. J. Vet. Res."},{"key":"ref_63","unstructured":"Sykes, J. (2013). Canine and Feline Infectious Diseases, Elsevier Saunders."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Aziz, M.U., Hussain, S., Song, B., Ghauri, H.N., Zeb, J., and Sparagano, O.A. (2022). Ehrlichiosis in dogs: A comprehensive review about the pathogen and its vectors with emphasis on south and east asian countries. Vet. Sci., 10.","DOI":"10.3390\/vetsci10010021"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0304-4017(97)00073-3","article-title":"Experimental transmission of Ehrlichia canis (Rickettsiales: Ehrlichieae) by Dermacentor variabilis (Acari: Ixodidae)","volume":"74","author":"Johnson","year":"1998","journal-title":"Vet. Parasitol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.eimc.2012.08.001","article-title":"Usefulness of rickettsial PCR assays for the molecular diagnosis of human rickettsioses","volume":"31","author":"Portillo","year":"2013","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Znazen, A., Sellami, H., Elleuch, E., Hattab, Z., Ben Sassi, L., Khrouf, F., Dammak, H., Letaief, A., Ben Jemaa, M., and Hammami, A. (2015). Comparison of two quantitative real time PCR assays for Rickettsia detection in patients from Tunisia. PLoS Negl. Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0003487"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1863-2378.2008.01149.x","article-title":"Molecular survey of Rickettsia spp. in sick dogs in Italy","volume":"55","author":"Trotta","year":"2008","journal-title":"Zoonoses Public. Health"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.2460\/ajvr.1990.51.08.1312","article-title":"Kinetics of IgM and IgG responses to experimental and naturally acquired Rickettsia rickettsii infection in dogs","volume":"51","author":"Breitschwerdt","year":"1990","journal-title":"Am. J. Vet. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1089\/vbz.2011.0684","article-title":"Domestic dogs (Canis familiaris) as reservoir hosts for Rickettsia conorii","volume":"12","author":"Levin","year":"2012","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ttbdis.2013.07.010","article-title":"Effects of homologous and heterologous immunization on the reservoir competence of domestic dogs for Rickettsia conorii (israelensis)","volume":"5","author":"Levin","year":"2014","journal-title":"Ticks Tick. Borne Dis."},{"key":"ref_72","first-page":"322","article-title":"Experimental infection of dogs with a zimbabwean strain of Rickettsia conorii","volume":"95","author":"Kelly","year":"1992","journal-title":"J. Trop. Med. Hyg."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10493-011-9440-x","article-title":"The hard-tick fauna of mainland Portugal (Acari: Ixodidae): An update on geographical distribution and known associations with hosts and pathogens","volume":"55","author":"Beati","year":"2011","journal-title":"Exp. Appl. Acarol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Tadesse, H., Grillini, M., Simonato, G., Mondin, A., Dotto, G., Frangipane di Regalbono, A., Kumsa, B., Cassini, R., and Menandro, M.L. (2023). Epidemiological survey on tick-borne pathogens with zoonotic potential in dog populations of southern Ethiopia. Trop. Med. Infect. Dis., 8.","DOI":"10.3390\/tropicalmed8020102"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.vetpar.2010.03.016","article-title":"Prevalence of Dirofilaria immitis, Ehrlichia canis, and Borrelia burgdorferi in pet dogs, racing greyhounds, and shelter dogs in Florida","volume":"171","author":"Tzipory","year":"2010","journal-title":"Vet. Parasitol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2460\/javma.235.2.160","article-title":"Characterization of animals with microchips entering animal shelters","volume":"235","author":"Lord","year":"2009","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/jvim.15352","article-title":"Repeated cross-sectional study of Trypanosoma cruzi in shelter dogs in Texas, in the context of Dirofilaria immitis and tick-borne pathogen prevalence","volume":"33","author":"Hodo","year":"2019","journal-title":"J. Vet. Intern. Med."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/13\/2\/129\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:50:59Z","timestamp":1760104259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/13\/2\/129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":77,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["pathogens13020129"],"URL":"https:\/\/doi.org\/10.3390\/pathogens13020129","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]}}}