{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:29:11Z","timestamp":1774549751544,"version":"3.50.1"},"reference-count":107,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Allergy and Infectious Diseases (NIAID)","award":["R01AI146065-01"],"award-info":[{"award-number":["R01AI146065-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Female genital tract infections (FGTIs) include vaginal infections (e.g., bacterial vaginosis [BV]), endometritis, pelvic inflammatory disease [PID], and chorioamnionitis [amniotic fluid infection]. They commonly occur in women of reproductive age and are strongly associated with multiple adverse health outcomes including increased risk of HIV\/sexually transmitted infection acquisition and transmission, infertility, and adverse birth outcomes such as preterm birth. These FGTIs are characterized by a disruption of the cervicovaginal microbiota which largely affects host immunity through the loss of protective, lactic acid-producing Lactobacillus spp. and the overgrowth of facultative and strict anaerobic bacteria. Prevotella species (spp.), anaerobic Gram-negative rods, are implicated in the pathogenesis of multiple bacterial FGTIs. Specifically, P. bivia, P. amnii, and P. timonensis have unique virulence factors in this setting, including resistance to antibiotics commonly used in treatment. Additionally, evidence suggests that the presence of Prevotella spp. in untreated BV cases can lead to infections of the upper female genital tract by ascension into the uterus. This narrative review aims to explore the most common Prevotella spp. in FGTIs, highlight their important role in the pathogenesis of FGTIs, and propose future research in this area.<\/jats:p>","DOI":"10.3390\/pathogens13050364","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T10:33:36Z","timestamp":1714386816000},"page":"364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Role of Prevotella Species in Female Genital Tract Infections"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7420-9753","authenticated-orcid":false,"given":"Sheridan D.","family":"George","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}]},{"given":"Olivia T.","family":"Van Gerwen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9739-3976","authenticated-orcid":false,"given":"Chaoling","family":"Dong","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7323-4025","authenticated-orcid":false,"given":"L\u00facia G. V.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Centre of Biological Engineering (CEB), Laboratory of Research in Biofilms Ros\u00e1rio Oliveira (LIBRO), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-3537","authenticated-orcid":false,"given":"Nuno","family":"Cerca","sequence":"additional","affiliation":[{"name":"Centre of Biological Engineering (CEB), Laboratory of Research in Biofilms Ros\u00e1rio Oliveira (LIBRO), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal"}]},{"given":"Jacob H.","family":"Elnaggar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7983-5275","authenticated-orcid":false,"given":"Christopher M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-3858","authenticated-orcid":false,"given":"Christina A.","family":"Muzny","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Han, Y., Liu, Z., and Chen, T. 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