{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T06:50:09Z","timestamp":1778395809240,"version":"3.51.4"},"reference-count":83,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT\u2014Foundation for Science and Technology","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["CEECIND\/00425\/2017"],"award-info":[{"award-number":["CEECIND\/00425\/2017"]}]},{"name":"FCT program contract","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"FCT program contract","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"FCT program contract","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]},{"name":"FCT program contract","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"FCT program contract","award":["CEECIND\/00425\/2017"],"award-info":[{"award-number":["CEECIND\/00425\/2017"]}]},{"name":"FCT Scientific Employment Stimulus","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"FCT Scientific Employment Stimulus","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"FCT Scientific Employment Stimulus","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]},{"name":"FCT Scientific Employment Stimulus","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"FCT Scientific Employment Stimulus","award":["CEECIND\/00425\/2017"],"award-info":[{"award-number":["CEECIND\/00425\/2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>This study investigates the biochemical composition and biological properties of different parts (leaves, roots, and twigs) of two Cistus species (Cistus monspeliasis and Cistus parviflorus). The extracts were analysed using UHPLC-MS\/MS to determine their chemical profiling. A range of antioxidant assays were performed to evaluate the extract\u2019s antioxidant capabilities. The enzyme inhibition studies focused on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), \u03b1-amylase, and \u03b1-glucosidase and tyrosinase. In addition, the study examined the antimicrobial effects on different bacteria and yeasts and evaluated the toxicity using the MTT assay. Quinic acid, citric acid, gallic acid, catechin, quercetin derivatives, kaempferol, myricetin, ellagic acid, prodelphinidins, procyanidins, scopoletin, and flavogallonic acid dilactone are the main bioactive compounds found in both species. In enzyme inhibition assays, C. monspeliasis roots exhibited significant activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with the values of 2.58 \u00b1 0.02 mg GALAE\/g and 11.37 \u00b1 1.93 mg GALAE\/g, respectively. Cytotoxicity studies showed mostly weak toxicity, with some samples moderately reducing viability in RAW and HepG2 cells. These findings underscore the diverse biochemical profiles and bioactive potential of Cistus species, suggesting their utility as natural sources of antioxidants and enzyme inhibitors for pharmaceutical and nutraceutical development.<\/jats:p>","DOI":"10.3390\/pathogens13090795","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T11:29:59Z","timestamp":1726226999000},"page":"795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Characterising the Metabolomic Diversity and Biological Potentials of Extracts from Different Parts of Two Cistus Species Using UHPLC-MS\/MS and In Vitro Techniques"],"prefix":"10.3390","volume":"13","author":[{"given":"Shakeel","family":"Ahmed","sequence":"first","affiliation":[{"name":"Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey"}]},{"given":"Selami","family":"Selvi","sequence":"additional","affiliation":[{"name":"Department of Plant and Animal Production, Alt\u0131noluk Vocational School, Bal\u0131kesir University, Bal\u0131kesir 10870, Turkey"}]},{"given":"Gunes","family":"Ak","sequence":"additional","affiliation":[{"name":"Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1846-3236","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Czi\u00e1ky","sequence":"additional","affiliation":[{"name":"Agricultural and Molecular Research and Service Institute, University of Ny\u00edregyh\u00e1za, 4400 Ny\u00edregyh\u00e1za, Hungary"}]},{"given":"J\u00f3zsef","family":"Jek\u0151","sequence":"additional","affiliation":[{"name":"Agricultural and Molecular Research and Service Institute, University of Ny\u00edregyh\u00e1za, 4400 Ny\u00edregyh\u00e1za, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-710X","authenticated-orcid":false,"given":"Maria J.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences, University of Algarve, Campus of Gambelas, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4338-7703","authenticated-orcid":false,"given":"Luisa","family":"Custodio","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences, University of Algarve, Campus of Gambelas, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-0468","authenticated-orcid":false,"given":"Roberto","family":"Venanzoni","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, University of Perugia, 06122 Perugia, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-9794","authenticated-orcid":false,"given":"Giancarlo Angeles","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, University of Perugia, 06122 Perugia, Italy"}]},{"given":"Gaia","family":"Cusumano","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, University of Perugia, 06122 Perugia, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-1079","authenticated-orcid":false,"given":"Paola","family":"Angelini","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, University of Perugia, 06122 Perugia, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nilofar, N., Ahmed, S., Zengin, G., Di Simone, S.C., Acquaviva, A., Libero, M.L., Chiavaroli, A., Orlando, G., Tacchini, M., and Di Vito, M. (2024). Combining the pharmaceutical and toxicological properties of select essential oils with their chemical components by GC-MS analysis. Chem. Biodivers., 21.","DOI":"10.1002\/cbdv.202400738"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Dimcheva, V., and Karsheva, M. (2018). Cistus incanus from Strandja mountain as a source of bioactive antioxidants. Plants, 7.","DOI":"10.20944\/preprints201711.0184.v2"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Nilofar, N., Zengin, G., Acar, M., Bouyayha, A., Youssra, A., Eldahshan, O., Fayez, S., and Fahmy, N. (2024). Assessing the chemical composition, antioxidant and enzyme inhibitory effects of Pentapleura subulifera and Cyclotrichium glabrescens extracts. Chem. Biodivers., 21.","DOI":"10.1002\/cbdv.202301651"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Eyupoglu, O.E., Nazzaro, F., Fratianni, F., Ahmed, S., Ferrante, C., Senkardes, I., and Zengin, G. (2024). An analytical framework combining online high-performance liquid chromatography methodologies and biological properties of different extracts of Leonurus cardiaca. J. Sep. Sci., 47.","DOI":"10.1002\/jssc.202300695"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ode.2009.01.001","article-title":"Historical biogeography and character evolution of Cistaceae (Malvales) based on analysis of plastid rbcL and trnL-trnF sequences","volume":"9","author":"Vargas","year":"2009","journal-title":"Org. Divers. Evol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Nur Onal, F., Ozturk, I., Aydin Kose, F., Der, G., Kilinc, E., and Baykan, S. (2023). Comparative evaluation of polyphenol contents and biological activities of five Cistus L. species native to Turkey. Chem. Biodivers., 20.","DOI":"10.1002\/cbdv.202200915"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Papaefthimiou, D., Papanikolaou, A., Falara, V., Givanoudi, S., Kostas, S., and Kanellis, A.K. (2014). Genus Cistus: A model for exploring labdane-type diterpenes\u2019 biosynthesis and a natural source of high value products with biological, aromatic, and pharmacological properties. Front. Chem., 2.","DOI":"10.3389\/fchem.2014.00035"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/09603123.2022.2133096","article-title":"Biological activities and determination of the mode of action of Tunisian Globularia alypum and Cistus monspeliensis ethanolic extracts","volume":"34","author":"Nefzi","year":"2024","journal-title":"Int. J. Environ. Health Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s11101-022-09827-y","article-title":"An updated review of genus Cistus L. since 2014: Traditional uses, phytochemistry, and pharmacological properties","volume":"21","author":"Tomou","year":"2022","journal-title":"Phytochem. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1080\/11263504.2024.2347864","article-title":"Morphological features of pollen, fruits, and seeds of Turkish Cistus species (Cistaceae)","volume":"158","author":"Duman","year":"2024","journal-title":"Plant Biosyst."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0378-8741(95)01241-5","article-title":"Traditional medicine in Turkey. V. Folk medicine in the inner Taurus Mountains","volume":"46","author":"Honda","year":"1995","journal-title":"J. Ethnopharmacol."},{"key":"ref_12","first-page":"47","article-title":"Turkish folk medicinal plants, VIII: Lalapa\u015fa (Edirne)","volume":"14","author":"Bulut","year":"2010","journal-title":"Marmara Pharm. J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zalegh, I., Akssira, M., Bourhia, M., Mellouki, F., Rhallabi, N., Salamatullah, A.M., Alkaltham, M.S., Khalil Alyahya, H., and Mhand, R.A. (2021). A review on Cistus sp.: Phytochemical and antimicrobial activities. Plants, 10.","DOI":"10.3390\/plants10061214"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0367-2530(17)30692-8","article-title":"Leaf trichomes in the genus Cistus","volume":"191","author":"Herrmann","year":"1996","journal-title":"Flora"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Benali, T., Bouyahya, A., Habbadi, K., Zengin, G., Khabbach, A., and Hammani, K. (2020). Chemical composition and antibacterial activity of the essential oil and extracts of Cistus ladaniferus subsp. ladanifer and Mentha suaveolens against phytopathogenic bacteria and their ecofriendly management of phytopathogenic bacteria. Biocatal. Agric. Biotechnol., 28.","DOI":"10.1016\/j.bcab.2020.101696"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ammendola, M., Haponska, M., Balik, K., Modrakowska, P., Matulewicz, K., Kazmierski, L., Lis, A., Kozlowska, J., Garcia-Valls, R., and Giamberini, M. (2020). Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-63444-3"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Bouothmany, K., Bourhia, M., Aoussar, N., Attaleb, M., Salamatullah, A.M., Nafidi, H.-A., Mellouki, F., El Mzibri, M., Aboul-Soud, M.A., and Benbacer, L. (2022). Leaf extracts of Cistus ladanifer exhibit potent antioxidant and antiproliferative activities against liver, prostate and breast cancer cells. Appl. Sci., 12.","DOI":"10.3390\/app12178603"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Haida, S., Bakkouche, K., Kribii, A.R., and Kribii, A. (2021). Chemical composition of essential oil, phenolic compounds content, and antioxidant activity of cistus monspeliensis from Northern Morocco. Biochem. Res. Int., 2021.","DOI":"10.1155\/2021\/6669877"},{"key":"ref_19","first-page":"179","article-title":"Species of the genus Cistus sp.\u2013taxonomy, distribution, chemical composition, therapeutic applications and biotechnological studies","volume":"3","author":"Kubica","year":"2016","journal-title":"Post\u0119py Fitoter."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Gori, A., Ferrini, F., Marzano, M.C., Tattini, M., Centritto, M., Baratto, M.C., Pogni, R., and Brunetti, C. (2016). Characterisation and antioxidant activity of crude extract and polyphenolic rich fractions from C. incanus leaves. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17081344"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gawe\u0142-B\u0119ben, K., Kukula-Koch, W., Hoian, U., Czop, M., Strz\u0119pek-Gom\u00f3\u0142ka, M., and Antosiewicz, B. (2020). Characterization of Cistus\u00d7 incanus L. and Cistus ladanifer L. extracts as potential multifunctional antioxidant ingredients for skin protecting cosmetics. Antioxidants, 9.","DOI":"10.3390\/antiox9030202"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Carev, I., Maravi\u0107, A., Ili\u0107, N., \u010cike\u0161 \u010culi\u0107, V., Politeo, O., Zori\u0107, Z., and Radan, M. (2020). UPLC-MS\/MS phytochemical analysis of two Croatian Cistus species and their biological activity. Life, 10.","DOI":"10.3390\/life10070112"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/pca.1281","article-title":"A systematic study of the polyphenolic composition of aqueous extracts deriving from several Cistus genus species: Evolutionary relationship","volume":"22","author":"Saura","year":"2011","journal-title":"Phytochem. Anal."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.envexpbot.2013.03.007","article-title":"Earlier summer drought affects leaf functioning of the Mediterranean species Cistus monspeliensis L.","volume":"93","author":"Micali","year":"2013","journal-title":"Environ. Exp. Bot."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1601-5223.2000.t01-1-00183.x","article-title":"Diversity and divergence in Cistus salvifolius (L.) populations from contrasting habitats","volume":"132","author":"Farley","year":"2000","journal-title":"Hereditas"},{"key":"ref_26","unstructured":"Hegnauer, R., and Hegnauer, M. (1963). Chemotaxonomie der Pflanzen: Eine \u00dcbersicht \u00fcber die Verbreitung und die systematische Bedeutung der Pflanzenstoffe. 2. Monocotyledoneae, Birkh\u00e4user."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5344\/ajev.1977.28.1.49","article-title":"Total phenol analysis: Automation and comparison with manual methods","volume":"28","author":"Slinkard","year":"1977","journal-title":"Am. J. Enol. Vitic."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.phytol.2017.03.005","article-title":"In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical profile of Potentilla thuringiaca","volume":"20","author":"Grochowski","year":"2017","journal-title":"Phytochem. Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1111\/j.1439-0507.2010.01926.x","article-title":"Identification and characterisation of human pathogenic filamentous fungi and susceptibility to Thymus schimperi essential oil","volume":"54","author":"Pagiotti","year":"2011","journal-title":"Mycoses"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Angelini, P., Pellegrino, R.M., Tirillini, B., Flores, G.A., Alabed, H.B., Ianni, F., Blasi, F., Cossignani, L., Venanzoni, R., and Orlando, G. (2021). Metabolomic profiling and biological activities of Pleurotus columbinus Qu\u00e9l. Cultivated on different agri-food byproducts. Antibiotics, 10.","DOI":"10.3390\/antibiotics10101245"},{"key":"ref_31","unstructured":"(2008). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts, Approved Standard-Third Edition (Standard No. M27-A3)."},{"key":"ref_32","unstructured":"(2012). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; 4th Informational Supplement (Standard No. M27-S4)."},{"key":"ref_33","unstructured":"(2012). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, Approved Standard, 9th ed (Standard No. M07-A9)."},{"key":"ref_34","unstructured":"(2008). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi; Approved Standard-Second Edition (Standard No. M38-A2)."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Mahomoodally, M.F., Sinan, K.I., Bene, K., Zengin, G., Orlando, G., Menghini, L., Veschi, S., Chiavaroli, A., Recinella, L., and Brunetti, L. (2020). Bridelia speciosa M\u00fcll. Arg. stem bark extracts as a potential biomedicine: From tropical western Africa to the pharmacy shelf. Antioxidants, 9.","DOI":"10.3390\/antiox9020128"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Velioglu, Y.S. (2009). 10 Food Acids: Organic Acids, Volatile Organic Acids, and Phenolic Acids. Advances in Food Biochemistry, CRC Press.","DOI":"10.1201\/9781420007695-c10"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodres.2013.12.004","article-title":"Inhibition of salivary and pancreatic \u03b1-amylases by a pinh\u00e3o coat (Araucaria angustifolia) extract rich in condensed tannin","volume":"56","author":"Koehnlein","year":"2014","journal-title":"Food Res. Int."},{"key":"ref_38","unstructured":"Sagra, M.E.T. (2017). Optimization of the Extraction of Procyanidin b-2 Rich Extract from Unfermented Cocoa Using Response Surface Methodology and Interaction of Procyanidin b-2 Rich Cocoa Extract with Collagenase and Elastase as Biomarkers of Skin Aging. [Master\u2019s Thesis, Louisiana State University and Agricultural & Mechanical College]."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/07352689.2011.616039","article-title":"Review scopoletin\u2014A coumarin phytoalexin with medicinal properties","volume":"31","author":"Gnonlonfin","year":"2012","journal-title":"Crit. Rev. Plant Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/cbdv.201600039","article-title":"Phytochemical profile, chemotaxonomic studies, and in vitro antioxidant activities of two endemisms from Madeira Archipelago: Melanoselinum decipiens and Monizia edulis (Apiaceae)","volume":"13","author":"Castilho","year":"2016","journal-title":"Chem. Biodivers."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kiokias, S., Proestos, C., and Oreopoulou, V. (2020). Phenolic acids of plant origin\u2014A review on their antioxidant activity in vitro (o\/w emulsion systems) along with their in vivo health biochemical properties. Foods, 9.","DOI":"10.3390\/foods9040534"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.tifs.2021.02.063","article-title":"Bioactive procyanidins from dietary sources: The relationship between bioactivity and polymerization degree","volume":"111","author":"Yang","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.phymed.2015.02.002","article-title":"Metabolite identification strategy of non-targeted metabolomics and its application for the identification of components in Chinese multicomponent medicine Abelmoschus manihot L.","volume":"22","author":"Guo","year":"2015","journal-title":"Phytomedicine"},{"key":"ref_44","first-page":"371","article-title":"Organic acids in fruits: Metabolism, functions and contents","volume":"45","author":"Walker","year":"2018","journal-title":"Hortic. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Dhanaraj, S. (2023). A critical review on quercetin bioflavonoid and its derivatives: Scope, synthesis, and biological applications with future prospects. Arab. J. Chem., 16.","DOI":"10.1016\/j.arabjc.2023.104881"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Saleem, A., Akhtar, M.F., Sharif, A., Akhtar, B., Siddique, R., Ashraf, G.M., Alghamdi, B.S., and Alharthy, S.A. (2022). Anticancer, cardio-protective and anti-inflammatory potential of natural-sources-derived phenolic acids. Molecules, 27.","DOI":"10.3390\/molecules27217286"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.2174\/1568026622666220623114450","article-title":"Phenolic acids-versatile natural moiety with numerous biological applications","volume":"22","author":"Sehrawat","year":"2022","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Cardullo, N., Muccilli, V., Cunsolo, V., and Tringali, C. (2020). Mass spectrometry and 1H-NMR study of Schinopsis lorentzii (Quebracho) tannins as a source of hypoglycemic and antioxidant principles. Molecules, 25.","DOI":"10.3390\/molecules25143257"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.phymed.2018.10.026","article-title":"Tannins and vascular complications of Diabetes: An update","volume":"56","author":"Laddha","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Kaurinovic, B., and Vastag, D. (2019). Flavonoids and Phenolic Acids as Potential Natural Antioxidants, IntechOpen.","DOI":"10.5772\/intechopen.83731"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Allegra, M. (2019). Antioxidant and anti-inflammatory properties of plants extract. Antioxidants, 8.","DOI":"10.3390\/antiox8110549"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.5740\/jaoacint.19-0131","article-title":"Phenolic substances in foods: Health effects as anti-inflammatory and antimicrobial agents","volume":"102","author":"Anastasi","year":"2019","journal-title":"J. AOAC Int."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Cano, F.J., and Castell, M. (2016). Flavonoids, inflammation and immune system. Nutrients, 8.","DOI":"10.3390\/nu8100659"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.foodchem.2007.01.064","article-title":"Antioxidant activity and total phenolic content of selected Jordanian plant species","volume":"104","author":"Tawaha","year":"2007","journal-title":"Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/BJI\/2016\/28500","article-title":"In vitro antibacterial activity of organic extracts from north-west Moroccan medicinal plant Myrtus communis (L.)","volume":"16","author":"Bouyahya","year":"2016","journal-title":"Biotechnol. J. Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2174\/0929867013373011","article-title":"Flavonoid antioxidants","volume":"8","year":"2001","journal-title":"Curr. Med. Chem."},{"key":"ref_57","unstructured":"Shahidi, F., and Naczk, M. (2011). 11 Analysis of Polyphenols. Methods of Analysis of Food Components and Additives, CRC Press."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Saleem, H., Khurshid, U., Sarfraz, M., Tousif, M.I., Alamri, A., Anwar, S., Alamri, A., Ahmad, I., Abdallah, H.H., and Mahomoodally, F.M. (2021). A comprehensive phytochemical, biological, toxicological and molecular docking evaluation of Suaeda fruticosa (L.) Forssk.: An edible halophyte medicinal plant. Food Chem. Toxicol., 154.","DOI":"10.1016\/j.fct.2021.112348"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.foodchem.2016.04.012","article-title":"Antioxidant activity of proanthocyanidins-rich fractions from Choerospondias axillaris peels using a combination of chemical-based methods and cellular-based assay","volume":"208","author":"Li","year":"2016","journal-title":"Food Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mppsy.2007.11.005","article-title":"Pharmacotherapy of Alzheimer\u2019s disease","volume":"7","author":"Wilkinson","year":"2008","journal-title":"Psychiatry"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3233\/JAD-2009-1010","article-title":"Iron toxicity in diseases of aging: Alzheimer\u2019s disease, Parkinson\u2019s disease and atherosclerosis","volume":"16","author":"Altamura","year":"2009","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.foodchem.2011.09.041","article-title":"Anticholinesterase and antioxidant effects of the ethanol extract, ethanol fractions and isolated flavonoids from Cistus laurifolius L. leaves","volume":"131","author":"Akkol","year":"2012","journal-title":"Food Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.fct.2013.06.040","article-title":"Chemistry and functional properties in prevention of neurodegenerative disorders of five Cistus species essential oils","volume":"59","author":"Loizzo","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/14756366.2016.1256882","article-title":"Skin whitening agents: Medicinal chemistry perspective of tyrosinase inhibitors","volume":"32","author":"Pillaiyar","year":"2017","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/j.1468-3083.2011.04130.x","article-title":"Natural options for the management of hyperpigmentation","volume":"25","author":"Leyden","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0001-2092(06)61065-X","article-title":"Diabetes mellitus and its chronic complications","volume":"76","author":"Bailes","year":"2002","journal-title":"AORN J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/mnfr.201200511","article-title":"Possible effects of dietary polyphenols on sugar absorption and digestion","volume":"57","author":"Williamson","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3109\/14756366.2015.1016510","article-title":"Crocus cancellatus subsp. damascenus stigmas: Chemical profile, and inhibition of \u03b1-amylase, \u03b1-glucosidase and lipase, key enzymes related to type 2 diabetes and obesity","volume":"31","author":"Loizzo","year":"2016","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Sayah, K., Marmouzi, I., Naceiri Mrabti, H., Cherrah, Y., and Faouzi, M.E.A. (2017). Antioxidant activity and inhibitory potential of Cistus salviifolius (L.) and Cistus monspeliensis (L.) aerial parts extracts against key enzymes linked to hyperglycemia. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/2789482"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Fraz\u00e3o, D.F., Martins-Gomes, C., D\u00edaz, T.S., Delgado, F., Gon\u00e7alves, J.C., and Silva, A.M. (2024). Labdanum resin from Cistus ladanifer L. as a source of compounds with anti-diabetic, neuroprotective and anti-proliferative activity. Molecules, 29.","DOI":"10.3390\/molecules29102222"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"\u0130nan, Y., Aky\u00fcz, S., Kurt-Celep, I., Celep, E., and Yesilada, E. (2021). Influence of in vitro human digestion simulation on the phenolics contents and biological activities of the aqueous extracts from Turkish Cistus Species. Molecules, 26.","DOI":"10.3390\/molecules26175322"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1573408012666160728100110","article-title":"\u03b1-Glucosidase inhibitory effect and antioxidant activity of the extracts of eighteen plant traditionally used in Algeria for diabetes","volume":"13","author":"Khachebaa","year":"2017","journal-title":"Curr. Enzym. Inhib."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.bbapap.2008.11.005","article-title":"Outer membrane permeability and antibiotic resistance","volume":"1794","author":"Delcour","year":"2009","journal-title":"Biochim. Et Biophys. Acta (BBA)-Proteins Proteom."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1615\/IntJMedMushrooms.2019032896","article-title":"Characterization of biological activities of methanol extract of Fuscoporia torulosa (Basidiomycetes) from Italy","volume":"21","author":"Covino","year":"2019","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Flores, G.A., Girometta, C.E., Cusumano, G., Angelini, P., Tirillini, B., Ianni, F., Blasi, F., Cossignani, L., Pellegrino, R.M., and Emiliani, C. (2022). Untargeted metabolomics used to describe the chemical composition, antioxidant and antimicrobial effects of extracts from Pleurotus spp. mycelium grown in different culture media. Antibiotics, 11.","DOI":"10.3390\/antibiotics11111468"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/IntJMedMushrooms.2023048295","article-title":"Diversity of Pleurotus spp.(Agaricomycetes) and their metabolites of Nutraceutical and Therapeutic Importance","volume":"25","author":"Flores","year":"2023","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_77","first-page":"2767","article-title":"Antimicrobial applications of nanotechnology: Methods and literature","volume":"7","author":"Seil","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Dresch, P., D\u2019 Aguanno, M.N., Rosam, K., Grienke, U., Rollinger, J.M., and Peintner, U. (2015). Fungal strain matters: Colony growth and bioactivity of the European medicinal polypores Fomes fomentarius, Fomitopsis pinicola. Amb Express, 5.","DOI":"10.1186\/s13568-014-0093-0"},{"key":"ref_79","unstructured":"(2009). Biological Evaluation of Medical Devices. Part 5: Tests for In Vitro Cytotoxicity (Standard No. ISO 10993-5:2009)."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Heydari, M., Rauf, A., Thiruvengadam, M., Chen, X., and Hashempur, M.H. (2022). Clinical safety of natural products, an evidence-based approach. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.960556"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/14786410802583148","article-title":"Antiproliferative and cytotoxic activity of extracts from Cistus incanus L. and Cistus monspeliensis L. on human prostate cell lines","volume":"25","author":"Vitali","year":"2011","journal-title":"Nat. Prod. Res."},{"key":"ref_82","first-page":"1","article-title":"Antiproliferative activity of hexane extract from Tunisian Cistus libanotis, Cistus monspeliensis and Cistus villosus","volume":"7","author":"Kchouk","year":"2013","journal-title":"Chem. Cent. J."},{"key":"ref_83","first-page":"688","article-title":"Antioxidant and cancer chemopreventive activities of Cistus and pomegranate polyphenols","volume":"74","author":"Moreira","year":"2017","journal-title":"Acta Poloniae Pharm."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/13\/9\/795\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:55:54Z","timestamp":1760111754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/13\/9\/795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,13]]},"references-count":83,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["pathogens13090795"],"URL":"https:\/\/doi.org\/10.3390\/pathogens13090795","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,13]]}}}