{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:55:26Z","timestamp":1760237726063,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/DTP\/04567\/2020"],"award-info":[{"award-number":["UID\/DTP\/04567\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Plectranthus ecklonii Benth. has widespread ethnobotanical use in African folk medicine for its medicinal properties in skin conditions. In this study, two different basic formulations containing P. ecklonii extracts were prepared, one in an organic solvent and the other using water. The aqueous extract only contained rosmarinic acid (RA) at 2.02 mM, and the organic extract contained RA and parvifloron D at 0.29 and 3.13 mM, respectively. RA in aqueous solution permeated skin; however, in P. ecklonii organic extract, this was not detected. Thus, P. ecklonii aqueous extract was further studied and combined with benzophenone-4, which elevated the sun protection factor (SPF) by 19.49%. No significant cytotoxic effects were observed from the aqueous extract. The Staphylococcus epidermidis strain was used to determine a minimum inhibitory concentration (MIC) value of 10 \u00b5g\u00b7mL\u22121. The aqueous extract inhibited the activity of acetylcholinesterase by 59.14 \u00b1 4.97%, and the IC50 value was 12.9 \u00b5g\u00b7mL\u22121. The association of the P. ecklonii extract with a UV filter substantially elevated its SPF efficacy. Following the multiple bioactivities of the extract and its active substances, a finished product could be claimed as a multifunctional cosmeceutical with broad skin valuable effects, from UV protection to antiaging action.<\/jats:p>","DOI":"10.3390\/ph13060120","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T05:02:24Z","timestamp":1591938144000},"page":"120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Assessment of the Potential Skin Application of Plectranthus ecklonii Benth."],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-2522","authenticated-orcid":false,"given":"Marisa","family":"Nicolai","sequence":"first","affiliation":[{"name":"CBIOS\u2014Universidade Lus\u00f3fona Research Centre for Biosciences &amp; Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal"}]},{"given":"Joana","family":"Mota","sequence":"additional","affiliation":[{"name":"CBIOS\u2014Universidade Lus\u00f3fona Research Centre for Biosciences &amp; Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6350-0641","authenticated-orcid":false,"given":"Ana S.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"CBIOS\u2014Universidade Lus\u00f3fona Research Centre for Biosciences &amp; Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal"}]},{"given":"Filipe","family":"Pereira","sequence":"additional","affiliation":[{"name":"CBIOS\u2014Universidade Lus\u00f3fona Research Centre for Biosciences &amp; Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6893-6812","authenticated-orcid":false,"given":"Paula","family":"Pereira","sequence":"additional","affiliation":[{"name":"CBIOS\u2014Universidade Lus\u00f3fona Research Centre for Biosciences &amp; Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal"},{"name":"CERENA\u2014Centre for Natural Resources and the Environment, Instituto Superior T\u00e9cnico (IST), Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-4031","authenticated-orcid":false,"given":"Catarina","family":"P. Reis","sequence":"additional","affiliation":[{"name":"iMed.ULisboa Research Institute for Medicines and Pharmaceutical Sciences, Universidade de Lisboa\u2014Faculdade de Farm\u00e1cia, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal"},{"name":"IBEB, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisbon, Portugal"}]},{"given":"Maria Val\u00e9ria","family":"Robles Velasco","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmaceutical Sciences, University of S\u00e3o Paulo BEB, 580 Lineu Prestes Av., Bloco 15, S\u00e3o Paulo\/SP 05508-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-3024","authenticated-orcid":false,"given":"Andr\u00e9 Rolim","family":"Baby","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmaceutical Sciences, University of S\u00e3o Paulo BEB, 580 Lineu Prestes Av., Bloco 15, S\u00e3o Paulo\/SP 05508-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6429-6213","authenticated-orcid":false,"given":"Catarina","family":"Rosado","sequence":"additional","affiliation":[{"name":"CBIOS\u2014Universidade Lus\u00f3fona Research Centre for Biosciences &amp; Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7992-8343","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Rijo","sequence":"additional","affiliation":[{"name":"CBIOS\u2014Universidade Lus\u00f3fona Research Centre for Biosciences &amp; Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal"},{"name":"iMed.ULisboa Research Institute for Medicines and Pharmaceutical Sciences, Universidade de Lisboa\u2014Faculdade de Farm\u00e1cia, Av. 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