{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:21:49Z","timestamp":1777645309771,"version":"3.51.4"},"reference-count":122,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FEEI (Fundos Europeus Estruturais e de Investimento), FEDER (Fundo Europeu de Desenvolvimento Regional) funds through the COMPETE2020, Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds throug","award":["Predicting patient\u2019s response to liposomal anticancer drugs: focusing on LRP1B endocytic activity\u2014PTDC\/MEC-ONC\/31520\/2017"],"award-info":[{"award-number":["Predicting patient\u2019s response to liposomal anticancer drugs: focusing on LRP1B endocytic activity\u2014PTDC\/MEC-ONC\/31520\/2017"]}]},{"name":"Programa Operacional Regional do Norte and co-funded by European Regional Development Fund under the project &quot;The Porto Comprehensive Cancer Center&quot;","award":["NORTE-01-0145-FEDER-072678 - Cons\u00f3rcio PORTO.CCC \u2013 Porto.Comprehensive Cancer Center."],"award-info":[{"award-number":["NORTE-01-0145-FEDER-072678 - Cons\u00f3rcio PORTO.CCC \u2013 Porto.Comprehensive Cancer Center."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Low-density lipoprotein receptor-related protein 1B (LRP1B) is a giant member of the LDLR protein family, which includes several structurally homologous cell surface receptors with a wide range of biological functions from cargo transport to cell signaling. LRP1B is among the most altered genes in human cancer overall. Found frequently inactivated by several genetic and epigenetic mechanisms, it has mostly been regarded as a putative tumor suppressor. Still, limitations in LRP1B studies exist, in particular associated with its huge size. Therefore, LRP1B expression and function in cancer remains to be fully unveiled. This review addresses the current understanding of LRP1B and the studies that shed a light on the LRP1B structure and ligands. It goes further in presenting increasing knowledge brought by technical and methodological advances that allow to better manipulate LRP1B expression in cells and to more thoroughly explore its expression and mutation status. New evidence is pushing towards the increased relevance of LRP1B in cancer as a potential target or translational prognosis and response to therapy biomarker.<\/jats:p>","DOI":"10.3390\/ph14090836","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T22:09:39Z","timestamp":1629842979000},"page":"836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["LRP1B: A Giant Lost in Cancer Translation"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1300-4006","authenticated-orcid":false,"given":"Catarina","family":"Pr\u00edncipe","sequence":"first","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-135 Porto, Portugal"},{"name":"Cancer Signalling and Metabolism Group, IPATIMUP\u2014Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2917-3143","authenticated-orcid":false,"given":"Isabel J.","family":"Dion\u00edsio de Sousa","sequence":"additional","affiliation":[{"name":"Department of Oncology, Centro Hospitalar  Universit\u00e1rio de S\u00e3o Jo\u00e3o, 4200-450 Porto, Portugal"},{"name":"Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Hugo","family":"Prazeres","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-135 Porto, Portugal"},{"name":"IPO-Coimbra, Portuguese Oncology Institute of Coimbra, 3000-075 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-6998","authenticated-orcid":false,"given":"Paula","family":"Soares","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-135 Porto, Portugal"},{"name":"Cancer Signalling and Metabolism Group, IPATIMUP\u2014Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal"},{"name":"Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"Department of Pathology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5838-9659","authenticated-orcid":false,"given":"Raquel T.","family":"Lima","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-135 Porto, Portugal"},{"name":"Cancer Signalling and Metabolism Group, IPATIMUP\u2014Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal"},{"name":"Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"Department of Pathology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"ref_1","first-page":"1961","article-title":"LRP-DIT, A Putative Endocytic Receptor Gene, is Frequently Inactivated in Non-Small Cell Lung Cancer Cell Lines","volume":"60","author":"Liu","year":"2000","journal-title":"Cancer Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/geno.2000.6331","article-title":"Genomic Organization of a New Candidate Tumor Suppressor Gene, LRP1B","volume":"69","author":"Liu","year":"2000","journal-title":"Genomics"},{"key":"ref_3","first-page":"93","article-title":"LRP1B (low density lipoprotein receptor-related protein 1B)","volume":"18","author":"Prazeres","year":"2014","journal-title":"Atlas Genet. 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