{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:40:59Z","timestamp":1768095659238,"version":"3.49.0"},"reference-count":106,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites Trypanosoma brucei and Trypanosoma cruzi, respectively. These diseases were circumscribed to South American and African countries in the past. However, human migration, military interventions, and climate changes have had an important effect on their worldwide propagation, particularly Chagas disease. Currently, the treatment of trypanosomiasis is not ideal, becoming a challenge in poor populations with limited resources. Exploring natural products from higher plants remains a valuable approach to find new hits and enlarge the pipeline of new drugs against protozoal human infections. This review covers the recent studies (2016\u20132021) on plant terpenoids, and their semi-synthetic derivatives, which have shown promising in vitro and in vivo activities against Trypanosoma parasites.<\/jats:p>","DOI":"10.3390\/ph15030340","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T20:19:10Z","timestamp":1646943550000},"page":"340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Plant Terpenoids as Hit Compounds against Trypanosomiasis"],"prefix":"10.3390","volume":"15","author":[{"given":"Raquel","family":"Dur\u00e3o","sequence":"first","affiliation":[{"name":"Research Institute for Medicines (iMED.Ulisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-4956","authenticated-orcid":false,"given":"C\u00e1tia","family":"Ramalhete","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMED.Ulisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"},{"name":"ATLANTICA\u2014Instituto Universit\u00e1rio, F\u00e1brica da P\u00f3lvora de Barcarena, 2730-036 Barcarena, Portugal"}]},{"given":"Ana Margarida","family":"Madureira","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMED.Ulisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7926-8821","authenticated-orcid":false,"given":"Eduarda","family":"Mendes","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMED.Ulisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3119-8745","authenticated-orcid":false,"given":"No\u00e9lia","family":"Duarte","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMED.Ulisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"ref_1","unstructured":"Ntuli, M.M. (2021). Ending the Neglect to Attain the Sustainable Development Goals. 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