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In this study, the use of natural ingredients, either from terrestrial or marine origin, in a panel of 444 sunscreen commercial formulations (2021) was analyzed. Ingredients from terrestrial organisms represent the large majority found in the analyzed sunscreen formulations (48%), whereas marine ingredients are present only in 13% of the analyzed products. A deeper analysis regarding the most prevalent families of ingredients from terrestrial and marine organisms used as top ingredients is also presented, as well as their mechanisms of action. This study provides an up-to-date overview of the sunscreen market regarding the use of natural ingredients, which is of relevance for scientists involved in the development of new sunscreens to identify opportunities for innovation.<\/jats:p>","DOI":"10.3390\/ph15030372","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:34:27Z","timestamp":1647812067000},"page":"372","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Up-to-Date Overview of the Use of Natural Ingredients in Sunscreens"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-6060","authenticated-orcid":false,"given":"Diana I. S. P.","family":"Resende","sequence":"first","affiliation":[{"name":"CIIMAR\u2014Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental, 4450-208 Matosinhos, Portugal"},{"name":"Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7425-9750","authenticated-orcid":false,"given":"Ana","family":"Jesus","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9518-8397","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Sousa Lobo","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5397-4672","authenticated-orcid":false,"given":"Em\u00edlia","family":"Sousa","sequence":"additional","affiliation":[{"name":"CIIMAR\u2014Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental, 4450-208 Matosinhos, Portugal"},{"name":"Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9846-6754","authenticated-orcid":false,"given":"Maria T.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra, 3004-531 Coimbra, Portugal"},{"name":"Center for Neuroscience and Cell Biology, 3004-504 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-1779","authenticated-orcid":false,"given":"Honorina","family":"Cidade","sequence":"additional","affiliation":[{"name":"CIIMAR\u2014Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental, 4450-208 Matosinhos, Portugal"},{"name":"Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-048X","authenticated-orcid":false,"given":"Isabel F.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"ref_1","unstructured":"(2021, August 30). Radiation: Ultraviolet (UV) Radiation. Available online: https:\/\/www.who.int\/news-room\/q-a-detail\/radiation-ultraviolet-(uv)."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Milito, A., Castellano, I., and Damiani, E. (2021). From Sea to Skin: Is There a Future for Natural Photoprotectants?. Mar. Drugs, 19.","DOI":"10.3390\/md19070379"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"a015370","DOI":"10.1101\/cshperspect.a015370","article-title":"Natural and Sun-Induced Aging of Human Skin","volume":"5","author":"Fisher","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3390\/antiox4020248","article-title":"Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals","volume":"4","author":"Bosch","year":"2015","journal-title":"Antioxidants"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"12222","DOI":"10.3390\/ijms140612222","article-title":"UV Radiation and the Skin","volume":"14","author":"Orazio","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1021\/acs.jnatprod.5b00198","article-title":"Naringenin Inhibits UVB Irradiation-Induced Inflammation and Oxidative Stress in the Skin of Hairless Mice","volume":"78","author":"Martinez","year":"2015","journal-title":"J. Nat. Prod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/pcmr.12273","article-title":"Differences in visible light-induced pigmentation according to wavelengths: A clinical and histological study in comparison with UVB exposure","volume":"27","author":"Duteil","year":"2014","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jphotobiol.2015.04.007","article-title":"Functional photostability and cutaneous compatibility of bioactive UVA sun care products","volume":"148","author":"Peres","year":"2015","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1755-148X.2008.00470.x","article-title":"Pigmentation effects of solar simulated radiation as compared with UVA and UVB radiation","volume":"21","author":"Wolber","year":"2008","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s13555-019-0282-5","article-title":"New Vision in Photoprotection and Photorepair","volume":"9","author":"Leccia","year":"2019","journal-title":"Dermatol. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1011-1344(01)00202-0","article-title":"The historical aspects of sunscreens","volume":"64","author":"Urbach","year":"2001","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Bens, G. (2014). Sunscreens. Sunlight, Vitamin D and Skin Cancer, Springer.","DOI":"10.1007\/978-1-4939-0437-2_25"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"122149","DOI":"10.1016\/j.jhazmat.2020.122149","article-title":"Toxicity of benzophenone-3 and its biodegradation in a freshwater microalga Scenedesmus obliquus","volume":"389","author":"Lee","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jaad.2018.06.033","article-title":"Review of environmental effects of oxybenzone and other sunscreen active ingredients","volume":"80","author":"Schneider","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/s10661-021-09626-6","article-title":"UV-filter pollution: Current concerns and future prospects","volume":"193","author":"Harvey","year":"2021","journal-title":"Environ. Monit. Assess."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"111161","DOI":"10.1016\/j.biopha.2020.111161","article-title":"Natural components in sunscreens: Topical formulations with sun protection factor (SPF)","volume":"134","author":"He","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/jidsymp.2009.14","article-title":"Non-Sunscreen Photoprotection: Antioxidants Add Value to a Sunscreen","volume":"14","author":"Matsui","year":"2009","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Pangestuti, R., Siahaan, E.A., and Kim, S.-K. (2018). Photoprotective Substances Derived from Marine Algae. Mar. Drugs, 16.","DOI":"10.3390\/md16110399"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"141576","DOI":"10.1016\/j.scitotenv.2020.141576","article-title":"Robust natural ultraviolet filters from marine ecosystems for the formulation of environmental friendlier bio-sunscreens","volume":"749","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1007\/s10811-019-02022-1","article-title":"Active phlorotannins from seven brown seaweeds commercially harvested in Brittany (France) detected by 1H NMR and in vitro assays: Temporal variation and potential valorization in cosmetic applications","volume":"32","author":"Gager","year":"2020","journal-title":"J. Appl. Phycol."},{"key":"ref_21","first-page":"1577","article-title":"Identification of potential anti-photoageing algal compounds using an in-vitro model of photoageing","volume":"58","author":"Borlon","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.fct.2012.01.004","article-title":"In vivo UVB-photoprotective activity of extracts from commercial marine macroalgae","volume":"50","author":"Guinea","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.marenvres.2019.04.001","article-title":"Photo-protective compounds in red macroalgae from Brittany: Considerable diversity in mycosporine-like amino acids (MAAs)","volume":"147","author":"Lalegerie","year":"2019","journal-title":"Mar. Environ. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10123-018-0005-2","article-title":"Exploring the UVB-protective efficacy of melanin precursor extracted from marine imperfect fungus: Featuring characterization and application studies under in vitro conditions","volume":"21","author":"Shanuja","year":"2018","journal-title":"Int. Microbiol."},{"key":"ref_25","unstructured":"Zastrow, L., Domloge, N., and Golz-Berner, K. (1999). Cosmetic Product Based on Artemia Salina Extracts for Regenerating and Stimulating Skin Cells. (WO1999038483A1)."},{"key":"ref_26","first-page":"207","article-title":"Artemia Extract \u2018Compensates\u2019 for Age-Related Decrease of Hsp70 in Skin","volume":"119","author":"Cucumel","year":"2002","journal-title":"J. Investig. Dermatol."},{"key":"ref_27","first-page":"456","article-title":"Artemia extract induces Hsp70 in human cells and enhances cell protection from stress","volume":"117","author":"Cucumel","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"ref_28","first-page":"69","article-title":"Artemia extract toward more extensive sun protection","volume":"2002","author":"Domloge","year":"2002","journal-title":"Cosmet. Toiletries"},{"key":"ref_29","unstructured":"Wang, L., Meng, L., Ye, S., Chen, F., Xie, S., and Wang, X. (2021). A Photoprotection Repairing Composition, Preparation Method and Application, and Skin Care Product Thereof [Machine Translation]. (CN112535657A)."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00227-017-3123-z","article-title":"Benthic dinoflagellate blooms in tropical intertidal rock pools: Elucidation of photoprotection mechanisms","volume":"164","author":"Patil","year":"2017","journal-title":"Mar. Biol."},{"key":"ref_31","unstructured":"Kersey, W.T., and Munger, S.P. (2009). Chapter 4\u2014Mycosporine-like amino acids in phytoplankton: Biochemistry, physiology and optics. Marine Phytoplankton, Nova Science Publishers."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/iroh.201801960","article-title":"Effect of ultraviolet radiation on clearance rate of planktonic copepods with different photoprotective strategies","volume":"104","author":"Laspoumaderes","year":"2019","journal-title":"Int. Rev. Hydrobiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sonntag, B., and Sommaruga, R. (2020). Effectiveness of photoprotective strategies in three mixotrophic planktonic ciliate species. Diversity, 12.","DOI":"10.3390\/d12060252"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/plankt\/12.5.909","article-title":"Occurrence of mycosporine-like amino acids in the red-tide dinoflagellate Alexandrium excavatum: UV-photoprotective compounds?","volume":"12","author":"Carreto","year":"1990","journal-title":"J. Plankton Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e02680","DOI":"10.1002\/ecy.2680","article-title":"Photoprotective benefits of pigmentation in the transparent plankton community: A comparative species experimental test","volume":"100","author":"Bashevkin","year":"2019","journal-title":"Ecology"},{"key":"ref_36","first-page":"165","article-title":"Photoprotective pigmentation in alpine zooplankton populations","volume":"20","author":"Hessen","year":"1990","journal-title":"Aqua Fenn."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF01313484","article-title":"Survey of mycosporine-like amino acid compounds in Antarctic marine organisms: Potential protection from ultraviolet exposure","volume":"108","author":"Karentz","year":"1991","journal-title":"Mar. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jembe.2010.03.020","article-title":"UV protective compounds transferred from a marine dinoflagellate to its copepod predator","volume":"389","author":"Hylander","year":"2010","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"ref_39","unstructured":"Nikitakis, J., and Lange, B. (2016). International Cosmetic Ingredient Dictionary and Handbook, Personal Care Products Council."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Kuete, V. (2013). 18-Antiproliferative Potential of African Medicinal Plants. Medicinal Plant Research in Africa, Elsevier.","DOI":"10.1016\/B978-0-12-405927-6.00018-7"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"767459","DOI":"10.3389\/fpls.2021.767459","article-title":"Peculiarities of the Transformation of Asteraceae Family Species: The Cases of Sunflower and Lettuce","volume":"12","author":"Darqui","year":"2021","journal-title":"Front. Plant Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/jsfa.5902","article-title":"Functional properties of carotenoids originating from algae","volume":"93","author":"Christaki","year":"2013","journal-title":"J. Sci. Food Agric."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"102273","DOI":"10.1016\/j.algal.2021.102273","article-title":"Trends in the use of marine ingredients in anti-aging cosmetics","volume":"55","author":"Resende","year":"2021","journal-title":"Algal Res."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Ferreira, M.S., Magalh\u00e3es, M.C., Oliveira, R., Sousa-Lobo, J.M., and Almeida, I.F. (2021). Trends in the Use of Botanicals in Anti-Aging Cosmetics. Molecules, 26.","DOI":"10.3390\/molecules26123584"},{"key":"ref_45","unstructured":"Caballero, B., Finglas, P.M., and Toldr\u00e1, F. (2016). Sunflower Oil. Encyclopedia of Food and Health, Academic Press."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Pal, D. (2011). Sunflower (Helianthus annuus L.) Seeds in Health and Nutrition. Nuts and Seeds in Health and Disease Prevention, Academic Press.","DOI":"10.1016\/B978-0-12-375688-6.10130-6"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1002\/fsn3.1783","article-title":"Oilseed crop sunflower (Helianthus annuus) as a source of food: Nutritional and health benefits","volume":"8","author":"Adeleke","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13065-017-0328-7","article-title":"A review of phytochemistry, metabolite changes, and medicinal uses of the common sunflower seed and sprouts (Helianthus annuus L.)","volume":"11","author":"Guo","year":"2017","journal-title":"Chem. Cent. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1051\/ocl\/2021022","article-title":"High stearic sunflower oil: Latest advances and applications","volume":"28","author":"Salas","year":"2021","journal-title":"OCL"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1080\/19476337.2018.1504121","article-title":"Optimization of total phenolic contents, antioxidant, and in-vitro xanthine oxidase inhibitory activity of sunflower head","volume":"16","author":"Mehmood","year":"2018","journal-title":"CYTA J. Food"},{"key":"ref_51","first-page":"33","article-title":"Determination Sunscreen Potential Based on Sunflower Seed Oil (Helianthus annuus) in Cream Preparation with Combination of Oxybenzone and Octyl Methoxycinnamate by in Vitro Method","volume":"60","author":"Tamara","year":"2019","journal-title":"Am. Sci. Res. J. Eng. Technol. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00217-012-1751-6","article-title":"Antioxidant activity of phenolic compounds identified in sunflower seeds","volume":"235","author":"Karamac","year":"2012","journal-title":"Eur. Food Res. Technol."},{"key":"ref_53","unstructured":"HELIOXINE\u00ae (2021, September 21). Sunflowers for a Photoprotection Strategy. Available online: https:\/\/www.silab.fr\/produit-27-helioxine_usa.html."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s10722-009-9513-4","article-title":"Natural introgression from cultivated soybean (Glycine max) into wild soybean (Glycine soja) with the implications for origin of populations of semi-wild type and for biosafety of wild species in China","volume":"57","author":"Wang","year":"2010","journal-title":"Genet. Resour. Crop Evol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3390\/antiox4030563","article-title":"Determination of Phenolic Content in Different Barley Varieties and Corresponding Malts by Liquid Chromatography-diode Array Detection-Electrospray Ionization Tandem Mass Spectrometry","volume":"4","author":"Carvalho","year":"2015","journal-title":"Antioxidants"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11738-006-0068-0","article-title":"Effects of quercetin and enhanced UV-B radiation on the soybean (Glycine max) leaves","volume":"28","author":"An","year":"2006","journal-title":"Acta Physiol. Plant."},{"key":"ref_57","unstructured":"(2021, October 09). Soybean Extract\u2014Supplied by Carruba. Available online: https:\/\/cosmetics.specialchem.com\/product\/i-carrubba-soybean-extract."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Chen, Q., Yuan, X., Zhang, C., Yan, N., Jing, C., Wang, X., and Shi, J. (2021). Comparison of Phenolic and Flavonoid Compound Profiles and Antioxidant and \u03b1-Glucosidase Inhibition Properties of Cultivated Soybean (Glycine max) and Wild Soybean (Glycine soja). Plants, 10.","DOI":"10.3390\/plants10040813"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.ijbiomac.2017.05.186","article-title":"Extraction optimization, preliminary characterization and antioxidant activities of polysaccharides from Glycine soja","volume":"103","author":"Jing","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.5897\/AJMR2016.8343","article-title":"Selection of anti-wetting agents and photoprotectants compatible with a soybean weed control bioagent","volume":"10","author":"Machado","year":"2016","journal-title":"Afr. J. Microbiol. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"10600","DOI":"10.1021\/jf802112c","article-title":"Protective Effect of Anthocyanins from Black Soybean Seed Coats on UVB-Induced Apoptotic Cell Death In Vitro and In Vivo","volume":"56","author":"Tsoyi","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1080\/10408398.2011.604142","article-title":"Nutritional Composition of Shea Products and Chemical Properties of Shea Butter: A Review","volume":"54","author":"Honfo","year":"2014","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_63","unstructured":"(2021, September 22). Butyrospermum Parkii (Shea) Butter. Available online: https:\/\/cosmeticsinfo.org\/ingredient\/butyrospermum-parkii-shea-butter."},{"key":"ref_64","first-page":"51","article-title":"Medicinal and Nutricional Benefits from the Shea-T- (Vitellaria paradoxa)","volume":"7","author":"Maanikuu","year":"2017","journal-title":"J. Biol. Agric. Healthc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S1085-5629(08)70005-1","article-title":"Active Naturals Have a Key Role in Atopic Dermatitis","volume":"27","author":"Fowler","year":"2008","journal-title":"Semin. Cutan. Med. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"6268","DOI":"10.1021\/jf034687t","article-title":"Phenolic constituents of Shea (Vitellaria paradoxa) kernels","volume":"51","author":"Maranz","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/jocd.13609","article-title":"In Vivo SPF from multifunctional sunscreen systems developed with natural compounds\u2014A review","volume":"20","author":"Freire","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1111\/jocd.13429","article-title":"Butyrospermum parkii butter increased the photostability and in vivo SPF of a molded sunscreen system","volume":"19","author":"Sarruf","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1111\/jocd.13238","article-title":"Influence of Shea (Butyrospermum parkii) butter, TiO2 and ethylhexyl methoxycinnamate on physical parameters and in vitro photoprotective efficacy","volume":"19","author":"Sarruf","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1523-1747.1999.00721.x","article-title":"Changes in ultraviolet absorption of sunscreens after ultraviolet irradiation","volume":"113","author":"Stenhagen","year":"1999","journal-title":"J. Investig. Dermatol."},{"key":"ref_71","unstructured":"(2021, September 23). Persea Gratissima (Avocado) Oil. Available online: https:\/\/cosmeticsinfo.org\/ingredient\/persea-gratissima-avocado-oil-0."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1080\/10408398.2011.556759","article-title":"Hass avocado composition and potential health effects","volume":"53","author":"Dreher","year":"2013","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/J157v02n03_03","article-title":"Fatty Acid Content of Selected Seed Oils","volume":"2","author":"Orhan","year":"2002","journal-title":"J. Herb. Pharmacother."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0367-326X(99)00125-2","article-title":"Constituents of the flowers of Persea gratissima","volume":"71","author":"Kruthiventi","year":"2000","journal-title":"Fitoterapia"},{"key":"ref_75","unstructured":"(2021, September 23). Special Chem\u2014Cosmetic Ingredients\u2014Avocado Oil. Available online: https:\/\/cosmetics.specialchem.com\/product\/i-oqema-avocado-oil."},{"key":"ref_76","first-page":"309","article-title":"Persea Gratissima (Avocado) Sterols decrease UVB induced proinflammatory mediators","volume":"53","author":"Joseph","year":"2002","journal-title":"J. Cosmet. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s10600-010-9552-2","article-title":"HPLC analysis of glycyrrhizin and licochalcone A in Glycyrrhiza inflata from Xinjiang (China)","volume":"46","author":"Xie","year":"2010","journal-title":"Chem. Nat. Compd."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.intimp.2009.01.031","article-title":"Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway","volume":"9","author":"Furusawa","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"ref_79","unstructured":"European Medicines Agency\u2014Committee on Herbal Medicinal Products (2013). Assessment report on Glycyrrhiza glabra L. and\/or Glycyrrhiza inflata Bat. and\/or Glycyrrhiza uralensis Fisch., Radix, European Medicines Agency\u2014Committee on Herbal Medicinal Products."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.foodchem.2013.03.089","article-title":"Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice","volume":"141","author":"Fu","year":"2013","journal-title":"Food Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1248\/cpb.37.2528","article-title":"Identification of antimicrobial and antioxidant constituents from licorice of Russian and Xinjiang origin","volume":"37","author":"Okada","year":"1989","journal-title":"Chem. Pharm. Bull."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Monico, G., Leo, M., Ma, B., Johal, R.S., Ma, T., and Sivamani, R.K. (2015). The use of botanical products and vitamins in sunscreens. Dermatol. Online J., 21.","DOI":"10.5070\/D32111029278"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"10","DOI":"10.22159\/ijap.2021v13i1.39806","article-title":"The Cosmetic Effects of Various Natural Biofunctional Ingredients against Skin Aging: A Review","volume":"13","author":"Naser","year":"2021","journal-title":"Int. J. Appl. Pharm."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.carbpol.2015.08.037","article-title":"Delivery of liquorice extract by liposomes and hyalurosomes to protect the skin against oxidative stress injuries","volume":"134","author":"Castangia","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/09546630310014369","article-title":"The treatment of atopic dermatitis with licorice gel","volume":"14","author":"Saeedi","year":"2008","journal-title":"J. Dermatol. Treat."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1111\/jocd.13344","article-title":"Bioactive ingredients in Korean cosmeceuticals: Trends and research evidence","volume":"19","author":"Nguyen","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/0973-7847.79105","article-title":"Feverfew (Tanacetum parthenium L.): A systematic review","volume":"5","author":"Pareek","year":"2011","journal-title":"Pharmacogn. Rev."},{"key":"ref_88","first-page":"1331","article-title":"Composition of essential oils and some antioxidants in flowers of three Chrysanthemum cultivars","volume":"23","author":"Grzeszczuk","year":"2018","journal-title":"J. Elem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/S0031-9422(00)85285-1","article-title":"Constituents of Artemisia and Crysanthemum species\u2014The structures of Chrysartemins A and B","volume":"9","author":"Romo","year":"1970","journal-title":"Phytochemistry"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/0031-9422(96)00156-2","article-title":"Sterol content as a similarity of different organs of two varietas of Chrysanthemum parthenium","volume":"42","author":"Whkomirski","year":"1996","journal-title":"Phytochemistry"},{"key":"ref_91","first-page":"498","article-title":"Polyphenolic content and antioxidant activity of Chrysanthemum Parthenium extract","volume":"64","author":"Hangaru","year":"2016","journal-title":"Farmacia"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0031-9422(94)00609-W","article-title":"A biologically active lipophilic flavonol from Tanacetum Parthenium","volume":"38","author":"Williams","year":"1995","journal-title":"Phytochemistry"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10616-014-9773-5","article-title":"Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoaging","volume":"68","author":"Sun","year":"2016","journal-title":"Cytotechnology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s11434-016-1136-5","article-title":"Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants","volume":"61","author":"Zhao","year":"2016","journal-title":"Sci. Bull."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ptr.5534","article-title":"Scutellaria radix Extract as a Natural UV Protectant for Human Skin","volume":"30","author":"Seok","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_96","unstructured":"Jouy, C., Ruiz, L., and Pygmalion, M.-J. (2013). Photoprotectant Compositions Comprising Baicalin. (FR2977490A1)."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Salehi, B., Albayrak, S., Antolak, H., Kregiel, D., Pawlikowska, E., Sharifi-Rad, M., Uprety, Y., Tsouh Fokou, P.V., Yousef, Z., and Amiruddin Zakaria, Z. (2018). Aloe Genus Plants: From Farm to Food Applications and Phytopharmacotherapy. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092843"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1039\/c5pp00409h","article-title":"Mechanism of Aloe Vera extract protection against UVA: Shelter of lysosomal membrane avoids photodamage","volume":"15","author":"Rodrigues","year":"2016","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_99","first-page":"22","article-title":"From aloe vera gel to stabilized vitamin C","volume":"118","author":"Fox","year":"2003","journal-title":"Cosmet. Toiletries"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s11306-015-0783-x","article-title":"Topical application of baby-and adult-aloe on ultraviolet B irradiated mouse skin with metabolite profiling","volume":"11","author":"Park","year":"2015","journal-title":"Metabolomics"},{"key":"ref_101","first-page":"666","article-title":"Structural changes in lipid membranes and collagen irradiated with UV light and the protective effect of plant extracts","volume":"49","author":"Yurin","year":"2004","journal-title":"Biofizika"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Lee, H., Choi, W., Ro, H., Kim, G., and Lee, H. (2021). Skin Antiaging Effects of the Fermented Outer Layers of Leaf Skin of Aloe barbadensis Miller Associated with the Enhancement of Mitochondrial Activities of UVb-Irradiated Human Skin Fibroblasts. Appl. Sci., 11.","DOI":"10.3390\/app11125660"},{"key":"ref_103","first-page":"265","article-title":"Plant saccharides and the prevention of sun-induced skin cancer","volume":"38","author":"Strickland","year":"2004","journal-title":"Med. Aromat. Plants Ind. Profiles"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"20876","DOI":"10.1007\/s11356-020-08543-4","article-title":"Exploring the photo protective potential of solid lipid nanoparticle-based sunscreen cream containing Aloe vera","volume":"27","author":"Rodrigues","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Savva, S.C., and Kafatos, A. (2016). Vegetable Oils: Dietary Importance. Encyclopedia of Food and Health, Elsevier.","DOI":"10.1016\/B978-0-12-384947-2.00709-1"},{"key":"ref_106","first-page":"65","article-title":"Antioxidant activities of de-fat coconut endocarp peptide","volume":"29","author":"Zhang","year":"2014","journal-title":"Zhongguo Liangyou Xuebao"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1002\/fsn3.1191","article-title":"Coconut (Cocos nucifera L.) sap as a potential source of sugar: Antioxidant and nutritional properties","volume":"8","author":"Asghar","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.foodchem.2007.08.083","article-title":"The antioxidant and antimicrobial properties of the methanolic extract from Cocos nucifera mesocarp","volume":"107","author":"Chakraborty","year":"2007","journal-title":"Food Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/0974-8490.60586","article-title":"In vitro sun protection factor determination of herbal oils used in cosmetics","volume":"2","author":"Kaur","year":"2010","journal-title":"Pharmacogn. Res."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Widiyati, E. (2017). Determination of ultraviolet filter activity on coconut oil cosmetic cream. 4th International Conference on Research, Implementation, and Education of Mathematics and Science (4TH ICRIEMS): Research and Education for Developing Scientific Attitude in Sciences And Mathematics, AIP Publishing.","DOI":"10.1063\/1.4995090"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"113246","DOI":"10.1016\/j.indcrop.2021.113246","article-title":"Photoprotective and antiglycation activities of non-toxic Cocos nucifera Linn. (Arecaceae) husk fiber ethanol extract and its phenol chemical composition","volume":"162","author":"Oliveira","year":"2021","journal-title":"Ind. Crops Prod."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1002\/fsn3.741","article-title":"Antioxidant and alpha-amylase inhibitory potentials of Cocos nucifera husk","volume":"6","author":"Muritala","year":"2018","journal-title":"Food Sci. Nutr."},{"key":"ref_113","first-page":"50","article-title":"Dermatologic Applications of Polypodium leucotomos: A Literature Review","volume":"14","author":"Segars","year":"2021","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s40257-015-0113-0","article-title":"Polypodium leucotomos: A potential new photoprotective agent","volume":"16","author":"Bhatia","year":"2015","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_115","first-page":"224","article-title":"Polypodium leucotomos\u2014An overview of basic investigative findings","volume":"15","author":"Berman","year":"2016","journal-title":"J. Drugs Dermatol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.clindermatol.2018.03.014","article-title":"Herbal sun protection agents: Human studies","volume":"36","author":"Rabinovich","year":"2018","journal-title":"Clin. Dermatol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/ijd.12611","article-title":"Sun protection in a pill: The photoprotective properties of Polypodium leucotomos extract","volume":"54","author":"Goldstein","year":"2015","journal-title":"Int. J. Dermatol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-0781.1996.tb00175.x","article-title":"Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by Polypodium leucotomos","volume":"12","author":"Gonzalez","year":"1996","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1600-0625.2007.00603.x","article-title":"A Polypodium leucotomos extract inhibits solar-simulated radiation-induced TNF-alpha and iNOS expression, transcriptional activation and apoptosis","volume":"16","author":"Janczyk","year":"2007","journal-title":"Exp. Dermatol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"336","DOI":"10.5897\/JMPR2018.6651","article-title":"Comparison of several hydrophilic extracts of Polypodium leucotomos reveals different antioxidant moieties and photoprotective effects in vitro","volume":"12","author":"Gonzalez","year":"2018","journal-title":"J. Med. Plants Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1007\/s10811-016-0883-7","article-title":"The pigments of kelps (Ochrophyta) as part of the flexible response to highly variable marine environments","volume":"28","author":"Fernandes","year":"2016","journal-title":"J. Appl. Phycol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2174\/0929867323666161028160416","article-title":"Algae Polysaccharides\u2019 Chemical Characterization and their Role in the Inflammatory Process","volume":"24","author":"Florez","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s10811-019-01958-8","article-title":"Environmentally friendly processing of Laminaria ochroleuca for soft food applications with bioactive properties","volume":"32","author":"Fradinho","year":"2020","journal-title":"J. Appl. Phycol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jpba.2018.09.057","article-title":"Application of pressurized liquid extraction (PLE) to obtain bioactive fatty acids and phenols from Laminaria ochroleuca collected in Galicia (NW Spain)","volume":"164","author":"Otero","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/S0031-9422(00)83820-0","article-title":"Phlorotannins of phaeophycea Laminaria ochroleuca","volume":"19","author":"Koch","year":"1980","journal-title":"Phytochemistry"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Choi, A., and Ben-Nissan, B. (2019). Brown Algal Polyphenol and Its Pharmaceutical Properties. Marine-Derived Biomaterials for Tissue Engineering Applications, Springer.","DOI":"10.1007\/978-981-13-8855-2"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.3390\/md11114594","article-title":"Bioprospecting Marine Plankton","volume":"11","author":"Abida","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Hylander, S. (2020). Mycosporine-Like Amino Acids (MAAs) in Zooplankton. Mar. Drugs, 18.","DOI":"10.3390\/md18020072"},{"key":"ref_129","first-page":"5512","article-title":"Mycosporine-Like Amino Acids for Skin Photoprotection","volume":"25","author":"Karl","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Rosic, N.N. (2019). Mycosporine-Like Amino Acids: Making the Foundation for Organic Personalised Sunscreens. Mar. Drugs, 17.","DOI":"10.3390\/md17110638"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0305-0491(81)90061-4","article-title":"Antioxidant activity of neuston and plankton extracts from vostok bay, sea of Japan","volume":"70","author":"Brekhman","year":"1981","journal-title":"Comp. Biochem. Physiol. B"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1271\/bbb.60593","article-title":"Antioxidant Properties of Aqueous Extracts from Red Tide Plankton Cultures","volume":"71","author":"Niwano","year":"2007","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_133","first-page":"e2061","article-title":"Assessment of Streptococcus salivarius sp. thermophiles Antioxidant Efficiency and its Role in Reducing Paracetamol Hepatotoxicity","volume":"17","author":"Riane","year":"2019","journal-title":"Iran J. Biotechnol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"131","DOI":"10.7813\/2075-4124.2012\/4-6\/A.19","article-title":"Antioxidant activity and biological evaluations of probiotic bacteria strains","volume":"4","author":"Afify","year":"2012","journal-title":"Int. J. Acad. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10620-010-1307-1","article-title":"Antioxidant properties of probiotics and their protective effects in the pathogenesis of radiation-induced Enteritis and Colitis","volume":"56","author":"Spyropoulos","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00253-012-4241-7","article-title":"Antioxidant properties of potentially probiotic bacteria: In vitro and in vivo activities","volume":"97","author":"Amaretti","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_137","unstructured":"Reinhart, G., and Traudt, M. (2013). Probiotic\/Antioxidant Synergistic Blend Applicable in Skin Inflammation. (WO2013137899A1)."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s12257-008-0113-5","article-title":"Prospective of the cosmeceuticals derived from marine organisms","volume":"13","author":"Kim","year":"2008","journal-title":"Biotechnol. Bioprocess Eng."},{"key":"ref_139","unstructured":"Mondon, P., Ringenbach, C., Marchand, T., and Ursulet, C. (2017). Thermus Thermophilus Fermentation Medium for Use in Prevention and Treatment of Infra-Red Related Skin Damages. (EP2986305B1)."},{"key":"ref_140","unstructured":"(2021, August 23). Venuceane\u2122. Available online: https:\/\/cosmetics.specialchem.com\/product\/i-croda-venuceane."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Farage, M.A., Miller, K.W., and Maibach, H.I. (2016). Topical Peptides and Proteins for Aging Skin. Textbook of Aging Skin, Springer.","DOI":"10.1007\/978-3-642-27814-3"},{"key":"ref_142","first-page":"415","article-title":"Hsp70 induction by Artemia extract exhibits anti-inflammatory effect and down-regulates IL-1 and IL-8 synthesis in human hacat cells","volume":"117","author":"Bauza","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3389\/fmars.2017.00221","article-title":"Skin protective effects of Nannochloropsis gaditana extract on H2O2-stressed human dermal fibroblasts","volume":"4","author":"Letsiou","year":"2017","journal-title":"Front. Mar. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Mourelle, M.L., G\u00f3mez, C.P., and Legido, J.L. (2017). The Potential Use of Marine Microalgae and Cyanobacteria in Cosmetics and Thalassotherapy. Cosmetics, 4.","DOI":"10.3390\/cosmetics4040046"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.bbabio.2017.05.003","article-title":"Photoprotection strategies of the alga Nannochloropsis gaditana","volume":"1858","author":"Chukhutsina","year":"2017","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.bbabio.2014.03.014","article-title":"Photoprotective sites in the violaxanthin-chlorophyll a binding Protein (VCP) from Nannochloropsis gaditana","volume":"1837","author":"Carbonera","year":"2014","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"ref_147","unstructured":"Koutsianas, N., Letsiou, S., Gardikis, K., and Dragani, P. (2017). A Combination of a Nannochloropsis Gaditana Extract and a Propolis Extract as Active Component in Cosmetic Formulations for Dermal Use. (WO2017216588A1)."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ijbiomac.2018.07.171","article-title":"Antioxidant, antibacterial and in vivo wound healing properties of laminaran purified from Cystoseira barbata seaweed","volume":"119","author":"Sellimi","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Agregan, R., Munekata, P.E.S., Franco, D., Carballo, J., Barba, F.J., and Lorenzo, J.M. (2018). Antioxidant potential of extracts obtained from macro- (Ascophyllum nodosum, Fucus vesiculosus and Bifurcaria bifurcata) and micro-algae (Chlorella vulgaris and Spirulina platensis) assisted by ultrasound. Medicines, 5.","DOI":"10.3390\/medicines5020033"},{"key":"ref_150","unstructured":"Sineiro Torres, J., Sanchez Guerrero, M., and Nunez Garcia, M.J. (2014). Antioxidant Extracts from Brown Macroalgae. (ES2441469A1)."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.foodres.2014.08.035","article-title":"Chemical composition, antioxidant activity and sensory evaluation of five different species of brown edible seaweeds","volume":"66","author":"Peinado","year":"2014","journal-title":"Food Res. Int."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.foodhyd.2013.10.021","article-title":"Antioxidant film development from unrefined extracts of brown seaweeds Laminaria digitata and Ascophyllum nodosum","volume":"37","author":"Montero","year":"2014","journal-title":"Food Hydrocoll."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ijbiomac.2013.04.035","article-title":"In vitro antioxidant activities of sulfated polysaccharide ascophyllan isolated from Ascophyllum nodosum","volume":"59","author":"Abu","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1007\/s12010-012-9761-1","article-title":"Antioxidant, Anti-inflammatory, and Anti-senescence Activities of a Phlorotannin-Rich Natural Extract from Brown Seaweed Ascophyllum nodosum","volume":"167","author":"Dutot","year":"2012","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_155","unstructured":"Bourges, C., and Pauquai, T. (2012). Antioxidant Composition Containing Extracts of Nettles, Ascophyllum, and Acerola, and Vitamin C. (FR2964875A1)."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2478\/s11696-010-0024-8","article-title":"Antioxidant, antimicrobial, and tyrosinase inhibition activities of acetone extract of Ascophyllum nodosum","volume":"64","author":"Jimenez","year":"2010","journal-title":"Chem. Pap."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jembe.2007.05.028","article-title":"Influence of day-night and tidal cycles on phenol content and antioxidant capacity in three temperate intertidal brown seaweeds","volume":"349","author":"Connan","year":"2007","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1023\/A:1008007313731","article-title":"Antioxidant and pro-oxidant activities of the brown algae, Laminaria digitata, Himanthalia elongata, Fucus vesiculosus, Fucus serratus and Ascophyllum nodosum","volume":"10","author":"Benslimane","year":"1998","journal-title":"J. Appl. Phycol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Ferreira, M.S., Resende, D.I.S.P., Lobo, J.M.S., Sousa, E., and Almeida, I.F. (2021). Marine Ingredients for Sensitive Skin: Market Overview. Mar. Drugs, 19.","DOI":"10.3390\/md19080464"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jphotobiol.2017.05.042","article-title":"Protective effect of Arthrospira platensis extracts against ultraviolet B-induced cellular senescence through inhibition of DNA damage and matrix metalloproteinase-1 expression in human dermal fibroblasts","volume":"173","author":"Lee","year":"2017","journal-title":"J. Photochem. Photobiol. B: Biol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.sajb.2020.01.001","article-title":"Photochemoprotective effects of Spirulina platensis extract against UVB irradiated human skin fibroblasts","volume":"130","author":"Mapoung","year":"2020","journal-title":"S. Afr. J. Bot."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1749-7345.2008.00199.x","article-title":"Accumulation of Mycosporine-like Amino Acids in Asparagopsis armata Grown in Tanks with Fishpond Effluents of Gilthead Sea Bream, Sparus aurata","volume":"39","author":"Figueroa","year":"2008","journal-title":"J. World Aquac. Soc."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1034\/j.1600-0625.12.s2.3.x","article-title":"Photoaging and oxidative stress","volume":"12","author":"Nishigori","year":"2003","journal-title":"Exp. Dermatol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1749-6632.2002.tb04602.x","article-title":"Ultraviolet-B Irradiation and Matrix Metalloproteinases","volume":"973","author":"Brenneisen","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/jidsymp.2008.3","article-title":"Skin Immune Systems and Inflammation: Protector of the Skin or Promoter of Aging?","volume":"13","author":"Bennett","year":"2008","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.mrfmmm.2004.06.059","article-title":"Mechanisms underlying UV-induced immune suppression","volume":"571","author":"Ullrich","year":"2005","journal-title":"Mutat Res."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Farage, M.A., Miller, K.W., and Maibach, H.I. (2010). DNA Damage and Repair in Skin Aging. Textbook of Aging Skin, Springer.","DOI":"10.1007\/978-3-540-89656-2"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1080\/10715760600911154","article-title":"Protein oxidation and degradation during aging: Role in skin aging and neurodegeneration","volume":"40","author":"Widmer","year":"2006","journal-title":"Free Radic. Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3109\/10715762.2014.976213","article-title":"Lipid oxidation in the skin","volume":"49","author":"Niki","year":"2015","journal-title":"Free Rad. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/exd.13076","article-title":"Advanced glycation end products in skin ageing and photoageing: What are the implications for epidermal function?","volume":"25","author":"Farrar","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00018-009-8703-8","article-title":"Cellular mechanisms regulating human melanogenesis","volume":"66","author":"Park","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jid.2020.09.031","article-title":"Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging","volume":"141","author":"Fitsiou","year":"2021","journal-title":"J. Investig. Dermatol."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/15\/3\/372\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:39:08Z","timestamp":1760135948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/15\/3\/372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,18]]},"references-count":172,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["ph15030372"],"URL":"https:\/\/doi.org\/10.3390\/ph15030372","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,18]]}}}