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(CNPq)","award":["164779\/2020-5"],"award-info":[{"award-number":["164779\/2020-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Wound healing is known to be a complicated and intricate process and commonly classified as chronic or acute. Patients with chronic wounds are of public health concern, and require more attention onto skin lesions, including atopic dermatitis. Despite being a natural process, healing can be impaired by existing chronic de diseases such as diabetes, for example. Recently, wound dressings based in nanotechnology systems have emerged as a viable option to improve the healing process. Current advances in nanotechnology-based systems to release growth factors and bioactive agents represent a great opportunity to develop new therapies for wound treatments. It is essential that healthcare professionals understand the key processes involved in the healing cascade, to maximize care with these patients and minimize the undesirable outcomes of non-healing wounds. Therefore, this review aims to summarize the healing process phases and provide a general overview of dressings based in nanotechnology using biomaterials for the release of active agents in wound site.<\/jats:p>","DOI":"10.3390\/ph15101286","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T22:19:53Z","timestamp":1666217993000},"page":"1286","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Nanotechnology-Based Dressings for Wound Management"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1929-9474","authenticated-orcid":false,"given":"Jana\u00edna A.","family":"Ataide","sequence":"first","affiliation":[{"name":"School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-888, Brazil"},{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (UC), Coimbra 3000-548, Portugal"}]},{"given":"Beatriz","family":"Zanchetta","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-888, Brazil"}]},{"given":"\u00c9rica M.","family":"Santos","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas 13083-871, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5342-2539","authenticated-orcid":false,"given":"Ana Laura M.","family":"Fava","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-888, Brazil"}]},{"given":"Thais F. R.","family":"Alves","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Nanotechnology, University of Sorocaba (UNISO), Sorocaba 18023-000, Brazil"}]},{"given":"Let\u00edcia C.","family":"Cefali","sequence":"additional","affiliation":[{"name":"Institute of Biology, University of Campinas (UNICAMP), Campinas 13083-862, Brazil"},{"name":"Center for Biological and Health Sciences, Mackenzie Presbyterian University, Sao Paulo 01302-907, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3618-8415","authenticated-orcid":false,"given":"Marco V.","family":"Chaud","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Nanotechnology, University of Sorocaba (UNISO), Sorocaba 18023-000, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4741-8493","authenticated-orcid":false,"given":"Laura","family":"Oliveira-Nascimento","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas 13083-871, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (UC), Coimbra 3000-548, Portugal"},{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal"},{"name":"REQUIMTE\/UCIBIO, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, n\u00ba. 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3795-8189","authenticated-orcid":false,"given":"Priscila G.","family":"Mazzola","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas 13083-871, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"ref_1","first-page":"475","article-title":"The physiology of wound healing","volume":"29","author":"Young","year":"2011","journal-title":"Surgery"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1089\/wound.2013.0506","article-title":"Traditional Therapies for Skin Wound Healing","volume":"5","author":"Pereira","year":"2016","journal-title":"Adv. Wound Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0022034509359125","article-title":"Factors Affecting Wound Healing","volume":"89","author":"Guo","year":"2010","journal-title":"J. Dent. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1053\/nbin.2001.23176","article-title":"Physiology of wound healing","volume":"1","author":"Strodtbeck","year":"2001","journal-title":"Newborn Infant Nurs. Rev."},{"key":"ref_5","first-page":"409","article-title":"Basic science of wound healing","volume":"28","author":"Beldon","year":"2010","journal-title":"Surgery"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.addr.2011.01.005","article-title":"Skin tissue engineering\u2014In vivo and in vitro applications","volume":"63","author":"Groeber","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_7","first-page":"491","article-title":"Wound dressings: Principles and practice","volume":"29","author":"Abdelrahman","year":"2011","journal-title":"Surgery"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"59S","DOI":"10.1097\/01.prs.0000225438.86758.21","article-title":"Using Physiology to Improve Surgical Wound Outcomes","volume":"117","author":"Ueno","year":"2006","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/iwj.12767","article-title":"The financial and quality-of-life cost to patients living with a chronic wound in the community","volume":"14","author":"Kapp","year":"2017","journal-title":"Int. Wound J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jddst.2017.03.002","article-title":"Nanotechnology-based delivery systems to release growth factors and other endogenous molecules for chronic wound healing","volume":"42","author":"Pedraz","year":"2017","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1016\/j.matpr.2017.06.178","article-title":"Albumin-natural rubber latex composite as a dermal wound dressing","volume":"4","author":"Wattanakaroon","year":"2017","journal-title":"Mater. Today Proc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"18031","DOI":"10.1038\/s41598-017-18271-4","article-title":"Bacterial Nanocellulose Loaded with Bromelain: Assessment of Antimicrobial, Antioxidant and Physical-Chemical Properties","volume":"7","author":"Ataide","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ejpb.2018.02.022","article-title":"Recent advances on antimicrobial wound dressing: A review","volume":"127","author":"Miguel","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.mtchem.2017.02.007","article-title":"Bioactive peptides grafted silicone dressings: A simple and specific method","volume":"4","author":"Pinese","year":"2017","journal-title":"Mater. Today Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5154","DOI":"10.3390\/ma8085154","article-title":"Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds","volume":"8","author":"Andreu","year":"2015","journal-title":"Materials"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.proeng.2017.03.006","article-title":"Polyvinyl Alcohol\/Soursop Leaves Extract Composite Nanofibers Synthesized Using Electrospinning Technique and their Potential as Antibacterial Wound Dressing","volume":"170","author":"Aruan","year":"2017","journal-title":"Procedia Eng."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ijpharm.2016.11.006","article-title":"Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications","volume":"523","author":"Gainza","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijbiomac.2015.10.087","article-title":"Composite wound dressings of pectin and gelatin with aloe vera and curcumin as bioactive agents","volume":"82","author":"Tummalapalli","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jddst.2018.01.009","article-title":"A review on nanoparticle based treatment for wound healing","volume":"44","author":"Rajendran","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Stoica, A.E., Chircov, C., and Grumezescu, A.M. (2020). Nanomaterials for Wound Dressings: An Up-to-Date Overview. Molecules, 25.","DOI":"10.3390\/molecules25112699"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.2217\/nnm.15.82","article-title":"Nanomaterials for wound healing: Scope and advancement","volume":"10","author":"Kalashnikova","year":"2015","journal-title":"Nanomedicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.msec.2017.03.226","article-title":"Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives","volume":"77","author":"Hussain","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_23","first-page":"1","article-title":"Nanoparticle Based Combination Treatments for Targeting Multiple Hallmarks of Cancer","volume":"S4","author":"VanDyke","year":"2016","journal-title":"Int. J. Nano Stud. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/archderm.1994.01690040093015","article-title":"Definitions and guidelines for assessment of wounds and evaluation of healing","volume":"130","author":"Lazarus","year":"1994","journal-title":"Arch. Dermatol."},{"key":"ref_25","first-page":"83","article-title":"Models for use in wound healing research: A survey focusing on in vitro and in vivo adult soft tissue","volume":"8","author":"Gottrup","year":"2000","journal-title":"Wound Repair Regen. Off. Publ. Wound Heal. Soc. Eur. Tissue Repair Soc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.276.5309.75","article-title":"Wound healing\u2014Aiming for perfect skin regeneration","volume":"276","author":"Martin","year":"1997","journal-title":"Science"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jep.2009.01.022","article-title":"Biological studies on Brazilian plants used in wound healing","volume":"122","author":"Schmidt","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound Repair and Regeneration","volume":"49","author":"Reinke","year":"2012","journal-title":"Eur. Surg. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jaad.2007.08.048","article-title":"Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings","volume":"58","author":"Fonder","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jep.2007.08.010","article-title":"Ethnopharmacological approaches to wound healing\u2014Exploring medicinal plants of India","volume":"114","author":"Kumar","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jaad.2015.08.068","article-title":"Wound healing and treating wounds: Differential diagnosis and evaluation of chronic wounds","volume":"74","author":"Morton","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.lfs.2017.02.015","article-title":"Effects of insulin on wound healing: A review of animal and human evidences","volume":"174","author":"Oryan","year":"2017","journal-title":"Life Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1383\/medc.32.12.4.55399","article-title":"Wound healing","volume":"32","author":"Williamson","year":"2004","journal-title":"Medicine"},{"key":"ref_35","unstructured":"Bryant, R.A., and Nix, D.P. (2016). Acute and Chronic Wounds: Current Management Concepts, Mosby. [5th ed.]."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/0005-2795(75)90106-3","article-title":"Characterization of the collagen of human hypertrophic and normal scars","volume":"405","author":"Bailey","year":"1975","journal-title":"Biochim. Biophys. Acta-Protein Struct."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0039-6109(16)40983-7","article-title":"Wound healing","volume":"56","author":"Schilling","year":"1976","journal-title":"Surg. Clin. N. Am."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00000658-196502000-00019","article-title":"Healing of Rat Skin Wounds","volume":"161","author":"Levenson","year":"1965","journal-title":"Ann. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1007\/s00018-016-2268-0","article-title":"Transition from inflammation to proliferation: A critical step during wound healing","volume":"73","author":"Li","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1067\/msg.2001.111167","article-title":"Wound healing: Biologic features and approaches to maximize healing trajectories","volume":"38","author":"Robson","year":"2001","journal-title":"Curr. Probl. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","article-title":"Regulation of Wound Healing by Growth Factors and Cytokines","volume":"83","author":"Werner","year":"2003","journal-title":"Physiol. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/wound.2015.0635","article-title":"Challenges in the Treatment of Chronic Wounds","volume":"4","author":"Frykberg","year":"2015","journal-title":"Adv. Wound Care"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.actbio.2017.04.034","article-title":"Preparation and in vivo evaluation of cationic elastic liposomes comprising highly skin-permeable growth factors combined with hyaluronic acid for enhanced diabetic wound-healing therapy","volume":"57","author":"Choi","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/193293a0","article-title":"Formation of the Scab and the Rate of Epithelization of Superficial Wounds in the Skin of the Young Domestic Pig","volume":"193","author":"Winter","year":"1962","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0029-6465(22)00232-8","article-title":"Optimizing wound healing. A practice within nursing\u2019s domain","volume":"25","author":"Cooper","year":"1990","journal-title":"Nurs. Clin. N. Am."},{"key":"ref_46","first-page":"53","article-title":"Wound care. Trial & error yields to knowledge","volume":"90","author":"Cuzzell","year":"1990","journal-title":"Am. J. Nurs."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/197091b0","article-title":"Effect of Air Drying and Dressings on the Surface of a Wound","volume":"197","author":"Winter","year":"1963","journal-title":"Nature"},{"key":"ref_48","first-page":"67","article-title":"Topical chemotherapy for the treatment of burns","volume":"28","year":"2005","journal-title":"Rev. Enferm."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1002\/jps.21210","article-title":"Wound healing dressings and drug delivery systems: A review","volume":"97","author":"Boateng","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"22","DOI":"10.7603\/s40681-015-0022-9","article-title":"Wound dressings\u2014A review","volume":"5","author":"Dhivya","year":"2015","journal-title":"BioMedicine"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1046\/j.1445-2197.2004.02916.x","article-title":"Cytotoxicity of topical antimicrobial agents used in burn wounds in Australasia","volume":"74","author":"Fraser","year":"2004","journal-title":"ANZ J. Surg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.burns.2006.06.010","article-title":"Effect of silver on burn wound infection control and healing: Review of the literature","volume":"33","author":"Atiyeh","year":"2007","journal-title":"Burns"},{"key":"ref_53","first-page":"489","article-title":"Wound dressings: Principles and practice","volume":"35","author":"Vowden","year":"2017","journal-title":"Surgery"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.biotechadv.2011.01.005","article-title":"Biomaterials based on chitin and chitosan in wound dressing applications","volume":"29","author":"Jayakumar","year":"2011","journal-title":"Biotechnol. Adv."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/mabi.201300561","article-title":"Electrospun Nanofibers as Dressings for Chronic Wound Care: Advances, Challenges, and Future Prospects","volume":"14","author":"Abrigo","year":"2014","journal-title":"Macromol. Biosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.carbpol.2016.11.040","article-title":"Spongy bilayer dressing composed of chitosan\u2013Ag nanoparticles and chitosan\u2013Bletilla striata polysaccharide for wound healing applications","volume":"157","author":"Ding","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"24","DOI":"10.7547\/87507315-92-1-24","article-title":"Dressing selection in chronic wound management","volume":"92","author":"Seaman","year":"2002","journal-title":"J. Am. Podiatr. Med. Assoc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10561-017-9621-x","article-title":"Cytotoxicity testing of burn wound dressings: First results","volume":"18","author":"Koller","year":"2017","journal-title":"Cell Tissue Bank."},{"key":"ref_59","first-page":"379","article-title":"Recent advances in topical wound care","volume":"45","author":"Sarabahi","year":"2012","journal-title":"Indian J. Plast. Surg. Off. Publ. Assoc. Plast. Surg. India"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ijpharm.2015.05.058","article-title":"Mechanical properties and in vivo healing evaluation of a novel Centella asiatica-loaded hydrocolloid wound dressing","volume":"490","author":"Jin","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jare.2017.01.005","article-title":"A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings","volume":"8","author":"Kamoun","year":"2017","journal-title":"J. Adv. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.omtn.2017.06.003","article-title":"MicroRNA as Therapeutic Targets for Chronic Wound Healing","volume":"8","author":"Mulholland","year":"2017","journal-title":"Mol. Ther.-Nucleic Acids"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3109\/1061186X.2014.992899","article-title":"Biomaterials-based nanofiber scaffold: Targeted and controlled carrier for cell and drug delivery","volume":"23","author":"Garg","year":"2015","journal-title":"J. Drug Target."},{"key":"ref_64","first-page":"27","article-title":"Chitosan Based Scaffolds and Their Applications in Wound Healing","volume":"10","author":"Ahmed","year":"2016","journal-title":"Achiev. Life Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.wndm.2017.07.002","article-title":"Natural and bio polymer curative films for wound dressing medical applications","volume":"18","author":"Ganesan","year":"2017","journal-title":"Wound Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.msec.2016.07.029","article-title":"Development of hydrocolloid Bi-layer dressing with bio-adhesive and non-adhesive properties","volume":"69","author":"Khan","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.enzmictec.2016.04.004","article-title":"Enzymatic modification of polysaccharides: Mechanisms, properties, and potential applications: A review","volume":"90","author":"Karaki","year":"2016","journal-title":"Enzym. Microb. Technol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.ijbiomac.2016.08.011","article-title":"Radiation formation of functionalized polysaccharide-protein based skin mimicking semi- inter penetrating network for biomedical application","volume":"92","author":"Singh","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jddst.2015.11.005","article-title":"Tailored-interpenetrating polymer network beads of \u03ba-carrageenan and sodium carboxymethyl cellulose for controlled drug delivery","volume":"31","author":"Lohani","year":"2016","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijpharm.2013.12.015","article-title":"Natural and synthetic polymers for wounds and burns dressing","volume":"463","author":"Grumezescu","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jmbbm.2016.09.008","article-title":"Physico-mechanical, morphological and biomedical properties of a novel natural wound dressing material","volume":"65","author":"Tavakoli","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.radphyschem.2016.02.003","article-title":"Hemostatic efficacy evaluation of radiation crosslinked carboxymethyl kappa-carrageenan and chitosan with varying degrees of substitution","volume":"124","author":"Barba","year":"2016","journal-title":"Radiat. Phys. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijbiomac.2016.11.095","article-title":"A review on synthesis, properties and applications of natural polymer based carrageenan blends and composites","volume":"96","author":"Zia","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.18520\/cs\/v111\/i4\/641-647","article-title":"Advanced trends in treatment of wounds","volume":"111","author":"Miranda","year":"2016","journal-title":"Curr. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.msec.2012.01.021","article-title":"Poly(3-hydroxyalkanoate)s: Diversification and biomedical applications: A state of the art review","volume":"32","author":"Hazer","year":"2012","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s40257-013-0046-4","article-title":"Wound Dressings: Selecting the Most Appropriate Type","volume":"14","author":"Broussard","year":"2013","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1002\/jps.24610","article-title":"Advanced Therapeutic Dressings for Effective Wound Healing\u2014A Review","volume":"104","author":"Boateng","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"ref_78","first-page":"21","article-title":"A review of the applications of the hydrofiber dressing with silver (Aquacel Ag) in wound care","volume":"6","author":"Barnea","year":"2010","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1021\/acsabm.2c00035","article-title":"Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing","volume":"5","author":"Kaur","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Bianchera, A., Catanzano, O., Boateng, J., and Elviri, L. (2020). The place of biomaterials in wound healing. Therapeutic Dressings and Wound Healing Applications, Wiley.","DOI":"10.1002\/9781119433316.ch15"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1080\/09205063.2022.2088528","article-title":"Polymeric biomaterials for wound healing applications: A comprehensive review","volume":"33","author":"Ijaola","year":"2022","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijbiomac.2015.07.037","article-title":"Development and functional characterization of alginate dressing as potential protein delivery system for wound healing","volume":"81","author":"Momoh","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10856-020-06370-0","article-title":"Alginate films augmented with chlorhexidine hexametaphosphate particles provide sustained antimicrobial properties for application in wound care","volume":"31","author":"Duckworth","year":"2020","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.actbio.2019.12.032","article-title":"A hydrogen sulfide-releasing alginate dressing for effective wound healing","volume":"104","author":"Zhao","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"121999","DOI":"10.1016\/j.cej.2019.121999","article-title":"Electroactive anti-oxidant polyurethane elastomers with shape memory property as non-adherent wound dressing to enhance wound healing","volume":"375","author":"Li","year":"2019","journal-title":"Chem. Eng. J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.msec.2016.10.019","article-title":"Rapid hemostatic and mild polyurethane-urea foam wound dressing for promoting wound healing","volume":"71","author":"Liu","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.eurpolymj.2018.05.016","article-title":"Characterization of PNIPAAm-co-AAm hydrogels for modified release of bromelain","volume":"105","author":"Croisfelt","year":"2018","journal-title":"Eur. Polym. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijpharm.2015.12.007","article-title":"Development of a novel sodium fusidate-loaded triple polymer hydrogel wound dressing: Mechanical properties and effects on wound repair","volume":"497","author":"Jin","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Nasir, A., Friedman, A., and Wang, S. (2013). Application of nanomedicine in wound healing. Nanotechnology in Dermatology, Springer.","DOI":"10.1007\/978-1-4614-5034-4"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1021\/acscentsci.6b00371","article-title":"Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications","volume":"3","author":"Hamdan","year":"2017","journal-title":"ACS Cent. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/aps.2018.33","article-title":"Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy\u2014An illustration with firsthand examples","volume":"39","author":"Zhang","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.msec.2016.01.069","article-title":"Amelioration of excision wounds by topical application of green synthesized, formulated silver and gold nanoparticles in albino Wistar rats","volume":"62","author":"Naraginti","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/10837450.2021.1898634","article-title":"Silver nanoparticles obtained from Brazilian pepper extracts with synergistic anti-microbial effect: Production, characterization, hydrogel formulation, cell viability, and in vitro efficacy","volume":"26","author":"Menezes","year":"2021","journal-title":"Pharm. Dev. Technol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejps.2017.01.015","article-title":"An in vitro study on the burn wound healing activity of cotton fabrics incorporated with phytosynthesized silver nanoparticles in male Wistar albino rats","volume":"100","author":"Pannerselvam","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1021\/la104825u","article-title":"Size-Dependent Bacterial Growth Inhibition and Mechanism of Antibacterial Activity of Zinc Oxide Nanoparticles","volume":"27","author":"Raghupathi","year":"2011","journal-title":"Langmuir"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.carbpol.2016.11.054","article-title":"Using chitosan nanoparticles as drug carriers for the development of a silver sulfadiazine wound dressing","volume":"158","author":"Sharaf","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"10195","DOI":"10.1038\/s41598-021-89376-0","article-title":"In vitro performance of free and encapsulated bromelain","volume":"11","author":"Ataide","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"102225","DOI":"10.1016\/j.jddst.2020.102225","article-title":"Freeze-dried chitosan nanoparticles to stabilize and deliver bromelain","volume":"61","author":"Ataide","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Ataide, J.A., Gerios, E.F., Cefali, L.C., Fernandes, A.R., Teixeira, M.D.C., Ferreira, N.R., Tambourgi, E.B., Jozala, A.F., Chaud, M.V., and Oliveira-Nascimento, L. (2019). Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain-Chitosan Nanoparticles. Polymers, 11.","DOI":"10.3390\/polym11101681"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.colsurfb.2017.07.029","article-title":"Nanostructured lipid systems modified with waste material of propolis for wound healing: Design, in vitro and in vivo evaluation","volume":"158","author":"Rosseto","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.1007\/s10570-018-2010-1","article-title":"Bacterial nanocellulose membranes combined with nisin: A strategy to prevent microbial growth","volume":"25","author":"Soeiro","year":"2018","journal-title":"Cellulose"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Dos Santos, G.R., Soeiro, V.S., Talarico, C.F., Ataide, J.A., Lopes, A.M., Mazzola, P.G., Oliveira, T.J., Oliveira Junior, J.M., Grotto, D., and Jozala, A.F. (2022). Bacterial Cellulose Membranes as Carriers for Nisin: Incorporation, Antimicrobial Activity, Cytotoxicity and Morphology. Polymers, 14.","DOI":"10.3390\/polym14173497"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4028\/www.scientific.net\/JNanoR.59.46","article-title":"Development and Characterization of Bilayer Wound Healing Patch Nanofiber Fabricated by Electrospinning","volume":"59","author":"Huanbutta","year":"2019","journal-title":"J. Nano Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ajps.2018.01.002","article-title":"Design and characterization of clindamycin-loaded nanofiber patches composed of polyvinyl alcohol and tamarind seed gum and fabricated by electrohydrodynamic atomization","volume":"13","author":"Sangnim","year":"2018","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Diniz, F.R., Maia, R.C.A.P., Rannier Andrade, L., Andrade, L.N., Vinicius Chaud, M., da Silva, C.F., Corr\u00eaa, C.B., de Albuquerque Junior, R.L.C., Pereira da Costa, L., and Shin, S.R. (2020). Silver Nanoparticles-Composing Alginate\/Gelatine Hydrogel Improves Wound Healing In Vivo. Nanomaterials, 10.","DOI":"10.3390\/nano10020390"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1021\/am300292v","article-title":"Flexible and Microporous Chitosan Hydrogel\/Nano ZnO Composite Bandages for Wound Dressing: In Vitro and In Vivo Evaluation","volume":"4","author":"Kumar","year":"2012","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11095-012-0898-y","article-title":"Evaluation of Wound Healing Potential of \u03b2-Chitin Hydrogel\/Nano Zinc Oxide Composite Bandage","volume":"30","author":"Kumar","year":"2013","journal-title":"Pharm. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.carbpol.2018.12.021","article-title":"Design and optimization of process parameters of polyvinyl (alcohol)\/chitosan\/nano zinc oxide hydrogels as wound healing materials","volume":"207","author":"Khorasani","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.carbpol.2017.01.061","article-title":"Bacterial cellulose-zinc oxide nanocomposites as a novel dressing system for burn wounds","volume":"164","author":"Khalid","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.carbpol.2007.07.025","article-title":"Impregnation of silver nanoparticles into bacterial cellulose for antimicrobial wound dressing","volume":"72","author":"Maneerung","year":"2008","journal-title":"Carbohydr. Polym."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10965-013-0347-6","article-title":"Electrospun polycaprolactone\/ZnO nanocomposite membranes as biomaterials with antibacterial and cell adhesion properties","volume":"21","author":"Augustine","year":"2014","journal-title":"J. Polym. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.biomaterials.2017.05.043","article-title":"Bio-inspired crosslinking and matrix-drug interactions for advanced wound dressings with long-term antimicrobial activity","volume":"138","author":"Dhand","year":"2017","journal-title":"Biomaterials"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Sanchez-Lopez, E., Gomes, D., Esteruelas, G., Bonilla, L., Lopez-Machado, A.L., Galindo, R., Cano, A., Espina, M., Ettcheto, M., and Camins, A. (2020). Metal-Based Nanoparticles as Antimicrobial Agents: An Overview. Nanomaterials, 10.","DOI":"10.3390\/nano10020292"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"7861","DOI":"10.1039\/c2nr32369a","article-title":"Zinc oxide nanoflowers make new blood vessels","volume":"4","author":"Barui","year":"2012","journal-title":"Nanoscale"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1039\/C7TB00664K","article-title":"ZnO nanoparticles as an antimicrobial tissue adhesive for skin wound closure","volume":"5","author":"Gao","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Souto, E.B., Macedo, A.S., Dias-Ferreira, J., Cano, A., Zielinska, A., and Matos, C.M. (2021). Elastic and Ultradeformable Liposomes for Transdermal Delivery of Active Pharmaceutical Ingredients (APIs). Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189743"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/10837450.2019.1647235","article-title":"Key production parameters for the development of solid lipid nanoparticles by high shear homogenization","volume":"24","author":"Souto","year":"2019","journal-title":"Pharm. Dev. Technol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejpb.2016.08.001","article-title":"Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation","volume":"108","author":"Doktorovova","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2014.02.005","article-title":"Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers\u2014A systematic review of in vitro data","volume":"87","author":"Doktorovova","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.xphs.2016.10.001","article-title":"Recent Advances in Lipid-Based Vesicles and Particulate Carriers for Topical and Transdermal Application","volume":"106","author":"Jain","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1164\/rccm.200504-613PP","article-title":"The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis","volume":"172","author":"Gelperina","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jcis.2017.05.038","article-title":"Effect of binary solid lipid matrix of wax and triglyceride on lipid crystallinity, drug-lipid interaction and drug release of ibuprofen-loaded solid lipid nanoparticles (SLN) for dermal delivery","volume":"504","author":"Chantaburanan","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"ref_123","first-page":"275","article-title":"Cyproterone acetate-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): Preparation and optimization","volume":"3","author":"Ghasemiyeh","year":"2017","journal-title":"Trends Pharm. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.2147\/DDDT.S264648","article-title":"Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages","volume":"14","author":"Ghasemiyeh","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/jps.24699","article-title":"Synergistic skin penetration enhancer and nanoemulsion formulations promote the human epidermal permeation of caffeine and naproxen","volume":"105","author":"Abd","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1211\/jpp.58.4.0001","article-title":"Can drug-bearing liposomes penetrate intact skin?","volume":"58","author":"Maghraby","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000086666","article-title":"Liposomes and niosomes as topical drug delivery systems","volume":"18","author":"Choi","year":"2005","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.apsusc.2014.10.074","article-title":"Functionalized hybrid nanofibers to mimic native ECM for tissue engineering applications","volume":"322","author":"Karuppuswamy","year":"2014","journal-title":"Appl. Surf. Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.msec.2014.08.018","article-title":"Biologically improved nanofibrous scaffolds for cardiac tissue engineering","volume":"44","author":"Bhaarathy","year":"2014","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijbiomac.2014.04.031","article-title":"Naturally derived biofunctional nanofibrous scaffold for skin tissue regeneration","volume":"68","author":"Suganya","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1007\/s00253-015-7243-4","article-title":"Bacterial nanocellulose production and application: A 10-year overview","volume":"100","author":"Jozala","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.biomaterials.2006.06.013","article-title":"Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization","volume":"28","author":"Woo","year":"2007","journal-title":"Biomaterials"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3389\/fphys.2016.00341","article-title":"Engineered biopolymeric scaffolds for chronic wound healing","volume":"7","author":"Dickinson","year":"2016","journal-title":"Front. Physiol."},{"key":"ref_134","first-page":"417","article-title":"Properties, engineering and applications of polymeric nanofibers: Current research and future advances","volume":"26","author":"Pelipenko","year":"2012","journal-title":"Chem. Biochem. Eng. Q."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1016\/j.biomaterials.2004.10.007","article-title":"Electrospun nano-to microfiber fabrics made of biodegradable copolyesters: Structural characteristics, mechanical properties and cell adhesion potential","volume":"26","author":"Kwon","year":"2005","journal-title":"Biomaterials"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/ten.2005.11.101","article-title":"Potential of nanofiber matrix as tissue-engineering scaffolds","volume":"11","author":"Ma","year":"2005","journal-title":"Tissue Eng."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/jbm.b.30475","article-title":"Wear and fatigue behavior of nano-structured dental resin composites","volume":"78","author":"Turssi","year":"2006","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2341\/06-9","article-title":"Surface texture of four nanofilled and one hybrid composite after finishing","volume":"32","author":"Jung","year":"2007","journal-title":"Oper. Dent."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2341\/07-107","article-title":"Color stability of nanocomposites polished with one-step systems","volume":"33","author":"Aladag","year":"2008","journal-title":"Oper. Dent."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jconrel.2017.03.392","article-title":"Protein-lipid nanohybrids as emerging platforms for drug and gene delivery: Challenges and outcomes","volume":"254","author":"Gaber","year":"2017","journal-title":"J. Control. 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